Alberto Elosegui-Artola
@aeloseguiartola.bsky.social
Head of the Cell and Tissue Mechanobiology Lab
@TheCrick, Senior Lecturer @KingsCollegeLon| Previously #MooneyLab
@Harvard and @PCusachs Lab.
@TheCrick, Senior Lecturer @KingsCollegeLon| Previously #MooneyLab
@Harvard and @PCusachs Lab.
Pinned
Elosegui-Artola Lab | Mechanical regulation of tissue dynamics by the extracellular matrix in development and cancer
www.crick.ac.uk
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...
Reposted by Alberto Elosegui-Artola
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 3:56 PM
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Reposted by Alberto Elosegui-Artola
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
How weakness in cell structure affects the host-microbiome relationship
Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk
November 13, 2025 at 7:56 PM
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
Reposted by Alberto Elosegui-Artola
This research was led by @luiz90vasc.bsky.social and Shaina Chor Mei Huang with corresponding author @drmichaelway.bsky.social
November 13, 2025 at 7:57 PM
This research was led by @luiz90vasc.bsky.social and Shaina Chor Mei Huang with corresponding author @drmichaelway.bsky.social
Reposted by Alberto Elosegui-Artola
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Reposted by Alberto Elosegui-Artola
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
October 22, 2025 at 2:06 PM
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
Reposted by Alberto Elosegui-Artola
Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors.
#morphogenesis
#morphogenesis
October 15, 2025 at 10:24 AM
Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors.
#morphogenesis
#morphogenesis
Reposted by Alberto Elosegui-Artola
🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel
tinyurl.com/stnczkc6
tinyurl.com/stnczkc6
Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion...
advanced.onlinelibrary.wiley.com
October 14, 2025 at 4:23 AM
🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel
tinyurl.com/stnczkc6
tinyurl.com/stnczkc6
Reposted by Alberto Elosegui-Artola
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...
Elosegui-Artola Lab | Mechanical regulation of tissue dynamics by the extracellular matrix in development and cancer
www.crick.ac.uk
October 9, 2025 at 7:28 AM
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...
Reposted by Alberto Elosegui-Artola
We are offering a super exciting project to develop new ways of targeting metastatic cancer cells!
Amazing supervisory team:
Primary supervisor: Professor Joanna Loizou
Associate supervisor: Professor Zoran Rankovic
Secondary supervisor: Professor Victoria Sanz-Moreno
@icr.ac.uk
Amazing supervisory team:
Primary supervisor: Professor Joanna Loizou
Associate supervisor: Professor Zoran Rankovic
Secondary supervisor: Professor Victoria Sanz-Moreno
@icr.ac.uk
Targeting AMPK as a metabolic vulnerability of metastatic cancer cells
Targeting AMPK as a metabolic vulnerability of metastatic cancer cells
www.icr.ac.uk
October 9, 2025 at 6:19 PM
We are offering a super exciting project to develop new ways of targeting metastatic cancer cells!
Amazing supervisory team:
Primary supervisor: Professor Joanna Loizou
Associate supervisor: Professor Zoran Rankovic
Secondary supervisor: Professor Victoria Sanz-Moreno
@icr.ac.uk
Amazing supervisory team:
Primary supervisor: Professor Joanna Loizou
Associate supervisor: Professor Zoran Rankovic
Secondary supervisor: Professor Victoria Sanz-Moreno
@icr.ac.uk
Reposted by Alberto Elosegui-Artola
Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social
www.colcc.ac.uk/2026-phd-pro...
crukradnet.colcc.ac.uk/phd-students...
www.colcc.ac.uk/2026-phd-pro...
crukradnet.colcc.ac.uk/phd-students...
October 9, 2025 at 7:04 AM
Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social
www.colcc.ac.uk/2026-phd-pro...
crukradnet.colcc.ac.uk/phd-students...
www.colcc.ac.uk/2026-phd-pro...
crukradnet.colcc.ac.uk/phd-students...
Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14!
