⚡️ Arousal states govern how animals respond to the world around them. Too much arousal may manifest as hyperactivity, anxiety, sensory overload and sleep loss. But how do neurodevelopmental processes shape arousal regulation? Are neural microexons part of the answer? 2/9
April 28, 2025 at 9:24 AM
⚡️ Arousal states govern how animals respond to the world around them. Too much arousal may manifest as hyperactivity, anxiety, sensory overload and sleep loss. But how do neurodevelopmental processes shape arousal regulation? Are neural microexons part of the answer? 2/9
To tackle this major open question, common to other tissue-specific splicing regulators, we generated CRISPR-Cas9 deletion mutants in zebrafish for 18 conserved neural-specific microexons regulated by srrm3/4, as well for srrm3 and srrm4. 4/9
December 30, 2024 at 4:07 PM
To tackle this major open question, common to other tissue-specific splicing regulators, we generated CRISPR-Cas9 deletion mutants in zebrafish for 18 conserved neural-specific microexons regulated by srrm3/4, as well for srrm3 and srrm4. 4/9
🚀 Check out our new review article “From Tiny Exons to Big Insights: The Expanding Field of #Microexons” now out in Annual Review of Genomics and Human Genetics!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
August 31, 2025 at 1:42 PM
🚀 Check out our new review article “From Tiny Exons to Big Insights: The Expanding Field of #Microexons” now out in Annual Review of Genomics and Human Genetics!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
doi.org/10.1146/annu...
Special thanks to @mirimiam.bsky.social, @crg.eu and @upf.edu!
🚨 New paper alert! 🚨
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates
Neuron-specific splicing of Agrin by Nova RNA-binding proteins is essential for neuromuscular synapse formation via acetylcholine receptor clustering. This study shows that this RNA splicing pathway i...
journals.plos.org
September 16, 2025 at 6:54 PM
🚨 New paper alert! 🚨
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Our paper entitled: "Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates" is out now on @plosbiology.org !
journals.plos.org/plosbiology/...
#splicing #microexons #NMJ #Ciona
🧵👇
Our paper is finally out there! And yes, we discovered the role of microexons in immunotherapy targeting in high-grade gliomas! www.cell.com/cell-reports...
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
Aberrant splicing of microexons yields non-canonical surface receptors, such as the
neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and
19. Sehgal et al. show that Δex5Δ...
www.cell.com
August 8, 2025 at 3:02 PM
Our paper is finally out there! And yes, we discovered the role of microexons in immunotherapy targeting in high-grade gliomas! www.cell.com/cell-reports...
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
Aberrant splicing of microexons yields non-canonical surface receptors, such as the
neuronal cell adhesion molecule (NRCAM) lacking amino acids encoded by exons 5 and
19. Sehgal et al. show that Δex5Δ...
www.cell.com
August 8, 2025 at 3:30 PM
3.5 years ago, we knew very little about #pediatric high-grade #glioma... our strengths were the working knowledge of #mRNA #splicing & #microexons and the ability to put together amazing teams of collaborators. Somehow, CureSearch for Children's Cancer had faith in us! www.cell.com/cell-reports...
Analysis of pediatric high-grade glioma tumors shows missing microexons in messenger RNA, offering a potential new target for immunotherapy that could spare healthy brain cells. doi.org/g9w7dt
Missing messenger RNA fragments could be key to new immunotherapy for hard-to-treat brain tumors
A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.
