Drunkeness is a social construct. Control over one's self is decided by one's resolve.
Decision-making is not affected by intoxication. Only inhibition and coordination are.
What you're seeing is an excuse, a dismissive reason why we're saying such horrible things. No actual evidence.
Decision-making is not affected by intoxication. Only inhibition and coordination are.
What you're seeing is an excuse, a dismissive reason why we're saying such horrible things. No actual evidence.
January 10, 2026 at 4:52 AM
Drunkeness is a social construct. Control over one's self is decided by one's resolve.
Decision-making is not affected by intoxication. Only inhibition and coordination are.
What you're seeing is an excuse, a dismissive reason why we're saying such horrible things. No actual evidence.
Decision-making is not affected by intoxication. Only inhibition and coordination are.
What you're seeing is an excuse, a dismissive reason why we're saying such horrible things. No actual evidence.
grindhousecinema.com/love-at-the-...
A shy bank clerk reinvents himself after a friend pushes him to abandon inhibition. Seduction becomes his ladder to confidence and status—until the thrill turns hollow.
#FrenchCinema #Erotic70s #70sCinema #JaneBirkin #RomySchneider #FlorindaBolkan #Erotica
A shy bank clerk reinvents himself after a friend pushes him to abandon inhibition. Seduction becomes his ladder to confidence and status—until the thrill turns hollow.
#FrenchCinema #Erotic70s #70sCinema #JaneBirkin #RomySchneider #FlorindaBolkan #Erotica
Love at the Top (1974) watch uncut - Grindhouse and Forgotten Exploitation Cinema
Also known as: Le mouton enragé, The French Way Is
grindhousecinema.com
January 10, 2026 at 4:23 AM
grindhousecinema.com/love-at-the-...
A shy bank clerk reinvents himself after a friend pushes him to abandon inhibition. Seduction becomes his ladder to confidence and status—until the thrill turns hollow.
#FrenchCinema #Erotic70s #70sCinema #JaneBirkin #RomySchneider #FlorindaBolkan #Erotica
A shy bank clerk reinvents himself after a friend pushes him to abandon inhibition. Seduction becomes his ladder to confidence and status—until the thrill turns hollow.
#FrenchCinema #Erotic70s #70sCinema #JaneBirkin #RomySchneider #FlorindaBolkan #Erotica
Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.08.698494v1
January 10, 2026 at 3:31 AM
Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.08.698494v1
Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.08.698494v1
January 10, 2026 at 3:31 AM
Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans https://www.biorxiv.org/content/10.64898/2026.01.08.698494v1
If our “developmental software” inadvertently fuels aging, slowing or resetting it could boost healthspan:
1️⃣ mTOR Inhibition (Rapamycin)
• mTOR drives cell growth and metabolism. Early in life, this is crucial for development. Later, overactive mTOR can accelerate tissue damage.
1️⃣ mTOR Inhibition (Rapamycin)
• mTOR drives cell growth and metabolism. Early in life, this is crucial for development. Later, overactive mTOR can accelerate tissue damage.
January 10, 2026 at 1:00 AM
If our “developmental software” inadvertently fuels aging, slowing or resetting it could boost healthspan:
1️⃣ mTOR Inhibition (Rapamycin)
• mTOR drives cell growth and metabolism. Early in life, this is crucial for development. Later, overactive mTOR can accelerate tissue damage.
1️⃣ mTOR Inhibition (Rapamycin)
• mTOR drives cell growth and metabolism. Early in life, this is crucial for development. Later, overactive mTOR can accelerate tissue damage.
Autism spectrum disorder and early-life stress converge on systemic hyperexcitability and stress epigenetics. Specific genes are epigenetically set toward a heightened excitatory state marked by increased arousal, sensitivity, and excitation–inhibition imbalance.
www.mdpi.com/2079-7737/15...
www.mdpi.com/2079-7737/15...
www.mdpi.com
January 9, 2026 at 11:37 PM
Autism spectrum disorder and early-life stress converge on systemic hyperexcitability and stress epigenetics. Specific genes are epigenetically set toward a heightened excitatory state marked by increased arousal, sensitivity, and excitation–inhibition imbalance.
www.mdpi.com/2079-7737/15...
www.mdpi.com/2079-7737/15...
It does say, however, that his dementia is showing more. Inhibition is falling apart.
January 9, 2026 at 9:49 PM
It does say, however, that his dementia is showing more. Inhibition is falling apart.
They used hemagglutination inhibition assays which are the standard correlate for strain-specific neutralizing antibodies. Subclade K is antigenically advanced relative to the vaccine strain (i.e. antibodies bind less well overall).
