Awesome research by Zachary Stavrou-Dowd, Lee Haines and team showing that topical application of Nitisinone (including tarsal uptake) kills insecticide-resistant mosquitos. Lots of potential for other haematophagus parasites too 😀 pmc.ncbi.nlm.nih.gov/articles/PMC...
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake
Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previous studies ...
pmc.ncbi.nlm.nih.gov
October 16, 2025 at 4:34 PM
Awesome research by Zachary Stavrou-Dowd, Lee Haines and team showing that topical application of Nitisinone (including tarsal uptake) kills insecticide-resistant mosquitos. Lots of potential for other haematophagus parasites too 😀 pmc.ncbi.nlm.nih.gov/articles/PMC...
An Improved, Rapid, and Sensitive LC‐MS/MS Method for Quantification of Nitisinone From Human Plasma #SSCplus analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
An Improved, Rapid, and Sensitive LC‐MS/MS Method for Quantification of Nitisinone From Human Plasma
Nitisinone (NTBC) has been the standard therapy for hereditary tyrosinemia type 1 (HT-1) since the early 1990s and remains the only effective treatment. To ascertain its therapeutic levels, a rapid a...
analyticalsciencejournals.onlinelibrary.wiley.com
October 9, 2025 at 11:15 AM
An Improved, Rapid, and Sensitive LC‐MS/MS Method for Quantification of Nitisinone From Human Plasma #SSCplus analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
#MedSky Nitisinone could open up new avenues to stop the spread of diseases like malaria and dengue. The poisoning process blocks an enzyme mosquitoes need to process proteins and amino acids in blood & can work by simply being on surfaces mosquitoes land on.
This drug can turn your blood into mosquito poison
Nitisinone kills even insecticide-resistant mosquitoes.
tinyurl.com
August 27, 2025 at 4:05 AM
#MedSky Nitisinone could open up new avenues to stop the spread of diseases like malaria and dengue. The poisoning process blocks an enzyme mosquitoes need to process proteins and amino acids in blood & can work by simply being on surfaces mosquitoes land on.
Une étude montre que la nitisinone, absorbée par les pattes, avait les mêmes effets, à savoir une paralysie et une couleur plus foncée, sur les moustiques n’ayant pas bu de sang et ceux qui en ont consommé. Ces travaux pourraient ouvrir une nouvelle voie dans la lutte contre les moustiques.
Non seulement la nitisinone transforme votre sang en poison pour les moustiques, mais elle les paralyse lorsqu'ils l'absorbent par les pattes
Quelques mois après avoir montré que le sang de personnes traitées à la nitisinone tuait les moustiques, une nouvelle étude révèle que cette substance est aussi toxique hors du corps humain.
Mehdi SMAINI
Publié le 13 Août 2025 à 11H00
[...] Toxique également en dehors du corps humain Une étude plus récente publiée le 31 juillet dernier dans la revue Parasites & Vectors, a montré que la nitisinone était toxique, même lorsqu’elle n’était pas mélangée au sang humain. En effet, ils ont tout d’abord mis en contact plusieurs espèces de moustiques avec des surfaces imprégnées de nitisinone et de quatre autres inhibiteurs de l’HPPD, l’enzyme qui régule détoxifie la tyrosine, avant et après qu’ils aient bu un échantillon de sang.
L’étude indique que la nitisinone, absorbée par les pattes, avait les mêmes effets, à savoir une paralysie et une couleur plus foncée, sur les moustiques n’ayant pas bu de sang et ceux qui en ont consommé. Ces travaux pourraient permettre de mieux lutter contre les moustiques, qui se montrent [de plus en plus] résistants aux différents insecticides et qui restent l’animal qui tue le plus d'humains dans le monde.
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake | Parasites & Vectors, 31.07.2025 https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-025-06939-0
Image : Graphical Abstract
sco.lt
August 23, 2025 at 4:45 PM
Une étude montre que la nitisinone, absorbée par les pattes, avait les mêmes effets, à savoir une paralysie et une couleur plus foncée, sur les moustiques n’ayant pas bu de sang et ceux qui en ont consommé. Ces travaux pourraient ouvrir une nouvelle voie dans la lutte contre les moustiques.
