4/7 This mirrors the UK's lauded "subscription model," which guarantees revenue for vital research.
Yet even Zoliflodacin—a new class of drug—is not a permanent fix.
Scientists are relieved, but they know the clock is already ticking. Resistance is inevitable.
Yet even Zoliflodacin—a new class of drug—is not a permanent fix.
Scientists are relieved, but they know the clock is already ticking. Resistance is inevitable.
December 29, 2025 at 11:56 PM
4/7 This mirrors the UK's lauded "subscription model," which guarantees revenue for vital research.
Yet even Zoliflodacin—a new class of drug—is not a permanent fix.
Scientists are relieved, but they know the clock is already ticking. Resistance is inevitable.
Yet even Zoliflodacin—a new class of drug—is not a permanent fix.
Scientists are relieved, but they know the clock is already ticking. Resistance is inevitable.
3/7 But a new model offers hope. The FDA just approved Zoliflodacin for gonorrhoea, a product of a partnership between a Swiss non-profit and private industry.
By defraying upfront costs, we can steer pharmaceutical giants toward areas of desperate global need.
By defraying upfront costs, we can steer pharmaceutical giants toward areas of desperate global need.
December 29, 2025 at 11:55 PM
3/7 But a new model offers hope. The FDA just approved Zoliflodacin for gonorrhoea, a product of a partnership between a Swiss non-profit and private industry.
By defraying upfront costs, we can steer pharmaceutical giants toward areas of desperate global need.
By defraying upfront costs, we can steer pharmaceutical giants toward areas of desperate global need.
🚨 FDA okays 2 oral therapies for urogenital gonorrhea: Nuzolvence (zoliflodacin, single dose) + Blujepa (gepotidacin, 2 doses; QTc warning). Ceftriaxone is standard. www.fda.gov/news-eve... #IDTwitter #AntimicrobialStewardship
FDA Approves Two Oral Therapies to Treat Gonorrhea
The U.S. Food and Drug Administration recently approved two new oral medicines to treat a common sexually transmitted infection called gonorrhea.
www.fda.gov
December 29, 2025 at 1:00 PM
🚨 FDA okays 2 oral therapies for urogenital gonorrhea: Nuzolvence (zoliflodacin, single dose) + Blujepa (gepotidacin, 2 doses; QTc warning). Ceftriaxone is standard. www.fda.gov/news-eve... #IDTwitter #AntimicrobialStewardship
Das Spiropyrimidintrion-Antibiotikum Zoliflodacin hat sich in einer Studie zur Therapie der urogenitalen Gonorrhö einer Kombination von Ceftriaxon und Azithromycin als ebenbürtig erwiesen. Dabei hat die neue Substanz einige Vorteile auf ihrer Seite. (kostenfrei nach Reg.) #medsky #Urologie #STI
Zoliflodacin als neue Option in der Therapie der Gonorrhö
Das Spiropyrimidintrion-Antibiotikum Zoliflodacin hat sich in einer Studie zur Therapie der urogenitalen Gonorrhö einer Kombination von Ceftriaxon und Azithromycin als ebenbürtig erwiesen. Dabei hat die neue Substanz einige Vorteile auf ihrer Seite.
www.springermedizin.de
December 23, 2025 at 5:30 PM
The #FDA just approved zoliflodacin, sold as #Nuzolvence, a new single-dose, oral pill to treat #gonorrhea in people 12 and up 🧪💊. It gives doctors and patients a much-needed, easier option against a sexually transmitted infection that’s been getting tougher to treat with older antibiotics ✨
FDA approves first new kind of drug to target gonorrhea in decades
The bacterium that causes gonorrhea has developed resistance to nearly every antibiotic used against it.
