Rienk Eelkema
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rienkeelkema.bsky.social
Rienk Eelkema
@rienkeelkema.bsky.social
480 followers 520 following 130 posts

I like making things. Like molecules, plants, photos, my kids happy. And food.
professor @ TU Delft, interested in complex systems, organic chemistry, soft materials, healthcare&biology

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Materials science 30%
Chemistry 26%
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rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 7d
Good luck Dave

Reposted by Rienk Eelkema

seadanourhussen.bsky.social
MediocreMigrant @seadanourhussen.bsky.social · 17d
Killjoy hier: 'Onthullen' dat FvD 'flirt' met extreemrechts is echt geen flex. Het levert applaus op en vaste een journalistieke prijs. Want onze sector houdt van vorm. Maar we zijn al jaren te laat met dit soort 'bewijzen'; waar blijft het bestrijden? We zijn lui en laat.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 19d
Importantly, we demonstrate this strategy on a real chemotherapeutic agent (gemcitabine) in 3D glioblastoma tumor models, highlighting its translational potential.
Outstanding work by Juncheng Liu, Bing Xu, and Mark de Geus, and a great collaboration with Antonia Denkova.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 19d
Here, we show that the well known benzylboronic acid caging group, traditionally removed using H₂O₂, can be rapidly and selectively uncaged by clinically relevant doses of ionizing radiation in the presence of organochlorides. This process is further enhanced through arylamine catalysis.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 19d
Ionizing radiation used in radiotherapy generates reactive oxygen species capable of removing specially designed caging groups (for a recent review, see: www.nature.com/articles/s41...).
The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics - Nature Reviews Chemistry
This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs...
www.nature.com

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 19d
Excited to announce our new publication on ionizing radiation–triggered uncaging of benzylboronic acid–caged chemotherapeutics, now published in Chemical Science (open access):
pubs.rsc.org/en/content/a...

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 21d
graag ook bij TU Delft
@tudelfttnw.bsky.social @tudelftlibrary.bsky.social

Reposted by Robbert Sanderman, Ben Crum, Rienk Eelkema

msmjetten.bsky.social
Mike Jetten @msmjetten.bsky.social · 21d
Ook in Nederland kan het: De @rug.nl in 2030 los van Big Tech. No #microsoft et al @linuxkernel.bsky.social @libreoffice.bsky.social #surfdrive
community-edtech.npuls.nl/groups/view/...
De RUG in 2030 los van Big Tech: hoe Nolda Tipping-Griffioen de beweging binnen de RUG is gestart richting digitale autonomie
Nolda Tipping-Griffioen is initiatiefnemer van de nieuwe ambitie van de RUG: zij willen in 2030 los zijn van Big Tech [1]. In december 2025 sprak ik…
community-edtech.npuls.nl

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 25d
congrats, well done

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · 25d
12/10 would recommend
happy b-day Wikipedia!
depthsofwikipedia.bsky.social depths of wikipedia @depthsofwikipedia.bsky.social · 25d
wikipedia turns 25 today! the last unenshittified major website! backbone of online info! triumph of humanity! powered by urge of unpaid randos to correct each other! somehow mostly reliable! "good thing wikipedia works in practice, because it sure doesn't work in theory" - old wiki adage

Reposted by Andy Purvis, Steve Peers, Peter Holmes , and 16 more

depthsofwikipedia.bsky.social
depths of wikipedia @depthsofwikipedia.bsky.social · 25d
wikipedia turns 25 today! the last unenshittified major website! backbone of online info! triumph of humanity! powered by urge of unpaid randos to correct each other! somehow mostly reliable! "good thing wikipedia works in practice, because it sure doesn't work in theory" - old wiki adage

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 22
Bravo 💪🏾

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 17
Recent contributions from our group on this topic:
doi.org/10.1039/D5SC....
doi.org/10.1021/acsa....
doi.org/10.31635/ccs....
Organochloride mediated prodrug activation induced by ionizing radiation
Boronic acid and ester-caged prodrugs have been widely investigated in cellular-generated hydrogen peroxide triggered release. Although it is well-known that ionizing radiation generates hydrogen pero...
doi.org

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 17
Many thanks to prof. Zhibo Liu (Peking University), a giant in this field, for useful input during the review process. I’m also very grateful to the journal and its editor @stephengdavey.bsky.social for an involved, constructive and rewarding review and editing process.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 17
We thought it would be useful to review the developments in this field and link these to the underlying radiation chemistry.
For us, this was a very insightful piece to research and write, it taught us a lot about the limits and opportunities in the field.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 17
Recent years have seen considerable advances in combined radio-chemotherapy, where therapeutic dose radiation is used to locally release or activate chemotherapeutics. This mostly goes via the radiolysis of water, where the formed reactive species react with polymer nanocarriers or caged drugs.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 17
Now out in @natrevchem.nature.com: The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics

by Dr. Juncheng Liu

Another great collaboration with prof. Antonia Denkova (Department of Radiation Science and Technology).

