Loïc Labache
@loiclabache.bsky.social
Postdoctoral Fellow at Rutgers University
Previously CEA 🇫🇷, Yale 🇺🇸
Website: loiclabache.github.io
Cognitive neuroscientist and statistician interested in hemispheric specialization 🧠
Previously CEA 🇫🇷, Yale 🇺🇸
Website: loiclabache.github.io
Cognitive neuroscientist and statistician interested in hemispheric specialization 🧠
Pinned
Loïc Labache
@loiclabache.bsky.social
· Apr 12
The molecular and cellular underpinnings of human brain lateralization
Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...
doi.org
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
Reposted by Loïc Labache
One to watch! 👇🏼🔥 Be sure to tune in Monday for the live event or check out the recording on youtube, along with all our WBHI lectures. Register for the full series at wbhi.ucsb.edu/about/events We’ve got an amazing 25-26 lineup.
September 5, 2025 at 5:30 PM
One to watch! 👇🏼🔥 Be sure to tune in Monday for the live event or check out the recording on youtube, along with all our WBHI lectures. Register for the full series at wbhi.ucsb.edu/about/events We’ve got an amazing 25-26 lineup.
Reposted by Loïc Labache
Les espèces classiques de la SVT : se reproduisent 🥱
Les reines des fourmis M. ibericus :
clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃
www.nature.com/articles/s41...
Les reines des fourmis M. ibericus :
clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃
www.nature.com/articles/s41...
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
www.nature.com
September 4, 2025 at 5:14 PM
Les espèces classiques de la SVT : se reproduisent 🥱
Les reines des fourmis M. ibericus :
clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃
www.nature.com/articles/s41...
Les reines des fourmis M. ibericus :
clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃
www.nature.com/articles/s41...
Reposted by Loïc Labache
New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al:
When age tips the balance: A dual mechanism affecting hemispheric specialization for language
doi.org/10.1162/IMAG...
When age tips the balance: A dual mechanism affecting hemispheric specialization for language
doi.org/10.1162/IMAG...
July 3, 2025 at 4:09 AM
New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al:
When age tips the balance: A dual mechanism affecting hemispheric specialization for language
doi.org/10.1162/IMAG...
When age tips the balance: A dual mechanism affecting hemispheric specialization for language
doi.org/10.1162/IMAG...
Excited to share that our work is now published in Imaging Neuroscience! 🧠🥳
We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan.
Check it out @imagingneurosci.bsky.social
We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan.
Check it out @imagingneurosci.bsky.social
New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al:
When age tips the balance: A dual mechanism affecting hemispheric specialization for language
doi.org/10.1162/IMAG...
When age tips the balance: A dual mechanism affecting hemispheric specialization for language
doi.org/10.1162/IMAG...
July 3, 2025 at 11:46 AM
Excited to share that our work is now published in Imaging Neuroscience! 🧠🥳
We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan.
Check it out @imagingneurosci.bsky.social
We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan.
Check it out @imagingneurosci.bsky.social
Reposted by Loïc Labache
Holmes Lab is representing at #OHBM2025! 🧵 Loic
@loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
@loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
June 28, 2025 at 12:00 AM
Holmes Lab is representing at #OHBM2025! 🧵 Loic
@loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
@loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
Reposted by Loïc Labache
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉
www.nature.com/articles/s41...
🧵1👇
www.nature.com/articles/s41...
🧵1👇
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data
Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
www.nature.com
June 4, 2025 at 6:30 PM
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉
www.nature.com/articles/s41...
🧵1👇
www.nature.com/articles/s41...
🧵1👇
Reposted by Loïc Labache
🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
May 30, 2025 at 7:47 PM
🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
www.biorxiv.org/content/10.1...
Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
Reposted by Loïc Labache
🎨🧑🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊
anniegbryant.github.io/subcortex_vi...
anniegbryant.github.io/subcortex_vi...
May 4, 2025 at 10:13 AM
🎨🧑🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊
anniegbryant.github.io/subcortex_vi...
anniegbryant.github.io/subcortex_vi...
Reposted by Loïc Labache
Check our latest work ‘Linking Subjective Experience of Anxiety to Brain Function using Natural Language Processing’. Our analyses link movie-evoked brain activity and subsequent interview recordings in a pediatric sample with and without anxiety disorders (doi.org/10.31234/osf...).
May 2, 2025 at 5:29 PM
Check our latest work ‘Linking Subjective Experience of Anxiety to Brain Function using Natural Language Processing’. Our analyses link movie-evoked brain activity and subsequent interview recordings in a pediatric sample with and without anxiety disorders (doi.org/10.31234/osf...).