www.statnews.com
December 23, 2025 at 1:28 PM
The #FDA just approved zoliflodacin, sold as #Nuzolvence, a new single-dose, oral pill to treat #gonorrhea in people 12 and up 🧪💊. It gives doctors and patients a much-needed, easier option against a sexually transmitted infection that’s been getting tougher to treat with older antibiotics ✨
Entasis Therapeutics received approval for Nuzolvence (zoliflodacin), a spiropyrimidinetrione inhibitor of bacterial type II topoisomerases. Exciting to see the involvement of the public-private partnership with @gardp.bsky.social to get this medication approved. (2/4)
December 19, 2025 at 12:09 PM
Entasis Therapeutics received approval for Nuzolvence (zoliflodacin), a spiropyrimidinetrione inhibitor of bacterial type II topoisomerases. Exciting to see the involvement of the public-private partnership with @gardp.bsky.social to get this medication approved. (2/4)
For the first time in decades, two new antibiotics for gonorrhoea have been approved by the FDA - arriving just as resistance to existing treatments is accelerating.
Gepotidacin and zoliflodacin both showed strong results in large phase 3 trials:
www.science.org/content/arti....
Gepotidacin and zoliflodacin both showed strong results in large phase 3 trials:
www.science.org/content/arti....
Science’s 2025 Breakthrough of the Year: The unstoppable rise of renewable energy
Clean energy infrastructure is being deployed with unmatched scale and speed—and China is leading the way
www.science.org
December 19, 2025 at 10:12 AM
For the first time in decades, two new antibiotics for gonorrhoea have been approved by the FDA - arriving just as resistance to existing treatments is accelerating.
Gepotidacin and zoliflodacin both showed strong results in large phase 3 trials:
www.science.org/content/arti....
Gepotidacin and zoliflodacin both showed strong results in large phase 3 trials:
www.science.org/content/arti....
Great to see the #zoliflodacin paper.
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
December 19, 2025 at 1:09 AM
Great to see the #zoliflodacin paper.
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
"New #gonorrhea drug is not just a scientific breakthrough but a business one - A not-for-profit R&D model will let #zoliflodacin reach people who need it most"
www.statnews.com/2025/12/17/z...
www.statnews.com/2025/12/17/z...
December 18, 2025 at 6:39 PM
"New #gonorrhea drug is not just a scientific breakthrough but a business one - A not-for-profit R&D model will let #zoliflodacin reach people who need it most"
www.statnews.com/2025/12/17/z...
www.statnews.com/2025/12/17/z...
"Zoliflodacin, also known by the brand name Nuzolvence, was approved by the US Food and Drug Administration on 12 December for use against gonorrhoea, which can cause serious health problems, including infertility."
December 18, 2025 at 7:43 AM
"Zoliflodacin, also known by the brand name Nuzolvence, was approved by the US Food and Drug Administration on 12 December for use against gonorrhoea, which can cause serious health problems, including infertility."
New gonorrhea drug is not just a scientific breakthrough but a business one https://www.statnews.com/2025/12/17/zoliflodacin-gonorrhea-gardp-innoviva-antibiotic-resistance/
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀 ⇢ CanadaHealthwatch.ca/newsletter
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀 ⇢ CanadaHealthwatch.ca/newsletter
December 18, 2025 at 2:54 AM
New gonorrhea drug is not just a scientific breakthrough but a business one https://www.statnews.com/2025/12/17/zoliflodacin-gonorrhea-gardp-innoviva-antibiotic-resistance/
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀 ⇢ CanadaHealthwatch.ca/newsletter
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀 ⇢ CanadaHealthwatch.ca/newsletter
💊FDA Approval Update | #FDA recently approved #Nuzolvence (#Zoliflodacin) and #Blujepa (#Gepotidacin)
👉For uncomplicated urogenital #gonorrhea
🌟MedChemExpress provides zoliflodacin and gepotidacin for research use only
👉For uncomplicated urogenital #gonorrhea
🌟MedChemExpress provides zoliflodacin and gepotidacin for research use only
December 17, 2025 at 9:30 PM
💊FDA Approval Update | #FDA recently approved #Nuzolvence (#Zoliflodacin) and #Blujepa (#Gepotidacin)
👉For uncomplicated urogenital #gonorrhea
🌟MedChemExpress provides zoliflodacin and gepotidacin for research use only
👉For uncomplicated urogenital #gonorrhea
🌟MedChemExpress provides zoliflodacin and gepotidacin for research use only
The FDA on Friday announced approval of zoliflodacin (Nuzolvence) as an oral treatment for gonorrhea, a day after approving oral gepotidacin (Blujepa) for the same indication.
