Ty Miller Lab
@tymillerlab.bsky.social
http://tymillerlab.org @CWRUSOM @UHhospitals | Researchers of #braincancer, myeloid cells, epigenetics, #immunotherapy | Dedicated to finding cures for patients
Pinned
Ty Miller Lab
@tymillerlab.bsky.social
· Feb 27
Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature
A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...
www.nature.com
Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...
Reposted by Ty Miller Lab
We also made a website and python API to run starCAT with several other published gene program catalogs including a myeloid reference from @tymillerlab.bsky.social et al and a hematapoetic stem cell reference from @bloodandtime.bsky.social and Hojun Li
September 3, 2025 at 4:46 PM
We also made a website and python API to run starCAT with several other published gene program catalogs including a myeloid reference from @tymillerlab.bsky.social et al and a hematapoetic stem cell reference from @bloodandtime.bsky.social and Hojun Li
Reposted by Ty Miller Lab
Case CCC/@uhcleveland.bsky.social researcher @tymillerlab.bsky.social targets myeloid cells in brain cancer www.uhhospitals.org/for-clinicia...
UH Seidman Researcher Parlaying Findings in Nature into More Effective Immunotherapy for Brain Tumors, Targeting Myeloid Cells
A major impediment to the successful use of immunotherapy in glioblastoma is the preponderance of a type of immune cell in the tumor, called myeloid cells, which can make up as much as 50% of all cell...
www.uhhospitals.org
August 22, 2025 at 1:12 PM
Case CCC/@uhcleveland.bsky.social researcher @tymillerlab.bsky.social targets myeloid cells in brain cancer www.uhhospitals.org/for-clinicia...
Home cooked meals are the best.
Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️
Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️
August 12, 2025 at 1:51 AM
Home cooked meals are the best.
Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️
Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️
Celebrating "UH100", the 100th brain tumor we've collected (in ~10 months!) & processed to learn more about these tumors & make patient organoids to test new therapies @uhreinstitute.bsky.social & @caseccc.bsky.social. Thanks to the patients, @staudtmd.bsky.social & Dr. Tiffany Hodges, & my lab!
August 6, 2025 at 11:16 AM
Celebrating "UH100", the 100th brain tumor we've collected (in ~10 months!) & processed to learn more about these tumors & make patient organoids to test new therapies @uhreinstitute.bsky.social & @caseccc.bsky.social. Thanks to the patients, @staudtmd.bsky.social & Dr. Tiffany Hodges, & my lab!
Congratulations to @terminallycurious.bsky.social, Huang-lab MSTP student @CWRU, on her main thesis project!! Very happy we could help support her great story as our lab's first collaborative project. Turns out mechano-sensors are important in tumor-associated myeloid cells!
@caseccc.bsky.social
@caseccc.bsky.social
I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story!
jitc.bmj.com/content/13/6...
jitc.bmj.com/content/13/6...
Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells
Background Tumor-associated myeloid cells (TAMCs) are an abundant, phenotypically plastic cell population that is critical for initiating a robust antitumor response. To properly combat cancer cells, ...
jitc.bmj.com
June 24, 2025 at 12:28 PM
Congratulations to @terminallycurious.bsky.social, Huang-lab MSTP student @CWRU, on her main thesis project!! Very happy we could help support her great story as our lab's first collaborative project. Turns out mechano-sensors are important in tumor-associated myeloid cells!
@caseccc.bsky.social
@caseccc.bsky.social
Reposted by Ty Miller Lab
I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story!
jitc.bmj.com/content/13/6...
jitc.bmj.com/content/13/6...
Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells
Background Tumor-associated myeloid cells (TAMCs) are an abundant, phenotypically plastic cell population that is critical for initiating a robust antitumor response. To properly combat cancer cells, ...
jitc.bmj.com
June 24, 2025 at 11:42 AM
I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story!
jitc.bmj.com/content/13/6...
jitc.bmj.com/content/13/6...
