Reliable and reproducible testing of Donor Specific HLA-Antibodies (DSA) is essential for clinical decisions in organ transplantation. In this prospec…

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The iBELL LUMINEX 900 is a premium, high-performance rechargeable torch designed to deliver exceptional brightness, long-distance illumination, and rugged durability. Ideal for home, outdoor, and emergency use, this flashlight combines powerful light output with convenient USB-C charging and a robust build — ensuring you’re never left in the dark. High-Power LED Illumination – Delivers super bright, long-range lighting suitable for outdoor exploration, security patrols, or emergency use.3 Light Modes – Switch easily between High, Medium, and Low settings to suit your lighting needs while conserving power when required.Telescopic Zoom Function – Adjustable beam focus lets you switch from a wide floodlight to a focused spotlight for long-distance visibility.USB Type-C Rechargeable – Equipped with a modern Type-C charging port for faster, more efficient charging. Compatible with power banks, car chargers, and wall adapters.1 Year Standard Warranty + 6 Months additional on registration. Registration should be done within 30 days from the date of purchase.

Be ready for whatever night, adventure or emergency throws at you with the iBELL LUMINEX 850 – a rugged, high-performance torch designed for home, outdoor and emergency use. Whether you’re managing a power cut, going for a late hike or prepping your vehicle kit, this torch delivers the power, flexibility and durability you need. High-power illumination – Built to deliver strong, reliable light when you need it most (home power-cuts, night walks, camping, roadside emergencies).Three versatile light modes – Easily switch between modes (for example: High, Medium, Low) to suit your task — whether you need full beam or ambient light.Telescopic zoom / focus adjustment – Expand or narrow the beam with the twist/pull zoom function — from wide-flood to long-distance spotlight.USB-C rechargeable – Modern Type-C charging port for easy recharging. Plug into your power bank, laptop charger or wall adaptor.1 Year Standard Warranty + 6 Months additional on registration. Registration should be done within 30 days from the date of purchase.

Light up the night or stay prepared for emergencies with the iBELL Luminex 800 – a rugged, high-performance torch designed for outdoor use, home emergencies and everyday carry. Built for durability, convenience and brightness, this flashlight delivers versatile lighting options and modern charging features. High-power LED output: The “800” in Luminex 800 hints at its bright illumination — ideal for outdoor hikes, power-outs and security use.Six flexible lighting modes: Tailor your beam to the situation with multiple modes (for example: High, Medium, Low, Strobe, SOS, Eco) to adapt to tasks such as search, signalling and ambient lighting.Zooming / focus adjustment: Pull or twist the head to narrow or widen the beam — perfect for long-distance spotlighting or broad flood-lighting.USB-C rechargeability: Comes with a Type-C charging port (and cable), making recharging simple and compatible with modern chargers — no need for disposable batteries.1 Year Standard Warranty + 6 Months additional on registration. Registration should be done within 30 days from the date of purchase.

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The health burden of Babesia microti, the primary causative agent of human babesiosis in the United States, is significant and increasing. Diagnosis of clinical babesiosis still remains challenging, resulting in misdiagnosis and underreporting. The gold standard for detection of B. microti–specific antibody, immunofluorescence assay (IFA), is cumbersome and resource-intensive. A high-throughput assay to detect serological biomarkers of B. microti exposure would facilitate epidemiological studies and clinical diagnosis.MethodsWe developed a multiantigen, high-throughput, and highly sensitive Luminex bead-based assay (LBA) for detection of Babesia microti­–specific antibodies in babesiosis patients and endemic populations. Serum samples from 191 individuals who had confirmed B. microti exposure (IFA or polymerase chain reaction [PCR] positive) were screened for antibody reactivity to 4 immunodominant antigens—MCFRP1, BAHCS1, SERA1, and PiβS1—by LBA.ResultsAmong the 4 antigens evaluated, MCFRP1 and BAHCS1 were the most sensitive biomarkers for B. microti exposure, detecting 96.6% and 100% of IFA+/PCR+ and 75.3% and 87.6% of IFA+/PCR- samples, respectively. The “window period” before IFA-detectable seroconversion is of particular concern for clinical diagnosis using serological detection methods. Importantly, combining all 4 antigens allowed detection of 6/13 (46.2%) PCR-positive cases that were missed by IFA. No single antigen yielded reactivity to more than 3/13 (23.1%) IFA-/PCR+ cases in our LBA, indicating diversity in the polarization of early immune responses following B. microti exposure.ConclusionsCombination of these antigens in our LBA would reduce the window period before IFA-detectable seroconversion of detection in Babesia microti–exposed individuals.

High throughput immunoassay is increasingly crucial for both scientific and clinical applications. Here we propose a “Lab-in-a-Tip” (LIT) concept to fabricate a pipette tip containing a high-density protein array and other essential reagents. The protein array is made by self-assembling digitally encoded microparticles inside the modified tip. Mounted on a robotic workstation, it automates liquid-handling steps. Notably, compared with Luminex, the current gold standard in multiplex immunoassays, such a design enables LIT to demonstrate multiple advantages in terms of analytical sensitivity, speed, and throughput. It detects analyte concentrations as low as fg/ml, representing a sensitivity improvement of two orders of magnitude over Luminex. Incubation time is reduced to 15 minutes from Luminex’s 210 minutes. Furthermore, LIT requires only 10 µl of sample, one-fifth of what Luminex needs. This makes LIT ideal for rapid diagnostics and studies with limited biological samples, greatly ex