Aled Edwards S.G.
@aledmedwards.bsky.social
Scientist. Frog hunter. Founder and Chief Executive of Structural Genomics Consortium.
Reposted by Aled Edwards S.G.
A Canadian-led collaboration is leading a global initiative to transform drug discovery with #AI and #OpenScience! 🍁
@uhn.ca, @sickkidsto.bsky.social & @thesgc.bsky.social, are partnering on a $26M grant to support the LIGAND-AI Project—an international effort to advance precision medicine.⬇️
@uhn.ca, @sickkidsto.bsky.social & @thesgc.bsky.social, are partnering on a $26M grant to support the LIGAND-AI Project—an international effort to advance precision medicine.⬇️
NEWS RELEASE: UHN, the Structural Genomics Consortium and The Hospital for Sick Children are harnessing AI and open science to advance drug discovery, securing a $26M grant. Learn more:
bit.ly/3LOojBQ
@uhnresearch.ca
bit.ly/3LOojBQ
@uhnresearch.ca
Canadian-led Alliance Harnesses AI and Open Science to Advance Drug Discovery
UHN, the Structural Genomics Consortium (SGC), and SickKids are joining forces to lead a major initiative to change how medicines are discovered using AI.
bit.ly
January 20, 2026 at 3:17 PM
A Canadian-led collaboration is leading a global initiative to transform drug discovery with #AI and #OpenScience! 🍁
@uhn.ca, @sickkidsto.bsky.social & @thesgc.bsky.social, are partnering on a $26M grant to support the LIGAND-AI Project—an international effort to advance precision medicine.⬇️
@uhn.ca, @sickkidsto.bsky.social & @thesgc.bsky.social, are partnering on a $26M grant to support the LIGAND-AI Project—an international effort to advance precision medicine.⬇️
Steve Kerr is an impressive individual. Wins with class, loses with class, and speaks the truth.
m.youtube.com/watch?v=5tmX...
m.youtube.com/watch?v=5tmX...
STEVE KERR calls US Government 'SHAMEFUL' for LYING about ICE shooting of Renee Nicole Good
YouTube video by Diario AS
m.youtube.com
January 11, 2026 at 1:05 AM
Steve Kerr is an impressive individual. Wins with class, loses with class, and speaks the truth.
m.youtube.com/watch?v=5tmX...
m.youtube.com/watch?v=5tmX...
After two years of method development, it’s out. Pretty excited about this method, which not only expedites hit-finding, but also expedites hit verification. www.nature.com/articles/s41...
Enantioselective protein affinity selection mass spectrometry (E-ASMS) - Nature Communications
High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand d...
www.nature.com
December 17, 2025 at 4:11 PM
After two years of method development, it’s out. Pretty excited about this method, which not only expedites hit-finding, but also expedites hit verification. www.nature.com/articles/s41...
I don’t read any scientific papers in which the authors use too many significant digits in their figures. It’s a strong proxy indicator of shoddy science and shoddy thinking. On the up side, it means I only need to read a few papers a week.
December 7, 2025 at 6:13 PM
I don’t read any scientific papers in which the authors use too many significant digits in their figures. It’s a strong proxy indicator of shoddy science and shoddy thinking. On the up side, it means I only need to read a few papers a week.
I moved to Canada from Wales as a young boy, grew up here, and stayed. A great place to live, raise a family, and do science. We’re a multicultural country of immigrants, and that’s not bad, it’s our superpower. Come explore for yourself! @uhnresearch.ca @utoronto.ca
www.science.org/content/arti...
www.science.org/content/arti...
Canada’s new budget aims to lure U.S. researchers to relocate
Spending plan also calls for smaller research spending cut than feared
www.science.org
November 7, 2025 at 8:55 PM
I moved to Canada from Wales as a young boy, grew up here, and stayed. A great place to live, raise a family, and do science. We’re a multicultural country of immigrants, and that’s not bad, it’s our superpower. Come explore for yourself! @uhnresearch.ca @utoronto.ca
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Aled Edwards S.G.
AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
blog.genesmindsmachines.com
October 9, 2025 at 6:13 PM
AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...
Feel good story of day. Went to outdoor movie night at granddaughter’s school yesterday in downtown Toronto. The children and parents comprised a rainbow of colours, speaking a Babel of languages. It was so joyful watching all the children run and play together. Canada has done something right.
