Ana Pombo
@apombo1.bsky.social
Research Professor Johns Hopkins University @jhuartssciences.bsky.social @mdc-berlin.bsky.social @mdc-bimsb.bsky.social @neurocure.bsky.social @spp2202.bsky.social
Pinned
Ana Pombo
@apombo1.bsky.social
· Mar 9
Reposted by Ana Pombo
More new NIH institute and center director positions posted
with a closing date of 11/26/25.
hr.nih.gov/careers/open...
These include the Center for Scientific Review (CSR), National Institute of Nursing Research (NINR), National Institute of Allergy and Infectious Diseases (NIAID), ...
1/3
with a closing date of 11/26/25.
hr.nih.gov/careers/open...
These include the Center for Scientific Review (CSR), National Institute of Nursing Research (NINR), National Institute of Allergy and Infectious Diseases (NIAID), ...
1/3
hr.nih.gov
November 12, 2025 at 4:18 PM
More new NIH institute and center director positions posted
with a closing date of 11/26/25.
hr.nih.gov/careers/open...
These include the Center for Scientific Review (CSR), National Institute of Nursing Research (NINR), National Institute of Allergy and Infectious Diseases (NIAID), ...
1/3
with a closing date of 11/26/25.
hr.nih.gov/careers/open...
These include the Center for Scientific Review (CSR), National Institute of Nursing Research (NINR), National Institute of Allergy and Infectious Diseases (NIAID), ...
1/3
Reposted by Ana Pombo
Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
www.science.org
September 18, 2025 at 1:10 AM
Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...
Reposted by Ana Pombo
New work from Iva Buljan @ivabuljan.bsky.social in our lab!
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
October 15, 2025 at 6:29 AM
New work from Iva Buljan @ivabuljan.bsky.social in our lab!
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
Reposted by Ana Pombo
October 12, 2025 at 9:25 AM
Reposted by Ana Pombo
We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025
September 3, 2025 at 2:00 PM
We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025
Reposted by Ana Pombo
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
October 3, 2025 at 7:14 AM
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
Reposted by Ana Pombo
Passionate about #SystemsBiology and ready to lead your own research group?
Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT!
Appl. by Oct 8:
www.nature.com/naturecareer...
#ScienceJobs #JobOffer
Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT!
Appl. by Oct 8:
www.nature.com/naturecareer...
#ScienceJobs #JobOffer
September 29, 2025 at 9:52 AM
Passionate about #SystemsBiology and ready to lead your own research group?
Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT!
Appl. by Oct 8:
www.nature.com/naturecareer...
#ScienceJobs #JobOffer
Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT!
Appl. by Oct 8:
www.nature.com/naturecareer...
#ScienceJobs #JobOffer
Reposted by Ana Pombo
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
August 7, 2025 at 8:05 AM
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...
#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
Reposted by Ana Pombo
NIMSB announces Four Independent Group Leader positions #ScienceJobs #AcademicSky
NIMSB announces Four Independent Group Leader positions
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
September 15, 2025 at 5:03 PM
NIMSB announces Four Independent Group Leader positions #ScienceJobs #AcademicSky
Reposted by Ana Pombo
3. The paper above looks at the role of "ex ante" peer review process, such as that of research grants, where results are not known at the time of review.
The paper below looks at inescapable incentive problems that arise when trying to incentivize both risk and effort.
The paper below looks at inescapable incentive problems that arise when trying to incentivize both risk and effort.
Rationalizing risk aversion in science: Why incentives to work hard clash with incentives to take risks
Scientific research requires taking risks, so why does much funded scientific research play it safe? This study uses an economic contracting model to argue that this can be explained in part by the no...
journals.plos.org
September 14, 2025 at 1:50 PM
3. The paper above looks at the role of "ex ante" peer review process, such as that of research grants, where results are not known at the time of review.
The paper below looks at inescapable incentive problems that arise when trying to incentivize both risk and effort.
The paper below looks at inescapable incentive problems that arise when trying to incentivize both risk and effort.