https://www.medpagetoday.com/infectiousdisease/stds/119026
https://www.medpagetoday.com/infectiousdisease/stds/119026
Second Oral Antibiotic for Gonorrhea Gets FDA Green Light
Zoliflodacin joins gepotidacin as new oral treatments for uncomplicated urogenital gonorrhea
www.medpagetoday.com
December 17, 2025 at 2:00 PM
The FDA on Friday announced approval of zoliflodacin (Nuzolvence) as an oral treatment for gonorrhea, a day after approving oral gepotidacin (Blujepa) for the same indication.
https://www.medpagetoday.com/infectiousdisease/stds/119026
https://www.medpagetoday.com/infectiousdisease/stds/119026
No matter how carefully we use today’s antibiotics, new classes of antibiotics are needed to beat #AMR. The FDA approval of zoliflodacin shows a not-for-profit R&D model can work. In a STAT op-ed, GARDP’s Manica Balasegaram reflects on why this moment matters
🔗https://tinyurl.pulse.ly/1iwk5oqc8i
🔗https://tinyurl.pulse.ly/1iwk5oqc8i
New gonorrhea drug is not just a scientific breakthrough but a business one
Turning the tide on antibiotic resistance will require new ways of working, writes executive director of the Global Antibiotic Research & Development Partnership.
tinyurl.pulse.ly
December 17, 2025 at 12:32 PM
No matter how carefully we use today’s antibiotics, new classes of antibiotics are needed to beat #AMR. The FDA approval of zoliflodacin shows a not-for-profit R&D model can work. In a STAT op-ed, GARDP’s Manica Balasegaram reflects on why this moment matters
🔗https://tinyurl.pulse.ly/1iwk5oqc8i
🔗https://tinyurl.pulse.ly/1iwk5oqc8i
A major breakthrough against antibiotic resistance: the
US FDA has approved zoliflodacin, the first new gonorrhoea treatment in decades, offering new hope as #STIs grow resistant to nearly all existing drugs.
✍️ @kerrycullinan.bsky.social
@gardp.bsky.social @fda.gov @ema.europa.eu pa.eu
📖⬇️ & 🙏
US FDA has approved zoliflodacin, the first new gonorrhoea treatment in decades, offering new hope as #STIs grow resistant to nearly all existing drugs.
✍️ @kerrycullinan.bsky.social
@gardp.bsky.social @fda.gov @ema.europa.eu pa.eu
📖⬇️ & 🙏
FDA Approves First New Gonorrhoea Treatment In Decades Amid Rising Antibiotic Resistance - Health Policy Watch
A new treatment has been approved for gonorrhoea, a sexually transmitted infection (STI) that is increasingly developing resistance to all current antibiotics.
healthpolicy-watch.news
December 17, 2025 at 10:15 AM
A major breakthrough against antibiotic resistance: the
US FDA has approved zoliflodacin, the first new gonorrhoea treatment in decades, offering new hope as #STIs grow resistant to nearly all existing drugs.
✍️ @kerrycullinan.bsky.social
@gardp.bsky.social @fda.gov @ema.europa.eu pa.eu
📖⬇️ & 🙏
US FDA has approved zoliflodacin, the first new gonorrhoea treatment in decades, offering new hope as #STIs grow resistant to nearly all existing drugs.
