Ariel K. Frame
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arielframe.bsky.social
Ariel K. Frame
@arielframe.bsky.social
1.2K followers 370 following 77 posts
BSc Biology || PhD Neuroscience || Postdoc with Andrew Lin @andrewclin.bsky.social at University of Sheffield @sheffielduni.bsky.social || Drosophila, aging, learning and memory, neurobiology. Host: linktr.ee/quitecurious bit.ly/ArielFrame_GoogleScholar
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arielframe.bsky.social
Ariel K. Frame @arielframe.bsky.social · Sep 4
First episode is out! I spoke with Professor James Marshall @sheffielduni.bsky.social @opteran.bsky.social about his research on modelling the #brain of #bees and implications for #ai . Take a listen! #neuroscience #sciencecommunication
Reposted by Ariel K. Frame
nature.com
Encased in a blanket of blubber that is nearly half a metre thick, the 80,000-kilogram bowhead whale does not, at first glance, seem a natural poster child for health and longevity

go.nature.com/4qTyrcz
This whale lives for centuries: its secret could help extend human lifespan
Nature - A cold-activated protein that mends damaged DNA could play a part in keeping the bowhead whale in tip-top shape.
go.nature.com
November 1, 2025 at 2:28 PM
Reposted by Ariel K. Frame
nature.com
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government

go.nature.com/47hn0n5
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
go.nature.com
November 1, 2025 at 5:39 PM
Reposted by Ariel K. Frame
hansonmark.bsky.social
PhD studentshipship available through @swbiodtp.bsky.social! This project will take advantage of an incredible RNAseq dataset we are generating using 40 species and multiple infection types to learn how immune systems evolve.

For more info, see: bit.ly/43zNa20

#Drosophila #Immunity
Advertisement for PhD studentship involving a host-pathogen panel, RNA sequencing, and functional genetics. The aim is to use fly species to learn how immune responses evolve.
October 29, 2025 at 4:08 PM
Reposted by Ariel K. Frame
albertosanzmon1.bsky.social
Two weeks left to apply for a PhD position in my laboratory at #Glasgow.
The project focuses on #Ageing, #Mitochondria, and #Drosophila, with emphasis on Complex I (CI) function.
Fees are fully covered for applicants eligible for UK Home Student status.
www.findaphd.com/phds/project...
FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow, listed on FindAPhD.com
www.findaphd.com
October 31, 2025 at 2:00 PM
Reposted by Ariel K. Frame
mirresimons.bsky.social
New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits.
www.biorxiv.org/content/10.1...
July 18, 2025 at 6:57 PM
Reposted by Ariel K. Frame
jefferis.bsky.social
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 5, 2025 at 3:40 PM
arielframe.bsky.social
This November, I am raising money for prostate #cancer research in Canada @ccsresearch.bsky.social by getting people to pay me to have a goofy looking face. Join in on the Movember fun and support a good cause, join the team or make a donation. Any amount makes a difference!
tiny.cc/MapleMovember
October 4, 2025 at 11:56 PM
arielframe.bsky.social
Fantastic little read! Time to dust off my system 2 thinking and engage in some realistic time budgeting! Educational and informative for #drosophila researchers and actually any experimentalists!
the-node.bsky.social the Node @the-node.bsky.social · Oct 1
The Kahneman Chronicles: Lessons from a Fly Lab

Entertaining post from @sameerthukral.bsky.social kicking of a series imagining what would transpire if Daniel Kahneman—the “grandfather of behavioural economics”—took a sabbatical and worked in a fly lab. 🪰

thenode.biologists.com/the-kahneman...
The Kahneman Chronicles: Lessons from a Fly Lab - the Node
The Kahneman Chronicles #1: When a Nobel Laureate Fixed Our Lab's Scheduling Disasters Daniel Kahneman (1934-2024) was a legendary psychologist who
thenode.biologists.com
October 2, 2025 at 11:20 PM
arielframe.bsky.social
“Even if you don’t think precautionary measures are warranted, it’s still really important for scientists to report what they have and haven’t done to insects in the course of their experiments..-..If you kill an animal in a certain way, that may affect the expression of certain genes.”- Craig Perl
science.org Science Magazine @science.org · Oct 2
Insects used in research are often excluded from legal and ethical guidelines designed to protect other laboratory animals.

Science chats with an entomologist and an expert in animal ethics who are monitoring how researchers report on the ethical treatment of insects. ⬇️ https://scim.ag/484NNUt
Insects aren’t ‘little robots’—so scientists are rethinking their welfare
Science chats with an entomologist and an expert in animal ethics who are monitoring how researchers report on the ethical treatment of insects
www.science.org
October 2, 2025 at 11:04 PM
arielframe.bsky.social
First episode is out! I spoke with Professor James Marshall @sheffielduni.bsky.social @opteran.bsky.social about his research on modelling the #brain of #bees and implications for #ai . Take a listen! #neuroscience #sciencecommunication
September 4, 2025 at 10:20 PM
Reposted by Ariel K. Frame
andrewclin.bsky.social
Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx doi.org/10.1113/JP28...
Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells
Abstract figure legend: We tested the effects of expressing the bacterial voltage-gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expressi...
doi.org
September 1, 2025 at 4:50 PM
Reposted by Ariel K. Frame
peiferlabunc.bsky.social
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu… https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team
August 23, 2025 at 12:18 PM
arielframe.bsky.social
Everybody working with #drosophila will tell you how essential FlyBase.org
@flybase.bsky.social is for their research. @flybehaviour.bsky.social is absolutely correct in saying major cuts at FlyBase are "utterly devastating"
tiny.cc/utir001
@thetransmitter.bsky.social
This NEEDS to be rectified!
August 22, 2025 at 7:01 AM
arielframe.bsky.social
Watch this pharate podcast eclose from its concept pupal case and emerge free on any #podcast player. First episode coming soon! Listen for fun #sciencecommunication #brain #science #biology #neuroscience #drosophila #aging and more! linktr.ee/quitecurious
July 25, 2025 at 11:39 PM
Reposted by Ariel K. Frame
simonsocial.bsky.social
Hi, if you are looking to come to Canada for a post-doc or a PhD, consider my lab to study the genetic basis of social interactions, using the fruit fly! My university (Western University) has a new program to welcome you! See below! #drosophila #postdoc #canada #PhD #social #behaviouralneurogenetic
July 11, 2025 at 5:08 PM
arielframe.bsky.social
Why use animals when we have AI and organoids? Among other reasons, “We also do not know enough about biology to know where real breakthroughs will come.” Says @jasonsynaptic.bsky.social in this excellent article.
July 13, 2025 at 11:17 PM
Reposted by Ariel K. Frame
xkcd.com
Good Science

