This review describes the function of the PI3K pathway, discusses how PIK3CA mutations rewire #CellSignaling, metabolism, & #TumorMicroenvironment, and provides an overview of PIK3CA-targeted therapeutics. @CWRUSOM @cwru
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 24, 2025 at 12:49 PM
This review describes the function of the PI3K pathway, discusses how PIK3CA mutations rewire #CellSignaling, metabolism, & #TumorMicroenvironment, and provides an overview of PIK3CA-targeted therapeutics. @CWRUSOM @cwru
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Spirits aren't dampened, but the ground will be. So the #CaseCancerInstitute/#ACS Lungevity 5K Walk/Run is postponed to 11/22. Same time and place. Hope to see you there! #caseccc #cwrusom #fightlungcancer #takeabreath
November 7, 2025 at 8:12 PM
Spirits aren't dampened, but the ground will be. So the #CaseCancerInstitute/#ACS Lungevity 5K Walk/Run is postponed to 11/22. Same time and place. Hope to see you there! #caseccc #cwrusom #fightlungcancer #takeabreath
Take a walk in the park on Sunday, Nov. 9 to benefit #lungcancerresearch. The #CaseCancerInitiative will be waiting for you to join them at Willard Park. Details below. #caseccc #cci #kickcancer #cwrusom #lungevity
November 7, 2025 at 7:02 PM
Take a walk in the park on Sunday, Nov. 9 to benefit #lungcancerresearch. The #CaseCancerInitiative will be waiting for you to join them at Willard Park. Details below. #caseccc #cci #kickcancer #cwrusom #lungevity
Too rainy to go out for lunch? Stay in and tune in to "Chromatin architecture and condensate dynamics govern PARP2 function and inhibition," Case CCC's Friday seminar by Tae Hun Kim, PhD. Live stream at 12p ET TODAY case.edu/livestream/s4.
#caseccc #cwrusom #cancerresearch
#caseccc #cwrusom #cancerresearch
November 7, 2025 at 2:54 PM
Too rainy to go out for lunch? Stay in and tune in to "Chromatin architecture and condensate dynamics govern PARP2 function and inhibition," Case CCC's Friday seminar by Tae Hun Kim, PhD. Live stream at 12p ET TODAY case.edu/livestream/s4.
#caseccc #cwrusom #cancerresearch
#caseccc #cwrusom #cancerresearch
Treat bag for undergrad science majors: $5,000, hands-on cancer research, pd housing, mentors at CWRU/Cleveland Clinic/UH. Case CCC CanSUR applications open TODAY!
https://case.edu/cancer/training-education/cansur/application-instructions
#summer2026 #CanSUR #STEM #CancerResearch #caseccc #cwrusom
https://case.edu/cancer/training-education/cansur/application-instructions
#summer2026 #CanSUR #STEM #CancerResearch #caseccc #cwrusom
October 31, 2025 at 4:05 AM
Treat bag for undergrad science majors: $5,000, hands-on cancer research, pd housing, mentors at CWRU/Cleveland Clinic/UH. Case CCC CanSUR applications open TODAY!
https://case.edu/cancer/training-education/cansur/application-instructions
#summer2026 #CanSUR #STEM #CancerResearch #caseccc #cwrusom
https://case.edu/cancer/training-education/cansur/application-instructions
#summer2026 #CanSUR #STEM #CancerResearch #caseccc #cwrusom
Listen to the incredible #NotebookLM generated 10-minute audio overview of our research oriented, small group, no test, no grade curriculum at the @ClevelandClinic Lerner College of Medicine of @CWRUSOM portal.cclcm.ccf.org/cclcm/CCLCMD...
https://portal.cclcm.ccf.org/cclcm/CCLCMDep…
June 1, 2025 at 8:13 PM
Listen to the incredible #NotebookLM generated 10-minute audio overview of our research oriented, small group, no test, no grade curriculum at the @ClevelandClinic Lerner College of Medicine of @CWRUSOM portal.cclcm.ccf.org/cclcm/CCLCMD...
Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:
March 31, 2025 at 10:40 AM
Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:
We are excited to share a new paper from the lab - led by first author and @cwrumstp @cwrusom student Meghan O'Keefe. 1/n
Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports www.cell.com/cell-reports...
Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports www.cell.com/cell-reports...
Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP
O’Keefe et al. determined that inflammasome agonists, working through the mitochondria,
rapidly inactivate ERK1/2. They further show that the ERK substrate, TTP, is also
inactivated, leading to increa...
www.cell.com
February 21, 2025 at 1:03 AM
We are excited to share a new paper from the lab - led by first author and @cwrumstp @cwrusom student Meghan O'Keefe. 1/n
Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports www.cell.com/cell-reports...
Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports www.cell.com/cell-reports...
". it takes a long time to tell whether a junior scientist is successful, estimating it would take at least 15 years to judge the impact of a developing neurobiologist."
RIP Lynn Landmesser--a giant as well as a wonderful colleague during my time @CWRUSOM
www.nature.com/articles/s41...
RIP Lynn Landmesser--a giant as well as a wonderful colleague during my time @CWRUSOM
www.nature.com/articles/s41...
Lynn T. Landmesser (1943–2024) - Nature Neuroscience
Lynn T. Landmesser, professor emerita of the Department of Neurosciences, School of Medicine at Case Western Reserve University, died on 29 November 2024 at the age of 80. In an illustrious and influe...
www.nature.com
January 31, 2025 at 7:25 PM
". it takes a long time to tell whether a junior scientist is successful, estimating it would take at least 15 years to judge the impact of a developing neurobiologist."
RIP Lynn Landmesser--a giant as well as a wonderful colleague during my time @CWRUSOM
www.nature.com/articles/s41...
RIP Lynn Landmesser--a giant as well as a wonderful colleague during my time @CWRUSOM
www.nature.com/articles/s41...
Getting ready for the 40th annual DocOpera directed and performed by the incredibly talented students @CWRUSOM and @CleClinicLCM ?(and a few uhhm not so talented faculty)
Raising money for the free clinic
Raising money for the free clinic
December 14, 2024 at 10:58 PM
Getting ready for the 40th annual DocOpera directed and performed by the incredibly talented students @CWRUSOM and @CleClinicLCM ?(and a few uhhm not so talented faculty)
Raising money for the free clinic
Raising money for the free clinic
I am honored and humbled to be appointed as the Paul and Betsy Shiverick Professor of Immuno-Oncology. I’m very grateful for generosity and the vision of Paul and Betsy to establish this Professorship &feel incredibly fortunate to be the inaugural chairholder @caseccc & @CWRUSOM!
December 12, 2024 at 8:12 AM
I am honored and humbled to be appointed as the Paul and Betsy Shiverick Professor of Immuno-Oncology. I’m very grateful for generosity and the vision of Paul and Betsy to establish this Professorship &feel incredibly fortunate to be the inaugural chairholder @caseccc & @CWRUSOM!
Are you finishing your fellowship and interested in a clinician educator or physician scientist position?
Are you a hepatologist looking for a growing and collegial group to join?
@UHhospitals @CWRUSOM is hiring!
Let’s talk @AASLDtweets #TLM24
DM me directly!
#livertwitter
Are you a hepatologist looking for a growing and collegial group to join?
@UHhospitals @CWRUSOM is hiring!
Let’s talk @AASLDtweets #TLM24
DM me directly!
#livertwitter
December 2, 2024 at 3:03 PM
Are you finishing your fellowship and interested in a clinician educator or physician scientist position?
Are you a hepatologist looking for a growing and collegial group to join?
@UHhospitals @CWRUSOM is hiring!
Let’s talk @AASLDtweets #TLM24
DM me directly!
#livertwitter
Are you a hepatologist looking for a growing and collegial group to join?
@UHhospitals @CWRUSOM is hiring!
Let’s talk @AASLDtweets #TLM24
DM me directly!
#livertwitter
Are you a graduating fellow or established hepatologist looking to join a rapidly growing, collegial liver/transplant program at a top 15 research institution?
@CWRUSOM digestive health institute is hiring! Let’s connect @AASLDtweets #TLM24 or message me! #livertwitter
@CWRUSOM digestive health institute is hiring! Let’s connect @AASLDtweets #TLM24 or message me! #livertwitter
December 2, 2024 at 3:13 PM
Are you a graduating fellow or established hepatologist looking to join a rapidly growing, collegial liver/transplant program at a top 15 research institution?