January 9, 2026 at 7:43 PM
They used hemagglutination inhibition assays which are the standard correlate for strain-specific neutralizing antibodies. Subclade K is antigenically advanced relative to the vaccine strain (i.e. antibodies bind less well overall).
Published a new piece on Biohackers Media, Cartilage Repair Through 15-PGDH Inhibition
#science #longevity #biohacking
#science #longevity #biohacking
Cartilage Repair Through 15-PGDH Inhibition
Breakthrough in cartilage repair: inhibiting 15-PGDH enzyme enhances regeneration, offering hope for osteoarthritis and joint injury recovery.
biohackers.media
January 9, 2026 at 6:01 PM
Published a new piece on Biohackers Media, Cartilage Repair Through 15-PGDH Inhibition
#science #longevity #biohacking
#science #longevity #biohacking
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice bioRxivpreprint
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice
Impulsive choice is the suboptimal preference for a smaller-sooner (SS, 'impulsive') option over a larger-later (LL, 'self-controlled') option. Fixed-interval (FI) training delivers delayed-reinforcement trials to increase LL choices and improve FI timing precision. While there are plenty of studies exploring the neurobiological factors underlying impulsive choice, it is unknown what neurobiological changes account for the FI training effects. The prelimbic cortex (PL) region is implicated in both impulsive choice and timing. To investigate the role of the PL, we used designer receptors exclusively activated by designer drugs (GiDREADDs) to reversibly inhibit the PL during either the FI training phase or the follow-up impulsive choice task in male and female Sprague-Dawley rats. Compared to a control group, the GiDREADDs rats showed reduced LL choices when CNO was administered during the FI training or impulsive choice tasks. GiDREADDS did not alter response rates or latency to choose. Overall, these data demonstrate that inhibition of the PL increases impulsive choice and may block the effect of the FI training to improve self-control.
dlvr.it
January 9, 2026 at 4:46 PM
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice bioRxivpreprint
1. In septic mice, CS knockdown or inhibition worsened lung injury and oxidative stress.
2. Citric acid supplementation reduced mitochondrial damage and supported the TCA cycle.
https://journals.lww.com/jtrauma/fulltext/2026/01000/citrate_synthases_improve_sepsis_induced_lung.12.aspx
2. Citric acid supplementation reduced mitochondrial damage and supported the TCA cycle.
https://journals.lww.com/jtrauma/fulltext/2026/01000/citrate_synthases_improve_sepsis_induced_lung.12.aspx
January 9, 2026 at 4:01 PM
1. In septic mice, CS knockdown or inhibition worsened lung injury and oxidative stress.
2. Citric acid supplementation reduced mitochondrial damage and supported the TCA cycle.
https://journals.lww.com/jtrauma/fulltext/2026/01000/citrate_synthases_improve_sepsis_induced_lung.12.aspx
2. Citric acid supplementation reduced mitochondrial damage and supported the TCA cycle.
https://journals.lww.com/jtrauma/fulltext/2026/01000/citrate_synthases_improve_sepsis_induced_lung.12.aspx
Khal had a new cuddly snake for Christmas. We have just made the exciting discovery that it is a puppet. Quickly followed by the discovery that Khal doesn't understand how puppets work, nor that my hand is inside it and so loses all bite inhibition😬
January 9, 2026 at 3:57 PM
Khal had a new cuddly snake for Christmas. We have just made the exciting discovery that it is a puppet. Quickly followed by the discovery that Khal doesn't understand how puppets work, nor that my hand is inside it and so loses all bite inhibition😬
Transient inhibition of type I interferon enhances CD8⁺ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
January 9, 2026 at 3:15 PM
Transient inhibition of type I interferon enhances CD8⁺ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues 👉 rupress.org/jem/article/...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Up front & free to read in our January issue #editorspicks: Improved wound healing by dual inhibition of miR‑146a‑5p and miR‑29a‑3p supports a network action of dysregulated miRNAs in diabetic skin link.springer.com/article/10.1...
January 9, 2026 at 2:07 PM
Up front & free to read in our January issue #editorspicks: Improved wound healing by dual inhibition of miR‑146a‑5p and miR‑29a‑3p supports a network action of dysregulated miRNAs in diabetic skin link.springer.com/article/10.1...
