Alberto Enrico Maraolo
albertoemaraolo.bsky.social
Alberto Enrico Maraolo
@albertoemaraolo.bsky.social
Assistant Professor of Infectious Diseases (University of Naples "Federico II", Italy). Passionate about antibiotic resistance, EBM, epidemiology and evidence synthesis in the ID field.
Nice brief overview on how to reconsider treatment targeting #PBPs, going beyond the simple fact that beta-lactams inhibit synthesis peptidoglycan.

@sidpharm.bsky.social @contagionlive.bsky.social

www.contagionlive.com/view/penicil...
Penicillin-Binding Proteins Reconsidered: A Clinician's Guide from Targets to Dynamic Cell-Wall Control | Contagion Live
PBPs are more than static β lactam targets. Host conditions rewire PBP activity and peptidoglycan architecture, shaping tolerance, resistance, and how we design salvage regimens.
www.contagionlive.com
November 10, 2025 at 7:56 AM
Proud of the acceptance of a comment on a relevant paper on the combination between colistin and meropenem for invasive #CRAB infections.
It is time to go beyond the association between colistin and meropenem for invasive carbapenem-resistant Acinetobacter baumannii infections

✅ Just Accepted
#IDSky
🔗 https://bit.ly/3Ksetom
October 1, 2025 at 4:17 PM
Just published in @cidjournal.bsky.social a letter on the need to definitely move on in the treatment of #CRAB (#acinetobacter) infection, without further investing energies in assessing regimens (colistin plus meropenem) largely suboptimal.

academic.oup.com/cid/article/...
It is time to go beyond the association between colistin and meropenem for invasive carbapenem-resistant Acinetobacter baumannii infections
Alberto Enrico Maraolo, Giancarlo Ceccarelli; It is time to go beyond the association between colistin and meropenem for invasive carbapenem-resistant Acin
academic.oup.com
September 26, 2025 at 8:35 PM
#SARSCoV2 has not disappeared. It has become even more insidious for immunosuppressed #patients, especially the ones with impaired humoral response, ensuing in a #chronic #infection.
A letter in #NewMicrobesAndNewInfections takes sticks of the evidence.

www.sciencedirect.com/science/arti...
COVID-19 in immunocompromised patients: proposed definition of a new entity with prolonged infection
www.sciencedirect.com
August 25, 2025 at 7:39 AM
Potentially useful alternative to benzathine penicillin G for early #syphilis: oral cefixime (although with the downside of a 14-day course).
Small but interesting #RCT.

#IDSky

academic.oup.com/jac/advance-...
Cefixime versus benzathine penicillin G for the treatment of early syphilis—a randomized, controlled open label trial
AbstractObjectives. Cefixime is a promising oral treatment alternative for early syphilis but only very limited efficacy data exist. We evaluated the effic
academic.oup.com
August 7, 2025 at 11:51 AM
Reposted by Alberto Enrico Maraolo
📺 New from FirstCallID: Non-Resolving Skin & Soft Tissue Infections

When cellulitis isn’t improving, it’s easy to reach for broader antibiotics. But there’s a better way.

Here is a clear, structured approach:
🧩 DDx
🚩 What to rule out
💊 Next steps

🔗 www.firstcallid.ca
#FirstCallID #idsky #MedEd
FirstcallID - How to do an Infectious Diseases Consultation - Non-resolving Cellulitis
YouTube video by FirstcallID
youtu.be
July 20, 2025 at 10:49 AM
Novel @idsainfo.bsky.social #guidelines on #urinary_tract_infections for the first time clearly address #complicated forms and revolve around 4 domains:
1) #definitions;
2) #empirical choices (crucial the presence of #sepsis);
3) #switch to oral #antibiotics;
4) #shorter therapies.

#IDSky
July 19, 2025 at 9:36 PM
Finally out the #guidelines by @idsainfo.bsky.social on #urinary_tract_infections, introducing new definitions and providing important nuanced indications for #treatment.

#IDSky #MedSky
🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)!

The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.

View guidelines: bit.ly/4lUjN1a
July 18, 2025 at 7:47 AM
Very informative #Pk_Pd study from @Clinicalpharmacokinetics on #acyclovir dosing for #HSV/#VZV #encephalitis. Standard regimens (10 mg/kg TID) may be inadequate . Alternative strategies: increasing dosing (QID) or extending infusion durations.

#IDSky

link.springer.com/article/10.1...
Revisiting Acyclovir Dosing for Adult Viral Encephalitis Using a Full Bayesian LeiCNS PBPK Modeling Approach - Clinical Pharmacokinetics
Background and Objective Acyclovir is a primary treatment for central nervous system (CNS) infections caused by herpes simplex virus (HSV) and varicella-zoster virus (VZV). However, patient outcomes r...
link.springer.com
July 15, 2025 at 4:53 PM
The primary cause of the resurgence in #measles cases is failure to vaccinate, not failure of the #vaccine".
Landmark #review on measles in @nejm.org, facing #pathogenesis, clinical #picture, #management and #prevention in the era of its #resurgence.

#MedSky #IDSky

www.nejm.org/doi/full/10....
Measles 2025 | NEJM
In this article on measles, the authors review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies.
www.nejm.org
June 28, 2025 at 9:10 AM
Finally in volume (on Expert Review of Anti-Infective Therapy) the narrative review on the management of methicillin-resistant Staphylococcus aureus bloodstream infections.

