Unlock hidden drug potential with our innovative data pipelines! Automate compound library annotation, integrate diverse bioactivity data, and uncover new repurposing opportunities. Empow...
🧵 Thread below
Full analysis: https://helixbrief.com/article/e632d78b-c15d-4256-b172-10ebd5f01406
🧵 Thread below
Full analysis: https://helixbrief.com/article/e632d78b-c15d-4256-b172-10ebd5f01406
October 29, 2025 at 8:31 PM
Unlock hidden drug potential with our innovative data pipelines! Automate compound library annotation, integrate diverse bioactivity data, and uncover new repurposing opportunities. Empow...
🧵 Thread below
Full analysis: https://helixbrief.com/article/e632d78b-c15d-4256-b172-10ebd5f01406
🧵 Thread below
Full analysis: https://helixbrief.com/article/e632d78b-c15d-4256-b172-10ebd5f01406
🧵 ¡Feliz #WorldCoffeeDay! ☕ ¿Sabías que al tostar café se genera un residuo llamado "silverskin" o "película plateada"? 🌱
Nuestro último artículo revela que este "desecho", lejos de ser basura, es una mina de nutrientes y antioxidantes. Te cuento 👇
doi.org/10.3390/food...
🧪🍎📃 #chemsky #foodtech
Nuestro último artículo revela que este "desecho", lejos de ser basura, es una mina de nutrientes y antioxidantes. Te cuento 👇
doi.org/10.3390/food...
🧪🍎📃 #chemsky #foodtech
October 1, 2025 at 7:27 AM
🧵 ¡Feliz #WorldCoffeeDay! ☕ ¿Sabías que al tostar café se genera un residuo llamado "silverskin" o "película plateada"? 🌱
Nuestro último artículo revela que este "desecho", lejos de ser basura, es una mina de nutrientes y antioxidantes. Te cuento 👇
doi.org/10.3390/food...
🧪🍎📃 #chemsky #foodtech
Nuestro último artículo revela que este "desecho", lejos de ser basura, es una mina de nutrientes y antioxidantes. Te cuento 👇
doi.org/10.3390/food...
🧪🍎📃 #chemsky #foodtech
#crustacean
The #remipede Xibalbanus tulumensis lives in cenote caves of #Mexico. Dr. Björn von Reumont
@ Goethe U. analyzed the venom, described a peptide named #xibalbine affecting K+ channels.
"...the xibalbines' bioactivity is exemplary of the untapped potential of marine biodiversity..."
The #remipede Xibalbanus tulumensis lives in cenote caves of #Mexico. Dr. Björn von Reumont
@ Goethe U. analyzed the venom, described a peptide named #xibalbine affecting K+ channels.
"...the xibalbines' bioactivity is exemplary of the untapped potential of marine biodiversity..."
Venomous crustacean from Mayan underwater caves provides new drug candidates
Many animals use venoms for self-defense or hunting. The components of such venom, known as toxins, interfere with various physiological processes—which is also the reason why they are so interesting ...
phys.org
October 5, 2024 at 11:21 AM
#crustacean
The #remipede Xibalbanus tulumensis lives in cenote caves of #Mexico. Dr. Björn von Reumont
@ Goethe U. analyzed the venom, described a peptide named #xibalbine affecting K+ channels.
"...the xibalbines' bioactivity is exemplary of the untapped potential of marine biodiversity..."
The #remipede Xibalbanus tulumensis lives in cenote caves of #Mexico. Dr. Björn von Reumont
@ Goethe U. analyzed the venom, described a peptide named #xibalbine affecting K+ channels.
"...the xibalbines' bioactivity is exemplary of the untapped potential of marine biodiversity..."
How to hide a functional peptide from an enzyme without to compromise its bioactivity? Here👇👇👇 is our suggestion #self-assembly
doi.org/10.1021/acsa...
@pubs.acs.org
doi.org/10.1021/acsa...
@pubs.acs.org
Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing
The copper complex of the tripeptide glycine–histidine–lysine (GHK) has proven benefits in wound healing and tissue remodeling by promoting blood vessel growth and increasing skin oxygen levels, but i...
doi.org
February 13, 2025 at 3:28 PM
How to hide a functional peptide from an enzyme without to compromise its bioactivity? Here👇👇👇 is our suggestion #self-assembly
doi.org/10.1021/acsa...
@pubs.acs.org
doi.org/10.1021/acsa...
@pubs.acs.org
Phycobacteria Biodiversity, Selected Isolation, and Bioactivity Elucidation of New Bacterial Species of Highly Toxic Marine Dinoflagellate Alexandrium minutum amtk4 https://pubmed.ncbi.nlm.nih.gov/40572086/
June 28, 2025 at 7:22 AM
Phycobacteria Biodiversity, Selected Isolation, and Bioactivity Elucidation of New Bacterial Species of Highly Toxic Marine Dinoflagellate Alexandrium minutum amtk4 https://pubmed.ncbi.nlm.nih.gov/40572086/
Alhamdulillah! I am honored to announce the acceptance of our article in RSC Advances.
