Amin Saberi
amnsbr.bsky.social
Amin Saberi
@amnsbr.bsky.social
Postdoc, Cognitive Neurogenerics Group at MPI-CBS & FZJ-INM7 | MD
aminsaberi.me
✨ New preprint ✨

Introducing cuBNM, a toolbox we developed to run brain simulations *much* more efficiently on GPUs 🎉🚀

Preprint: www.biorxiv.org/content/10.1...
Documentation: cubnm.readthedocs.io/en/stable/
GitHub: github.com/amnsbr/cubnm

1/n 🧵
November 14, 2025 at 5:29 PM
Reposted by Amin Saberi
Great review on The Genetics of Human Handedness: Microtubules and Beyond www.cell.com/trends/genet... - handedness is such an interesting phenotype!
Genetics of human handedness: microtubules and beyond
Handedness (i.e., the preference to use either the left or the right hand for fine motor tasks) is a widely investigated trait. Handedness heritability is consistently estimated to be 25%. After decad...
www.cell.com
October 16, 2025 at 6:12 PM
Reposted by Amin Saberi
Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉

📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
September 22, 2025 at 9:51 PM
Reposted by Amin Saberi
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...

Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
September 10, 2025 at 1:07 PM
Reposted by Amin Saberi
🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n
September 10, 2025 at 3:08 PM
Reposted by Amin Saberi
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...

Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
August 4, 2025 at 2:27 PM
Reposted by Amin Saberi
My lab is at @ohbmofficial.bsky.social in Brisbane! Find us at the @gradientsworkshop.bsky.social - great talks by @wanb.bsky.social Katerina Manoli (and others)

Then we are at the educational sessions where @claraweber.bsky.social will present @amnsbr.bsky.social work on E/I balance.
June 21, 2025 at 11:47 AM
Reposted by Amin Saberi
Very happy about this paper and what we learned from it!! Please see Amins thread for more juice 🧃 and let us know if you are also on the E/I journey and like to try our toolbox
🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence?
We asked this in our new paper just out in #ScienceAdvances
“Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling”
📄 www.science.org/doi/full/10....
🧵⤵️
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.
www.science.org
June 5, 2025 at 7:55 AM
Reposted by Amin Saberi
Amazing new paper on individual development of E/I balance during adolescence, first-authored by @amnsbr.bsky.social!

Read @ Science Advances: www.science.org/doi/10.1126/...

Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he?
cubnm.readthedocs.io
June 5, 2025 at 1:45 PM
Reposted by Amin Saberi
This is awesome!
🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence?
We asked this in our new paper just out in #ScienceAdvances
“Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling”
📄 www.science.org/doi/full/10....
🧵⤵️
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.
www.science.org
June 5, 2025 at 1:05 PM
Reposted by Amin Saberi
⭐ new paper

Maturation of cortical excitation-inhibition (EI) in adolescence

now in Science Advances 💥

A true tour de force of multimodal MRI, connectomics & GPU-powered 🤖!! biophysical modelling

by hiball superheroes 🦸‍♂️🦸‍♀️🦸‍♂️
@amnsbr.bsky.social @sofievalk.bsky.social @sbe.bsky.social
🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence?
We asked this in our new paper just out in #ScienceAdvances
“Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling”
📄 www.science.org/doi/full/10....
🧵⤵️
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.
www.science.org
June 5, 2025 at 12:48 PM
🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence?
We asked this in our new paper just out in #ScienceAdvances
“Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling”
📄 www.science.org/doi/full/10....
🧵⤵️
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.
www.science.org
June 5, 2025 at 7:53 AM
Reposted by Amin Saberi
We are seeking a scientific coordinator for my research group at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig 😊🧠🌈

Could be ideal for a gap year between MSc and PhD or PhD and postdoc!