medicalxpress.com
August 15, 2025 at 6:13 PM
Analysis of pediatric high-grade glioma tumors shows missing microexons in messenger RNA, offering a potential new target for immunotherapy that could spare healthy brain cells. doi.org/g9w7dt
This story is published back-to-back with @sthyme.bsky.social lab, who deleted 45 microexons (only two in common with us) and assessed larval brain activity, morphology and behavior. They also found that most individual mutants had minimal or no phenotypes: elifesciences.org/reviewed-pre.... 9/9
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function
elifesciences.org
December 30, 2024 at 4:07 PM
This story is published back-to-back with @sthyme.bsky.social lab, who deleted 45 microexons (only two in common with us) and assessed larval brain activity, morphology and behavior. They also found that most individual mutants had minimal or no phenotypes: elifesciences.org/reviewed-pre.... 9/9
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
July 23, 2025 at 2:28 PM
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
MEPDB: Database of microExons in plants
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
September 5, 2025 at 6:35 AM
MEPDB: Database of microExons in plants
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #CommunityResource by Islamov, et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
High-content imaging reveals the ability of microexons to shape protein localisation https://www.biorxiv.org/content/10.1101/2025.09.30.679652v1
October 2, 2025 at 3:21 AM
High-content imaging reveals the ability of microexons to shape protein localisation https://www.biorxiv.org/content/10.1101/2025.09.30.679652v1
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function https://www.biorxiv.org/content/10.1101/2024.08.19.608697v1
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function https://www.biorxiv.org/content/10.1101/2024.08.19.608697v1
Microexon splicing is a vertebrate-conserved process through which small, often in-frame, exons are
www.biorxiv.org
August 20, 2024 at 2:15 PM
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function https://www.biorxiv.org/content/10.1101/2024.08.19.608697v1
The preprint is finally out! Microexons to the rescue, and potentially targetable in deadly high-grade gliomas. www.biorxiv.org/content/10.1...
Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma
To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing ev...
www.biorxiv.org
January 23, 2025 at 9:37 PM
The preprint is finally out! Microexons to the rescue, and potentially targetable in deadly high-grade gliomas. www.biorxiv.org/content/10.1...
The hallmark of pediatric high-grade glioma is pervasive mis-splicing of microexons•Transcripts encoding NRCAM skip exons 5 and 19•Δex5Δex19, but not full-length NRCAM drives tumor growth in orthotopic glioma models•Δex5Δex19 NRCAM-selective mAb enables killing by T cells armed with the Fc receptor.
August 8, 2025 at 3:33 PM
The hallmark of pediatric high-grade glioma is pervasive mis-splicing of microexons•Transcripts encoding NRCAM skip exons 5 and 19•Δex5Δex19, but not full-length NRCAM drives tumor growth in orthotopic glioma models•Δex5Δex19 NRCAM-selective mAb enables killing by T cells armed with the Fc receptor.
Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish https://www.biorxiv.org/content/10.1101/2024.10.23.619860v1
Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish https://www.biorxiv.org/content/10.1101/2024.10.23.619860v1
Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regula
www.biorxiv.org
October 27, 2024 at 6:17 PM
Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish https://www.biorxiv.org/content/10.1101/2024.10.23.619860v1
🧬 Neural microexons (3–51 nt) are tiny but highly conserved across vertebrates, and frequently mis-spliced in neurological disorders like autism and schizophrenia. A key master regulator of microexons is SRRM3. 3/9
April 28, 2025 at 9:24 AM
🧬 Neural microexons (3–51 nt) are tiny but highly conserved across vertebrates, and frequently mis-spliced in neurological disorders like autism and schizophrenia. A key master regulator of microexons is SRRM3. 3/9
MEPDB: Database of microExons in plants – Islamov – New Phytologist Foundation – Wiley
Microexons, ≤ 51-nucleotide (nt), particularly ultra-short ones (1–15 nt), are challenging to identify due to… Read original article: Read More
Microexons, ≤ 51-nucleotide (nt), particularly ultra-short ones (1–15 nt), are challenging to identify due to… Read original article: Read More
MEPDB: Database of microExons in plants – Islamov – New Phytologist Foundation – Wiley
Microexons, ≤ 51-nucleotide (nt), particularly ultra-short ones (1–15 nt), are challenging to identify due to… Read original article: Read More
drwebdomain.blog
August 17, 2025 at 4:42 AM
MEPDB: Database of microExons in plants – Islamov – New Phytologist Foundation – Wiley
Microexons, ≤ 51-nucleotide (nt), particularly ultra-short ones (1–15 nt), are challenging to identify due to… Read original article: Read More
Microexons, ≤ 51-nucleotide (nt), particularly ultra-short ones (1–15 nt), are challenging to identify due to… Read original article: Read More
The importance of being small: only microexons are conserved between vertebrates and invertebrates.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Regulated microexon alternative splicing in single neurons tunes synaptic function | EMBO reports
imageimageAlternative splicing of a conserved microexon in the unc-13 synaptic gene is regulated
by a pair of cell-specific RNA binding proteins. Microexon-included and microexon-skipped
isoforms are ...