1st July, 2025.
Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach.
doi: https:// doi.org/10.1039/D5RA03404C
1st July, 2025.
Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach.
doi: https:// doi.org/10.1039/D5RA03404C
July 1, 2025 at 12:44 PM
Alhamdulillah! I am honored to announce the acceptance of our article in RSC Advances.
1st July, 2025.
Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach.
doi: https:// doi.org/10.1039/D5RA03404C
1st July, 2025.
Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach.
doi: https:// doi.org/10.1039/D5RA03404C
as well as provide evidence-based information about the bioactivity potential of different honeys and use of medical-grade honeys for wound healing in clinical settings. He will also provide up-to-date information from the bioactivity analysis of local TX honeys by the HONEY Pathway students.
4/4
4/4
July 9, 2025 at 11:37 AM
as well as provide evidence-based information about the bioactivity potential of different honeys and use of medical-grade honeys for wound healing in clinical settings. He will also provide up-to-date information from the bioactivity analysis of local TX honeys by the HONEY Pathway students.
4/4
4/4
Exploring the bioactivity potential of fruit-associated Fungi: Antifungal, antiparasitic, and antiviral activities of natural extracts pubmed.ncbi.nlm.nih.gov/41046078/
October 5, 2025 at 6:46 PM
Exploring the bioactivity potential of fruit-associated Fungi: Antifungal, antiparasitic, and antiviral activities of natural extracts pubmed.ncbi.nlm.nih.gov/41046078/
#Sweetmarjoram from 1,300–1,400 m shows the highest phenolic content and antioxidant activity, with #EssentialOils displaying strong antimicrobial effects, underscoring altitude’s impact on bioactivity. @fatih-öner-b5975287
#OpenAccess in Open Chemistry:
#OpenAccess in Open Chemistry:
Elevational gradients shape total phenolic content and bioactive potential of sweet marjoram (Origanum majorana L.): A comparative study across altitudinal zones
Sweet marjoram ( Origanum majorana L.) is a species of economic and industrial importance from the Lamiaceae family, whose leaves are used as spices and condiments, fresh or dried. Additionally, it…
doi.org
September 21, 2025 at 10:15 PM
#Sweetmarjoram from 1,300–1,400 m shows the highest phenolic content and antioxidant activity, with #EssentialOils displaying strong antimicrobial effects, underscoring altitude’s impact on bioactivity. @fatih-öner-b5975287
#OpenAccess in Open Chemistry:
#OpenAccess in Open Chemistry:
Combining the new tool with the bioluminescent bioreporter strains from Heike Brötz-Oesterhelt and her students Julian Schubert and Leonard Boldt was a key element to achieve the high sensitivity of the bioactivity assays needed for microfractions.
October 26, 2025 at 9:53 PM
Combining the new tool with the bioluminescent bioreporter strains from Heike Brötz-Oesterhelt and her students Julian Schubert and Leonard Boldt was a key element to achieve the high sensitivity of the bioactivity assays needed for microfractions.
Today I'm performing some tests with my actinobacterias against some phytopathogenic fungus.
It is like a UFC of microorganisms where they fight to growth!!!
This kind of screening by antagonism can show promising bioactivity for future biotechnological applications.
#microbiology
#science
🧪
It is like a UFC of microorganisms where they fight to growth!!!
This kind of screening by antagonism can show promising bioactivity for future biotechnological applications.
#microbiology
#science
🧪
September 11, 2024 at 4:18 PM
Today I'm performing some tests with my actinobacterias against some phytopathogenic fungus.
It is like a UFC of microorganisms where they fight to growth!!!
This kind of screening by antagonism can show promising bioactivity for future biotechnological applications.
#microbiology
#science
🧪
It is like a UFC of microorganisms where they fight to growth!!!
This kind of screening by antagonism can show promising bioactivity for future biotechnological applications.
#microbiology
#science
🧪
Excellent news: 𝐒𝐞𝐛𝐚𝐬𝐭𝐢𝐚𝐧 𝐰𝐢𝐥𝐥 𝐫𝐞𝐜𝐞𝐢𝐯𝐞 𝐚𝐧 #𝐄𝐑𝐂 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐝 𝐆𝐫𝐚𝐧𝐭!
𝐁𝐢𝐧𝐝𝐢𝐧𝐠𝐒𝐡𝐚𝐝𝐨𝐰𝐬 will develop ML models to predict whether some query molecule has a particular bioactivity or is binding to a certain protein, where the only information we have about the query molecule is its tandem mass spectrum.
