Leon Lotter
@leondlotter.de
👨💻 MD | PhD candidate
🧠 Neurodevelopment | ADHD | ASD
📊 Multimodal neuroimaging
🏫 INM-7, Research Centre Juelich
🎓 Max Planck School of Cognition
🐮 Vegan
👤 He/him
📷 By N. Brade
🌐 https://leondlotter.de
🧠 Neurodevelopment | ADHD | ASD
📊 Multimodal neuroimaging
🏫 INM-7, Research Centre Juelich
🎓 Max Planck School of Cognition
🐮 Vegan
👤 He/him
📷 By N. Brade
🌐 https://leondlotter.de
Reposted by Leon Lotter
Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
September 30, 2025 at 7:39 PM
Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Leon Lotter
Serious concerns about a new cortical biomarker for pain sensitivity
jamanetwork.com/journals/jam...
We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results.
👇 1/13
jamanetwork.com/journals/jam...
We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results.
👇 1/13
Concern About Predictive Performance of a Pain Sensitivity Biomarker
To the Editor Chowdhury et al1 evaluated a biomarker for pain sensitivity, combining peak alpha frequency and corticomotor excitability. The authors report outstanding performance (validation set area...
jamanetwork.com
July 22, 2025 at 3:24 PM
Serious concerns about a new cortical biomarker for pain sensitivity
jamanetwork.com/journals/jam...
We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results.
👇 1/13
jamanetwork.com/journals/jam...
We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results.
👇 1/13
Reposted by Leon Lotter
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
July 17, 2025 at 1:36 AM
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
Reposted by Leon Lotter
After some time since completing my Master’s thesis, I’m excited to share that our work has now been published! It’s rewarding to see the project come full circle and contribute to the field alongside a fantastic team.
You can read the full article here: doi.org/10.1093/brai...
Published in Brain 🧠
You can read the full article here: doi.org/10.1093/brai...
Published in Brain 🧠
July 2, 2025 at 10:26 AM
After some time since completing my Master’s thesis, I’m excited to share that our work has now been published! It’s rewarding to see the project come full circle and contribute to the field alongside a fantastic team.
You can read the full article here: doi.org/10.1093/brai...
Published in Brain 🧠
You can read the full article here: doi.org/10.1093/brai...
Published in Brain 🧠
Amazing new paper on individual development of E/I balance during adolescence, first-authored by @amnsbr.bsky.social!
Read @ Science Advances: www.science.org/doi/10.1126/...
Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he?
cubnm.readthedocs.io
Read @ Science Advances: www.science.org/doi/10.1126/...
Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he?
cubnm.readthedocs.io
June 5, 2025 at 1:45 PM
Amazing new paper on individual development of E/I balance during adolescence, first-authored by @amnsbr.bsky.social!
Read @ Science Advances: www.science.org/doi/10.1126/...
Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he?
cubnm.readthedocs.io
Read @ Science Advances: www.science.org/doi/10.1126/...
Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he?
cubnm.readthedocs.io
Reposted by Leon Lotter
🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
May 30, 2025 at 7:47 PM
🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
Reposted by Leon Lotter
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
The history and future of resting-state functional magnetic resonance imaging - Nature
This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...
www.nature.com
May 28, 2025 at 3:52 PM
When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...
Reposted by Leon Lotter
🏁 Big news from #Cogitate!🏁
We’re proud to deliver the first part of our promised open multimodal dataset:
iEEG data from 38 patients across 3 centers, collected under a unified protocol.
📄 Paper: doi.org/10.1038/s415...
📀 Data: www.arc-cogitate.com/data-release
💻 Code: github.com/Cogitate-con...
We’re proud to deliver the first part of our promised open multimodal dataset:
iEEG data from 38 patients across 3 centers, collected under a unified protocol.
📄 Paper: doi.org/10.1038/s415...
📀 Data: www.arc-cogitate.com/data-release
💻 Code: github.com/Cogitate-con...
May 27, 2025 at 6:27 PM
🏁 Big news from #Cogitate!🏁
We’re proud to deliver the first part of our promised open multimodal dataset:
iEEG data from 38 patients across 3 centers, collected under a unified protocol.
📄 Paper: doi.org/10.1038/s415...
📀 Data: www.arc-cogitate.com/data-release
💻 Code: github.com/Cogitate-con...
We’re proud to deliver the first part of our promised open multimodal dataset:
iEEG data from 38 patients across 3 centers, collected under a unified protocol.
