Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response
Organisms can activate innate immunity not only by detecting pathogens but also by sensing disturbances to essential cellular processes. Such damage-based surveillance provides a means to identify cel...
www.biorxiv.org
December 13, 2025 at 4:39 AM
Happy to share another story by Annesha Ghosh. Here, we show that inhibition of the mRNA cap methyltransferase CMTR-1 activates a protective immune response via the GATA transcription factor ELT-2.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response https://www.biorxiv.org/content/10.64898/2025.12.09.693339v1
December 12, 2025 at 7:16 PM
RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response https://www.biorxiv.org/content/10.64898/2025.12.09.693339v1
RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response https://www.biorxiv.org/content/10.64898/2025.12.09.693339v1
December 12, 2025 at 7:16 PM
RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response https://www.biorxiv.org/content/10.64898/2025.12.09.693339v1
The 2026 CMTR Calendar is here!
Featuring gorgeous 2025 race-location shots by @tyholtanphoto, with every dollar going straight to our trail partners.
Calendars ship by Dec 15. Add one to your order when you register for Diez Vista, Run Ridge Run, Survival of the Fittest, or Buckin’ Hell.
Featuring gorgeous 2025 race-location shots by @tyholtanphoto, with every dollar going straight to our trail partners.
Calendars ship by Dec 15. Add one to your order when you register for Diez Vista, Run Ridge Run, Survival of the Fittest, or Buckin’ Hell.
November 18, 2025 at 5:48 PM
The 2026 CMTR Calendar is here!
Featuring gorgeous 2025 race-location shots by @tyholtanphoto, with every dollar going straight to our trail partners.
Calendars ship by Dec 15. Add one to your order when you register for Diez Vista, Run Ridge Run, Survival of the Fittest, or Buckin’ Hell.
Featuring gorgeous 2025 race-location shots by @tyholtanphoto, with every dollar going straight to our trail partners.
Calendars ship by Dec 15. Add one to your order when you register for Diez Vista, Run Ridge Run, Survival of the Fittest, or Buckin’ Hell.
Photos from the Coast Mountain Trail Race volunteer appreciation party November 9, 2025. Food, drink & prizes galore! Felt very appreciated! Thanks so much! www.facebook.com/share/1EkdeH...
#CMTR #thesweatlife #trailrace #racevolunteer #northvancouver
#CMTR #thesweatlife #trailrace #racevolunteer #northvancouver
November 10, 2025 at 4:12 AM
Photos from the Coast Mountain Trail Race volunteer appreciation party November 9, 2025. Food, drink & prizes galore! Felt very appreciated! Thanks so much! www.facebook.com/share/1EkdeH...
#CMTR #thesweatlife #trailrace #racevolunteer #northvancouver
#CMTR #thesweatlife #trailrace #racevolunteer #northvancouver
As usual, CMTR shows how it's done. Multiple posts over multiple days on all platforms, plus email newsletters, and the web site had registration dates up a month ago. Their newest race sold out in FIVE HOURS. Gary, Geoff, & co stay winning!
Also hi Elaine! Good job!
Also hi Elaine! Good job!
Well, that escalated quickly. The 2026 Alpenglow 100 has SOLD OUT in 5 hours!
Thank you for the incredible enthusiasm. We’ll see 800 of you in the middle of everywhere in July.
No waitlists, no extra spots. You’re either in… or volunteering 😉
📷 @jelmersnoeck
Thank you for the incredible enthusiasm. We’ll see 800 of you in the middle of everywhere in July.
No waitlists, no extra spots. You’re either in… or volunteering 😉
📷 @jelmersnoeck
November 8, 2025 at 2:41 AM
As usual, CMTR shows how it's done. Multiple posts over multiple days on all platforms, plus email newsletters, and the web site had registration dates up a month ago. Their newest race sold out in FIVE HOURS. Gary, Geoff, & co stay winning!
Also hi Elaine! Good job!
Also hi Elaine! Good job!
