Nitisinone: Warnings & Precautions.
Nitisinone use has been linked to low platelet counts, often known as severe thrombocytopenia and leukopenia.
#Nitisinone #NitisinoneWarnings #NitisinonePrecautions #TyrosinemiaType1 #HT1Treatment #MedicationSafety
theindianpharma.com/nitisinone/
Nitisinone use has been linked to low platelet counts, often known as severe thrombocytopenia and leukopenia.
#Nitisinone #NitisinoneWarnings #NitisinonePrecautions #TyrosinemiaType1 #HT1Treatment #MedicationSafety
theindianpharma.com/nitisinone/
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theindianpharma.com
May 27, 2024 at 12:08 PM
Nitisinone: Warnings & Precautions.
Nitisinone use has been linked to low platelet counts, often known as severe thrombocytopenia and leukopenia.
#Nitisinone #NitisinoneWarnings #NitisinonePrecautions #TyrosinemiaType1 #HT1Treatment #MedicationSafety
theindianpharma.com/nitisinone/
Nitisinone use has been linked to low platelet counts, often known as severe thrombocytopenia and leukopenia.
#Nitisinone #NitisinoneWarnings #NitisinonePrecautions #TyrosinemiaType1 #HT1Treatment #MedicationSafety
theindianpharma.com/nitisinone/
The approach yes.
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.
www.science.org
July 24, 2025 at 1:26 PM
The approach yes.
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Ivermectin itself no, because it does not kill Aedes vectors of arboviruses as well as it kills Anopheles that transmit malaria.
But there are other systemic insecticides such as Nitisinone, which could do the trick www.science.org/doi/10.1126/...
Nitisinone, a drug that turns your blood into mosquito poison
www.popsci.com/health/mosqu...
www.popsci.com/health/mosqu...
This drug can turn your blood into mosquito poison
Nitisinone kills even insecticide-resistant mosquitoes.
www.popsci.com
August 14, 2025 at 3:13 PM
Nitisinone, a drug that turns your blood into mosquito poison
www.popsci.com/health/mosqu...
www.popsci.com/health/mosqu...
A study found that the drug nitisinone works as a potent contact insecticide for killing the mosquito species that spread malaria, dengue, and other emerging mosquito-borne viral threats, offering hope of a new approach to combating insecticide resistance. #AMR
www.ghtcoalition.org/blog/researc...
www.ghtcoalition.org/blog/researc...
Research Roundup: New mosquito killer drug, Women's health R&D funding, HIV vaccine clinical trial
In today's Research Roundup for August 11, 2025, we highlight some of the most interesting reads in global health research and development from the past week.
www.ghtcoalition.org
August 12, 2025 at 2:25 PM
A study found that the drug nitisinone works as a potent contact insecticide for killing the mosquito species that spread malaria, dengue, and other emerging mosquito-borne viral threats, offering hope of a new approach to combating insecticide resistance. #AMR
www.ghtcoalition.org/blog/researc...
www.ghtcoalition.org/blog/researc...
Zanzare, esercizi di cattiveria umana con nitisinone
https://ilmanifesto.it/zanzare-esercizi-di-cattiveria-umana-con-nitisinone
https://ilmanifesto.it/zanzare-esercizi-di-cattiveria-umana-con-nitisinone
April 3, 2025 at 10:50 PM
Zanzare, esercizi di cattiveria umana con nitisinone
https://ilmanifesto.it/zanzare-esercizi-di-cattiveria-umana-con-nitisinone
https://ilmanifesto.it/zanzare-esercizi-di-cattiveria-umana-con-nitisinone
Scientists have discovered that a drug called nitisinone, originally used to treat rare diseases, can kill mosquitoes. When mosquitoes drink the blood of someone who has taken the drug, they die within hours because it blocks their ability to digest the blood properly.
August 13, 2025 at 9:57 PM
Scientists have discovered that a drug called nitisinone, originally used to treat rare diseases, can kill mosquitoes. When mosquitoes drink the blood of someone who has taken the drug, they die within hours because it blocks their ability to digest the blood properly.
