Alex Y. Kreins
@alexyema.bsky.social
Wellcome Trust career development fellow treating #IEI patients (athymia/SCID) @GreatOrmondSt & translational research @uclchildhealth to improve their outcomes!
https://profiles.ucl.ac.uk/70769-alexandra-kreins
https://profiles.ucl.ac.uk/70769-alexandra-kreins
Pinned
Alex Y. Kreins
@alexyema.bsky.social
· Feb 13
Check out our new collection on lymphocyte cell differentiation in specific microenvironments and innate immune memory, accompanying the upcoming @keystonesymposia.bsky.social joint meetings on these topics 👉 https://buff.ly/3CgbKL7
#KSTCells25 #KSInnateImmune25
#KSTCells25 #KSInnateImmune25
Delighted & proud that this wonderful collection in @jem.org includes our study characterising dominant negative variants in ITPR3 in syndromic combined immunodeficiency patients due to calcium channel leakiness of the IP3 receptor, causing ER Ca2+ store depletion and impaired Ca2+ T cell dynamics.
Reposted by Alex Y. Kreins
1/ We are celebrating the Novo Nordisk Prize Symposium: Inborn Errors of Immunity – a huge success yesterday at the @institutimagine.bsky.social in Paris featuring talks by 19 leading European researchers on human IEI
September 25, 2025 at 2:54 PM
1/ We are celebrating the Novo Nordisk Prize Symposium: Inborn Errors of Immunity – a huge success yesterday at the @institutimagine.bsky.social in Paris featuring talks by 19 leading European researchers on human IEI
Delighted to be speaking at the Novo Nordisk Symposium: Inborn Errors of Immunity, celebrating Jean-Laurent Casanova (my PhD advisor) and his landmark contributions. Join us Sept 24 at Institut Imagine, Paris. Free to attend!
Details & registration 👇
#NNFPrize #Immunology
Details & registration 👇
#NNFPrize #Immunology
1/ Join us on 24 Sept 2025 at the @institutimagine.bsky.social in Paris for the Novo Nordisk Prize Symposium: Inborn Errors of Immunity. Registration is free at:
my.weezevent.com/novo-nordisk...
my.weezevent.com/novo-nordisk...
July 28, 2025 at 8:18 PM
Delighted to be speaking at the Novo Nordisk Symposium: Inborn Errors of Immunity, celebrating Jean-Laurent Casanova (my PhD advisor) and his landmark contributions. Join us Sept 24 at Institut Imagine, Paris. Free to attend!
Details & registration 👇
#NNFPrize #Immunology
Details & registration 👇
#NNFPrize #Immunology
Exciting milestone for #HumanImmunity with the very first full issue of @jhumimmunity.org out now, including the #IUIS update on inborn errors of immunity + resources for clinicians. rupress.org/jhi/issue/1/1 #OpenAccess #IEI 👏👏👏
May 8, 2025 at 9:26 PM
Exciting milestone for #HumanImmunity with the very first full issue of @jhumimmunity.org out now, including the #IUIS update on inborn errors of immunity + resources for clinicians. rupress.org/jhi/issue/1/1 #OpenAccess #IEI 👏👏👏
Delighted to share our manuscript highlighting the lessons learned from the clinical use of ex vivo T-lymphopoiesis assays to assist therapeutic decision-making btw #HCT and #thymus transplantation in patients without a molecular diagnosis after TREC-based newborn screening 👉 tinyurl.com/yzd8xe7p
May 7, 2025 at 9:26 PM
Delighted to share our manuscript highlighting the lessons learned from the clinical use of ex vivo T-lymphopoiesis assays to assist therapeutic decision-making btw #HCT and #thymus transplantation in patients without a molecular diagnosis after TREC-based newborn screening 👉 tinyurl.com/yzd8xe7p
Reposted by Alex Y. Kreins
1/ I was honored to accept the 2025 Novo Nordisk Prize from @novo-nordisk.bsky.social at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of The BioInnovation Institute, lunch at @novo-nordisk.bsky.social, and an evening award celebration and dinner.
April 25, 2025 at 8:02 PM
1/ I was honored to accept the 2025 Novo Nordisk Prize from @novo-nordisk.bsky.social at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of The BioInnovation Institute, lunch at @novo-nordisk.bsky.social, and an evening award celebration and dinner.
Reposted by Alex Y. Kreins
1/ Today we spotlight @sanchoshimizu.bsky.social, a postdoc in our Paris branch from 2006-12 and now Reader/Associate Professor at @imperialcollegeldn.bsky.social in the department of infectious diseases and head of both of a lab there and a satellite lab at the @crick.ac.uk
April 24, 2025 at 1:57 PM
1/ Today we spotlight @sanchoshimizu.bsky.social, a postdoc in our Paris branch from 2006-12 and now Reader/Associate Professor at @imperialcollegeldn.bsky.social in the department of infectious diseases and head of both of a lab there and a satellite lab at the @crick.ac.uk
Reposted by Alex Y. Kreins
Open access, peer reviewed, and co-owned, @jhumimmunity.org from @rupress.org represents a new business model in scientific publishing. Rockefeller's Jean-Laurent Casanova is the founding editor-in-chief.
