Alex Clarke
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ajclarke.bsky.social
Alex Clarke
@ajclarke.bsky.social
110 followers 98 following 15 posts
Immunologist. Kennedy Institute of Rheumatology, University of Oxford. https://www.kennedy.ox.ac.uk/research/research-groups/translational-immunometabolism
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Reposted by Alex Clarke
y-luo.bsky.social
🚨 New preprint from the lab!
We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...
November 28, 2025 at 9:56 AM
Reposted by Alex Clarke
nickjonesimmuno.bsky.social
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.

www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 10:20 AM
Reposted by Alex Clarke
nickjonesimmuno.bsky.social
Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸

Please give it a read!

www.jci.org/articles/vie...
JCI - T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges
www.jci.org
October 23, 2025 at 5:37 PM
Reposted by Alex Clarke
nickjonesimmuno.bsky.social
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.

www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 21, 2025 at 9:37 AM
Reposted by Alex Clarke
kiroxford.bsky.social
On Monday 20 October, Dr James Peters will join us to present 'The promise of proteomics: insights into autoimmune disease pathogenesis and translational potential'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/ef1...
A purple and white poster reads 'The Kennedy Institute of Rheumatology External Seminar: The promise of proteomics: insights into autoimmune disease pathogenesis and translational potential'. The speaker is Dr James Peters from Imperial College London. 20 October 2025, in the Kennedy Lecture Theatre, 12:00-13:00. Open to all members of the University of Oxford. Hosted by Alex Clarke.
October 15, 2025 at 2:37 PM
Reposted by Alex Clarke
bealelab.bsky.social
Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...
Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses
www.crick.ac.uk
October 10, 2025 at 1:08 PM
Reposted by Alex Clarke
diniscalado.bsky.social
New preprint from the lab! Lactate, a tumor-derived metabolite, blocks B cells from entering tumors and forming tertiary lymphoid structures (TLSs). Congratulations Victoire Boulat - in a great collaboration with Anita Grigoriadis! tinyurl.com/3vvk9kec #Immunology #TLS #CancerMetabolism #Bcells
October 6, 2025 at 4:48 PM
Reposted by Alex Clarke
y-luo.bsky.social
🌟 Postdoc Opportunity – MRC CoRE in Exposome Immunology 🌟
Join us to explore how the exposome shapes complex disease risk using multi-omics & global biobank data. @kiroxford.bsky.social , @exposomeimmunology.bsky.social

✅ Apply: lnkd.in/gJHJDvKn

🗓️ Deadline: 12pm, 30 Oct 2025
October 2, 2025 at 2:45 PM
Reposted by Alex Clarke
profjudiallen.bsky.social
Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social
www.bmh.manchester.ac.uk
September 30, 2025 at 10:57 AM
Reposted by Alex Clarke
pallettlab.bsky.social
SOOOOO excited to see this online IN REAL-LIFE!!

Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
September 22, 2025 at 12:35 PM
Reposted by Alex Clarke
mdphdintraining.bsky.social
A shoutout to the event organizers and presenters! Also, to the Clarke Lab, which received several awards this year 🏆

#Rheumatology #Immunology #KISS2025 #OxfordResearch #OxfordUni
September 19, 2025 at 3:35 PM
Reposted by Alex Clarke
ndorms.bsky.social
🔬 🧫 🖥️ 🧬 Applications are now open to study at the Kennedy Institute @kiroxford.bsky.social next year!

Look at available projects, meet our supervisors and find out what it’s like studying at the University of Oxford. www.kennedy.ox.ac.uk/study
Woman sitting at a microscope Fully-funded four-year PhD studentships available at the Kennedy Institute in Oxford
September 18, 2025 at 7:02 AM
Reposted by Alex Clarke
mdphdintraining.bsky.social
The Kennedy Institute Student Symposium | Day 1 💡

Hosted by the kiroxford.bsky.social!

Such a brilliant day filled with science, multidisciplinary ideas, and inspiring presentations.

It was wonderful to hear about everyone’s projects and to get thoughtful feedback on my own!
September 18, 2025 at 12:34 PM
ajclarke.bsky.social
Great work Tom!
September 10, 2025 at 12:16 PM
Reposted by Alex Clarke
tom-riffel.bsky.social
Just in time for #Cd1Mr12025

Our Review on Innate-like T cell Metabolism is out!

Access free here: rdcu.be/eEV67

Please share with your Immunometabolism friends!