Nitisinone reduce el ácido homogentísico en orina en adultos con alcaptonuria que conduce a osteoartritis y ocronosis , disminuyendo el dolor y mejorando la energía y el funcionamiento físico firstwordpharma.com/story/5974576
FirstWord
firstwordpharma.com
June 22, 2025 at 10:07 AM
Nitisinone reduce el ácido homogentísico en orina en adultos con alcaptonuria que conduce a osteoartritis y ocronosis , disminuyendo el dolor y mejorando la energía y el funcionamiento físico firstwordpharma.com/story/5974576
New drug for controlling mosquito numbers and fighting #malaria: Nitisinone
www.sciencealert.com/drug-for-rar...
www.sciencealert.com/drug-for-rar...
Drug For Rare Disease Turns Human Blood Into Mosquito Poison
Scientists have a radical new plan for controlling mosquito numbers and fighting malaria: lacing human blood with a drug that's poisonous for the insects, so sucking on this blood marks their last mea...
www.sciencealert.com
April 3, 2025 at 8:22 AM
New drug for controlling mosquito numbers and fighting #malaria: Nitisinone
www.sciencealert.com/drug-for-rar...
www.sciencealert.com/drug-for-rar...
Unlike ivermectin, nitisinone does not target the nervous system, so it is less neurotoxic. What's more, studies indicate that ivermectin kills other insects. Malaria is still responsible for >1/2 million deaths each year, efforts have stalled with growing populations & treatment resistance.
April 4, 2025 at 6:02 PM
Unlike ivermectin, nitisinone does not target the nervous system, so it is less neurotoxic. What's more, studies indicate that ivermectin kills other insects. Malaria is still responsible for >1/2 million deaths each year, efforts have stalled with growing populations & treatment resistance.
from University of Notre Dame:
When patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
-- Lee R. Haines, associate research professor of biological sciences at the University of Notre Dame.
When patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
-- Lee R. Haines, associate research professor of biological sciences at the University of Notre Dame.
April 7, 2025 at 7:45 AM
from University of Notre Dame:
When patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
-- Lee R. Haines, associate research professor of biological sciences at the University of Notre Dame.
When patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
-- Lee R. Haines, associate research professor of biological sciences at the University of Notre Dame.
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine www.science.org/doi/10.1126/...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.
www.science.org
March 28, 2025 at 1:01 PM
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine www.science.org/doi/10.1126/...
www.thenakedscientists.com/articles/int... Many thanks to Chris Smith and the @NakeScientists for the short podcast about our recent publication on #Nitisinone & #Anopheles #mosquitoes
Safe human drug can poison mosquitoes
Another potential mitigation for malaria...
www.thenakedscientists.com
April 11, 2025 at 4:06 PM
www.thenakedscientists.com/articles/int... Many thanks to Chris Smith and the @NakeScientists for the short podcast about our recent publication on #Nitisinone & #Anopheles #mosquitoes
Discover nitisinone, a drug for rare diseases that could also combat mosquitoes and their transmission of malaria.
This Medication Could Make Human Blood Deadly to Mosquitos, Combatting Malaria
Discover nitisinone, a drug for rare diseases that could also combat mosquitoes and their transmission of malaria.
buff.ly
March 27, 2025 at 8:01 PM
Discover nitisinone, a drug for rare diseases that could also combat mosquitoes and their transmission of malaria.
The drug in question is #nitisinone, and a proof-of-concept study led by a team from the Liverpool School of Tropical Medicine in the UK found that it could be deadly to mosquitoes at a low dose in human blood. The insects died within 12 hours.
April 4, 2025 at 5:52 PM
The drug in question is #nitisinone, and a proof-of-concept study led by a team from the Liverpool School of Tropical Medicine in the UK found that it could be deadly to mosquitoes at a low dose in human blood. The insects died within 12 hours.
Check out this awesome study from our Notre Dame colleagues, @aacostaserrano.bsky.social and Lee Haines!! Nitisinone kills insecticide-resistant mosquitoes through cuticular uptake
parasitesandvectors.biomedcentral.com/articles/10....
parasitesandvectors.biomedcentral.com/articles/10....