✍️ @kerrycullinan.bsky.social
@gardp.bsky.social @fda.gov @ema.europa.eu pa.eu
📖⬇️ & 🙏
🎬 2025 marked a defining moment for GARDP
Zoliflodacin received FDA approval – the first novel oral antibiotic for uncomplicated urogenital gonorrhoea in decades. A clear demonstration that a not-for-profit partnership model can deliver new antibiotics with access built in from the start.
Zoliflodacin received FDA approval – the first novel oral antibiotic for uncomplicated urogenital gonorrhoea in decades. A clear demonstration that a not-for-profit partnership model can deliver new antibiotics with access built in from the start.
December 17, 2025 at 8:01 AM
🎬 2025 marked a defining moment for GARDP
Zoliflodacin received FDA approval – the first novel oral antibiotic for uncomplicated urogenital gonorrhoea in decades. A clear demonstration that a not-for-profit partnership model can deliver new antibiotics with access built in from the start.
Zoliflodacin received FDA approval – the first novel oral antibiotic for uncomplicated urogenital gonorrhoea in decades. A clear demonstration that a not-for-profit partnership model can deliver new antibiotics with access built in from the start.
"Public health experts said they were especially encouraged by public-private partnership that developed zoliflodacin, which was initially discovered by another drug company that declined to take it to market."
F.D.A. Approves Two New Drugs to Treat Gonorrhea
www.nytimes.com
December 17, 2025 at 7:38 AM
"Public health experts said they were especially encouraged by public-private partnership that developed zoliflodacin, which was initially discovered by another drug company that declined to take it to market."
Non-profit drug for gonorrhoea approved--An oral antibiotic, zoliflodacin, approved for the sexually transmitted disease gonorrhoea by the US FDA. Zoliflodacin is the first of a new class of antibiotics, offering hope against ‘super gonorrhoea’ that is resistant to most standard treatments.
Nature
Nature
December 17, 2025 at 2:36 AM
Non-profit drug for gonorrhoea approved--An oral antibiotic, zoliflodacin, approved for the sexually transmitted disease gonorrhoea by the US FDA. Zoliflodacin is the first of a new class of antibiotics, offering hope against ‘super gonorrhoea’ that is resistant to most standard treatments.
Nature
Nature
A new antibiotic just beat drug-resistant gonorrhea—without a single government mandate. Zoliflodacin, developed by private science and global partnerships, proves innovation still thrives when freedom, not ideology, drives progress.
A New Hope in the Fight Against Drug-Resistant Gonorrhea
The FDA approves zoliflodacin, a new antibiotic for gonorrhea, marking a breakthrough in treating drug-resistant strains.
epochtrace.com
December 16, 2025 at 10:18 PM
A new antibiotic just beat drug-resistant gonorrhea—without a single government mandate. Zoliflodacin, developed by private science and global partnerships, proves innovation still thrives when freedom, not ideology, drives progress.
4/4
Zoliflodacin is the first antibiotic developed solely for gonorrhea in decades, with a novel mechanism and support from a global public–private partnership 🤝.
A nice moment of scientific progress worth celebrating ✨.
Zoliflodacin is the first antibiotic developed solely for gonorrhea in decades, with a novel mechanism and support from a global public–private partnership 🤝.
A nice moment of scientific progress worth celebrating ✨.
December 16, 2025 at 9:04 PM
4/4
Zoliflodacin is the first antibiotic developed solely for gonorrhea in decades, with a novel mechanism and support from a global public–private partnership 🤝.
A nice moment of scientific progress worth celebrating ✨.
Zoliflodacin is the first antibiotic developed solely for gonorrhea in decades, with a novel mechanism and support from a global public–private partnership 🤝.
A nice moment of scientific progress worth celebrating ✨.
2/4
Zoliflodacin and gepotidacin were shown in phase 3 trials to be as effective as ceftriaxone ± azithromycin 🧪. Zoliflodacin is single-dose oral; gepotidacin is also oral, giving more flexibility in treatment.