@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com
Metabolic control of innate-like T cells - Nature Reviews Immunology
Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...
www.nature.com
September 8, 2025 at 6:45 PM
Reposted by Alex Clarke
exposomeimmunology.bsky.social
🎓 6x fully-funded 4-year PhD studentships 🎓

We are recruiting our first cohort of PhD students to start Oct 2026.

Students will shape their own projects within supervisory teams spanning the universities of Manchester & Oxford.

www.findaphd.com/phds/program/mrc-core-in-exposome-immunology/?p6899
FindAPhD : MRC CoRE in Exposome Immunology at The University of Manchester
Apply for a PhD: MRC CoRE in Exposome Immunology at The University of Manchester
www.findaphd.com
September 9, 2025 at 11:06 AM
Reposted by Alex Clarke
exposomeimmunology.bsky.social
WE ARE HIRING! www.manchester.ac.uk/exposome-jobs

Vacancies inc. 3x PDRA positions, 2x data scientists and a Transition Fellowship in Air Pollution.

Join us as we embark on a 14 year journey to understand how the exposome impacts immune regulation and chronic inflammation.

#hiring #immunosky
September 8, 2025 at 3:55 PM
Reposted by Alex Clarke
kiroxford.bsky.social
Did you know that we have:
📆 A packed external seminar series, open to anyone from the University of Oxford.
🎊 Themed, fun monthly social events for Kennedy staff and students.
🙋 Support for Kennedy researchers to run their own events.

Check out what we do! www.kennedy.ox.ac.uk/events
Events
www.kennedy.ox.ac.uk
September 3, 2025 at 3:11 PM
Reposted by Alex Clarke
kiroxford.bsky.social
Want to coordinate our exciting seminar series, and be the go-to person for events at the Kennedy Institute?

We're hiring an Administrative Assistant (Meetings, Events, and Communications!)

Apply by 12 Sept. 👇

www.kennedy.ox.ac.uk/jobs/adminis...
Administrative Assistant (Meetings, events, and Communications) (181623)
The Administrative Assistant will lead the scheduling and administration of external and internal seminars, with management and faculty meetings, social events, and special events such as institute re...
www.kennedy.ox.ac.uk
September 2, 2025 at 1:54 PM
Reposted by Alex Clarke
y-luo.bsky.social
🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠
🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics
kennedy.ox.ac.uk
September 1, 2025 at 11:25 AM
Reposted by Alex Clarke
nanaborsa.bsky.social
Bittersweet farewell weeks at @kiroxford.bsky.social, a place pivotal to my growth as an independent scientist. With deep gratitude for this chapter, I'm thrilled to begin the next at @unibas.ch @biomedizin.unibas.ch, where my lab will study organelle inheritance in T cells in the context of ageing.
August 18, 2025 at 9:34 AM
Reposted by Alex Clarke
ryanlab.bsky.social
It was a pleasure to write this News & Views piece with Eloïse marques on the latest work from the lab of Jing Fan @natmetabolism.nature.com ⬇️⬇️

News & Views:
Macrophages say NO to nucleotide synthesis and salvage instead
nature.com/articles/s42...

Article:
nature.com/articles/s42...
Macrophages say NO to nucleotide synthesis and salvage instead - Nature Metabolism
Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a pre...
nature.com
August 4, 2025 at 11:18 AM
Reposted by Alex Clarke
y-luo.bsky.social
📣First paper from the lab is out in @science.org‬! 📣https://www.science.org/doi/10.1126/sciadv.adu3461 It’s well known that HLA shapes the TCR repertoire — but how does this change under immune checkpoint blockade (ICB)?
Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade
Immune checkpoint blockade influences the genetically determined relationship between TCR repertoire and HLA alleles in cancer.
www.science.org
July 28, 2025 at 10:09 AM
Reposted by Alex Clarke
kiroxford.bsky.social
Huge news! A £50M MRC CoRE will bring together Manchester & Oxford to study how environmental exposures cause chronic inflammatory disease.

The CoRE will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.

www.kennedy.ox.ac.uk/news/new-ps5...
New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases
A new Medical Research Council Centre of Research Excellence (MRC CoRE) will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases, such as asthma, ...
www.kennedy.ox.ac.uk
July 16, 2025 at 9:38 AM
Reposted by Alex Clarke
alidvorscek.bsky.social
Incredibly excited to share my final project from Monash which was recently published in @jimmunol.bsky.social! Together with Jesse Mulder from the Robinson Group @robinsonmj.bsky.social, we found a role for IL-21 in allergy responses by promoting type 2 memory B cell formation. Check it out !👇🏼
July 11, 2025 at 8:16 AM