Rupert Beale
@bealelab.bsky.social
Group Leader, Cell Biology of Infection Lab @thecrick; Nephrologist @Royal Free Hospital. Own views etc.
Pinned
Rupert Beale
@bealelab.bsky.social
· Aug 8
https://cell.com/molecular-cell…
We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in @MolecularCell cell.com/molecular-cell…. 1/16
Reposted by Rupert Beale
Did they read what they cite?
In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease!
www.nature.com/articles/s41...
www.annenbergpublicpolicycenter.org/public-confi...
In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease!
www.nature.com/articles/s41...
www.annenbergpublicpolicycenter.org/public-confi...
January 16, 2026 at 4:38 PM
Did they read what they cite?
In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease!
www.nature.com/articles/s41...
www.annenbergpublicpolicycenter.org/public-confi...
In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease!
www.nature.com/articles/s41...
www.annenbergpublicpolicycenter.org/public-confi...
Reposted by Rupert Beale
João Monteiro and the editorial board of @naturemedicine.bsky.social should be ashamed of themselves for publishing this trash. www.nature.com/articles/s41...
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID) - Nature Medicine
Preparing for tomorrow’s threats by enhancing our ability to help patients today.
www.nature.com
January 16, 2026 at 2:23 PM
João Monteiro and the editorial board of @naturemedicine.bsky.social should be ashamed of themselves for publishing this trash. www.nature.com/articles/s41...
Reposted by Rupert Beale
My main PhD paper is finally out! 🎉
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
January 2, 2026 at 4:57 PM
My main PhD paper is finally out! 🎉
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com
It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.
1/11 🧵
Reposted by Rupert Beale
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
www.biorxiv.org
December 16, 2025 at 6:35 AM
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Reposted by Rupert Beale
Oh! And happy St Lucy’s Day, one and all, may your eyes be healthy and free of infection
December 13, 2025 at 3:39 PM
Oh! And happy St Lucy’s Day, one and all, may your eyes be healthy and free of infection
Lamb Koftas (before and after).
November 25, 2025 at 10:16 PM
Lamb Koftas (before and after).
Reposted by Rupert Beale
From the Rare Kidney Disease Centre
November 11, 2025 at 9:30 AM
From the Rare Kidney Disease Centre
Reposted by Rupert Beale
In London for the @lifearc.bsky.social annual meeting
November 11, 2025 at 9:11 AM
In London for the @lifearc.bsky.social annual meeting
Reposted by Rupert Beale
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
Doctoral clinical fellows
The Crick's clinical PhD programme.
www.crick.ac.uk
October 30, 2025 at 9:41 AM
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
Are you a clinician who wants to do a PhD? Come to @crick.ac.uk (you can even come to my lab).
October 30, 2025 at 11:51 AM
Are you a clinician who wants to do a PhD? Come to @crick.ac.uk (you can even come to my lab).
Reposted by Rupert Beale
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
October 11, 2025 at 3:05 AM
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...
Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses
www.crick.ac.uk
October 10, 2025 at 1:08 PM
Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...
@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?
September 13, 2025 at 12:59 AM
@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?
Reposted by Rupert Beale
The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS.
All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.
This will, and already does, cost lives.
All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.
This will, and already does, cost lives.
New: I spent the week looking into the cancelled mRNA contracts. Interviews with HHS officials and MAGA and MAHA influencers reveal an HHS agency plagued by dysfunction as Kennedy chips away at the nation’s public health.
www.msnbc.com/news/news-an...
www.msnbc.com/news/news-an...
How RFK Jr. alienated MAGA, MAHA and the White House in a single week
The botched announcement about mRNA vaccines reveals a health department full of dysfunction and infighting.
www.msnbc.com
August 15, 2025 at 4:07 AM
The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS.
All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.
This will, and already does, cost lives.
All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.
This will, and already does, cost lives.
Reposted by Rupert Beale
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven
with population-based datasets used to quantify musical achievement.
www.cell.com
August 7, 2025 at 11:10 AM
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
Reposted by Rupert Beale
I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.
I learned beginner Basque at UChicago, an experience that i still cherish. This is fucking appalling to hear
Wow. The University of Chicago, a world-class institution whose humanities faculty in the past has included Homi Bhabha & Lauren Berlant & Ralph Ellison & Hannah freaking Arendt, is getting rid of basically every graduate department involving the acknowledgment that other cultures & languages exist.
August 13, 2025 at 10:44 PM
I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.
Surely you meant to write ‘formerly a world class institution’?