Researchers at @lstmnews.bsky.social show that nitisinone, a licensed drug for rare genetic conditions, kills multiple mosquito species (Anopheles, Aedes, Culex), including insecticide-resistant vectors of malaria, dengue, Zika & emerging viral threats.
🔗 www.lstmed.ac.uk/news-events/...
🔗 www.lstmed.ac.uk/news-events/...
Drug kills mosquitoes when they feed through ingestion and surface contact
A new study led by Liverpool School of Tropical Medicine shows that mosquitoes are killed when they feed on blood and then land on a surface sprayed with nitisinone, a drug currently used to treat a
www.lstmed.ac.uk
August 20, 2025 at 1:58 PM
Researchers at @lstmnews.bsky.social show that nitisinone, a licensed drug for rare genetic conditions, kills multiple mosquito species (Anopheles, Aedes, Culex), including insecticide-resistant vectors of malaria, dengue, Zika & emerging viral threats.
🔗 www.lstmed.ac.uk/news-events/...
🔗 www.lstmed.ac.uk/news-events/...
Nitisinone, a drug that turns your blood into mosquito poison
www.popsci.com/health/mosqu...
www.popsci.com/health/mosqu...
This drug can turn your blood into mosquito poison
Nitisinone kills even insecticide-resistant mosquitoes.
www.popsci.com
August 14, 2025 at 3:13 PM
Nitisinone, a drug that turns your blood into mosquito poison
www.popsci.com/health/mosqu...
www.popsci.com/health/mosqu...
Even walking on surfaces coated with the drug is enough to kill them. This breakthrough could help fight mosquito-borne diseases like malaria. Researchers are now exploring ways to use nitisinone in things like bed nets or screens to protect people from bites.
August 13, 2025 at 9:57 PM
Even walking on surfaces coated with the drug is enough to kill them. This breakthrough could help fight mosquito-borne diseases like malaria. Researchers are now exploring ways to use nitisinone in things like bed nets or screens to protect people from bites.
Scientists have discovered that a drug called nitisinone, originally used to treat rare diseases, can kill mosquitoes. When mosquitoes drink the blood of someone who has taken the drug, they die within hours because it blocks their ability to digest the blood properly.
August 13, 2025 at 9:57 PM
Scientists have discovered that a drug called nitisinone, originally used to treat rare diseases, can kill mosquitoes. When mosquitoes drink the blood of someone who has taken the drug, they die within hours because it blocks their ability to digest the blood properly.
A study found that the drug nitisinone works as a potent contact insecticide for killing the mosquito species that spread malaria, dengue, and other emerging mosquito-borne viral threats, offering hope of a new approach to combating insecticide resistance. #AMR
www.ghtcoalition.org/blog/researc...
www.ghtcoalition.org/blog/researc...
Research Roundup: New mosquito killer drug, Women's health R&D funding, HIV vaccine clinical trial
In today's Research Roundup for August 11, 2025, we highlight some of the most interesting reads in global health research and development from the past week.
www.ghtcoalition.org
August 12, 2025 at 2:25 PM
A study found that the drug nitisinone works as a potent contact insecticide for killing the mosquito species that spread malaria, dengue, and other emerging mosquito-borne viral threats, offering hope of a new approach to combating insecticide resistance. #AMR
www.ghtcoalition.org/blog/researc...
www.ghtcoalition.org/blog/researc...
Check out this awesome study from our Notre Dame colleagues, @aacostaserrano.bsky.social and Lee Haines!! Nitisinone kills insecticide-resistant mosquitoes through cuticular uptake
parasitesandvectors.biomedcentral.com/articles/10....
parasitesandvectors.biomedcentral.com/articles/10....
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
parasitesandvectors.biomedcentral.com
August 7, 2025 at 4:57 PM
Check out this awesome study from our Notre Dame colleagues, @aacostaserrano.bsky.social and Lee Haines!! Nitisinone kills insecticide-resistant mosquitoes through cuticular uptake
parasitesandvectors.biomedcentral.com/articles/10....
parasitesandvectors.biomedcentral.com/articles/10....
