Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins https://www.biorxiv.org/content/10.1101/2025.02.06.636829v1
February 8, 2025 at 6:17 AM
Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins https://www.biorxiv.org/content/10.1101/2025.02.06.636829v1
Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications
Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications - PubMed
Antimicrobial resistance is a significant global public health issue, and the dissemination of antibiotic resistance in Gram-positive bacterial pathogens has significantly increased morbidity, mortality...
buff.ly
November 17, 2024 at 9:05 AM
Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications
When normal traditional #phagetherapy via phage isolation proves to be difficult… is there other way? Panos Kalatzis presents a tripartite strategy that includes also lysis from prophages, and endolysins to target
#ESCMIDGlobal
#ESCMIDGlobal
April 12, 2025 at 9:45 AM
When normal traditional #phagetherapy via phage isolation proves to be difficult… is there other way? Panos Kalatzis presents a tripartite strategy that includes also lysis from prophages, and endolysins to target
#ESCMIDGlobal
#ESCMIDGlobal
We think that extensive domain mosaicism is the result of the coevolutionary arms race between phages and their hosts. Receptor-binding proteins and endolysins are known to be specific and domain shuffling clearly plays an important role in their evolution. 6/7
November 28, 2023 at 1:55 PM
We think that extensive domain mosaicism is the result of the coevolutionary arms race between phages and their hosts. Receptor-binding proteins and endolysins are known to be specific and domain shuffling clearly plays an important role in their evolution. 6/7
🍊 Nature meets tech to protect citrus
We develop biocontrol solutions:
🧬 dsRNA to silence citrus pest vectors
🦠 Endolysins vs. citrus greening bacteria
🧪 Fermented compounds to fight CBS
🎯 Smart delivery via encapsulation
🌱 Bioaugmentation with beneficial microbes
We develop biocontrol solutions:
🧬 dsRNA to silence citrus pest vectors
🦠 Endolysins vs. citrus greening bacteria
🧪 Fermented compounds to fight CBS
🎯 Smart delivery via encapsulation
🌱 Bioaugmentation with beneficial microbes
August 13, 2025 at 12:07 PM
🍊 Nature meets tech to protect citrus
We develop biocontrol solutions:
🧬 dsRNA to silence citrus pest vectors
🦠 Endolysins vs. citrus greening bacteria
🧪 Fermented compounds to fight CBS
🎯 Smart delivery via encapsulation
🌱 Bioaugmentation with beneficial microbes
We develop biocontrol solutions:
🧬 dsRNA to silence citrus pest vectors
🦠 Endolysins vs. citrus greening bacteria
🧪 Fermented compounds to fight CBS
🎯 Smart delivery via encapsulation
🌱 Bioaugmentation with beneficial microbes
🔔 New issue! Articles on #Virology, #CellularTransport, & more:
🧑🔬 Scientists' Forum: Problematic figures are undermining #SystematicReviews
✳️ Editor's Choice: Clathrin in #endocystosis & intracellular sorting
🔎 Perspective: A new class of endolysins in tailed #bacteriophages
➡️ bit.ly/4kQWvJ2
🧑🔬 Scientists' Forum: Problematic figures are undermining #SystematicReviews
✳️ Editor's Choice: Clathrin in #endocystosis & intracellular sorting
🔎 Perspective: A new class of endolysins in tailed #bacteriophages
➡️ bit.ly/4kQWvJ2
June 9, 2025 at 2:40 PM
🔔 New issue! Articles on #Virology, #CellularTransport, & more:
🧑🔬 Scientists' Forum: Problematic figures are undermining #SystematicReviews
✳️ Editor's Choice: Clathrin in #endocystosis & intracellular sorting
🔎 Perspective: A new class of endolysins in tailed #bacteriophages
➡️ bit.ly/4kQWvJ2
🧑🔬 Scientists' Forum: Problematic figures are undermining #SystematicReviews
✳️ Editor's Choice: Clathrin in #endocystosis & intracellular sorting
🔎 Perspective: A new class of endolysins in tailed #bacteriophages
➡️ bit.ly/4kQWvJ2
Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins https://www.biorxiv.org/content/10.1101/2025.02.06.636829v1
February 9, 2025 at 3:23 AM
Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins https://www.biorxiv.org/content/10.1101/2025.02.06.636829v1
Characteristics of the Enterococcus Phage vB_EfS_SE, and the Properties of Its Chimeric Endolysins Harboring a PlySE-Carbohydrate-Binding Domain and a Synthetic Enzymatic Domain.