Rockefeller University Press launches new journal in partnership with scientists - News
Open access, peer reviewed, and co-owned, the Journal of Human Immunity represents a new business model in scientific publishing.
www.rockefeller.edu
April 15, 2025 at 5:18 PM
Open access, peer reviewed, and co-owned, @jhumimmunity.org from @rupress.org represents a new business model in scientific publishing. Rockefeller's Jean-Laurent Casanova is the founding editor-in-chief.
The #IBEX Knowledge-Base is an exciting initiative promoting open science and collaboration for immunofluorescence multiplexed imaging! New to this wonderful community and excited for the research ahead! Find out more 👇🏾
The IBEX Knowledge-Base is an important tool that will enhance scientific collaboration by providing a centralised, community-driven resource for immunofluorescence imaging and reagent validation.
buff.ly/BF4WO38
buff.ly/BF4WO38
April 14, 2025 at 5:13 PM
The #IBEX Knowledge-Base is an exciting initiative promoting open science and collaboration for immunofluorescence multiplexed imaging! New to this wonderful community and excited for the research ahead! Find out more 👇🏾
Reposted by Alex Y. Kreins
The @alexyema.bsky.social lab and colleagues show that dominant negative variants in ITPR3 impair T cell Ca²⁺ dynamics causing combined immunodeficiency. rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 9, 2025 at 6:15 PM
The @alexyema.bsky.social lab and colleagues show that dominant negative variants in ITPR3 impair T cell Ca²⁺ dynamics causing combined immunodeficiency. rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
Very grateful to have been introduced to the wonderful #IBEX Knowledge-Base community 👇🏾 and to this novel spatial proteomics technique. Looking forward to more multiplexed imaging!
Multiplexed imaging is a powerful approach in spatial biology, but is complex, expensive & labor-intensive. This Community Page presents the IBEX Knowledge-Base, a central resource for reagents, protocols & more, to enhance knowledge sharing & innovation of multiplexing techniques.🧪
plos.io/41FoJP9
plos.io/41FoJP9
March 22, 2025 at 3:18 PM
Very grateful to have been introduced to the wonderful #IBEX Knowledge-Base community 👇🏾 and to this novel spatial proteomics technique. Looking forward to more multiplexed imaging!
Reposted by Alex Y. Kreins
1/ I am both delighted and relieved to share my inaugural editorial for the @jhumimmunity.org
rupress.org/jhi/article/...
rupress.org/jhi/article/...
Human immunity | Journal of Human Immunity | Rockefeller University Press
Human immunity is often insufficient against infectious agents and sometimes over-reactive to innocuous components of the environment or the human body. Ge
rupress.org
March 4, 2025 at 6:46 PM
1/ I am both delighted and relieved to share my inaugural editorial for the @jhumimmunity.org
rupress.org/jhi/article/...
rupress.org/jhi/article/...
Reposted by Alex Y. Kreins
Unjustified silence in the face of this new war in eastern DR Congo
"Inaction implies resignation to the idea that the survival of the fittest governs the world's fate"
Correspondence in @thelancet.bsky.social
www.thelancet.com/journals/lan...
"Inaction implies resignation to the idea that the survival of the fittest governs the world's fate"
Correspondence in @thelancet.bsky.social
www.thelancet.com/journals/lan...
Unjustified silence in the face of this new war in eastern DR Congo
Since Jan 23, 2025, the rebel March 23 Movement (M23), with the support of Rwanda,
has launched an offensive in eastern Democratic Republic of the Congo, further exacerbating
the region's ongoing conf...
www.thelancet.com
March 1, 2025 at 8:46 AM
Unjustified silence in the face of this new war in eastern DR Congo
"Inaction implies resignation to the idea that the survival of the fittest governs the world's fate"
Correspondence in @thelancet.bsky.social
www.thelancet.com/journals/lan...
"Inaction implies resignation to the idea that the survival of the fittest governs the world's fate"
Correspondence in @thelancet.bsky.social
www.thelancet.com/journals/lan...
Our clinical experience using ex vivo T-lymphopoiesis assays to assist clinical decision-making between #HCT for #SCID & #thymus transplantation for #athymia in genetically undefined T-lymphocytopaenia is published 👉 doi.org/10.1016/j.cl...
Thank you to all collaborators and referring clinicians!
Thank you to all collaborators and referring clinicians!
February 27, 2025 at 5:35 PM
Our clinical experience using ex vivo T-lymphopoiesis assays to assist clinical decision-making between #HCT for #SCID & #thymus transplantation for #athymia in genetically undefined T-lymphocytopaenia is published 👉 doi.org/10.1016/j.cl...
Thank you to all collaborators and referring clinicians!
Thank you to all collaborators and referring clinicians!