@CWRUSOM digestive health institute is hiring! Let’s connect @AASLDtweets #TLM24 or message me! #livertwitter
@CWRUSOM digestive health institute is hiring! Let’s connect @AASLDtweets #TLM24 or message me! #livertwitter
Happy to support the @theABTA this morning in the first annual Cleveland BT5K!
Thanks to my co-captain of the @caseccc team, @JustinLathia - proud to have @ClevelandClinic, @CWRUSOM, @UHhospitals researcher & docs team up!
Cleveland is the place to be for #braintumor research!
Thanks to my co-captain of the @caseccc team, @JustinLathia - proud to have @ClevelandClinic, @CWRUSOM, @UHhospitals researcher & docs team up!
Cleveland is the place to be for #braintumor research!
December 12, 2024 at 8:12 AM
Happy to support the @theABTA this morning in the first annual Cleveland BT5K!
Thanks to my co-captain of the @caseccc team, @JustinLathia - proud to have @ClevelandClinic, @CWRUSOM, @UHhospitals researcher & docs team up!
Cleveland is the place to be for #braintumor research!
Thanks to my co-captain of the @caseccc team, @JustinLathia - proud to have @ClevelandClinic, @CWRUSOM, @UHhospitals researcher & docs team up!
Cleveland is the place to be for #braintumor research!
@theABTA @caseccc @CCLRI @CWRUSOM @JustinLathia @cg_hubert @jenniferyumdphd @OConnorVirusLab @JuyeunLee31 Daniel Silver
December 12, 2024 at 8:23 AM
@theABTA @caseccc @CCLRI @CWRUSOM @JustinLathia @cg_hubert @jenniferyumdphd @OConnorVirusLab @JuyeunLee31 Daniel Silver
Cleveland is the place to be to conduct brain tumor research! The CLE contingent at #AARN24 - a meeting for researchers who have been funded by @theABTA. CLE researchers representing @caseccc @CCLRI & @CWRUSOM made up >10% of attendees!
#ABTAResearcher
#ABTAResearcher
December 12, 2024 at 8:17 AM
Cleveland is the place to be to conduct brain tumor research! The CLE contingent at #AARN24 - a meeting for researchers who have been funded by @theABTA. CLE researchers representing @caseccc @CCLRI & @CWRUSOM made up >10% of attendees!
#ABTAResearcher
#ABTAResearcher
On a clear day, you can see forever… @inthecircle @UHhospitals @CWRUSOM @cwru
December 2, 2024 at 3:19 PM
On a clear day, you can see forever… @inthecircle @UHhospitals @CWRUSOM @cwru
The @CWRUSOM @CWRUdeptMED @UHhospitals family is shocked and in mourning at the news that our chair of medicine Dr. Robert Salata passed away suddenl.
To state that Dr. Salata was a giant of medicine would be an understatement.
May his memory be a blessing to all of us.
To state that Dr. Salata was a giant of medicine would be an understatement.
May his memory be a blessing to all of us.
December 2, 2024 at 3:19 PM
The @CWRUSOM @CWRUdeptMED @UHhospitals family is shocked and in mourning at the news that our chair of medicine Dr. Robert Salata passed away suddenl.
To state that Dr. Salata was a giant of medicine would be an understatement.
May his memory be a blessing to all of us.
To state that Dr. Salata was a giant of medicine would be an understatement.
May his memory be a blessing to all of us.
.@yifficientYiFan and colleagues in the team headed by Drew Adams @DrewAdamsLab @cwrusom @cwru identified a degrader of XPO1, which diminishes the chromatin occupancy of XPO1 and P300 and kills cancer cells. http://dlvr.it/T9qBtW
July 19, 2024 at 8:00 PM
.@yifficientYiFan and colleagues in the team headed by Drew Adams @DrewAdamsLab @cwrusom @cwru identified a degrader of XPO1, which diminishes the chromatin occupancy of XPO1 and P300 and kills cancer cells. http://dlvr.it/T9qBtW
.@yifficientYiFan and colleagues in the team headed by Drew Adams @DrewAdamsLab @cwrusom @cwru identified a degrader of XPO1, which diminishes the chromatin occupancy of XPO1 and P300 and kills cancer cells. http://dlvr.it/T8j4QV
June 24, 2024 at 3:30 PM
.@yifficientYiFan and colleagues in the team headed by Drew Adams @DrewAdamsLab @cwrusom @cwru identified a degrader of XPO1, which diminishes the chromatin occupancy of XPO1 and P300 and kills cancer cells. http://dlvr.it/T8j4QV
A giant in every sense of the word but perhaps more importantly, a great human being.