DOI: 10.3390/pharmaceutics16101312
https://pubmed.ncbi.nlm.nih.gov/39458641/
DOI: 10.3390/pharmaceutics16101312
https://pubmed.ncbi.nlm.nih.gov/39458641/
Characteristics of the Enterococcus Phage vB_EfS_SE, and the Properties of Its Chimeric Endolysins Harboring a PlySE-Carbohydrate-Binding Domain and a Synthetic Enzymatic Domain - PubMed
<span><b>Background/Objectives:</b> The World Health Organization has selected enterococci as one of the priority multidrug-resistant microorganisms for the development of new antibacterial drugs. Bacteriophages are promising antibacterial agents, but the biology of bacteriophages requires deeper understa</span> …
pubmed.ncbi.nlm.nih.gov
November 24, 2024 at 2:37 AM
Characteristics of the Enterococcus Phage vB_EfS_SE, and the Properties of Its Chimeric Endolysins Harboring a PlySE-Carbohydrate-Binding Domain and a Synthetic Enzymatic Domain.
DOI: 10.3390/pharmaceutics16101312
https://pubmed.ncbi.nlm.nih.gov/39458641/
DOI: 10.3390/pharmaceutics16101312
https://pubmed.ncbi.nlm.nih.gov/39458641/
2/2 Not only have dairy practices influenced bacterial evolution, but they have also shaped the evolution of phages, favoring the emergence of virulent phages with heat-resistant endolysins.
September 29, 2023 at 10:01 PM
2/2 Not only have dairy practices influenced bacterial evolution, but they have also shaped the evolution of phages, favoring the emergence of virulent phages with heat-resistant endolysins.
Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents https://www.biorxiv.org/content/10.1101/2024.04.29.591658v1
Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents https://www.biorxiv.org/content/10.1101/2024.04.29.591658v1
Background: As antibiotic resistance has become a major global threat; the World Health Organization
www.biorxiv.org
April 30, 2024 at 3:18 AM
Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents https://www.biorxiv.org/content/10.1101/2024.04.29.591658v1
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis.
DOI: 10.1016/j.bbrep.2024.101844
https://pubmed.ncbi.nlm.nih.gov/39483175/
DOI: 10.1016/j.bbrep.2024.101844
https://pubmed.ncbi.nlm.nih.gov/39483175/
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis - PubMed
<span><i>Streptococcus pneumoniae</i> (pneumococcus) is a multidrug-resistant pathogen associated with pneumonia, otitis media, meningitis and other severe complications that are currently a global threat to human health. The World Health Organization listed <i>Pneumococcus</i> as the fourth of twelve glo</span> …
pubmed.ncbi.nlm.nih.gov
November 21, 2024 at 12:36 PM
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis.
DOI: 10.1016/j.bbrep.2024.101844
https://pubmed.ncbi.nlm.nih.gov/39483175/
DOI: 10.1016/j.bbrep.2024.101844
https://pubmed.ncbi.nlm.nih.gov/39483175/
Emerging phage-encoded endolysins to combat multidrug-resistant Staphylococcus aureus to boon prevent surgical site infection.
DOI: 10.1097/MS9.0000000000002615
https://pubmed.ncbi.nlm.nih.gov/39649922/
DOI: 10.1097/MS9.0000000000002615
https://pubmed.ncbi.nlm.nih.gov/39649922/
Emerging phage-encoded endolysins to combat multidrug-resistant Staphylococcus aureus to boon prevent surgical site infection - PubMed
Emerging phage-encoded endolysins to combat multidrug-resistant Staphylococcus aureus to boon prevent surgical site infection
pubmed.ncbi.nlm.nih.gov
January 12, 2025 at 9:38 AM
Emerging phage-encoded endolysins to combat multidrug-resistant Staphylococcus aureus to boon prevent surgical site infection.
DOI: 10.1097/MS9.0000000000002615
https://pubmed.ncbi.nlm.nih.gov/39649922/
DOI: 10.1097/MS9.0000000000002615
https://pubmed.ncbi.nlm.nih.gov/39649922/
🧬 Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections - Molecular Medicine
Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or...
link.springer.com
May 16, 2025 at 1:45 PM
🧬 Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications.
DOI: 10.1007/s40121-024-01069-z
https://pubmed.ncbi.nlm.nih.gov/39549153/
DOI: 10.1007/s40121-024-01069-z
https://pubmed.ncbi.nlm.nih.gov/39549153/
Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications - PubMed
Antimicrobial resistance is a significant global public health issue, and the dissemination of antibiotic resistance in Gram-positive bacterial pathogens has significantly increased morbidity, mortality rates, and healthcare costs. Among them, Staphylococcus, especially methicillin-resistant Staphyl …
pubmed.ncbi.nlm.nih.gov
November 21, 2024 at 12:36 AM
Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications.