www.embopress.org
July 24, 2025 at 9:41 AM
The importance of being small: only microexons are conserved between vertebrates and invertebrates.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
A project three years in the making finally sees the light of day. Microexons meet macroglia… cancerous macroglia meet engineered T cells (at your peril). Joint venture with @hagentilgner.bsky.social @yosephbarash.bsky.social et al @childrensphila.bsky.social www.biorxiv.org/content/10.1...
Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma
To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns in pHGGs and normal brain samples. Among alternative splicing ev...
www.biorxiv.org
January 17, 2025 at 1:56 AM
A project three years in the making finally sees the light of day. Microexons meet macroglia… cancerous macroglia meet engineered T cells (at your peril). Joint venture with @hagentilgner.bsky.social @yosephbarash.bsky.social et al @childrensphila.bsky.social www.biorxiv.org/content/10.1...
MICROEXONS! 💪
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Regulated microexon alternative splicing in single neurons tunes synaptic function | EMBO reports
imageimageAlternative splicing of a conserved microexon in the unc-13 synaptic gene is regulated
by a pair of cell-specific RNA binding proteins. Microexon-included and microexon-skipped
isoforms are ...
www.embopress.org
June 16, 2025 at 3:43 PM
MICROEXONS! 💪
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Mighty microexons!
MICROEXONS! 💪
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org
www.embopress.org/doi/full/10....
Regulated microexon alternative splicing in single neurons tunes synaptic function | EMBO reports
imageimageAlternative splicing of a conserved microexon in the unc-13 synaptic gene is regulated
by a pair of cell-specific RNA binding proteins. Microexon-included and microexon-skipped
isoforms are ...
www.embopress.org
June 17, 2025 at 6:54 AM
Mighty microexons!
🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
September 1, 2025 at 10:20 AM
🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Beautiful work on mis-splicing, microexons and molecular mechanisms of autism.
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
December 4, 2024 at 4:23 PM
Beautiful work on mis-splicing, microexons and molecular mechanisms of autism.
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
By the labs of @xsalvatella1.bsky.social and #Raul_Mendez at the @irbbarcelona.bsky.social , and the collaboration of #Jose_Lucas lab at the @cbm-csic-uam.bsky.social .
www.nature.com/articles/s41...
Jonas Juan-Mateu, from the EvoMG Program and @melisupf.bsky.social presented his work on microexons and diabetes and the plans to investigate diet adaptations in bats.
October 12, 2025 at 3:50 PM
Jonas Juan-Mateu, from the EvoMG Program and @melisupf.bsky.social presented his work on microexons and diabetes and the plans to investigate diet adaptations in bats.
Mighty microexons take center stage in shaping of the brain #autism #science
medicalnewstoday.com/releases/29184…
medicalnewstoday.com/releases/29184…
Mighty microexons take center stage in shaping of the brain
Complex brain disorders, such as autism or schizophrenia, still puzzle scientists because their causes lie hidden in early events of brain development, which are still poorly understood.
t.co
December 9, 2024 at 5:15 AM
Mighty microexons take center stage in shaping of the brain #autism #science
medicalnewstoday.com/releases/29184…
medicalnewstoday.com/releases/29184…