Alberto Enrico Maraolo
albertoemaraolo.bsky.social
Alberto Enrico Maraolo
@albertoemaraolo.bsky.social
Assistant Professor of Infectious Diseases (University of Naples "Federico II", Italy). Passionate about antibiotic resistance, EBM, epidemiology and evidence synthesis in the ID field.
Good question for the next #UTI #guidelines or meanwhile for dedicated studies... Now the focus is on #ShorterIsBetter but the topic of modifying doses over the #antibiotic course in case of improvement according to primary infection site/source is still neglected.
July 20, 2025 at 6:56 PM
Indeed even low doses of aminopenicillins can reach very high concentrations in the urinary tract allowing to use them for #VRE cystitis although isolates turn out to be resistant according to the antibiogram.

shea-online.org/shea-journal...
Undisclosed: the role of aminopenicillins for the treatment of enterococcal UTIs despite in vitro resistance – SHEA
shea-online.org
July 20, 2025 at 4:23 PM
Not statistically significant differences among drugs but a slight preferable trend in favour of Meropenem_Vaborbactam, as already highlighted in previous and smaller studies.
July 16, 2025 at 1:56 PM
Exactly. The key is the proper selection of the patient, focusing on the ones undergoing systemic antibiotics at higher risk. Unfortunately evidence is mainly driven by observational findings but several RCTs are underway.

pubmed.ncbi.nlm.nih.gov/35203786/
Oral Vancomycin Prophylaxis for Primary and Secondary Prevention of Clostridioides difficile Infection in Patients Treated with Systemic Antibiotic Therapy: A Systematic Review, Meta-Analysis and Tria...
OVP appears to be an efficacious option for prevention of CDI in high-risk subjects undergoing SAT. Nevertheless, additional data from RCTs are needed to establish OVP as good clinical practice and de...
pubmed.ncbi.nlm.nih.gov
March 22, 2025 at 8:05 AM
Minocycline usually shows the highest susceptibility rate but Pk/Pd features make it a suboptimal choice for BSI or pneumonia... Combination therapy and/or doubling the dose might be potential solutions. Lastly, IV administration is available in few countries.

www.sciencedirect.com/science/arti...
In vitro susceptibilities of Stenotrophomonas maltophilia isolates to antimicrobial agents commonly used for related infections: Results from the Antimicrobial Testing Leadership and Surveillance (ATL...
Stenotrophomonas maltophilia is an emerging opportunistic pathogen for which there are limited therapeutic options because of intrinsic multidrug resi…
www.sciencedirect.com
February 8, 2025 at 8:04 AM
Interesting combinations from #POET but some are quite controversial, e.g. linezolid plus rifampicin for #MRSE

www.idstewardship.com/drug-drug-in...
Drug-Drug Interaction Between Rifampin And Linezolid: Is It A Big Deal?
Is the drug-drug interaction between rifampin and linezolid worth worrying about? In this article two infectious diseases pharmacists discuss existing data on the topic.  Authored By: Ryan Stevens, Ph...
www.idstewardship.com
January 10, 2025 at 9:33 AM