October 4, 2025 at 3:28 PM
Feel good story of day. Went to outdoor movie night at granddaughter’s school yesterday in downtown Toronto. The children and parents comprised a rainbow of colours, speaking a Babel of languages. It was so joyful watching all the children run and play together. Canada has done something right.
If anything, this analysis on “what would have happened if the NIH had spent 40% less over past years” underestimates the impact of NIH on innovation. The most valuable IP walks on two feet. And guess who paid for the training of many industry scientists?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
September 27, 2025 at 1:37 PM
If anything, this analysis on “what would have happened if the NIH had spent 40% less over past years” underestimates the impact of NIH on innovation. The most valuable IP walks on two feet. And guess who paid for the training of many industry scientists?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
In selecting an antibody to use for your experiment, you should look in the literature and find the one that one is most cited. NOT!
September 12, 2025 at 10:06 AM
In selecting an antibody to use for your experiment, you should look in the literature and find the one that one is most cited. NOT!
For the non-Canadians out there, one of our best just died. Ken Dryden was an athlete, scholar, public servant. Bill Bradley is the closest equivalent in the United States. Dryden was my childhood hero. You want to understand a lot about Canada, read his book “The Game”.
www.cbc.ca/news/canada/...
www.cbc.ca/news/canada/...
Tributes pour in for hockey legend, former politician and author Ken Dryden | CBC News
Tributes are pouring in from across Canada and beyond after former Montreal Canadiens goalie Ken Dryden — a legend of Canadian hockey — died at the age of 78.
www.cbc.ca
September 6, 2025 at 5:20 PM
For the non-Canadians out there, one of our best just died. Ken Dryden was an athlete, scholar, public servant. Bill Bradley is the closest equivalent in the United States. Dryden was my childhood hero. You want to understand a lot about Canada, read his book “The Game”.
www.cbc.ca/news/canada/...
www.cbc.ca/news/canada/...
Reposted by Aled Edwards S.G.
#ICYMI Congratulations to @uhn.ca’s Drs. Cheryl Arrowsmith and John Dick for receiving the Awards for Excellence in Cancer Research from the Canadian Cancer Society!
Read more on their research and awards ➡️ www.uhnresearch.ca/news/recogni...
Read more on their research and awards ➡️ www.uhnresearch.ca/news/recogni...
September 5, 2025 at 2:57 PM
#ICYMI Congratulations to @uhn.ca’s Drs. Cheryl Arrowsmith and John Dick for receiving the Awards for Excellence in Cancer Research from the Canadian Cancer Society!
Read more on their research and awards ➡️ www.uhnresearch.ca/news/recogni...
Read more on their research and awards ➡️ www.uhnresearch.ca/news/recogni...
Reposted by Aled Edwards S.G.
CACHE 7 is launched with support from the @gatesfoundation.bsky.social and unpublished data from Damian Young at @bcmhouston.bsky.social, Tim Willson @thesgc.bsky.social and Neelagandan Kamaria InSTEM. Design selective PGK2 inhibitors. We'll test them experimentally.
bit.ly/4lnVYOs
bit.ly/4lnVYOs
August 12, 2025 at 7:07 PM
CACHE 7 is launched with support from the @gatesfoundation.bsky.social and unpublished data from Damian Young at @bcmhouston.bsky.social, Tim Willson @thesgc.bsky.social and Neelagandan Kamaria InSTEM. Design selective PGK2 inhibitors. We'll test them experimentally.
bit.ly/4lnVYOs
bit.ly/4lnVYOs
Reposted by Aled Edwards S.G.
In 2016, before Trump secured the GOP nomination, the Boston Globe made a fictional dystopian front page of what a nightmare world it would be if Trump won. And those just pretty much are our actual headlines now.
August 11, 2025 at 2:52 PM
In 2016, before Trump secured the GOP nomination, the Boston Globe made a fictional dystopian front page of what a nightmare world it would be if Trump won. And those just pretty much are our actual headlines now.
Reposted by Aled Edwards S.G.
#HepatitisC is a curable disease, but life-saving treatment is priced out of reach for millions of people who need it.