Below is the eprint link for free download.

www.tandfonline.com/eprint/IE3MK...
Management of methicillin-resistant Staphylococcus aureus bloodstream infections: a comprehensive narrative review of available evidence focusing on current controversies and the challenges ahead
Bloodstream infections (BSIs) caused by Staphylococcus aureus are common worldwide, representing one of the most relevant issues in clinical infectious diseases practice. In particular, BSIs by met...
www.tandfonline.com
June 2, 2025 at 8:23 PM
Very precious indications from Canadian Society of Internal Medicine for "high-value, low-carbon care" against the backdrop of climate change.

Emphasis is put on oral antibiotics instead of intravenous whenever possible.

link.springer.com/article/10.1...
May 29, 2025 at 12:39 PM
#Vitamins are just "a small piece of the puzzle that determines infection susceptibility and severity" so general #supplementation is not a way to treat or prevent #infections. An exception is #Vitamin_A useful against #measles, especially in (malnourished) #children.

#MedSky #IDSky
asm.org ASM @asm.org · May 1
Vitamins support immune function, but evidence on their role (and the role of vitamin supplements) in infection is mixed. How should we think about vitamins in the context of infectious disease? 💊 asm.org/articles/202...
Can Taking Vitamins Combat Infection? | ASM.org
Vitamins support immune function, but evidence on their role (and the role of vitamin supplements) in infection is mixed. How should we think about vitamins in the context of infectious disease?
asm.org
May 1, 2025 at 4:47 PM
Very informative review from @nature.com (Reviews #Microbiology) on how #vaccination in #pregnancy protects newborns, covering immunological aspects and providing practical recommendations.

#IDsky #MedSky

www.nature.com/articles/s41...
Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology
In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...
www.nature.com
April 26, 2025 at 10:32 AM
Reposted by Alberto Enrico Maraolo
Tecovirimat is available to treat mpox in the United States and Europe, but evidence for its efficacy and safety from randomized, controlled trials has been lacking. Findings from the PALM007 trial are summarized in a new Quick Take video. nej.md/4js3uHE

#MedSky #IDSky
Placebo-Controlled Trial of Tecovirimat for Endemic Mpox | NEJM
Quick Take Video Summary from The New England Journal of Medicine — Placebo-Controlled Trial of Tecovirimat for Endemic Mpox
nej.md
April 23, 2025 at 1:12 PM
Just published a multi-author #review born from a successful multidisciplinary approach (infectious diseases, microbiology, clinical pharmacology, intensive care) on #MRSA #BSI.
Focus on #classification, #diagnosis and #therapy.
Link to the paper:
www.tandfonline.com/eprint/IE3MK...
#IDsky #MedSky
April 10, 2025 at 8:02 PM
#FUTURE_AI: an international consensus guideline for trustworthy and deployable #AI in #healthcare from
@bmj.com in its "Research Methods & Reporting" section. A set of 30 best practices to cover the entire lifecycle of healthcare #AI.

#MedSky #IDSky

www.bmj.com/content/388/...
FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare
Despite major advances in artificial intelligence (AI) research for healthcare, the deployment and adoption of AI technologies remain limited in clinical practice. This paper describes the FUTURE-AI f...
www.bmj.com
February 8, 2025 at 9:09 PM
Just published commentary in Critical_Care
about the pitfalls underlying the "culture-negative" #sepsis definition, especially when dealing with #antibiotic appropriateness. Novel and fast #microbiology techniques are essential.

#IDSky #IDsky

ccforum.biomedcentral.com/articles/10....
The elusive concept of appropriate antibiotic for septic patients when a pathogen is not detected by standard culture methods - Critical Care
ccforum.biomedcentral.com
January 6, 2025 at 11:13 AM

Worrying prediction according to mathematical modeling of the advent of a pandrug-resistant E. coli: #sepsis death in the #UnitedStates could increase 18- to 46-fold within 5 years.

www.nature.com/articles/s43...

#IDSky; #idsky
Predicting sepsis mortality into an era of pandrug-resistant E. coli through modeling - Communications Medicine
Koch et al. model scenarios of emergence of a single pan-resistant Escherichia coli strain in the United States. Findings suggest dire mortality outcomes and highlight the importance of measures to pr...
www.nature.com
January 2, 2025 at 9:40 PM
Notable article: #ELIMINATE phase 2 #RCT testing a cocktail of six bacteriophages in the setting of uncomplicated #urinary tract #infection.
#Phage therapy is the future to counter #AMR, at least as complementary strategy to traditional antibiotics.
#IDSky #MedSky

www.thelancet.com/journals/lan...
Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial
A regimen consisting of 2 days of intraurethral LBP-EC01 and 3 days of concurrent intravenous LBP-EC01 (1 × 1010 PFU) and oral TMP–SMX twice a day was well tolerated, with consistent pharmacokinetic profiles in urine and blood. LBP-EC01 and TMP–SMX dosing resulted in a rapid and durable reduction of E coli, with corresponding elimination of clinical symptoms in evaluable patients. LBP-EC01 holds promise in providing an alternative therapy for uncomplicated UTIs, with further testing of the group A dosing regimen planned in the controlled, double-blind, second part of ELIMINATE.
www.thelancet.com
December 17, 2024 at 12:42 PM
#Infections of the #eye are frequent (although of minor severity in most cases), but are often a neglected topic in the training path of an #ID physician.
Usually well-written #review from @cidjournal.bsky.social takes stock of the subject.

academic.oup.com/cid/article/...
State-of-the-Art Review: Ocular Infections
Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review
academic.oup.com
November 23, 2024 at 11:31 AM