𝐁𝐢𝐧𝐝𝐢𝐧𝐠𝐒𝐡𝐚𝐝𝐨𝐰𝐬 will develop ML models to predict whether some query molecule has a particular bioactivity or is binding to a certain protein, where the only information we have about the query molecule is its tandem mass spectrum.
July 28, 2025 at 11:16 AM
Excellent news: 𝐒𝐞𝐛𝐚𝐬𝐭𝐢𝐚𝐧 𝐰𝐢𝐥𝐥 𝐫𝐞𝐜𝐞𝐢𝐯𝐞 𝐚𝐧 #𝐄𝐑𝐂 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐝 𝐆𝐫𝐚𝐧𝐭!
𝐁𝐢𝐧𝐝𝐢𝐧𝐠𝐒𝐡𝐚𝐝𝐨𝐰𝐬 will develop ML models to predict whether some query molecule has a particular bioactivity or is binding to a certain protein, where the only information we have about the query molecule is its tandem mass spectrum.
𝐁𝐢𝐧𝐝𝐢𝐧𝐠𝐒𝐡𝐚𝐝𝐨𝐰𝐬 will develop ML models to predict whether some query molecule has a particular bioactivity or is binding to a certain protein, where the only information we have about the query molecule is its tandem mass spectrum.
🦠ChEMBL
Are you looking for data on bioactive molecules with drug-like properties? ChEMBL brings together chemical, bioactivity, and genomic data to aid the translation of genomic information into effective new drugs. #database
www.ebi.ac.uk/chembl/
Are you looking for data on bioactive molecules with drug-like properties? ChEMBL brings together chemical, bioactivity, and genomic data to aid the translation of genomic information into effective new drugs. #database
www.ebi.ac.uk/chembl/
ChEMBL - ChEMBL
www.ebi.ac.uk
January 30, 2025 at 2:30 AM
🦠ChEMBL
Are you looking for data on bioactive molecules with drug-like properties? ChEMBL brings together chemical, bioactivity, and genomic data to aid the translation of genomic information into effective new drugs. #database
www.ebi.ac.uk/chembl/
Are you looking for data on bioactive molecules with drug-like properties? ChEMBL brings together chemical, bioactivity, and genomic data to aid the translation of genomic information into effective new drugs. #database
www.ebi.ac.uk/chembl/
AutoPeptideML: Automated Machine Learning for Building Trustworthy Peptide Bioactivity Predictors https://www.biorxiv.org/content/10.1101/2023.11.13.566825v1
AutoPeptideML: Automated Machine Learning for Building Trustworthy Peptide Bioactivity Predictors https://www.biorxiv.org/content/10.1101/2023.11.13.566825v1
Automated machine learning (AutoML) solutions can bridge the gap between new computational advances
www.biorxiv.org
November 16, 2023 at 12:51 AM
AutoPeptideML: Automated Machine Learning for Building Trustworthy Peptide Bioactivity Predictors https://www.biorxiv.org/content/10.1101/2023.11.13.566825v1
A foundation model for bioactivity prediction using pairwise meta-learning https://www.biorxiv.org/content/10.1101/2023.10.30.564861v1
A foundation model for bioactivity prediction using pairwise meta-learning https://www.biorxiv.org/content/10.1101/2023.10.30.564861v1
Compound bioactivity plays an important role in different stages of drug development and discovery.
www.biorxiv.org
November 2, 2023 at 5:52 PM
A foundation model for bioactivity prediction using pairwise meta-learning https://www.biorxiv.org/content/10.1101/2023.10.30.564861v1
ScienceGuardians dot com presents as a 'Journal Club' where people can comment on scientific papers using anonymous accounts.
Very similar to PubPeer, actually.
Here, anonymous user "VelvetPhantom" comments on a paper about silver nanoparticles.
/
Very similar to PubPeer, actually.
Here, anonymous user "VelvetPhantom" comments on a paper about silver nanoparticles.
/
April 18, 2025 at 6:57 PM
ScienceGuardians dot com presents as a 'Journal Club' where people can comment on scientific papers using anonymous accounts.
Very similar to PubPeer, actually.
Here, anonymous user "VelvetPhantom" comments on a paper about silver nanoparticles.
/
Very similar to PubPeer, actually.
Here, anonymous user "VelvetPhantom" comments on a paper about silver nanoparticles.