Wow. The University of Chicago, a world-class institution whose humanities faculty in the past has included Homi Bhabha & Lauren Berlant & Ralph Ellison & Hannah freaking Arendt, is getting rid of basically every graduate department involving the acknowledgment that other cultures & languages exist.
August 14, 2025 at 1:29 AM
Surely you meant to write ‘formerly a world class institution’?
Reposted by Rupert Beale
🎥 The Keystone Symposium on Autophagosomes & Endolysosomes is now on demand!
Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field
.
👉 keysym.us/KSAutophagy2...
#KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social
Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field
.
👉 keysym.us/KSAutophagy2...
#KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social
July 17, 2025 at 5:21 PM
🎥 The Keystone Symposium on Autophagosomes & Endolysosomes is now on demand!
Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field
.
👉 keysym.us/KSAutophagy2...
#KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social
Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field
.
👉 keysym.us/KSAutophagy2...
#KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social
Reposted by Rupert Beale
The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy.
👏 Congrats to our Keystone scholarship awardees—your future in science is bright!
🔗 keysym.us/scholarships...
#KSAutophagy25 @bealelab.bsky.social
👏 Congrats to our Keystone scholarship awardees—your future in science is bright!
🔗 keysym.us/scholarships...
#KSAutophagy25 @bealelab.bsky.social
June 28, 2025 at 5:33 PM
The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy.
👏 Congrats to our Keystone scholarship awardees—your future in science is bright!
🔗 keysym.us/scholarships...
#KSAutophagy25 @bealelab.bsky.social
👏 Congrats to our Keystone scholarship awardees—your future in science is bright!
🔗 keysym.us/scholarships...
#KSAutophagy25 @bealelab.bsky.social
Cheering myself up by reminding myself this is happening next week.
How many Bluesky people can you spot as speakers? @kraftlabfr.bsky.social @martenslab.bsky.social @maxgg.bsky.social @jimhurley.bsky.social for starters. Exciting #autophagy talks guaranteed! #KSAutophagy25
If you are wondering if you should come to the Keystone #autophagy meeting this year, the answer is – yes! Of course you should! www.keystonesymposia.org/conferences/...
June 20, 2025 at 8:11 PM
Cheering myself up by reminding myself this is happening next week.
Reposted by Rupert Beale
Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology
Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...
www.nature.com
June 17, 2025 at 1:13 PM
Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...
Reposted by Rupert Beale
Sharing this on the eve of tomorrow's vote.
I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong.
www.theguardian.com/commentisfre...
I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong.
www.theguardian.com/commentisfre...
MPs have personal beliefs, but also solemn duties: that’s why they must reject the assisted dying bill this week | Gordon Brown
Our obligations to each other are ill served if laws focus unduly on those who want assisted dying. The priority should be the best palliative care, says former prime minister Gordon Brown
www.theguardian.com
June 19, 2025 at 1:02 PM
Sharing this on the eve of tomorrow's vote.
I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong.
www.theguardian.com/commentisfre...
I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong.
www.theguardian.com/commentisfre...
Reposted by Rupert Beale
Robert F Kennedy Jr said he is “retiring” all 17 members of a crucial government panel of vaccine advisors
He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention
This could serious damage US health
www.cnbc.com/2025/06/09/r...
He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention
This could serious damage US health
www.cnbc.com/2025/06/09/r...
RFK Jr. removes all members of CDC panel advising U.S. on vaccines
It's the latest move by Kennedy – a prominent vaccine skeptic – to change and potentially undermine vaccinations in the U.S. since he took the helm at HHS.
www.cnbc.com
June 10, 2025 at 6:39 PM
Robert F Kennedy Jr said he is “retiring” all 17 members of a crucial government panel of vaccine advisors
He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention
This could serious damage US health
www.cnbc.com/2025/06/09/r...
He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention
This could serious damage US health
www.cnbc.com/2025/06/09/r...
Reposted by Rupert Beale
We have raised concerns about existing deficiencies in the Terminally Ill Adults (End of Life) Bill.
We believe the bill in its current form lacks adequate protections for patients and professionals.
Full statement: ow.ly/EOhP50W692q
We believe the bill in its current form lacks adequate protections for patients and professionals.
Full statement: ow.ly/EOhP50W692q
‘Deficiencies in protecting patients and professionals’ - RCP publishes its position on the Terminally Ill Adults (End of Life) Bill
ow.ly
June 9, 2025 at 12:53 PM
We have raised concerns about existing deficiencies in the Terminally Ill Adults (End of Life) Bill.
We believe the bill in its current form lacks adequate protections for patients and professionals.
Full statement: ow.ly/EOhP50W692q
We believe the bill in its current form lacks adequate protections for patients and professionals.
Full statement: ow.ly/EOhP50W692q