May Dr. Nate Berger's memory be a blessing to all of us @cwru @CWRUSOM @UHhospitals
https://obits.cleveland.com/us/obituaries/cleveland/name/nathan-berger-obituary?id=55358987
May Dr. Nate Berger's memory be a blessing to all of us @cwru @CWRUSOM @UHhospitals
https://obits.cleveland.com/us/obituaries/cleveland/name/nathan-berger-obituary?id=55358987
December 2, 2024 at 3:44 PM
A giant in every sense of the word but perhaps more importantly, a great human being.
May Dr. Nate Berger's memory be a blessing to all of us @cwru @CWRUSOM @UHhospitals
https://obits.cleveland.com/us/obituaries/cleveland/name/nathan-berger-obituary?id=55358987
May Dr. Nate Berger's memory be a blessing to all of us @cwru @CWRUSOM @UHhospitals
https://obits.cleveland.com/us/obituaries/cleveland/name/nathan-berger-obituary?id=55358987
it will be a pleasure to give medical grand rounds @UHhospitals @CWRUSOM @CWRUdeptMED at noon tomorrow on the very exciting and hot topic of #MASH the ultimate case for multidisciplinary care. open to @UHhospitals providers in person at Kulas or via zoom.
December 2, 2024 at 3:44 PM
it will be a pleasure to give medical grand rounds @UHhospitals @CWRUSOM @CWRUdeptMED at noon tomorrow on the very exciting and hot topic of #MASH the ultimate case for multidisciplinary care. open to @UHhospitals providers in person at Kulas or via zoom.
I am incredibly excited to announce the opening of the @TyMillerLab at @CWRUSOM and @UHhospitals in Cleveland! My lab will be dedicated to creating effective immunotherapies for brain tumor patients. Learn more at our freshly minted website - https://tymillerlab.org
December 12, 2024 at 8:23 AM
I am incredibly excited to announce the opening of the @TyMillerLab at @CWRUSOM and @UHhospitals in Cleveland! My lab will be dedicated to creating effective immunotherapies for brain tumor patients. Learn more at our freshly minted website - https://tymillerlab.org
Less than 48 hours to our upcoming liver rounds! You do not want to miss this edition!
@CWRU_GI @ClevelandClinic @metrohealthCLE @CWRUSOM @CWRUdeptMED
@CWRU_GI @ClevelandClinic @metrohealthCLE @CWRUSOM @CWRUdeptMED
The next edition of @OHIOLIVER Tavill citywide liver rounds is coming up on May 1!
Join us for fantastic presentations on topics ranging from pediatric liver disease to the latest in testing and therapies! #gitwitter #livertwitter
Register at:
http://Www.liveralliance.org
Join us for fantastic presentations on topics ranging from pediatric liver disease to the latest in testing and therapies! #gitwitter #livertwitter
Register at:
http://Www.liveralliance.org
Northeast Ohio Liver Alliance - Your Liver Health Matters
We are a local organization formed by physicians to promo...
Www.liveralliance.org
December 2, 2024 at 4:25 PM
Less than 48 hours to our upcoming liver rounds! You do not want to miss this edition!
@CWRU_GI @ClevelandClinic @metrohealthCLE @CWRUSOM @CWRUdeptMED
@CWRU_GI @ClevelandClinic @metrohealthCLE @CWRUSOM @CWRUdeptMED
@aderlinder @SofiDamjanovska @biancaislam @CWRU_GI @CWRUdeptMED @CWRUSOM @metrohealthCLE @ClevelandClinic @CLindenmeyerMD @SNLaiqueMD @keitharmitage @GlobalLiver @AlkhouriNaim @guts44
December 2, 2024 at 4:25 PM
@aderlinder @SofiDamjanovska @biancaislam @CWRU_GI @CWRUdeptMED @CWRUSOM @metrohealthCLE @ClevelandClinic @CLindenmeyerMD @SNLaiqueMD @keitharmitage @GlobalLiver @AlkhouriNaim @guts44