On #WorldHepatitisDay, join us as we call for access to affordable treatments globally!
👉 Read more about the study presented at the 2025 #EASLCongress in May: bit.ly/4fdYoxS
On #WorldHepatitisDay, join us as we call for access to affordable treatments globally!
👉 Read more about the study presented at the 2025 #EASLCongress in May: bit.ly/4fdYoxS
July 28, 2025 at 10:55 AM
#HepatitisC is a curable disease, but life-saving treatment is priced out of reach for millions of people who need it.
On #WorldHepatitisDay, join us as we call for access to affordable treatments globally!
👉 Read more about the study presented at the 2025 #EASLCongress in May: bit.ly/4fdYoxS
On #WorldHepatitisDay, join us as we call for access to affordable treatments globally!
👉 Read more about the study presented at the 2025 #EASLCongress in May: bit.ly/4fdYoxS
After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published.
rdcu.be/exxi7
rdcu.be/exxi7
Protein–ligand data at scale to support machine learning
Nature Reviews Chemistry - Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap...
rdcu.be
July 23, 2025 at 5:25 PM
After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published.
rdcu.be/exxi7
rdcu.be/exxi7
Reposted by Aled Edwards S.G.
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
July 21, 2025 at 7:07 PM
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
Reposted by Aled Edwards S.G.
Come join our faculty. Rank is open (assistant, associate, full professor) in experimental physical chemistry.
A department with a distinguished past and bright future.
A department with a distinguished past and bright future.
July 16, 2025 at 2:27 PM
Come join our faculty. Rank is open (assistant, associate, full professor) in experimental physical chemistry.
A department with a distinguished past and bright future.
A department with a distinguished past and bright future.
Groan….
Now THIS is basic science by definition!
And that's a wrap on another Purine and Pyrimidine Society meeting. Held every 2 years - this one in Barcelona - an excellent meeting for those interested in nucleotide metabolism. Lots of discussions between folks at all career stages.
Check out the program here - ppsociety.org/symposium/
#PP25
Check out the program here - ppsociety.org/symposium/
#PP25
July 4, 2025 at 1:23 AM
Groan….
Not a minute goes by over the past 60 years that I have regretted my parents’ decision to move us to Canada. A country that is, and has always been, great. Happy Canada Day to all! 🇨🇦
July 1, 2025 at 10:57 AM
Not a minute goes by over the past 60 years that I have regretted my parents’ decision to move us to Canada. A country that is, and has always been, great. Happy Canada Day to all! 🇨🇦
This is heartbreaking, and shame on Trump, Musk and Rubio. But given USAID and the US people did a huge public service by investing in the infrastructure to distribute medicine in Africa, why can’t Canada step up, leverage this, and fund some of the programs?
www.nytimes.com/2025/06/21/o...
www.nytimes.com/2025/06/21/o...
Opinion | The Waste Musk Created
www.nytimes.com
June 21, 2025 at 1:33 PM
This is heartbreaking, and shame on Trump, Musk and Rubio. But given USAID and the US people did a huge public service by investing in the infrastructure to distribute medicine in Africa, why can’t Canada step up, leverage this, and fund some of the programs?
www.nytimes.com/2025/06/21/o...
www.nytimes.com/2025/06/21/o...
Reposted by Aled Edwards S.G.
CACHE4 results are out! All previously known CBLCB ligands shared the same scaffold. Congrats to Keunwan Park who successfully designed a chemically novel series, to the experimental team at @thesgc.bsky.social and thanks to @conscience-network.bsky.social for greasing the wheels! bit.ly/4mYNe3r
June 16, 2025 at 4:14 PM
CACHE4 results are out! All previously known CBLCB ligands shared the same scaffold. Congrats to Keunwan Park who successfully designed a chemically novel series, to the experimental team at @thesgc.bsky.social and thanks to @conscience-network.bsky.social for greasing the wheels! bit.ly/4mYNe3r
June 11, 2025 at 9:12 PM
The United States has levied sanctions on Harvard but not on Russia. A curious set of values.
May 27, 2025 at 8:25 PM
The United States has levied sanctions on Harvard but not on Russia. A curious set of values.
Waiting for Trump to emerge
May 8, 2025 at 5:15 PM
Waiting for Trump to emerge