Reposted by Loïc Labache
Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
a man applauds with the words so proud of my team above him
ALT: a man applauds with the words so proud of my team above him
media.tenor.com
April 28, 2025 at 12:56 PM
Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Loïc Labache
Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
The molecular and cellular underpinnings of human brain lateralization
Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...
doi.org
April 15, 2025 at 9:38 PM
Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥
Reposted by Loïc Labache
The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
The molecular and cellular underpinnings of human brain lateralization
Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...
doi.org
April 12, 2025 at 12:29 PM
The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
The molecular and cellular underpinnings of human brain lateralization
Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...
doi.org
April 12, 2025 at 10:28 AM
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
🔗 doi.org/10.1101/2025...
🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇
#neuroskyence
Reposted by Loïc Labache
Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social.
#neuroskyence
www.thetransmitter.org/future-of-fm...
#neuroskyence
www.thetransmitter.org/future-of-fm...
fMRI must break out of its silo
We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.
www.thetransmitter.org
April 8, 2025 at 1:15 PM
Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social.
#neuroskyence
www.thetransmitter.org/future-of-fm...
#neuroskyence
www.thetransmitter.org/future-of-fm...
Reposted by Loïc Labache
🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia"
medrxiv.org/content/10.1...
We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
medrxiv.org/content/10.1...
We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
March 24, 2025 at 1:28 AM
🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia"
medrxiv.org/content/10.1...
We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
medrxiv.org/content/10.1...
We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
Reposted by Loïc Labache
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more!
Unfortunately, we cannot sponsor visas for this position.
Please rt and reach out if you're interested👀
Unfortunately, we cannot sponsor visas for this position.
Please rt and reach out if you're interested👀
March 3, 2025 at 2:50 PM
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more!
Unfortunately, we cannot sponsor visas for this position.
Please rt and reach out if you're interested👀
Unfortunately, we cannot sponsor visas for this position.
Please rt and reach out if you're interested👀
📢 Excited and honored to have our latest work on the molecular and cellular underpinnings of human brain lateralization accepted for an oral and poster presentation at #OHBM2025! 🎉
Catch it at poster #1792 and in the Language: Anatomy, Networks, and Pathology oral session.
🔜 Preprint coming soon! 🧠
Catch it at poster #1792 and in the Language: Anatomy, Networks, and Pathology oral session.
🔜 Preprint coming soon! 🧠
📢 Poster Presenter Notifications Sent! 📢
All Poster Presenter notifications were emailed on February 11, 2025! 🎉 Check your inbox for details.
🔜 Abstracts selected for Oral Presentations will be notified in the coming week. Stay tuned!
All Poster Presenter notifications were emailed on February 11, 2025! 🎉 Check your inbox for details.
🔜 Abstracts selected for Oral Presentations will be notified in the coming week. Stay tuned!
February 25, 2025 at 8:14 PM
📢 Excited and honored to have our latest work on the molecular and cellular underpinnings of human brain lateralization accepted for an oral and poster presentation at #OHBM2025! 🎉
Catch it at poster #1792 and in the Language: Anatomy, Networks, and Pathology oral session.
🔜 Preprint coming soon! 🧠
Catch it at poster #1792 and in the Language: Anatomy, Networks, and Pathology oral session.
🔜 Preprint coming soon! 🧠
Reposted by Loïc Labache
New paper‼️ Interested in the protective impacts of parenthood on brain dynamics? 👨👩👦👦🧠 Read Edwina Orchard & @sidchop.bsky.social's new paper, out now in PNAS @pnas.org !
With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more!
🔗https://tinyurl.com/parentalbrain
With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more!
🔗https://tinyurl.com/parentalbrain
February 25, 2025 at 7:15 PM
New paper‼️ Interested in the protective impacts of parenthood on brain dynamics? 👨👩👦👦🧠 Read Edwina Orchard & @sidchop.bsky.social's new paper, out now in PNAS @pnas.org !
With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more!
🔗https://tinyurl.com/parentalbrain
With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more!
🔗https://tinyurl.com/parentalbrain
Reposted by Loïc Labache
Interested in #MRI and #psychiatry? Our lab is hiring a research assistant (@holmeslab-bhi.bsky.social)! Please RT and share.
@geneticssociety.bsky.social
@ohbmofficial.bsky.social
@sfnjournals.bsky.social
@pgcgenetics.bsky.social
@hitop-system.bsky.social
@blackinneuro.bsky.social
@geneticssociety.bsky.social
@ohbmofficial.bsky.social
@sfnjournals.bsky.social
@pgcgenetics.bsky.social
@hitop-system.bsky.social
@blackinneuro.bsky.social
Holmes Lab – Rutgers Department of Psychiatry
holmeslab.rutgers.edu
February 25, 2025 at 3:28 PM
Interested in #MRI and #psychiatry? Our lab is hiring a research assistant (@holmeslab-bhi.bsky.social)! Please RT and share.