Reposted by Alex Y. Kreins
Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb
#OpenAccess
#OpenAccess
February 26, 2025 at 5:15 PM
Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb
#OpenAccess
#OpenAccess
Reposted by Alex Y. Kreins
Our thymus, a critical source and trainer of T cells, involutes with aging. 2 new studies find a growth factor (FGF21) that delays involution (in mouse models) and may be a way to rejuvenate our immune system and promote healthy aging in the future.
February 19, 2025 at 2:53 PM
Our thymus, a critical source and trainer of T cells, involutes with aging. 2 new studies find a growth factor (FGF21) that delays involution (in mouse models) and may be a way to rejuvenate our immune system and promote healthy aging in the future.
Delighted & proud that this wonderful collection in @jem.org includes our study characterising dominant negative variants in ITPR3 in syndromic combined immunodeficiency patients due to calcium channel leakiness of the IP3 receptor, causing ER Ca2+ store depletion and impaired Ca2+ T cell dynamics.
Check out our new collection on lymphocyte cell differentiation in specific microenvironments and innate immune memory, accompanying the upcoming @keystonesymposia.bsky.social joint meetings on these topics 👉 https://buff.ly/3CgbKL7
#KSTCells25 #KSInnateImmune25
#KSTCells25 #KSInnateImmune25
February 13, 2025 at 9:20 PM
Delighted & proud that this wonderful collection in @jem.org includes our study characterising dominant negative variants in ITPR3 in syndromic combined immunodeficiency patients due to calcium channel leakiness of the IP3 receptor, causing ER Ca2+ store depletion and impaired Ca2+ T cell dynamics.
Reposted by Alex Y. Kreins
Auschwitz was at the end of a long process. It did not start from gas chambers.
This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.
Auschwitz took time.
This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.
Auschwitz took time.
January 27, 2025 at 10:00 AM
Auschwitz was at the end of a long process. It did not start from gas chambers.
This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.
Auschwitz took time.
This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.
Auschwitz took time.
Reposted by Alex Y. Kreins
Welcome to the future of #HumanImmunity research! @rupress.org and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 https://buff.ly/4ajqm8W
January 16, 2025 at 4:00 PM
Welcome to the future of #HumanImmunity research! @rupress.org and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 https://buff.ly/4ajqm8W
Reposted by Alex Y. Kreins
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.
www.cuimc.columbia.edu
January 1, 2025 at 5:45 PM
What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼
On behalf of @ESIDsociety clinical working party, we have written guidelines with clinical practice recommendations focused on the diagnosis, investigation, risk stratification, and management of congenital #athymia with the aim to improve patient outcomes. Out now in @jacionline: bit.ly/4g4qkUs
European Society for Immunodeficiencies guidelines for the management of patients with congenital athymia
Congenital athymia is a life-limiting disorder due to rare inborn errors of immunity causing impaired thymus organogenesis or abnormal thymic stromal …
bit.ly
December 15, 2024 at 1:24 PM
On behalf of @ESIDsociety clinical working party, we have written guidelines with clinical practice recommendations focused on the diagnosis, investigation, risk stratification, and management of congenital #athymia with the aim to improve patient outcomes. Out now in @jacionline: bit.ly/4g4qkUs
Reposted by Alex Y. Kreins
last 2 days to apply! : We have a fully funded #PhD #studentship available in my lab for Oct25 @UCLchildhealth. Project will research new treatments/targets for airway inflammation during viral infection using complex in vitro models. Deadline 13th Dec
Apply here: forms.office.com/pages/respon...
Apply here: forms.office.com/pages/respon...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
ucl.ac.uk
December 11, 2024 at 4:48 PM
last 2 days to apply! : We have a fully funded #PhD #studentship available in my lab for Oct25 @UCLchildhealth. Project will research new treatments/targets for airway inflammation during viral infection using complex in vitro models. Deadline 13th Dec
Apply here: forms.office.com/pages/respon...
Apply here: forms.office.com/pages/respon...
Reposted by Alex Y. Kreins
We are thrilled to announce that Prof. Claudia Mauri will join Clinical & Experimental Immunology (CEI) as Editor-in-Chief from January 2025 🎊
Find out more and hear about Prof. Mauri's plans for the journal here👉 www.immunology.org/news/welcome...
Find out more and hear about Prof. Mauri's plans for the journal here👉 www.immunology.org/news/welcome...
December 11, 2024 at 12:49 PM
We are thrilled to announce that Prof. Claudia Mauri will join Clinical & Experimental Immunology (CEI) as Editor-in-Chief from January 2025 🎊
Find out more and hear about Prof. Mauri's plans for the journal here👉 www.immunology.org/news/welcome...
Find out more and hear about Prof. Mauri's plans for the journal here👉 www.immunology.org/news/welcome...
Reposted by Alex Y. Kreins
Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 6, 2024 at 10:16 AM
Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
Reposted by Alex Y. Kreins
December 4, 2024 at 9:49 AM
Reposted by Alex Y. Kreins
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Development is excited to announce our call for our Pathway to Independence program...
journals.biologists.com
December 4, 2024 at 9:37 AM
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...