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
parasitesandvectors.biomedcentral.com
August 7, 2025 at 4:57 PM
Check out this awesome study from our Notre Dame colleagues, @aacostaserrano.bsky.social and Lee Haines!! Nitisinone kills insecticide-resistant mosquitoes through cuticular uptake
parasitesandvectors.biomedcentral.com/articles/10....
parasitesandvectors.biomedcentral.com/articles/10....
Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs https://www.biorxiv.org/content/10.1101/2024.06.18.599347v1
Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs https://www.biorxiv.org/content/10.1101/2024.06.18.599347v1
Bed bugs are blood-feeders that rapidly proliferate into large indoor infesta-tions. Their bites can
www.biorxiv.org
June 24, 2024 at 3:02 PM
Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs https://www.biorxiv.org/content/10.1101/2024.06.18.599347v1
Une étude montre que la nitisinone, absorbée par les pattes, avait les mêmes effets, à savoir une paralysie et une couleur plus foncée, sur les moustiques n’ayant pas bu de sang et ceux qui en ont consommé. Ces travaux pourraient ouvrir une nouvelle voie dans la lutte contre les moustiques.
Non seulement la nitisinone transforme votre sang en poison pour les moustiques, mais elle les paralyse lorsqu'ils l'absorbent par les pattes
Quelques mois après avoir montré que le sang de personnes traitées à la nitisinone tuait les moustiques, une nouvelle étude révèle que cette substance est aussi toxique hors du corps humain.
Mehdi SMAINI
Publié le 13 Août 2025 à 11H00
[...] Toxique également en dehors du corps humain Une étude plus récente publiée le 31 juillet dernier dans la revue Parasites & Vectors, a montré que la nitisinone était toxique, même lorsqu’elle n’était pas mélangée au sang humain. En effet, ils ont tout d’abord mis en contact plusieurs espèces de moustiques avec des surfaces imprégnées de nitisinone et de quatre autres inhibiteurs de l’HPPD, l’enzyme qui régule détoxifie la tyrosine, avant et après qu’ils aient bu un échantillon de sang.
L’étude indique que la nitisinone, absorbée par les pattes, avait les mêmes effets, à savoir une paralysie et une couleur plus foncée, sur les moustiques n’ayant pas bu de sang et ceux qui en ont consommé. Ces travaux pourraient permettre de mieux lutter contre les moustiques, qui se montrent [de plus en plus] résistants aux différents insecticides et qui restent l’animal qui tue le plus d'humains dans le monde.
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake | Parasites & Vectors, 31.07.2025 https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-025-06939-0
Image : Graphical Abstract
sco.lt
August 23, 2025 at 4:45 PM
Une étude montre que la nitisinone, absorbée par les pattes, avait les mêmes effets, à savoir une paralysie et une couleur plus foncée, sur les moustiques n’ayant pas bu de sang et ceux qui en ont consommé. Ces travaux pourraient ouvrir une nouvelle voie dans la lutte contre les moustiques.
Un estudio descubrió que cuando los pacientes toman el medicamento nitisinona, su sangre se vuelve mortal para los mosquitos.
University of Notre Dame.
A study found when patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
University of Notre Dame.
A study found when patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
April 1, 2025 at 12:06 PM
Un estudio descubrió que cuando los pacientes toman el medicamento nitisinona, su sangre se vuelve mortal para los mosquitos.
University of Notre Dame.
A study found when patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
University of Notre Dame.
A study found when patients take the drug nitisinone, their blood becomes deadly to mosquitoes.
