Antonis Antoniou
@antonis02.bsky.social
Professor of Cancer Risk Prediction
Director, Cancer Data-Driven Detection
University of Cambridge
Genetic epidemiology, Data Science, Cancer prevention and early detection
Director, Cancer Data-Driven Detection
University of Cambridge
Genetic epidemiology, Data Science, Cancer prevention and early detection
New study from group, extends the BOADICEA/CanRisk breast cancer risk model to include continuous mammographic density (MD) from automated tools like Volpara & STRATUS
Available via CanRisk (www.canrisk.org)
📄 Ficorella et al, JCO Precision Oncology: doi.org/10.1200/PO-2...
Available via CanRisk (www.canrisk.org)
📄 Ficorella et al, JCO Precision Oncology: doi.org/10.1200/PO-2...
October 24, 2025 at 6:49 AM
New study from group, extends the BOADICEA/CanRisk breast cancer risk model to include continuous mammographic density (MD) from automated tools like Volpara & STRATUS
Available via CanRisk (www.canrisk.org)
📄 Ficorella et al, JCO Precision Oncology: doi.org/10.1200/PO-2...
Available via CanRisk (www.canrisk.org)
📄 Ficorella et al, JCO Precision Oncology: doi.org/10.1200/PO-2...
Reposted by Antonis Antoniou
Are you looking for a statistics/ML postdoc? Come to work with @antonis02.bsky.social and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection.
www.cam.ac.uk/jobs/researc...
www.cam.ac.uk/jobs/researc...
Research Associate*/Research Assistant in Multi-omics Early Detection of Ovarian Cancer (Fixed Term)
An exciting opportunity has arisen for a highly motivated Research Associate to join the Centre for Cancer Genetic Epidemiology (CCGE) at the Department of Public Health & Primary Care, University of
www.cam.ac.uk
August 13, 2025 at 9:09 AM
Are you looking for a statistics/ML postdoc? Come to work with @antonis02.bsky.social and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection.
www.cam.ac.uk/jobs/researc...
www.cam.ac.uk/jobs/researc...
Reposted by Antonis Antoniou
1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants.
🔗 www.nature.com/articles/s41...
🧵
🔗 www.nature.com/articles/s41...
🧵
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification - Nature Communications
BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to pro...
www.nature.com
May 26, 2025 at 6:56 AM
1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants.
🔗 www.nature.com/articles/s41...
🧵
🔗 www.nature.com/articles/s41...
🧵
Reposted by Antonis Antoniou
Just published in The Lancet, interim results from the BRAID randomised trial of supplemental breast imaging for women with dense breast tissue.
Read the open access Article here 👉 www.thelancet.com/journals/lan...
@thelancet.com
Read the open access Article here 👉 www.thelancet.com/journals/lan...
@thelancet.com
Comparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial
Abbreviated MRI and contrast-enhanced mammography detected three times as many invasive
cancers compared with ABUS, with cancers being half the size. This study shows that
supplemental imaging could l...
www.thelancet.com
May 22, 2025 at 10:25 AM
Just published in The Lancet, interim results from the BRAID randomised trial of supplemental breast imaging for women with dense breast tissue.
Read the open access Article here 👉 www.thelancet.com/journals/lan...
@thelancet.com
Read the open access Article here 👉 www.thelancet.com/journals/lan...
@thelancet.com
Reposted by Antonis Antoniou
This thread reminded me of the work of my late father as a medic and epidemiologist in Papua New Guinea in the 1960's. In the highlands of PNG endemic goitre was very common and in some remote valleys endemic cretinism was also common. The Jimi Valley was one such area. 1/n
May 15, 2025 at 10:31 PM
This thread reminded me of the work of my late father as a medic and epidemiologist in Papua New Guinea in the 1960's. In the highlands of PNG endemic goitre was very common and in some remote valleys endemic cretinism was also common. The Jimi Valley was one such area. 1/n
Reposted by Antonis Antoniou
Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl
Research Assistant/Research Associate* in Cardiovascular Epidemiology (BHF Scholarship) (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant/Research Associate* in Cardiovascular Epidemiology (BHF Scholarship) (Fixed Term) in the Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit at the…
buff.ly
May 14, 2025 at 10:08 AM
Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl
Reposted by Antonis Antoniou
This research, published in the @thelancet.bsky.social Oncology, was led by Hend Hassan, a PhD student at the Centre for @ccge-cambridge.bsky.social @dphpc.bsky.social.
Read more: crukcambridgecentre.org.uk/news/removin...
Read more: crukcambridgecentre.org.uk/news/removin...
May 9, 2025 at 1:17 PM
This research, published in the @thelancet.bsky.social Oncology, was led by Hend Hassan, a PhD student at the Centre for @ccge-cambridge.bsky.social @dphpc.bsky.social.