xkcd.com/3101/
5-panel comic. (1) [teacher with long hair next to whiteboard] TEACHER: I’m supposed to give you the tools to do good science. (2) [teacher addressing students] But what *are* those tools? Methodology is hard and there are so many ways to get incorrect results. What is the magic ingredient that makes for good science? (3) TEACHER: To figure it out, I ran a regression with all the factors people say are important: [embedded list in sub-panel, cut off at end] Outcome variable: correct scientific results. Predictors: collaboration; skepticism of others’ claims; questioning your own beliefs; trying to falsify hypotheses; checking citations; statistical rigor; blinded analysis; financial disclosure; open data (4) TEACHER: The regression says two ingredients are the most crucial: 1) genuine curiosity about the answer to a question, and 2) ammonium hydroxide. (5) STUDENT: Wait, why did *ammonia* score so high? How did it even get on the list? LONG HAIR: ...And now you’re doing good science!
June 12, 2025 at 8:28 PM
arielframe.bsky.social
I had a great time at #CANfly2025 @mcgill.ca! Thanks to Vincent Archambault, @emery-lab.bsky.social, David Hipfner, Nam-Sung Moon, Laura Nilson, Frieder Schöck, @biologists.bsky.social @ircm.bsky.social @genomejournal.bsky.social @genetics-gsa.bsky.social @healthcare.nikon.com et al. #drosophila
Drosophila flies with little name tags and coffee conversing at a poster session at a conference
June 21, 2025 at 6:37 PM
Reposted by Ariel K. Frame
poppi62.bsky.social
Towards more sustainable research: reducing the environmental impact when working with #Drosophila. Challiner, Saurya., Patel, Raff, Fostier, Prokop, A. (2025) @genetics-gsa.bsky.social‬, in press -- doi.org/10.1093/gene... - Always happy to discuss and hear your ideas and views!
June 13, 2025 at 6:01 AM
Reposted by Ariel K. Frame
stephenfgoodwin.bsky.social
New preprint from lab: www.biorxiv.org/content/10.1... Sexual dimorphism arises not through wholesale transcriptional reprogramming, but via selective sex-specific survival of neurons defined by birth order and shared developmental programs.
A Role for Exaptation in Sculpting Sexually Dimorphic Brains from Shared Neural Lineages
Sex differences in behaviours arise from variations in female and male nervous systems, yet the cellular and molecular bases of these differences remain poorly defined. Here, we take an unbiased, sing...
www.biorxiv.org
June 9, 2025 at 1:12 PM
Reposted by Ariel K. Frame
marcofesta.bsky.social
Marchand: compared to those born to a bighorn ewe when she's young, lambs born when she's old have shorter lives, wean fewer lambs. At any age, ewes that live longer have lambs that live longer and have higher reproductive success. url:https://academic.oup.com/beheco/article/36/4/araf046/8126721
Offspring longevity for bighorn sheep at Ram Mountain, Alberta, Canada (1971-2013). Solid lines represent model predictions for female offspring under average female density conditions (results for male offspring are reported in Table 1). Shaded bands represent 95% confidence intervals while gray lines are modeled trends for individual mothers. (A) Offspring longevity as a function of maternal age at birth. (B) Offspring longevity as a function of maternal longevity, estimated by the age at last sighting
June 15, 2025 at 3:09 PM
Reposted by Ariel K. Frame
poppi62.bsky.social
SUSTAINABILITY & #DROSOPHILA - If you keep flies & have tried to re-use containers but then given up on it, please could you let us know & tell us the reasons? We urgently need statements for a publication about sustainability in fly labs. Please, contact Andreas.Prokop@manchester.ac.uk
June 4, 2025 at 8:47 AM
Reposted by Ariel K. Frame
callimcflurry.bsky.social
FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social
FlyBase funding squashed amid Harvard grant terminations
The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.
www.thetransmitter.org
June 4, 2025 at 9:11 PM
Reposted by Ariel K. Frame
simonsocial.bsky.social
"The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper": www.sciencedirect.com/science/arti...
@arielframe.bsky.social
@ibangs.bsky.social
@brentsinclair.bsky.social
‪@westernu.bsky.social‬
The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper
This short review is targeted at researchers new to the Drosophila model (thereafter: a Drosophilist) in the field of neuroscience. We aim to provide …
www.sciencedirect.com
May 20, 2025 at 3:47 PM
arielframe.bsky.social
Do you work in a #Drosophila lab studying #neuroscience? This is for you. We made this overview extra digestible for new people to the field. This #openaccess paper will help all new Drosophilists understand the field and find helpful resources and reviews needed for their burgeoning #brain studies.
May 20, 2025 at 4:23 PM