Nitisinone, a drug approved for rare genetic conditions, has been shown to kill multiple mosquito species through both ingestion and contact, including those resistant to current insecticides. doi.org/g9wgq6
Drug used for rare disease can turn human blood and surfaces deadly to mosquitoes
A drug that makes human blood lethal to mosquitoes also acts as a potent contact insecticide absorbed through the feet, providing a promising new approach to combating insecticide resistance.
phys.org
August 7, 2025 at 4:16 PM
Nitisinone, a drug approved for rare genetic conditions, has been shown to kill multiple mosquito species through both ingestion and contact, including those resistant to current insecticides. doi.org/g9wgq6
Just out: LSTM’s blog post on our latest paper exploring how nitisinone kills malaria mosquitoes, even the resistant ones, through tarsal contact.
From rare disease drug to vector control tool.
@aacostaserrano.bsky.social
📄 Paper: doi.org/10.1186/s130...
#malaria #vectorcontrol #entomology #HPPD
From rare disease drug to vector control tool.
@aacostaserrano.bsky.social
📄 Paper: doi.org/10.1186/s130...
#malaria #vectorcontrol #entomology #HPPD
August 7, 2025 at 12:59 PM
Just out: LSTM’s blog post on our latest paper exploring how nitisinone kills malaria mosquitoes, even the resistant ones, through tarsal contact.
From rare disease drug to vector control tool.
@aacostaserrano.bsky.social
📄 Paper: doi.org/10.1186/s130...
#malaria #vectorcontrol #entomology #HPPD
From rare disease drug to vector control tool.
@aacostaserrano.bsky.social
📄 Paper: doi.org/10.1186/s130...
#malaria #vectorcontrol #entomology #HPPD
🦟 New mosquito killer from a surprising source?
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
parasitesandvectors.biomedcentral.com
August 4, 2025 at 4:52 AM
🦟 New mosquito killer from a surprising source?
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
Here we show that #nitisinone kills insecticide-resistant mosquitoes via cuticular uptake. Great work Zach Stavrou-Dowd, Lee Haines, & LITE. Thanks @gatesfoundation.bsky.social & @RoseTrees Trust @notredame.bsky.social @lstmnews.bsky.social parasitesandvectors.biomedcentral.com/articles/10....
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
parasitesandvectors.biomedcentral.com
August 1, 2025 at 10:18 PM
Here we show that #nitisinone kills insecticide-resistant mosquitoes via cuticular uptake. Great work Zach Stavrou-Dowd, Lee Haines, & LITE. Thanks @gatesfoundation.bsky.social & @RoseTrees Trust @notredame.bsky.social @lstmnews.bsky.social parasitesandvectors.biomedcentral.com/articles/10....
New paper out in Parasites & Vectors!
We show that nitisinone, a repurposed β-triketone, kills Anopheles gambiae via tarsal contact, even in pyrethroid-resistant strains.
doi.org/10.1186/s130...
#VectorBiology #Nitisinone #IRS #PublicHealth #malaria #mosquito
We show that nitisinone, a repurposed β-triketone, kills Anopheles gambiae via tarsal contact, even in pyrethroid-resistant strains.
doi.org/10.1186/s130...
#VectorBiology #Nitisinone #IRS #PublicHealth #malaria #mosquito
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
doi.org
August 1, 2025 at 3:02 PM
New paper out in Parasites & Vectors!
We show that nitisinone, a repurposed β-triketone, kills Anopheles gambiae via tarsal contact, even in pyrethroid-resistant strains.
doi.org/10.1186/s130...
#VectorBiology #Nitisinone #IRS #PublicHealth #malaria #mosquito
We show that nitisinone, a repurposed β-triketone, kills Anopheles gambiae via tarsal contact, even in pyrethroid-resistant strains.
doi.org/10.1186/s130...
#VectorBiology #Nitisinone #IRS #PublicHealth #malaria #mosquito
"After 25 years of work by NIH researchers, the drug nitisinone has received FDA approval for the treatment of alkaptonuria."
August 1, 2025 at 1:25 PM
"After 25 years of work by NIH researchers, the drug nitisinone has received FDA approval for the treatment of alkaptonuria."
The approach yes.
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.
www.science.org
July 24, 2025 at 1:26 PM
The approach yes.