The Chromosome Dynamics team at IPS2 identified a global mechanism of transcriptional repression in Arabidopsis hal-05394413 #PlantScience cnrs.hal.science/hal-05394413
January 9, 2026 at 1:33 PM
The Chromosome Dynamics team at IPS2 identified a global mechanism of transcriptional repression in Arabidopsis hal-05394413 #PlantScience cnrs.hal.science/hal-05394413
The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition www.frontiersin.org/journals/cel... #hvhebron #onco [Text complet]
Frontiers | The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition
MYC performs a dual role in DNA Damage Response (DDR), promoting genomic instability through replication stress, R-loop formation, and topoisomerase-mediated...
www.frontiersin.org
January 9, 2026 at 1:23 PM
The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition www.frontiersin.org/journals/cel... #hvhebron #onco [Text complet]
Julie Nielsen, Richard Treisman and colleagues @crick.ac.uk find that MRTFs link cytoskeletal dynamics to cell cycle progression.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
January 9, 2026 at 9:25 AM
Julie Nielsen, Richard Treisman and colleagues @crick.ac.uk find that MRTFs link cytoskeletal dynamics to cell cycle progression.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
Exogenous Oxytocin Alleviates Prodromal and Clinical Parkinson's Disease Phenotypes via the Inhibition of Enteric Glial Cell-triggered Neuroinflammation #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-8516406/latest
https://www.researchsquare.com/article/rs-8516406/latest
January 9, 2026 at 8:02 AM
Exogenous Oxytocin Alleviates Prodromal and Clinical Parkinson's Disease Phenotypes via the Inhibition of Enteric Glial Cell-triggered Neuroinflammation #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-8516406/latest
https://www.researchsquare.com/article/rs-8516406/latest
Cell-cycle inhibition preserves robust development but rebalances lineages in mouse gastruloids #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.01.08.698406v1
https://www.biorxiv.org/content/10.64898/2026.01.08.698406v1
January 9, 2026 at 8:00 AM
Cell-cycle inhibition preserves robust development but rebalances lineages in mouse gastruloids #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.01.08.698406v1
https://www.biorxiv.org/content/10.64898/2026.01.08.698406v1
Phase-specific premotor inhibition modulates leech rhythmic motor output
https://www.europesays.com/ie/275532/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
https://www.europesays.com/ie/275532/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
Phase-specific premotor inhibition modulates leech rhythmic motor output - Ireland
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth movements, diverse regulatory
www.europesays.com
January 9, 2026 at 7:45 AM
Phase-specific premotor inhibition modulates leech rhythmic motor output
https://www.europesays.com/ie/275532/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
https://www.europesays.com/ie/275532/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice https://www.biorxiv.org/content/10.64898/2026.01.08.698432v1
January 9, 2026 at 7:45 AM
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice https://www.biorxiv.org/content/10.64898/2026.01.08.698432v1
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice https://www.biorxiv.org/content/10.64898/2026.01.08.698432v1
January 9, 2026 at 7:45 AM
The Effects of Prelimbic Inhibition on Time-based Intervention and Impulsive Choice https://www.biorxiv.org/content/10.64898/2026.01.08.698432v1
Indeed, a low inhibition threshold does not mean no military or police background when they are hired, all the opposite in fact.
ICE is responsible to train them properly, it would be an unacceptable standard anywhere else.
Perhaps proper training was never the aim here.
Quantitiy over quality.
ICE is responsible to train them properly, it would be an unacceptable standard anywhere else.
Perhaps proper training was never the aim here.
Quantitiy over quality.
January 9, 2026 at 6:40 AM
Indeed, a low inhibition threshold does not mean no military or police background when they are hired, all the opposite in fact.
ICE is responsible to train them properly, it would be an unacceptable standard anywhere else.
Perhaps proper training was never the aim here.
Quantitiy over quality.
ICE is responsible to train them properly, it would be an unacceptable standard anywhere else.
Perhaps proper training was never the aim here.
Quantitiy over quality.
Phase-specific premotor inhibition modulates leech rhythmic motor output
https://www.newsbeep.com/nz/224495/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
https://www.newsbeep.com/nz/224495/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
Phase-specific premotor inhibition modulates leech rhythmic motor output - New Zealand News Beep
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth movements, diverse regulatory
www.newsbeep.com
January 9, 2026 at 6:00 AM
Phase-specific premotor inhibition modulates leech rhythmic motor output
https://www.newsbeep.com/nz/224495/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
https://www.newsbeep.com/nz/224495/
Animal locomotion involves the coordination of multiple muscles under the control of the nervous system. To ensure smooth…
Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster
#Drosophila
#Drosophila
Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 9, 2026 at 5:23 AM
Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster
#Drosophila
#Drosophila