Read more: crukcambridgecentre.org.uk/news/removin...
Read more: crukcambridgecentre.org.uk/news/removin...
Reposted by Antonis Antoniou
Online first: Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of #breastcancer: a retrospective cohort study using linked electronic health records
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
May 8, 2025 at 12:53 PM
Online first: Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of #breastcancer: a retrospective cohort study using linked electronic health records
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Yes v important question! Unfortunately the linked prescriptions dataset was only available from 2015 onwards and in fact there was a very small number of carriers who received hrt. The numbers did not allow for adjustments in the analysis or for stratified analysis by hrt.
May 8, 2025 at 2:00 PM
Yes v important question! Unfortunately the linked prescriptions dataset was only available from 2015 onwards and in fact there was a very small number of carriers who received hrt. The numbers did not allow for adjustments in the analysis or for stratified analysis by hrt.
See also:
🗞️ Press release: www.cam.ac.uk/research/new...
🖊️ Editorial: www.thelancet.com/journals/lan...
🗞️ Press release: www.cam.ac.uk/research/new...
🖊️ Editorial: www.thelancet.com/journals/lan...
Removing ovaries and fallopian tubes linked to lower risk of early death among certain breast cancer patients
Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this
www.cam.ac.uk
May 8, 2025 at 9:19 AM
See also:
🗞️ Press release: www.cam.ac.uk/research/new...
🖊️ Editorial: www.thelancet.com/journals/lan...
🗞️ Press release: www.cam.ac.uk/research/new...
🖊️ Editorial: www.thelancet.com/journals/lan...
Great team effort across @dphpc.bsky.social, @cambridgeuni.bsky.social @crukcamcentre.bsky.social the CanGene-CanVar programme, NHS England’s National Disease Registration Service. Huge thanks to all involved. Funded by @cancerresearchuk.org
May 8, 2025 at 9:19 AM
Great team effort across @dphpc.bsky.social, @cambridgeuni.bsky.social @crukcamcentre.bsky.social the CanGene-CanVar programme, NHS England’s National Disease Registration Service. Huge thanks to all involved. Funded by @cancerresearchuk.org
Based on linking national cancer registry, hospital records, and genetic testing data — a major step forward in evaluating preventive surgery in high-risk groups.
May 8, 2025 at 9:19 AM
Based on linking national cancer registry, hospital records, and genetic testing data — a major step forward in evaluating preventive surgery in high-risk groups.
✅ Key findings:
• BSO associated with lower all-cause & breast cancer-specific mortality
• No increased risk for CVD, ischaemic heart disease, cerebrovascular disease, or depression
• Lower uptake of BSO among Black & Asian women → highlighting disparities in access/decision-making
• BSO associated with lower all-cause & breast cancer-specific mortality
• No increased risk for CVD, ischaemic heart disease, cerebrovascular disease, or depression
• Lower uptake of BSO among Black & Asian women → highlighting disparities in access/decision-making
May 8, 2025 at 9:19 AM
✅ Key findings:
• BSO associated with lower all-cause & breast cancer-specific mortality
• No increased risk for CVD, ischaemic heart disease, cerebrovascular disease, or depression
• Lower uptake of BSO among Black & Asian women → highlighting disparities in access/decision-making
• BSO associated with lower all-cause & breast cancer-specific mortality
• No increased risk for CVD, ischaemic heart disease, cerebrovascular disease, or depression
• Lower uptake of BSO among Black & Asian women → highlighting disparities in access/decision-making
📢 New publication from the group in @thelancetoncol.bsky.social led by Hend Hasan for her PhD, we used linked EHR + genetic testing data to study 3,400+ BRCA1/2 carriers with history of breast cancer. What happens long-term after BSO?
📄 Paper: www.thelancet.com/journals/lan...
🧵
📄 Paper: www.thelancet.com/journals/lan...
🧵
May 8, 2025 at 9:19 AM
📢 New publication from the group in @thelancetoncol.bsky.social led by Hend Hasan for her PhD, we used linked EHR + genetic testing data to study 3,400+ BRCA1/2 carriers with history of breast cancer. What happens long-term after BSO?
📄 Paper: www.thelancet.com/journals/lan...
🧵
📄 Paper: www.thelancet.com/journals/lan...
🧵
Only 10 days left to apply for these positions👇
📣 Job Opportunities - Alongside our recently advertised Senior Research Programme Manager position, we now have 2 more exciting opportunities to join the Cancer Data-Driven Detection (CD3) programme
1️⃣ Research Programme Manager
shorturl.at/Cs1kg
2️⃣ Research Community Coordinator
shorturl.at/4w9Na
1️⃣ Research Programme Manager
shorturl.at/Cs1kg
2️⃣ Research Community Coordinator
shorturl.at/4w9Na
April 16, 2025 at 6:37 AM
Only 10 days left to apply for these positions👇
Reposted by Antonis Antoniou
After UK, Denmark announces a national gateway to access health data
novonordiskfonden.dk/en/news/new-...
novonordiskfonden.dk/en/news/new-...