Please out more here: recruitingapp-5218.de.umantis.com/Vacancies/43...?
Scientific Coordinator (m/f/d) Part-time (50%) | Karriereportal Max-Planck-Institut für Kognitions- und Neurowissenschaften
Scientific Coordinator (m/f/d) Part-time (50%) | Karriereportal Max-Planck-Institut für Kognitions- und Neurowissenschaften
recruitingapp-5218.de.umantis.com
June 3, 2025 at 3:10 PM
Reposted by Amin Saberi
⭐ preprint ⭐

In-vivo evidence for increased tau deposition in temporal lobe epilepsy

➡️ Using [¹⁸F]MK-6240 PET, we show increased tau in young and middle aged TLE
➡️ Tau aggregation potential mechanism of disease progression & cognitive decline
➡️ pdf bit.ly/4mmlTYH

by Raul Cruces & a super team
May 19, 2025 at 12:31 PM
Reposted by Amin Saberi
The gradients workshop is happening soon! Please join us on June 23rd in Brisbane for a full day of gradient fun! 🌈

✅ Amazing speaker line up
✅ Poster presentation
✅ Flash talks for selected abstracts

Deets on program, abstract submission, and registration 👉 gradients-workshop.github.io
Gradients of Brain Organisation, Brisbane 2025
GRADIENTS WORKSHOP
gradients-workshop.github.io
May 12, 2025 at 1:55 PM
Reposted by Amin Saberi
Our #metaanalysis (n = 231) in JAMAPsych reveals consistent brain abnormalities across #sleep disorders involving affective and cognitive hubs in sgACC, amygdala/hippocampus

Short-term sleep deprivation shows a distinct picture, affecting the thalamus

jamanetwork.com/journals/jam...
April 24, 2025 at 8:42 PM
Reposted by Amin Saberi
in press @natcomms.nature.com 🌟

"Multimodal gradients unify local and global cortical organization"

7T MRI + cytoarchitectonics reveal a sensory-paralimbic axis of areal specialization & integration

led by superstar Yezhou Wang & a terrific team of friends & colleagues

▶️ doi.org/10.1038/s414...
April 25, 2025 at 12:58 PM
Reposted by Amin Saberi
✨ What makes the brain's functional organization different in each #TLE patient? 🧠
✨ We used a large sample (298 healthy adults, 282 TLE, 45 disease controls) + normative modeling to capture individualized functional disruptions. 🔎 #epilepsy #neuroimaging #precisionmedicine
doi.org/10.1101/2025...
Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) presents with substantial inter-patient variability in clinical and neuroimaging manifestations. This multicenter study examined inter-individual differences in spatial pa...
doi.org
April 27, 2025 at 7:48 AM
Reposted by Amin Saberi
Top-down feedback is ubiquitous in the brain and computationally distinct, but rarely modeled in deep neural networks. What happens when a DNN has biologically-inspired top-down feedback? 🧠📈

Our new paper explores this: elifesciences.org/reviewed-pre...
Top-down feedback matters: Functional impact of brainlike connectivity motifs on audiovisual integration
elifesciences.org
April 15, 2025 at 8:11 PM
Reposted by Amin Saberi
While the world burns, we cook up a new preprint! doi.org/10.1101/2025...

Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
April 11, 2025 at 1:35 AM
Reposted by Amin Saberi
Our study is now out in @naturecomms.bsky.social! Here, we integrate large-scale registry musicality data from twins to investigate the genetics of music enjoyment 🧬🎶🧑‍🤝‍🧑
“What an odd thing“ wrote Oliver Sacks “to see an entire species playing with listening to meaningless tonal patterns, preoccupied for much of their time by what they call ‘music’...“. Our new paper, led by ace student @giacomobignardi.bsky.social, unpacks this puzzle from a genetic perspective. 🧪
Twin modelling reveals partly distinct genetic pathways to music enjoyment - Nature Communications
Here, Bignardi et al. report on a study of over 9,000 Swedish twins that indicates the ability to enjoy music is influenced by multiple partly distinct genetic factors.
www.nature.com
March 26, 2025 at 8:52 AM
Reposted by Amin Saberi
📢 We have a new #NeuroAI postdoctoral position in the lab!

If you have a strong background in #NeuroAI or computational neuroscience, I’d love to hear from you.

(Repost please)

🧠📈🤖
March 14, 2025 at 1:02 PM
Reposted by Amin Saberi
Brain function fluctuates daily—but what drives these changes?
direct.mit.edu/imag/article... super proud of Deniz Yilmaz and Bianca Serio and thankful for the open data of @emilyjacobs.bsky.social and Laura Pritschet 🌈👫 studying hormonal fluctuations in functional gradients ❤️‍🔥
direct.mit.edu
March 6, 2025 at 8:18 AM