/
BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature https://www.biorxiv.org/content/10.1101/2025.04.22.648951v1
April 25, 2025 at 12:46 AM
BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature https://www.biorxiv.org/content/10.1101/2025.04.22.648951v1
Semantical and Topological Protein Encoding Toward Enhanced Bioactivity and Thermostability https://www.biorxiv.org/content/10.1101/2023.12.01.569522v1
Semantical and Topological Protein Encoding Toward Enhanced Bioactivity and Thermostability https://www.biorxiv.org/content/10.1101/2023.12.01.569522v1
Protein engineering is a pivotal aspect of synthetic biology, involving the modification of amino ac
www.biorxiv.org
December 3, 2023 at 1:48 AM
Semantical and Topological Protein Encoding Toward Enhanced Bioactivity and Thermostability https://www.biorxiv.org/content/10.1101/2023.12.01.569522v1
Another one of interests (this one for connecting MS-NMR-Bioactivity #secmet #naturalproducts):
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Data Fusion‐based Discovery (DAFdiscovery) pipeline to aid compound annotation and bioactive compound discovery across diverse spectral data
We present DAFdiscovery, a tool developed to combine MS, NMR and bioactivity data using a STOCSY function to calculate correlations among every feature. Jupyter Notebook was chosen since it is an ope...
analyticalsciencejournals.onlinelibrary.wiley.com
November 24, 2024 at 11:11 PM
Another one of interests (this one for connecting MS-NMR-Bioactivity #secmet #naturalproducts):
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
that integrates: (1) DECIMER Segmentation and MolVec for chemical structure recognition, (2) Qwen2.5-VL-32B for compound identifier association, and (3) PaddleOCR with Gemini-2.0-flash for bioactivity extraction and unit normalization. We evaluated [3/6 of https://arxiv.org/abs/2504.10525v1]
April 16, 2025 at 6:16 AM
that integrates: (1) DECIMER Segmentation and MolVec for chemical structure recognition, (2) Qwen2.5-VL-32B for compound identifier association, and (3) PaddleOCR with Gemini-2.0-flash for bioactivity extraction and unit normalization. We evaluated [3/6 of https://arxiv.org/abs/2504.10525v1]
The Bioactivity of Janus-like CuO-Ag Nanoparticles on Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae and their Mechanism of Action
https://doi.org/doi:10.1007/s00284-025-04381-0
https://doi.org/doi:10.1007/s00284-025-04381-0
August 5, 2025 at 2:02 PM
The Bioactivity of Janus-like CuO-Ag Nanoparticles on Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae and their Mechanism of Action
https://doi.org/doi:10.1007/s00284-025-04381-0
https://doi.org/doi:10.1007/s00284-025-04381-0
These hydrogels are engineered to maintain a moist, antimicrobial environment while promoting tissue regeneration through enhanced conductivity and bioactivity.
October 7, 2025 at 6:38 PM
These hydrogels are engineered to maintain a moist, antimicrobial environment while promoting tissue regeneration through enhanced conductivity and bioactivity.
A chemical structure and machine learning approach to assess the potential bioactivity of endogenous metabolites and their association with early-childhood hs-CRP levels https://www.biorxiv.org/content/10.1101/2023.11.15.567095v1
A chemical structure and machine learning approach to assess the potential bioactivity of endogenous metabolites and their association with early-childhood hs-CRP levels https://www.biorxiv.org/content/10.1101/2023.11.15.567095v1
Metabolomics has gained much attraction due to its potential to reveal molecular disease mechanisms
www.biorxiv.org
November 17, 2023 at 3:52 AM
A chemical structure and machine learning approach to assess the potential bioactivity of endogenous metabolites and their association with early-childhood hs-CRP levels https://www.biorxiv.org/content/10.1101/2023.11.15.567095v1
However, at the end it's all worth the effort because cells like these materials more than they like synthetic ones.
And very cool research groups are transitioning towards only using collagen, gelatin, fibrinogen, hyaluronic acid or ECMs, due to their inherent bioactivity.
⬇️🧵
And very cool research groups are transitioning towards only using collagen, gelatin, fibrinogen, hyaluronic acid or ECMs, due to their inherent bioactivity.
⬇️🧵
March 11, 2025 at 5:44 PM
However, at the end it's all worth the effort because cells like these materials more than they like synthetic ones.
And very cool research groups are transitioning towards only using collagen, gelatin, fibrinogen, hyaluronic acid or ECMs, due to their inherent bioactivity.
⬇️🧵
And very cool research groups are transitioning towards only using collagen, gelatin, fibrinogen, hyaluronic acid or ECMs, due to their inherent bioactivity.
⬇️🧵
recognition (OCSR) tools fail to autonomously associate molecular structures with their bioactivity profiles, creating a critical bottleneck in structure-activity relationship (SAR) analysis. Here, we present BioChemInsight, an open-source pipeline [2/6 of https://arxiv.org/abs/2504.10525v1]
April 16, 2025 at 6:16 AM
recognition (OCSR) tools fail to autonomously associate molecular structures with their bioactivity profiles, creating a critical bottleneck in structure-activity relationship (SAR) analysis. Here, we present BioChemInsight, an open-source pipeline [2/6 of https://arxiv.org/abs/2504.10525v1]