#Paludisme La nitisinone, un médicament approuvé, pourrait tuer les moustiques qui se nourrissent de sang humain. Elle agit rapidement et reste plus longtemps dans le sang que l’ivermectine, augmentant son efficacité tout en étant moins neurotoxique.
sco.lt/5bd75M
Innovant
sco.lt/5bd75M
Innovant
« Du sang mortel pour les moustiques » : ce médicament contre une maladie rare transforme les patients en piège létal pour insectes | EntomoNews
Les chercheurs explorent de nouvelles voies pour lutter contre le paludisme, une maladie qui continue de faire des ravages, causant plus de 500 000 décès annuels. Parmi ces pistes, une étude menée par...
sco.lt
April 4, 2025 at 4:20 PM
#Paludisme La nitisinone, un médicament approuvé, pourrait tuer les moustiques qui se nourrissent de sang humain. Elle agit rapidement et reste plus longtemps dans le sang que l’ivermectine, augmentant son efficacité tout en étant moins neurotoxique.
sco.lt/5bd75M
Innovant
sco.lt/5bd75M
Innovant
Nitisinone, a drug approved for rare genetic conditions, has been shown to kill multiple mosquito species through both ingestion and contact, including those resistant to current insecticides. doi.org/g9wgq6
Drug used for rare disease can turn human blood and surfaces deadly to mosquitoes
A drug that makes human blood lethal to mosquitoes also acts as a potent contact insecticide absorbed through the feet, providing a promising new approach to combating insecticide resistance.
phys.org
August 7, 2025 at 4:16 PM
Nitisinone, a drug approved for rare genetic conditions, has been shown to kill multiple mosquito species through both ingestion and contact, including those resistant to current insecticides. doi.org/g9wgq6
Here we show that #nitisinone kills insecticide-resistant mosquitoes via cuticular uptake. Great work Zach Stavrou-Dowd, Lee Haines, & LITE. Thanks @gatesfoundation.bsky.social & @RoseTrees Trust @notredame.bsky.social @lstmnews.bsky.social parasitesandvectors.biomedcentral.com/articles/10....
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
parasitesandvectors.biomedcentral.com
August 1, 2025 at 10:18 PM
Here we show that #nitisinone kills insecticide-resistant mosquitoes via cuticular uptake. Great work Zach Stavrou-Dowd, Lee Haines, & LITE. Thanks @gatesfoundation.bsky.social & @RoseTrees Trust @notredame.bsky.social @lstmnews.bsky.social parasitesandvectors.biomedcentral.com/articles/10....
Interesting news about a potential anti-malarial drug, thanks to Science.
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine www.science.org/doi/10.1126/...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine www.science.org/doi/10.1126/...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.
www.science.org
March 27, 2025 at 12:06 PM
Interesting news about a potential anti-malarial drug, thanks to Science.
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine www.science.org/doi/10.1126/...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine www.science.org/doi/10.1126/...
Nitisinone is a competitive inhibitor of HPPD. Recent studies found that HPPD is essential for mosquitoes to digest their blood meals, and now scientists have found that the blood patients taking nitisinone is deadly to the malaria mosquito vector Anopheles gambiae.
Rare disease drug can make human blood toxic to mosquitoes
Insect enzyme inhibitor could help control malaria
www.chemistryworld.com
April 9, 2025 at 3:06 PM
Nitisinone is a competitive inhibitor of HPPD. Recent studies found that HPPD is essential for mosquitoes to digest their blood meals, and now scientists have found that the blood patients taking nitisinone is deadly to the malaria mosquito vector Anopheles gambiae.
Cycle Wins First FDA Nod for Ultra-Rare Genetic Disease
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
Cycle Wins First FDA Nod for Ultra-Rare Genetic Disease - United Kingdom
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed under the brand name Harliku, for use in
www.europesays.com
June 21, 2025 at 7:17 AM
Cycle Wins First FDA Nod for Ultra-Rare Genetic Disease
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
https://www.europesays.com/uk/201905/
The FDA approved the use of Cycle Pharmaceuticals’ oral drug nitisinone on Thursday. The product will be marketed…#uk #news #uknews
🦟 New mosquito killer from a surprising source?
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake - Parasites & Vectors
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previo...
parasitesandvectors.biomedcentral.com
August 4, 2025 at 4:52 AM
🦟 New mosquito killer from a surprising source?
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪
A new study finds that nitisinone, a drug used to treat a rare genetic disorder, can kill even insecticide-resistant mosquitoes by targeting how they digest blood.
🔗 parasitesandvectors.biomedcentral.com/articles/10....
#SciComm #Mosquitoes 🧪