📄 Paper: doi.org/10.1038/s415...
📀 Data: www.arc-cogitate.com/data-release
💻 Code: github.com/Cogitate-con...
Reposted by Leon Lotter
First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ...
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
Autonomic physiological coupling of the global fMRI signal
Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.
rdcu.be
May 7, 2025 at 1:42 PM
First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ...
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
Reposted by Leon Lotter
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications
Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.
www.nature.com
March 26, 2025 at 1:54 AM
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
Reposted by Leon Lotter
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
The molecular and cellular underpinnings of human brain lateralization
Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...
doi.org
April 12, 2025 at 10:28 AM
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
Reposted by Leon Lotter
🧠🌱 New preprint from the IGOR Sustainability project!
"There is no research on a dead planet"
How can we balance neuroscience, open science, and climate responsibility?
📄 Read our position paper on OSF:
osf.io/preprints/osf/rju75_v1
"There is no research on a dead planet"
How can we balance neuroscience, open science, and climate responsibility?
📄 Read our position paper on OSF:
osf.io/preprints/osf/rju75_v1
OSF
osf.io
April 12, 2025 at 2:31 PM
🧠🌱 New preprint from the IGOR Sustainability project!
"There is no research on a dead planet"
How can we balance neuroscience, open science, and climate responsibility?
📄 Read our position paper on OSF:
osf.io/preprints/osf/rju75_v1
"There is no research on a dead planet"
How can we balance neuroscience, open science, and climate responsibility?
📄 Read our position paper on OSF:
osf.io/preprints/osf/rju75_v1
Reposted by Leon Lotter
Now out in NPJ Digital Medicine our manuscript on real-world evidence for altered communication preferences in autism: nature.com/articles/s41...
@sbe.bsky.social
@leoschilbach.bsky.social
@sbe.bsky.social
@leoschilbach.bsky.social
Real world evidence for altered communication patterns in individuals with autism spectrum disorder - npj Digital Medicine
npj Digital Medicine - Real world evidence for altered communication patterns in individuals with autism spectrum disorder
nature.com
March 12, 2025 at 11:29 AM
Now out in NPJ Digital Medicine our manuscript on real-world evidence for altered communication preferences in autism: nature.com/articles/s41...
@sbe.bsky.social
@leoschilbach.bsky.social
@sbe.bsky.social
@leoschilbach.bsky.social
Reposted by Leon Lotter
Bluetorial-A dream and a bit of a nightmare
Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.
Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
January 21, 2025 at 5:56 PM
Bluetorial-A dream and a bit of a nightmare
Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.
Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.
Reposted by Leon Lotter
🎉 New Year, New Preprint.
Happy to share the first preprint from my #PhD! 🧠
🤔 TL;DR:
Our findings are relevant to anyone using EEG / MEG functional connectivity analyses. They affect the choice of method when analysing your data.
Check it out and tell me your thoughts: shorturl.at/TD3wc
1/6
Happy to share the first preprint from my #PhD! 🧠
🤔 TL;DR:
Our findings are relevant to anyone using EEG / MEG functional connectivity analyses. They affect the choice of method when analysing your data.
Check it out and tell me your thoughts: shorturl.at/TD3wc
1/6
Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional connectivity metrics
Zero-phase-delay synchrony between the activity of distant neural populations has been robustly observed. Nevertheless, contemporary electroencephalography and magnetencephalography functional connect...
www.biorxiv.org
January 5, 2025 at 11:30 AM
🎉 New Year, New Preprint.
Happy to share the first preprint from my #PhD! 🧠
🤔 TL;DR:
Our findings are relevant to anyone using EEG / MEG functional connectivity analyses. They affect the choice of method when analysing your data.
Check it out and tell me your thoughts: shorturl.at/TD3wc
1/6
Happy to share the first preprint from my #PhD! 🧠
🤔 TL;DR:
Our findings are relevant to anyone using EEG / MEG functional connectivity analyses. They affect the choice of method when analysing your data.
Check it out and tell me your thoughts: shorturl.at/TD3wc
1/6
Reposted by Leon Lotter
A New Year's rant, for 2025 😊:
January 3, 2025 at 6:17 PM
A New Year's rant, for 2025 😊:
Reposted by Leon Lotter
The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
December 20, 2024 at 2:39 PM
The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Reposted by Leon Lotter
The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes
Thought provoking work my Martin Gell et al:
www.nature.com/articles/s41...