Wow! Fun morning at CMTR HQ! Alpenglow stats so far:
38K - SOLD OUT
65K - 48 spots remain
100K - 12 spots remain
Over 680 runners have signed up so far and 54% are women!
📷 @tyholtanphoto
38K - SOLD OUT
65K - 48 spots remain
100K - 12 spots remain
Over 680 runners have signed up so far and 54% are women!
📷 @tyholtanphoto
November 7, 2025 at 5:02 PM
Wow! Fun morning at CMTR HQ! Alpenglow stats so far:
38K - SOLD OUT
65K - 48 spots remain
100K - 12 spots remain
Over 680 runners have signed up so far and 54% are women!
📷 @tyholtanphoto
38K - SOLD OUT
65K - 48 spots remain
100K - 12 spots remain
Over 680 runners have signed up so far and 54% are women!
📷 @tyholtanphoto
Olympia: bsky.app/profile/cmtr...
Olympia is out in force for the No Kings protest! #NoKingsOlympia
🚫👑❤️🇺🇸
🚫👑❤️🇺🇸
October 18, 2025 at 10:38 PM
Olympia: bsky.app/profile/cmtr...
Grateful for the miles, the mud, the climbs, and the people who make this sport what it is. Runners, volunteers, sponsors, crew—thank you for being the heartbeat of every CMTR race.
📷 @tameywanders
📷 @tameywanders
October 13, 2025 at 4:32 PM
Grateful for the miles, the mud, the climbs, and the people who make this sport what it is. Runners, volunteers, sponsors, crew—thank you for being the heartbeat of every CMTR race.
📷 @tameywanders
📷 @tameywanders
Here’s when registration opens for the 2026 CMTR race season.
Nov 7 - The Alpenglow 100
Nov 14 - Squamish 50
Nov 21 - Diez Vista 50K
Dec 5 - CMTR races
Jan 1 - Whistler Half Marathon
Set your alarms, grab your crew, and let’s make 2026 one for the books.
📷 @tyholtanphoto
Nov 7 - The Alpenglow 100
Nov 14 - Squamish 50
Nov 21 - Diez Vista 50K
Dec 5 - CMTR races
Jan 1 - Whistler Half Marathon
Set your alarms, grab your crew, and let’s make 2026 one for the books.
📷 @tyholtanphoto
October 11, 2025 at 8:53 PM
Here’s when registration opens for the 2026 CMTR race season.
Nov 7 - The Alpenglow 100
Nov 14 - Squamish 50
Nov 21 - Diez Vista 50K
Dec 5 - CMTR races
Jan 1 - Whistler Half Marathon
Set your alarms, grab your crew, and let’s make 2026 one for the books.
📷 @tyholtanphoto
Nov 7 - The Alpenglow 100
Nov 14 - Squamish 50
Nov 21 - Diez Vista 50K
Dec 5 - CMTR races
Jan 1 - Whistler Half Marathon
Set your alarms, grab your crew, and let’s make 2026 one for the books.
📷 @tyholtanphoto
Pete Hegseth has challenged America’s generals to look more like him. Does that mean his Pentagon make-up room is now open for all?
October 3, 2025 at 2:45 AM
At CMTR, we strive to bring the most competitive potato sack races to BC. (Just kidding… unless you’re in?)
📷 @liamdueck
📷 @liamdueck
September 16, 2025 at 9:40 PM
At CMTR, we strive to bring the most competitive potato sack races to BC. (Just kidding… unless you’re in?)
📷 @liamdueck
📷 @liamdueck
Thanks so much to @coastmtntrail for the volunteer draw prize, amazing Suunto Wing headphones! What a great improvement from my 20 year old iPod! I always love volunteering for CMTR races! Thanks so much!
#CMTR #trailrace #buckinhell #thesweatlife #racevolunteer #suuntowing #ipod
#CMTR #trailrace #buckinhell #thesweatlife #racevolunteer #suuntowing #ipod
August 28, 2025 at 3:05 AM
Thanks so much to @coastmtntrail for the volunteer draw prize, amazing Suunto Wing headphones! What a great improvement from my 20 year old iPod! I always love volunteering for CMTR races! Thanks so much!