Zoliflodacin and gepotidacin were shown in phase 3 trials to be as effective as ceftriaxone ± azithromycin 🧪. Zoliflodacin is single-dose oral; gepotidacin is also oral, giving more flexibility in treatment.
December 16, 2025 at 9:04 PM
2/4
Zoliflodacin and gepotidacin were shown in phase 3 trials to be as effective as ceftriaxone ± azithromycin 🧪. Zoliflodacin is single-dose oral; gepotidacin is also oral, giving more flexibility in treatment.
Zoliflodacin and gepotidacin were shown in phase 3 trials to be as effective as ceftriaxone ± azithromycin 🧪. Zoliflodacin is single-dose oral; gepotidacin is also oral, giving more flexibility in treatment.
FDA approves 2 new oral gonorrhea antibiotics
Zoliflodacin and gepotidacin are the first new antibiotics approved for treating gonorrhea in decades.
www.cidrap.umn.edu/a...
Zoliflodacin and gepotidacin are the first new antibiotics approved for treating gonorrhea in decades.
www.cidrap.umn.edu/a...
December 16, 2025 at 5:26 PM
FDA approves 2 new oral gonorrhea antibiotics
Zoliflodacin and gepotidacin are the first new antibiotics approved for treating gonorrhea in decades.
www.cidrap.umn.edu/a...
Zoliflodacin and gepotidacin are the first new antibiotics approved for treating gonorrhea in decades.
www.cidrap.umn.edu/a...
A study, led by @gardp.bsky.social, testing zoliflodacin, found that the antibiotic was as effective and tolerable as the standard treatment for gonorrhea and was effective against drug-resistant strains of the bacteria, as #AMR continues to rise globally.
www.ghtcoalition.org/blog/researc...
www.ghtcoalition.org/blog/researc...
Research Roundup: New gonorrhea antibiotic, Scientists use AI to develop mpox drug, mRNA vaccine against emerging virus
In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week.
www.ghtcoalition.org
December 16, 2025 at 2:12 PM
A study, led by @gardp.bsky.social, testing zoliflodacin, found that the antibiotic was as effective and tolerable as the standard treatment for gonorrhea and was effective against drug-resistant strains of the bacteria, as #AMR continues to rise globally.
www.ghtcoalition.org/blog/researc...
www.ghtcoalition.org/blog/researc...
Two new antibiotics, zoliflodacin and gepotidacin, approved by the FDA on 11–12 Dec 2025, represents major breakthrough against drug-resistant gonorrhoea. They are the first new treatments in decades.
#AMR
#InfectiousDisease
www.theguardian.com/global-devel...
#AMR
#InfectiousDisease
www.theguardian.com/global-devel...
New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea
First new treatments for sexually transmitted disease in decades approved by US Food and Drug Administration as number of cases worldwide surge to 82m
www.theguardian.com
December 16, 2025 at 9:23 AM
Two new antibiotics, zoliflodacin and gepotidacin, approved by the FDA on 11–12 Dec 2025, represents major breakthrough against drug-resistant gonorrhoea. They are the first new treatments in decades.
#AMR
#InfectiousDisease
www.theguardian.com/global-devel...
#AMR
#InfectiousDisease
www.theguardian.com/global-devel...
Zoliflodacin approved for gonorrhoea treatment 💊😄
Roll back #AMR ! 🧫
www.theguardian.com/global-devel...
Roll back #AMR ! 🧫
www.theguardian.com/global-devel...
New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea
First new treatments for sexually transmitted disease in decades approved by US Food and Drug Administration as number of cases worldwide surge to 82m
www.theguardian.com
December 16, 2025 at 9:06 AM
Zoliflodacin approved for gonorrhoea treatment 💊😄
Roll back #AMR ! 🧫
www.theguardian.com/global-devel...
Roll back #AMR ! 🧫
www.theguardian.com/global-devel...