@geneticssociety.bsky.social
@ohbmofficial.bsky.social
@sfnjournals.bsky.social
@pgcgenetics.bsky.social
@hitop-system.bsky.social
@blackinneuro.bsky.social
@geneticssociety.bsky.social
@ohbmofficial.bsky.social
@sfnjournals.bsky.social
@pgcgenetics.bsky.social
@hitop-system.bsky.social
@blackinneuro.bsky.social
Reposted by Loïc Labache
I'm thrilled to share that my graduate school project was just published in Nature Mental Health! We found that resting-state functional network predictors are more similar within vs between categories of internalizing and externalizing behavior in children (ABCD), adolescents (HBN) and adults (HCP)
New @holmeslab-bhi.bsky.social paper by Lydia Qu. Here, we map shared and unique brain features for individual variation in internalizing and externalizing across development. w/@bttyeo.bsky.social, @elvisha.bsky.social, @carrisacocuzza.bsky.social, and many others.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Distinct brain network features predict internalizing and externalizing traits in children, adolescents and adults - Nature Mental Health
In this study, the authors present work showing shared and distinct predictive network features associated with internalizing and externalizing behaviors in children, adolescents and adults.
www.nature.com
February 19, 2025 at 4:55 PM
I'm thrilled to share that my graduate school project was just published in Nature Mental Health! We found that resting-state functional network predictors are more similar within vs between categories of internalizing and externalizing behavior in children (ABCD), adolescents (HBN) and adults (HCP)
Reposted by Loïc Labache
Great work by @halleeshearer.bsky.social in her first first-author paper. With 🎀 shiny app 🎀 to explore how FC reliability fares ACROSS DIFFERENT movies versus rest, region-by-region. Thanks @sneuroble.bsky.social @tingsterx.bsky.social @ninetlab.bsky.social for 👍 collab.
doi.org/10.1162/imag...
doi.org/10.1162/imag...
January 3, 2025 at 5:39 PM
Great work by @halleeshearer.bsky.social in her first first-author paper. With 🎀 shiny app 🎀 to explore how FC reliability fares ACROSS DIFFERENT movies versus rest, region-by-region. Thanks @sneuroble.bsky.social @tingsterx.bsky.social @ninetlab.bsky.social for 👍 collab.
doi.org/10.1162/imag...
doi.org/10.1162/imag...
End-of-year hot take 🤯: 'Avoid the use of covariates' 👀
Better approach: Define your research question, examine your data, define what's possible, and carefully consider your covariates. Iterate. ‼️ Blanket rules are meaningless‼️
Better approach: Define your research question, examine your data, define what's possible, and carefully consider your covariates. Iterate. ‼️ Blanket rules are meaningless‼️
December 31, 2024 at 5:32 PM
End-of-year hot take 🤯: 'Avoid the use of covariates' 👀
Better approach: Define your research question, examine your data, define what's possible, and carefully consider your covariates. Iterate. ‼️ Blanket rules are meaningless‼️
Better approach: Define your research question, examine your data, define what's possible, and carefully consider your covariates. Iterate. ‼️ Blanket rules are meaningless‼️
Love this "Where is Waldo" end-of-the-year science special edition from @imagingneurosci.bsky.social! 🧠🎉
Curious about Waldo? Find out more here: doi.org/10.1162/imag...
#neuroscience
Curious about Waldo? Find out more here: doi.org/10.1162/imag...
#neuroscience
December 29, 2024 at 11:40 PM
Love this "Where is Waldo" end-of-the-year science special edition from @imagingneurosci.bsky.social! 🧠🎉
Curious about Waldo? Find out more here: doi.org/10.1162/imag...
#neuroscience
Curious about Waldo? Find out more here: doi.org/10.1162/imag...
#neuroscience
Reposted by Loïc Labache
2024 was the first full calendar year for Imaging Neuroscience @mitpress - 350 papers published.
We're proud of how the brain imaging community enthusiastically embraced open access non-profit publishing. Our aim is to be *your* journal.
Full size PDF: drive.google.com/file/d/1M170...
We're proud of how the brain imaging community enthusiastically embraced open access non-profit publishing. Our aim is to be *your* journal.
Full size PDF: drive.google.com/file/d/1M170...
December 29, 2024 at 9:20 AM
2024 was the first full calendar year for Imaging Neuroscience @mitpress - 350 papers published.
We're proud of how the brain imaging community enthusiastically embraced open access non-profit publishing. Our aim is to be *your* journal.
Full size PDF: drive.google.com/file/d/1M170...
We're proud of how the brain imaging community enthusiastically embraced open access non-profit publishing. Our aim is to be *your* journal.
Full size PDF: drive.google.com/file/d/1M170...
Reposted by Loïc Labache
📣 First three years of my PhD have culminated in this work now published at PLoS Computational Biology! 🥳 We take a deep dive into all the many ways we can slice n dice fMRI dynamics to quantify biologically relevant properties 🧠🧮
doi.org/10.1371/jour...
doi.org/10.1371/jour...
December 27, 2024 at 2:44 AM
📣 First three years of my PhD have culminated in this work now published at PLoS Computational Biology! 🥳 We take a deep dive into all the many ways we can slice n dice fMRI dynamics to quantify biologically relevant properties 🧠🧮
doi.org/10.1371/jour...
doi.org/10.1371/jour...