#CMTR #trailrace #buckinhell #thesweatlife #racevolunteer #suuntowing #ipod
#CMTR #trailrace #buckinhell #thesweatlife #racevolunteer #suuntowing #ipod
Super chill sunny Costco hotdog & poutine catch up with new ultramarathoner, Colin! Got him a congratulations cake! He picked up my volunteer draw prize-Suunto Wing headphones! Thanks CMTR!
#vancouverrunners #squamish50 #thesweatlife #costcohotdog #ultramarathoner
#vancouverrunners #squamish50 #thesweatlife #costcohotdog #ultramarathoner
August 21, 2025 at 2:10 AM
Super chill sunny Costco hotdog & poutine catch up with new ultramarathoner, Colin! Got him a congratulations cake! He picked up my volunteer draw prize-Suunto Wing headphones! Thanks CMTR!
#vancouverrunners #squamish50 #thesweatlife #costcohotdog #ultramarathoner
#vancouverrunners #squamish50 #thesweatlife #costcohotdog #ultramarathoner
Photos from CMTR’s Buckin’ Hell 35K, 50K & relay in North Vancouver! Team Horny 2025 volunteered at aid stations 3 & 4! Lots of fun cheering on the racers! www.facebook.com/media/set/?v... #buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
July 27, 2025 at 6:16 AM
Photos from CMTR’s Buckin’ Hell 35K, 50K & relay in North Vancouver! Team Horny 2025 volunteered at aid stations 3 & 4! Lots of fun cheering on the racers! www.facebook.com/media/set/?v... #buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
Team Horny 2025 is ready for our trail racer friends doing the Buckin’ Hell trail race. Team Horny will be helping racers at aid stations 3 & 4! If you’re too slow, expect a poke!
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
July 26, 2025 at 3:56 PM
Team Horny 2025 is ready for our trail racer friends doing the Buckin’ Hell trail race. Team Horny will be helping racers at aid stations 3 & 4! If you’re too slow, expect a poke!
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
Good luck to my trail racer friends doing the Buckin’ Hell trail race Saturday! Team Horny will be helping racers at aid stations 3 & 4! If you’re too slow, expect a poke!
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
July 26, 2025 at 5:21 AM
Good luck to my trail racer friends doing the Buckin’ Hell trail race Saturday! Team Horny will be helping racers at aid stations 3 & 4! If you’re too slow, expect a poke!
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
#buckinhell #trailrace #cmtr #thesweatlife #vancouverrunner #racevolunteer
BREAKING NEWS:
HOUSE OVERSIGHT CMTR. SUBPOENAS GHISLAINE MAXWELL!
HOUSE OVERSIGHT CMTR. SUBPOENAS GHISLAINE MAXWELL!
July 23, 2025 at 7:49 PM
BREAKING NEWS:
HOUSE OVERSIGHT CMTR. SUBPOENAS GHISLAINE MAXWELL!
HOUSE OVERSIGHT CMTR. SUBPOENAS GHISLAINE MAXWELL!
BS, out of the gate. It's impossible to design & implement a study like this, especially given the wholesale firings, /and/ expect to have genuine results in 6 months.
Unless, of course, you already know what results you're going to get, & retcon the data to fit them. I guess that could work. 🤦♂️
Unless, of course, you already know what results you're going to get, & retcon the data to fit them. I guess that could work. 🤦♂️
They'll probably just make something up. But what if hypothetically they discover the "artificial thing out there that's doing this" is a result of burning coal?
April 28, 2025 at 7:12 AM
He was out there campaigning like crazy for Harris. You chose to ignore him. That election was when there was a choice. Now there no longer is until November 2026.
March 23, 2025 at 7:32 PM
January 31, 2025 at 1:48 AM