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Nitisinone reduce el ácido homogentísico en orina en adultos con alcaptonuria que conduce a osteoartritis y ocronosis , disminuyendo el dolor y mejorando la energía y el funcionamiento físico firstwordpharma.com/story/5974576
FirstWord
firstwordpharma.com
June 22, 2025 at 10:07 AM
Nitisinone reduce el ácido homogentísico en orina en adultos con alcaptonuria que conduce a osteoartritis y ocronosis , disminuyendo el dolor y mejorando la energía y el funcionamiento físico firstwordpharma.com/story/5974576
Cycle Wins First FDA Nod for Ultra-Rare Genetic Disease
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
Cycle Wins First FDA Nod for Ultra-Rare Genetic Disease - United Kingdom
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed under the brand name Harliku, for use in
www.europesays.com
June 21, 2025 at 7:17 AM
Cycle Wins First FDA Nod for Ultra-Rare Genetic Disease
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
Good news for folks living with alkaptonuria:
FDA OKs Nitisinone for Ultra-Rare Black Urine Disease www.medpagetoday.com/primarycare/...
FDA OKs Nitisinone for Ultra-Rare Black Urine Disease www.medpagetoday.com/primarycare/...
FDA OKs Nitisinone for Ultra-Rare Black Urine Disease
The drug was approved for the reduction of urine homogentisic acid in adults with alkaptonuria
www.medpagetoday.com
June 21, 2025 at 12:11 AM
Good news for folks living with alkaptonuria:
FDA OKs Nitisinone for Ultra-Rare Black Urine Disease www.medpagetoday.com/primarycare/...
FDA OKs Nitisinone for Ultra-Rare Black Urine Disease www.medpagetoday.com/primarycare/...
10. A malaria drug might be hiding in plain sight. When mosquitoes feed on blood from people taking nitisinone—a drug for a rare disorder—they die. It blocks an enzyme they need to breakdown tyrosine, which builds up in toxic amounts and kills them.
May 2, 2025 at 4:20 PM
10. A malaria drug might be hiding in plain sight. When mosquitoes feed on blood from people taking nitisinone—a drug for a rare disorder—they die. It blocks an enzyme they need to breakdown tyrosine, which builds up in toxic amounts and kills them.
Santé : La nitisinone, ce médicament serait une arme efficace contre les moustiques
La nitisinone, un médicament déjà existant, pourrait tuer les moustiques après une piqûre en bloquant leur digestion du sang
La nitisinone, un médicament déjà existant, pourrait tuer les moustiques après une piqûre en bloquant leur digestion du sang
La nitisinone pourrait éliminer les moustiques résistants aux insecticides
La nitisinone, un médicament déjà existant, pourrait tuer les moustiques après une piqûre en bloquant leur digestion du sang
www.20minutes.fr
April 24, 2025 at 9:59 PM
Santé : La nitisinone, ce médicament serait une arme efficace contre les moustiques
La nitisinone, un médicament déjà existant, pourrait tuer les moustiques après une piqûre en bloquant leur digestion du sang
La nitisinone, un médicament déjà existant, pourrait tuer les moustiques après une piqûre en bloquant leur digestion du sang
Rare Disease Drug Nitisinone Makes Human Blood Deadly to Mosquitoes
->Newswise | #Health #Disease | More info from EcoSearch
->Newswise | #Health #Disease | More info from EcoSearch
Rare Disease Drug Nitisinone Makes Human Blood Deadly to Mosquitoes
In the fight against malaria, controlling the mosquito population is crucial. Several methods are currently used to reduce mosquito numbers and malaria risk. One of these includes the antiparasitic medication ivermectin. When mosquitoes ingest blood containing ivermectin, it shortens the...
www.newswise.com
April 16, 2025 at 2:27 AM
www.thenakedscientists.com/articles/int... Many thanks to Chris Smith and the @NakeScientists for the short podcast about our recent publication on #Nitisinone & #Anopheles #mosquitoes
Safe human drug can poison mosquitoes
Another potential mitigation for malaria...
www.thenakedscientists.com
April 11, 2025 at 4:06 PM
www.thenakedscientists.com/articles/int... Many thanks to Chris Smith and the @NakeScientists for the short podcast about our recent publication on #Nitisinone & #Anopheles #mosquitoes