Reposted by Rienk Eelkema

shuntaroamano.bsky.social
Shuntaro Amano 天野俊太郎 @shuntaroamano.bsky.social · Dec 10
Our new paper "A Versatile Strategy for Light-Driven Active Transport of Ions" is now online in @angewandtechemie.bsky.social!

shorturl.at/jr1wY

We used an azobenzene photoswitch to transport ions against their concentration gradients from one aqueous compartment to the other. This was achieved

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 4
These findings could have exciting implications for low dose-rate cancer treatments, including radionuclide therapy and brachytherapy.
Wonderful work from Bing Xu and Juncheng Liu, and a great collaboration with prof. Antonia Denkova
Open Access publication here: www.cell.com/cell-reports...
Low-dose-rate ionizing radiation increases singlet oxygen production by photosensitizers
Xu et al. reveal that ionizing radiation drives singlet oxygen generation from Ce6 through superoxide anions rather than Cerenkov light, with low dose rates favoring the process by reducing radical re...
www.cell.com

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 4
The ionized photosensitizer and superoxide then react to form singlet oxygen, a key cytotoxic species in PDT. We hypothesize that low dose-rate radiation leads to more spatially dispersed reactive oxygen species from water radiolysis, reducing recombination and boosting superoxide formation.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 4
Bing’s work suggests a compelling mechanism: instead of generating triplets (as in classic PDT), ionizing radiation ionizes the photosensitizer and simultaneously produces superoxide radicals from dissolved oxygen.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 4
Ionizing radiation, on the other hand, reaches deep into the body, as used in radiotherapy but also opening the door to deep-tissue photodynamic-like effects.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 4
So, what’s going on here? In ordinary PDT, light-induced excitation of a photosensitizer such as Chlorin e6 will lead to singlet oxygen formation via the photosensitizer triplet state. Photodynamic therapy (PDT) is powerful, but limited by how poorly light penetrates tissue.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Dec 4
You probably know Photodynamic Therapy (PDT), but how about Radiodynamic Therapy?
Now out in Cell Reports Physical Science, Bing Xu shows how lowering the radiation dose rate on solutions of the photosensitizer Chlorin e6 leads to increased production of highly cytotoxic singlet oxygen.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Nov 29
Published a paper warning that something doesn't work as commonly accepted in SciRep some years ago, that journal has done some dubious things in the mean time though. I generally like the approach and integrity of CellRepPhysSci, I could imagine they might be up for something like this

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Nov 28
Want to come to Maine? I wanted to contact your journal but GRC doesn't allow me to. Would be great to have you there

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Nov 28
🔬 Registration Now Open!
GRC Systems Chemistry 2026
“Bridging Molecular Complexity and Multiscale Systems Integration”
📅 June 21 – 26, 2026
📍 Portland, Maine (USA)
www.grc.org/systems-chem...
Feel free to share this announcement with anyone who may be interested.
#GRC @systemschem-grc.bsky.social

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Nov 28
The project was led by Dr. Benjamin Klemm, in close collaboration with Dr. Margherita Tavasso and Prof. Pouyan Boukany @pboukany.bsky.social. Funding from the @erc.europa.eu , Open Access publication.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Nov 28
The kinetics of drug release depend heavily on the type of nucleophilic trigger: thiols are fast, amines are much slower (minutes to days). Application of a gefinitib construct to a lung cancer cell model (A549) showed ~100% wound-closure inhibition upon signal activation.

rienkeelkema.bsky.social
Rienk Eelkema @rienkeelkema.bsky.social · Nov 28
These prodrugs can be activated by biologically relevant nucleophiles enabling precisely controlled drug release.
We went on to embed anti-cancer and antibiotic prodrugs into hydrogel scaffolds, testing them in aqueous and cellular environments.