Reposted by Ty Miller Lab
🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/
April 16, 2025 at 12:35 AM
🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/
A real privilege to be part of this meeting with so many leaders in the field that I admire. It is an inspiring group of passionate & dedicated physicians/scientists trying to tackle #GBM. Hoping that our collective efforts will lead to effective therapies for these patients. Thanks for the invite!
Thank you to participants of "Glioblastoma" for productive and invigorating discussions, with special thanks to organizers Drs. Melissa Bondy, Peter Dirks, and Bill Weiss. We are grateful to the @cshlnews.bsky.social - @northwellhealth.bsky.social Affiliation for support.
Agenda: bit.ly/GBM-25
Agenda: bit.ly/GBM-25
April 16, 2025 at 12:43 PM
A real privilege to be part of this meeting with so many leaders in the field that I admire. It is an inspiring group of passionate & dedicated physicians/scientists trying to tackle #GBM. Hoping that our collective efforts will lead to effective therapies for these patients. Thanks for the invite!
Our lab @caseccc.bsky.social, CWRU SOM, & University Hospitals is recruiting! We are looking for 2 talented immunotherapy postdocs eager to make an impact for brain tumor patients using cutting edge single-cell & spatial genomics & patient-tissue organoids - join us!
Please share positions below:
Please share positions below:
April 15, 2025 at 1:58 PM
Our lab @caseccc.bsky.social, CWRU SOM, & University Hospitals is recruiting! We are looking for 2 talented immunotherapy postdocs eager to make an impact for brain tumor patients using cutting edge single-cell & spatial genomics & patient-tissue organoids - join us!
Please share positions below:
Please share positions below:
Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:
March 31, 2025 at 10:40 AM
Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:
Celebrating two summer fellowships today with ice cream @ Mitchells! Congrats to Kaylie for being awarded the CanSUR fellowship for undergraduates and Medical student Alex Wang the @caseccc.bsky.social Medical Training Award! Both awards will support their work in the lab this summer 🔬
March 22, 2025 at 3:51 AM
Celebrating two summer fellowships today with ice cream @ Mitchells! Congrats to Kaylie for being awarded the CanSUR fellowship for undergraduates and Medical student Alex Wang the @caseccc.bsky.social Medical Training Award! Both awards will support their work in the lab this summer 🔬
Was great to see friends and colleagues in London as part of the @braintumourcharity.bsky.social annual Scientific Advisory Board meeting! There are exciting things happening in brain tumor research around the world and honored to get to help guide it. Views were pretty good toon
March 14, 2025 at 9:15 PM
Was great to see friends and colleagues in London as part of the @braintumourcharity.bsky.social annual Scientific Advisory Board meeting! There are exciting things happening in brain tumor research around the world and honored to get to help guide it. Views were pretty good toon
Reposted by Ty Miller Lab
New research uncovers four gene expression “programs” in immune cells that either suppress the immune system or make it more active — and could explain why brain cancer is often resistant to immunotherapy.
@danafarbernews.bsky.social @nature.com
@danafarbernews.bsky.social @nature.com
Why brain cancer is often resistant to immunotherapy
Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.
www.broadinstitute.org
February 26, 2025 at 5:58 PM
New research uncovers four gene expression “programs” in immune cells that either suppress the immune system or make it more active — and could explain why brain cancer is often resistant to immunotherapy.
@danafarbernews.bsky.social @nature.com
@danafarbernews.bsky.social @nature.com
Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...
Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature
A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...
www.nature.com
February 27, 2025 at 4:05 AM
Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...
At #TRCCC @ejohnwherry.bsky.social gave an amazing talk about changing delivery of checkpoint blockade to increase efficacy, then ended with this slide, maybe his most important of the day. Share this information with your friends, family, neighbor!
February 23, 2025 at 12:19 PM
At #TRCCC @ejohnwherry.bsky.social gave an amazing talk about changing delivery of checkpoint blockade to increase efficacy, then ended with this slide, maybe his most important of the day. Share this information with your friends, family, neighbor!
Proud of my lab members who gave great talks today @ the #TRCCC conference!! Vrishab Kumar & Regan Murphy presented their computational projects this morning, and Shawn Ho & Alex Crane presented myeloid targeting projects this evening.