Thought provoking work my Martin Gell et al:
www.nature.com/articles/s41...
How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications
Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...
www.nature.com
December 13, 2024 at 11:24 PM
The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes
Thought provoking work my Martin Gell et al:
www.nature.com/articles/s41...
Thought provoking work my Martin Gell et al:
www.nature.com/articles/s41...
Reposted by Leon Lotter
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 3, 2024 at 2:10 PM
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
Reposted by Leon Lotter
New paper out today in PNAS 🎉 demonstrating:
1) an association between social disadvantage & child brain function can be observed as early as birth
2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity
doi.org/10.1073/pnas...
1) an association between social disadvantage & child brain function can be observed as early as birth
2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity
doi.org/10.1073/pnas...
December 2, 2024 at 11:26 PM
New paper out today in PNAS 🎉 demonstrating:
1) an association between social disadvantage & child brain function can be observed as early as birth
2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity
doi.org/10.1073/pnas...
1) an association between social disadvantage & child brain function can be observed as early as birth
2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity
doi.org/10.1073/pnas...
Reposted by Leon Lotter
Three ManyBabies projects - big collaborative replications of infancy phenomena - wrapped up this year. The first paper came out this fall. I thought I'd take this chance to comment on what I make of the non-replication result. 🧵
bsky.app/profile/laur...
bsky.app/profile/laur...
The Manybabies4 paper is out! Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study onlinelibrary.wiley.com/doi/abs/10.1... 1000 babies tested in 37 labs; "Overall, 49.34% of infants preferred Helpers over Hinderers in the social condition"
Infants’ Social Evaluation of Helpers and Hinderers: A Large‐Scale, Multi‐Lab, Coordinated Replication Study
Evaluating whether someone's behavior is praiseworthy or blameworthy is a fundamental human trait. A seminal study by Hamlin and colleagues in 2007 suggested that the ability to form social evaluatio...
onlinelibrary.wiley.com
December 3, 2024 at 11:56 PM
Three ManyBabies projects - big collaborative replications of infancy phenomena - wrapped up this year. The first paper came out this fall. I thought I'd take this chance to comment on what I make of the non-replication result. 🧵
bsky.app/profile/laur...
bsky.app/profile/laur...
Reposted by Leon Lotter
🍾 Now in press @elife.bsky.social
Multimodal correlates of childhood psychopathology
co-led by @jroyer.bsky.social , Valeria Kebets, @bttyeo.bsky.social & our many fantastic co-authors
🙏 based on the ABCD dataset
👉 elifesciences.org/articles/87992
Multimodal correlates of childhood psychopathology
co-led by @jroyer.bsky.social , Valeria Kebets, @bttyeo.bsky.social & our many fantastic co-authors
🙏 based on the ABCD dataset
👉 elifesciences.org/articles/87992
December 3, 2024 at 8:29 PM
🍾 Now in press @elife.bsky.social
Multimodal correlates of childhood psychopathology
co-led by @jroyer.bsky.social , Valeria Kebets, @bttyeo.bsky.social & our many fantastic co-authors
🙏 based on the ABCD dataset
👉 elifesciences.org/articles/87992
Multimodal correlates of childhood psychopathology
co-led by @jroyer.bsky.social , Valeria Kebets, @bttyeo.bsky.social & our many fantastic co-authors
🙏 based on the ABCD dataset
👉 elifesciences.org/articles/87992
Study design features increase replicability in brain-wide association studies
www.nature.com/articles/s41...
#neuroscience #neuroimaging
#neuroscience #neuroimaging
Study design features increase replicability in brain-wide association studies - Nature
Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide association ...
www.nature.com
December 3, 2024 at 8:36 AM
Study design features increase replicability in brain-wide association studies
www.nature.com/articles/s41...
#neuroscience #neuroimaging
#neuroscience #neuroimaging
Reposted by Leon Lotter
What happens when our stream of consciousness turns inward, towards the body? Our new fMRI study of 536 individuals finds that 'body-wandering' is associated with distinct patterns of brain connectivity, physiology, affect, and mental health:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 28, 2024 at 3:54 PM
What happens when our stream of consciousness turns inward, towards the body? Our new fMRI study of 536 individuals finds that 'body-wandering' is associated with distinct patterns of brain connectivity, physiology, affect, and mental health:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...