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...
www.isscr.org
October 9, 2025 at 8:57 AM
Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14!
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...
Elosegui-Artola Lab | Mechanical regulation of tissue dynamics by the extracellular matrix in development and cancer
www.crick.ac.uk
October 9, 2025 at 7:28 AM
The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...
Reposted by Alberto Elosegui-Artola
Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
September 23, 2025 at 7:39 PM
Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!
Reposted by Alberto Elosegui-Artola
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability
The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...
journals.aps.org
September 16, 2025 at 7:46 PM
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Reposted by Alberto Elosegui-Artola
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 26, 2025 at 8:28 AM
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Reposted by Alberto Elosegui-Artola
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
August 15, 2025 at 10:50 AM
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
Reposted by Alberto Elosegui-Artola
Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
August 14, 2025 at 9:10 AM
Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
August 14, 2025 at 9:10 AM
Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!
Reposted by Alberto Elosegui-Artola
Congrats to everyone including JCS @jcellsci.bsky.social Editor Megan King @luskinglab.bsky.social & Editorial Advisory Board members Dennis Discher, Miho Iijima, James Olzmann @olzmannlab.bsky.social, Kristen Verhey @kjverhey1.bsky.social for becoming ASCB fellows
www.ascb.org/society-news...
www.ascb.org/society-news...
Fourteen Visionary Scientists Named 2025 ASCB Fellows - ASCB
The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...
www.ascb.org
August 11, 2025 at 3:20 PM
Congrats to everyone including JCS @jcellsci.bsky.social Editor Megan King @luskinglab.bsky.social & Editorial Advisory Board members Dennis Discher, Miho Iijima, James Olzmann @olzmannlab.bsky.social, Kristen Verhey @kjverhey1.bsky.social for becoming ASCB fellows
www.ascb.org/society-news...
www.ascb.org/society-news...
Reposted by Alberto Elosegui-Artola
🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….
August 9, 2025 at 8:03 AM
🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….
Reposted by Alberto Elosegui-Artola
Reposted by Alberto Elosegui-Artola
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
August 1, 2025 at 10:10 AM
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
Reposted by Alberto Elosegui-Artola
Paper accepted 🥳 Many congratulations @tobyandrews.bsky.social So proud of what you have achieved! Can’t wait to see what you do next... Onwards and upwards from here!
July 23, 2025 at 9:27 PM
Paper accepted 🥳 Many congratulations @tobyandrews.bsky.social So proud of what you have achieved! Can’t wait to see what you do next... Onwards and upwards from here!
Reposted by Alberto Elosegui-Artola
Data drop! We just released an updated list of anti-ECM antibodies curated from the #HumanBioMolecularAtlasProgram Organ Mapping Antibody Panels #OMAP and the 9th release of the Human Reference Atlas #HRA. Check it out: sites.google.com/uic.edu/matr...
July 15, 2025 at 12:16 AM
Data drop! We just released an updated list of anti-ECM antibodies curated from the #HumanBioMolecularAtlasProgram Organ Mapping Antibody Panels #OMAP and the 9th release of the Human Reference Atlas #HRA. Check it out: sites.google.com/uic.edu/matr...
Reposted by Alberto Elosegui-Artola
Check out our latest preprint, which is the latest production from our long-lasting collaboration with Andrey Klymchenko
> functionnalizing NPs with humanized antibodies (i.e. Trastuzumab).
Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab.
www.biorxiv.org/content/10.1...
> functionnalizing NPs with humanized antibodies (i.e. Trastuzumab).
Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab.
www.biorxiv.org/content/10.1...
July 7, 2025 at 7:34 AM
Check out our latest preprint, which is the latest production from our long-lasting collaboration with Andrey Klymchenko
> functionnalizing NPs with humanized antibodies (i.e. Trastuzumab).
Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab.
www.biorxiv.org/content/10.1...
> functionnalizing NPs with humanized antibodies (i.e. Trastuzumab).
Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab.
www.biorxiv.org/content/10.1...