CWRU SOM & @caseccc.bsky.social representing 💯
CWRU SOM & @caseccc.bsky.social representing 💯
February 20, 2025 at 11:05 PM
Proud of my lab members who gave great talks today @ the #TRCCC conference!! Vrishab Kumar & Regan Murphy presented their computational projects this morning, and Shawn Ho & Alex Crane presented myeloid targeting projects this evening.
CWRU SOM & @caseccc.bsky.social representing 💯
CWRU SOM & @caseccc.bsky.social representing 💯
Annual @sitcancer.bsky.social crew picture at #TRCCC 2025
@immunegirl.bsky.social
@ Michelle Williams and Sarah Gitto
@immunegirl.bsky.social
@ Michelle Williams and Sarah Gitto
February 20, 2025 at 4:12 AM
Annual @sitcancer.bsky.social crew picture at #TRCCC 2025
@immunegirl.bsky.social
@ Michelle Williams and Sarah Gitto
@immunegirl.bsky.social
@ Michelle Williams and Sarah Gitto
The @tymillerlab.bsky.social rolling into #TRCCC 2025 and looking forward to 3 great days learning about the latest in immunotherapy!!
#Roadtrip
#Roadtrip
February 19, 2025 at 6:38 PM
The @tymillerlab.bsky.social rolling into #TRCCC 2025 and looking forward to 3 great days learning about the latest in immunotherapy!!
#Roadtrip
#Roadtrip
Excited to be at @UCSF & @UCSFCancer to give the @UcsfPspg seminar today about our work and meet with friends and colleagues!
Thanks to @LuRongze for the invite!
Thanks to @LuRongze for the invite!
December 11, 2024 at 6:16 PM
Excited to be at @UCSF & @UCSFCancer to give the @UcsfPspg seminar today about our work and meet with friends and colleagues!
Thanks to @LuRongze for the invite!
Thanks to @LuRongze for the invite!
The Miller Lab birthday tradition continues at Mitchell's - happy birthday Namita!
December 12, 2024 at 8:12 AM
The Miller Lab birthday tradition continues at Mitchell's - happy birthday Namita!
I'll say it again, the best part of #SITC2024 is the people
@NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁
Thanks for hosting @AkoyaBio!
@NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁
Thanks for hosting @AkoyaBio!
December 12, 2024 at 8:12 AM
I'll say it again, the best part of #SITC2024 is the people
@NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁
Thanks for hosting @AkoyaBio!
@NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁
Thanks for hosting @AkoyaBio!
Excited to be at #SITC2024 - as faculty for the first time! 🤎 badge ribbons, which basically lay out my @sitcancer & @sitcancerECS journey 😀
Recruiting postdocs that are motivated to create effective immunotherapies for brain tumor patients! Reach out! http://Tymillerlab.org
Recruiting postdocs that are motivated to create effective immunotherapies for brain tumor patients! Reach out! http://Tymillerlab.org
December 12, 2024 at 8:12 AM
Excited to be at #SITC2024 - as faculty for the first time! 🤎 badge ribbons, which basically lay out my @sitcancer & @sitcancerECS journey 😀
Recruiting postdocs that are motivated to create effective immunotherapies for brain tumor patients! Reach out! http://Tymillerlab.org
Recruiting postdocs that are motivated to create effective immunotherapies for brain tumor patients! Reach out! http://Tymillerlab.org
I am honored and humbled to be appointed as the Paul and Betsy Shiverick Professor of Immuno-Oncology. I’m very grateful for generosity and the vision of Paul and Betsy to establish this Professorship &feel incredibly fortunate to be the inaugural chairholder @caseccc & @CWRUSOM!
December 12, 2024 at 8:12 AM
I am honored and humbled to be appointed as the Paul and Betsy Shiverick Professor of Immuno-Oncology. I’m very grateful for generosity and the vision of Paul and Betsy to establish this Professorship &feel incredibly fortunate to be the inaugural chairholder @caseccc & @CWRUSOM!
December 12, 2024 at 8:12 AM