DOI: 10.1007/s40121-024-01069-z
https://pubmed.ncbi.nlm.nih.gov/39549153/
DOI: 10.1007/s40121-024-01069-z
https://pubmed.ncbi.nlm.nih.gov/39549153/
The antibacterial activity of endolysins against food-borne pathogenic bacteria in vitro and foods.
DOI: 10.1080/10408398.2025.2458742
https://pubmed.ncbi.nlm.nih.gov/39887157/
DOI: 10.1080/10408398.2025.2458742
https://pubmed.ncbi.nlm.nih.gov/39887157/
The antibacterial activity of endolysins against food-borne pathogenic bacteria in vitro and foods - PubMed
Food-borne pathogenic bacteria cause infection and death in humans, and impose great economic losses in the food industry worldwide annually. Therefore, researchers have turned to the use of different types of antimicrobials to control pathogenic bacteria in foods. Due to the side effects of synthet …
pubmed.ncbi.nlm.nih.gov
March 24, 2025 at 1:43 PM
The antibacterial activity of endolysins against food-borne pathogenic bacteria in vitro and foods.
DOI: 10.1080/10408398.2025.2458742
https://pubmed.ncbi.nlm.nih.gov/39887157/
DOI: 10.1080/10408398.2025.2458742
https://pubmed.ncbi.nlm.nih.gov/39887157/
Synergism of colistin and globular endolysins against multidrug-resistant gram-negative bacteria.
DOI: 10.1016/j.ijbiomac.2024.134670
https://pubmed.ncbi.nlm.nih.gov/39151868/
DOI: 10.1016/j.ijbiomac.2024.134670
https://pubmed.ncbi.nlm.nih.gov/39151868/
Synergism of colistin and globular endolysins against multidrug-resistant gram-negative bacteria - PubMed
Endolysins (lysins), a novel class of antibacterial agents derived from bacteriophages, efficiently lyse bacteria by degrading the peptidoglycan layer within the bacterial wall. Colistin, a classic peptide antibiotic with the ability to permeabilize the outer membrane, has recently shown great promi …
pubmed.ncbi.nlm.nih.gov
February 18, 2025 at 1:40 PM
Synergism of colistin and globular endolysins against multidrug-resistant gram-negative bacteria.
DOI: 10.1016/j.ijbiomac.2024.134670
https://pubmed.ncbi.nlm.nih.gov/39151868/
DOI: 10.1016/j.ijbiomac.2024.134670
https://pubmed.ncbi.nlm.nih.gov/39151868/
Biofilm-disrupting effects of phage endolysins LysAm24, LysAp22, LysECD7, and LysSi3: breakdown the matrix.
DOI: 10.1007/s11274-024-03999-9
https://pubmed.ncbi.nlm.nih.gov/38683213/
DOI: 10.1007/s11274-024-03999-9
https://pubmed.ncbi.nlm.nih.gov/38683213/
Biofilm-disrupting effects of phage endolysins LysAm24, LysAp22, LysECD7, and LysSi3: breakdown the matrix - PubMed
The ability of most opportunistic bacteria to form biofilms, coupled with antimicrobial resistance, hinder the efforts to control widespread infections, resulting in high risks of negative outcomes and economic costs. Endolysins are promising compounds that efficiently combat bacteria, including mul …
pubmed.ncbi.nlm.nih.gov
November 26, 2024 at 6:37 AM
Biofilm-disrupting effects of phage endolysins LysAm24, LysAp22, LysECD7, and LysSi3: breakdown the matrix.
DOI: 10.1007/s11274-024-03999-9
https://pubmed.ncbi.nlm.nih.gov/38683213/
DOI: 10.1007/s11274-024-03999-9
https://pubmed.ncbi.nlm.nih.gov/38683213/
The Synergistic and Chimeric Mechanism of Bacteriophage Endolysins: Opportunities for Application in Biotherapeutics, Food, and Health Sectors.
DOI: 10.1007/s12602-024-10394-1
https://pubmed.ncbi.nlm.nih.gov/39508962/
DOI: 10.1007/s12602-024-10394-1
https://pubmed.ncbi.nlm.nih.gov/39508962/
The Synergistic and Chimeric Mechanism of Bacteriophage Endolysins: Opportunities for Application in Biotherapeutics, Food, and Health Sectors - PubMed
A major growing concern in the human and animal health sector is the emergence of antibiotic-resistant pathogenic bacteria due to the indiscriminate use of antibiotics. The exogenous application of bacteriophage endolysins causes abrupt lysis of the bacterial cell wall, which computes them as altern …
pubmed.ncbi.nlm.nih.gov
November 24, 2024 at 6:37 PM
The Synergistic and Chimeric Mechanism of Bacteriophage Endolysins: Opportunities for Application in Biotherapeutics, Food, and Health Sectors.