Reposted by Ana Pombo
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
September 2, 2025 at 5:26 PM
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
Reposted by Ana Pombo
New preprint from @apombo1.bsky.social’s lab on gene regulation; insights into super-enhancers and their role in establishing complex regulatory networks of cell-type specific interactions with other enhancers and genes with specialized cellular functions 🧪🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Specialised super-enhancer networks in stem cells and neurons
Super-enhancers (SEs) are clusters of enhancers with high transcriptional activity that play essential roles in defining cell identity through regulation of nearby genes. SEs preferentially form multi...
www.biorxiv.org
August 14, 2025 at 7:16 AM
New preprint from @apombo1.bsky.social’s lab on gene regulation; insights into super-enhancers and their role in establishing complex regulatory networks of cell-type specific interactions with other enhancers and genes with specialized cellular functions 🧪🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ana Pombo
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 2:19 PM
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Reposted by Ana Pombo
(3/n) Inspired by work by Eric Betzig, @heilemannlab.bsky.social, @apombo1.bsky.social and others, we adopted Tokuyasu cryosectioning to enable TIRF-based DNA-PAINT imaging throughout fixed HeLa cells without range constraint. We started with the nucleus & Pol II to explore tkPAINT’s potential.
August 13, 2025 at 2:19 PM
(3/n) Inspired by work by Eric Betzig, @heilemannlab.bsky.social, @apombo1.bsky.social and others, we adopted Tokuyasu cryosectioning to enable TIRF-based DNA-PAINT imaging throughout fixed HeLa cells without range constraint. We started with the nucleus & Pol II to explore tkPAINT’s potential.
Reposted by Ana Pombo
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
July 23, 2025 at 10:49 AM
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Tons of open slots, invited and selected speakers all get 20 mins ❤️
#EESNucleus
Reposted by Ana Pombo
I’m really happy to present #SCALPEL, a new #Nextflow tool to quantify transcript isoforms at the single-cell level using conventional 3’ scRNA-seq data #scRNA-seq #single-cell #tools #isoforms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Quantification of transcript isoforms at the single-cell level using SCALPEL - Nature Communications
Single-cell RNA-seq facilitates the study of transcriptome diversity in individual cells. Here, authors introduce a tool for isoform quantification at the single-cell level using 3’ scRNA-seq data, co...
www.nature.com
July 14, 2025 at 10:31 AM
I’m really happy to present #SCALPEL, a new #Nextflow tool to quantify transcript isoforms at the single-cell level using conventional 3’ scRNA-seq data #scRNA-seq #single-cell #tools #isoforms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ana Pombo
As requested - A Starter Pack of PIs in Biology (or related fields) who are recruiting PHD STUDENTS! If you would like to be added, feel free to ask! go.bsky.app/Bf4DRFm
July 18, 2025 at 6:21 PM
As requested - A Starter Pack of PIs in Biology (or related fields) who are recruiting PHD STUDENTS! If you would like to be added, feel free to ask! go.bsky.app/Bf4DRFm
Reposted by Ana Pombo
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Ana Pombo
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
June 26, 2025 at 8:15 AM
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
Reposted by Ana Pombo
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
June 27, 2025 at 6:03 AM
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
Reposted by Ana Pombo
The Chromatin And Development lab are hiring a postdoc!
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
lms.mrc.ac.uk
June 26, 2025 at 3:19 PM
The Chromatin And Development lab are hiring a postdoc!
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
Reposted by Ana Pombo
A few months ago, Nature published how-to guide for using ChatGPT to write your peer reviews in 30 minutes.
This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .
This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .
AI, peer review and the human activity of science
When researchers cede their scientific judgement to machines, we lose something important.
www.nature.com
June 25, 2025 at 1:01 PM
A few months ago, Nature published how-to guide for using ChatGPT to write your peer reviews in 30 minutes.
This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .
This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .
Reposted by Ana Pombo
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
June 25, 2025 at 1:59 PM
The call just opened!
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
ki.se/en/about-ki/...
You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics
ki.varbi.com/what:job/job...
Reposted by Ana Pombo
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
June 23, 2025 at 12:57 PM
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
Reposted by Ana Pombo
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Decoding gene networks controlling hypothalamic and prethalamic neuron development
Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus
using single-cell multiomics, identifying regulators of regionalization and neurogenesis.
They further show...
www.cell.com
June 14, 2025 at 12:48 AM
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
www.cell.com/cell-reports...