New national gateway to health data will drive health solutions of the future - Novo Nordisk Fonden
novonordiskfonden.dk
April 15, 2025 at 4:48 PM
After UK, Denmark announces a national gateway to access health data
novonordiskfonden.dk/en/news/new-...
novonordiskfonden.dk/en/news/new-...
Reposted by Antonis Antoniou
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
April 9, 2025 at 9:09 PM
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Reposted by Antonis Antoniou
📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/
Flexible funding - many research areas in scope + ideas welcome
Check out our group www.inouyelab.org/home
And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
Flexible funding - many research areas in scope + ideas welcome
Check out our group www.inouyelab.org/home
And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
April 8, 2025 at 11:50 AM
📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/
Flexible funding - many research areas in scope + ideas welcome
Check out our group www.inouyelab.org/home
And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
Flexible funding - many research areas in scope + ideas welcome
Check out our group www.inouyelab.org/home
And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
Reposted by Antonis Antoniou
[1/5] We welcome today’s Government announcement of the creation of a Health Data Research Service. This is a vital step towards enabling cancer researchers to access the right data at the right time, improving outcomes for patients ⏱️🔍 www.gov.uk/government/n...
Prime Minister turbocharges medical research
Better and faster access to NHS data for researchers with gold standard security and privacy measures.
www.gov.uk
April 7, 2025 at 4:30 PM
[1/5] We welcome today’s Government announcement of the creation of a Health Data Research Service. This is a vital step towards enabling cancer researchers to access the right data at the right time, improving outcomes for patients ⏱️🔍 www.gov.uk/government/n...
Reposted by Antonis Antoniou
[1/5] Getting the right data at the right time is essential for researchers looking to beat cancer sooner. Using advanced data modelling and AI, the CD3 programme is a £10m commitment to understanding who is likely to get cancer and when. 🔬
However to deliver on its promise Government must:
However to deliver on its promise Government must:
March 19, 2025 at 3:16 PM
[1/5] Getting the right data at the right time is essential for researchers looking to beat cancer sooner. Using advanced data modelling and AI, the CD3 programme is a £10m commitment to understanding who is likely to get cancer and when. 🔬
However to deliver on its promise Government must:
However to deliver on its promise Government must:
Reposted by Antonis Antoniou
CCGE researchers evaluate the contribution of gene variants to cancer risk for multiple cancer types. The results highlight several potential new susceptibility genes including the DNA repair gene NHEJ1. Follow the link below to find out more
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...
The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data
We developed a method to estimate the contribution of rare coding variants to cancer
heritability and applied it to 11 cancers in the UK Biobank. Our results provide insights
into the contribution of ...
www.cell.com
March 12, 2025 at 12:22 PM
CCGE researchers evaluate the contribution of gene variants to cancer risk for multiple cancer types. The results highlight several potential new susceptibility genes including the DNA repair gene NHEJ1. Follow the link below to find out more
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...
Reposted by Antonis Antoniou
“It’s been exhaustively studied.” www.nytimes.com/2025/03/07/h...
C.D.C. Will Investigate Debunked Link Between Vaccines and Autism
Dozens of studies have failed to find evidence of a link. The decision to re-examine the question comes as a measles outbreak, driven by low vaccination rates, widens in Texas.
www.nytimes.com
March 8, 2025 at 10:54 AM
“It’s been exhaustively studied.” www.nytimes.com/2025/03/07/h...
📣 Job Opportunities - Alongside our recently advertised Senior Research Programme Manager position, we now have 2 more exciting opportunities to join the Cancer Data-Driven Detection (CD3) programme
1️⃣ Research Programme Manager
shorturl.at/Cs1kg
2️⃣ Research Community Coordinator
shorturl.at/4w9Na
1️⃣ Research Programme Manager
shorturl.at/Cs1kg
2️⃣ Research Community Coordinator
shorturl.at/4w9Na
March 5, 2025 at 11:44 AM
📣 Job Opportunities - Alongside our recently advertised Senior Research Programme Manager position, we now have 2 more exciting opportunities to join the Cancer Data-Driven Detection (CD3) programme
1️⃣ Research Programme Manager
shorturl.at/Cs1kg
2️⃣ Research Community Coordinator
shorturl.at/4w9Na
1️⃣ Research Programme Manager
shorturl.at/Cs1kg
2️⃣ Research Community Coordinator
shorturl.at/4w9Na
Reposted by Antonis Antoniou
📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!
March 4, 2025 at 12:27 PM
📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!
Reposted by Antonis Antoniou
📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41...
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
March 4, 2025 at 10:27 AM
📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41...
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!