DOI: 10.1007/s12602-024-10394-1
https://pubmed.ncbi.nlm.nih.gov/39508962/
DOI: 10.1007/s12602-024-10394-1
https://pubmed.ncbi.nlm.nih.gov/39508962/
🎙️ New PhageLine episode out now! This week, we discuss the applications of phage-derived endolysins for food safety. 🦠🔬
New episodes every Sunday, 12 AM CET.
🎧 Listen on Spotify, Apple Podcasts, any Podcatcher or here:
t1p.de/phageline
#PhageLine#Podcast#Bacteriophages#food#safety
New episodes every Sunday, 12 AM CET.
🎧 Listen on Spotify, Apple Podcasts, any Podcatcher or here:
t1p.de/phageline
#PhageLine#Podcast#Bacteriophages#food#safety
Sie werden weitergeleitet ...
t1p.de
March 23, 2025 at 6:10 PM
🎙️ New PhageLine episode out now! This week, we discuss the applications of phage-derived endolysins for food safety. 🦠🔬
New episodes every Sunday, 12 AM CET.
🎧 Listen on Spotify, Apple Podcasts, any Podcatcher or here:
t1p.de/phageline
#PhageLine#Podcast#Bacteriophages#food#safety
New episodes every Sunday, 12 AM CET.
🎧 Listen on Spotify, Apple Podcasts, any Podcatcher or here:
t1p.de/phageline
#PhageLine#Podcast#Bacteriophages#food#safety
.@GabrielPerron Endolysins are cool, but I am VERY skeptical about the claim that resistance evolution is unlikely.
November 6, 2014 at 2:16 PM
.@GabrielPerron Endolysins are cool, but I am VERY skeptical about the claim that resistance evolution is unlikely.
Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins https://www.biorxiv.org/content/10.1101/2025.02.06.636829v1
February 8, 2025 at 6:17 AM
Diversity, structure-function relationships and evolution of cell wall-binding domains of staphylococcal phage endolysins https://www.biorxiv.org/content/10.1101/2025.02.06.636829v1
We then used sequence information to find more cases of recently emerged domain mosaicism. We saw examples of domain swap and shuffling not only in receptor-binding proteins and endolysins, but also in replication proteins like ribonucleotide reductases or replication initiation proteins. 5/7
November 28, 2023 at 1:55 PM
We then used sequence information to find more cases of recently emerged domain mosaicism. We saw examples of domain swap and shuffling not only in receptor-binding proteins and endolysins, but also in replication proteins like ribonucleotide reductases or replication initiation proteins. 5/7
#PBVAB19 Giritch:
Nomad got R&D interest in combatting antibiotic resistant bacteria
Antibacterial proteins acteriocins and endolysins very well produced in plants, are active and easily purified - 85% of 150 genes at 1-8 biomass
Nomad got R&D interest in combatting antibiotic resistant bacteria
Antibacterial proteins acteriocins and endolysins very well produced in plants, are active and easily purified - 85% of 150 genes at 1-8 biomass
November 22, 2024 at 3:36 AM
#PBVAB19 Giritch:
Nomad got R&D interest in combatting antibiotic resistant bacteria
Antibacterial proteins acteriocins and endolysins very well produced in plants, are active and easily purified - 85% of 150 genes at 1-8 biomass
Nomad got R&D interest in combatting antibiotic resistant bacteria
Antibacterial proteins acteriocins and endolysins very well produced in plants, are active and easily purified - 85% of 150 genes at 1-8 biomass
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis.
DOI: 10.1016/j.bbrep.2024.101844
https://doi.org/10.1016/j.bbrep.2024.101844
DOI: 10.1016/j.bbrep.2024.101844
https://doi.org/10.1016/j.bbrep.2024.101844
November 18, 2024 at 11:45 PM
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis.
DOI: 10.1016/j.bbrep.2024.101844
https://doi.org/10.1016/j.bbrep.2024.101844
DOI: 10.1016/j.bbrep.2024.101844
https://doi.org/10.1016/j.bbrep.2024.101844
Dairy practices select for thermostable endolysins in phages https://www.biorxiv.org/content/10.1101/2023.09.27.559745v1
Dairy practices select for thermostable endolysins in phages https://www.biorxiv.org/content/10.1101/2023.09.27.559745v1
Endolysins are phage lytic enzymes that degrade the bacterial cell wall to release phage progeny. We
www.biorxiv.org
September 28, 2023 at 3:17 AM
Dairy practices select for thermostable endolysins in phages https://www.biorxiv.org/content/10.1101/2023.09.27.559745v1