Paul Adamson MD MPH
@padamsonmd.bsky.social
ID doc and researcher. Asst Professor at UCLA. Interests in HIV, sexually transmitted infections, global health, & AMR. 🇲🇽|🇺🇸 He/him. Views are mine.
Pinned
Drug-resistant #gonorrhea is an urgent issue, threatening our empiric treatment options. Resistance to ceftriaxone is rapidly increasing in the Asia-Pacific region.
Happy to share our study from Vietnam, now out in @jidjournal.bsky.social
academic.oup.com/jid/article/...
#IDsky #STIsky #AMR
Happy to share our study from Vietnam, now out in @jidjournal.bsky.social
academic.oup.com/jid/article/...
#IDsky #STIsky #AMR
Interesting report of a #gonorrhea FC428 strain with #penA60 in Ontario w/ elevated ceftriaxone MIC. Fortunately, cleared w/ 500mg CRO.
The infection was apparently non-travel related, suggesting infections might be circulating in some local settings.
#STIsky #AMR
www.canada.ca/en/public-he...
The infection was apparently non-travel related, suggesting infections might be circulating in some local settings.
#STIsky #AMR
www.canada.ca/en/public-he...
Detection of non-travel-associated, ceftriaxone non-susceptible Neisseria gonorrhoeae FC428-like harbouring the mosaic penA60 allele - Canada.ca
First known case of ceftriaxone non-susceptible N. gonorrhoeae FC428 infection with the mosaic penA60 allele identified in an Ontario patient
www.canada.ca
December 23, 2025 at 1:37 AM
Interesting report of a #gonorrhea FC428 strain with #penA60 in Ontario w/ elevated ceftriaxone MIC. Fortunately, cleared w/ 500mg CRO.
The infection was apparently non-travel related, suggesting infections might be circulating in some local settings.
#STIsky #AMR
www.canada.ca/en/public-he...
The infection was apparently non-travel related, suggesting infections might be circulating in some local settings.
#STIsky #AMR
www.canada.ca/en/public-he...
Reposted by Paul Adamson MD MPH
🧵 Essential ID Papers for 2025: A Clinician’s Guide
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
December 22, 2025 at 3:22 PM
🧵 Essential ID Papers for 2025: A Clinician’s Guide
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
Each year brings a flood of amazing ID literature.
Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines.
👇
Great to see the #zoliflodacin paper.
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
December 19, 2025 at 1:09 AM
Great to see the #zoliflodacin paper.
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
With #gepotidacin, we have TWO new antibiotics to use for #gonorrhea! 🎉
But big Qs about use and access remain, esp in Asia Pacific, where ceftriaxone resistance is already sky high (nearly 30% in 🇻🇳)
#IDSky #STIsky #AMR
🔗: www.thelancet.com/journals/lan...
Fascinating story here!
We will need to monitor these mutations as we start to use these new antibiotics, especially in the Asia Pacific region, where ceftriaxone resistance is already nearly 30% and the ParC D86N is a concern.
N. gonorrhoeae is such a humbling bug...
#Gonorrhea #AMR
We will need to monitor these mutations as we start to use these new antibiotics, especially in the Asia Pacific region, where ceftriaxone resistance is already nearly 30% and the ParC D86N is a concern.
N. gonorrhoeae is such a humbling bug...
#Gonorrhea #AMR
New preprint: with increasing resistance to ceftriaxone, the last recommended antibiotic for gonorrhea, we urgently need new drugs. Two--zoliflodacin & gepotdiacin--are up for approval by the FDA in Dec. Here we show a point mutation can result in cross-resistance. www.biorxiv.org/content/10.1...
Zoliflodacin and gepotidacin cross-resistance in Neisseria gonorrhoeae
Resistance to zoliflodacin, a first-in-class antibiotic for gonorrhea treatment, can occur through gyrBD429N, but this mutation's impact on fitness and resistance to other topoisomerase targeting drug...
www.biorxiv.org
December 19, 2025 at 12:02 AM
Fascinating story here!
We will need to monitor these mutations as we start to use these new antibiotics, especially in the Asia Pacific region, where ceftriaxone resistance is already nearly 30% and the ParC D86N is a concern.
N. gonorrhoeae is such a humbling bug...
#Gonorrhea #AMR
We will need to monitor these mutations as we start to use these new antibiotics, especially in the Asia Pacific region, where ceftriaxone resistance is already nearly 30% and the ParC D86N is a concern.
N. gonorrhoeae is such a humbling bug...
#Gonorrhea #AMR
Reposted by Paul Adamson MD MPH
🧪 #Zoliflodacin a truly new #antibiotic just for #gonorrhoea
Maybe even more important is the controversial debate about how best to use it
We work with UZH, @yhgrad.bsky.social and @gardp.bsky.social to model the best strategies in 🇿🇦
@ispm.unibe.ch @unibe.ch
www.science.org/content/arti...
Maybe even more important is the controversial debate about how best to use it
We work with UZH, @yhgrad.bsky.social and @gardp.bsky.social to model the best strategies in 🇿🇦
@ispm.unibe.ch @unibe.ch
www.science.org/content/arti...
New antibiotic for gonorrhea could help beat back drug-resistant infections
Two treatments for the sexually transmitted disease are expected to become available soon
www.science.org
December 12, 2025 at 11:34 AM
🧪 #Zoliflodacin a truly new #antibiotic just for #gonorrhoea
Maybe even more important is the controversial debate about how best to use it
We work with UZH, @yhgrad.bsky.social and @gardp.bsky.social to model the best strategies in 🇿🇦
@ispm.unibe.ch @unibe.ch
www.science.org/content/arti...
Maybe even more important is the controversial debate about how best to use it
We work with UZH, @yhgrad.bsky.social and @gardp.bsky.social to model the best strategies in 🇿🇦
@ispm.unibe.ch @unibe.ch
www.science.org/content/arti...
IDSA has selected Jeanne Marrazzo, MD, MPH, FIDSA, as its next chief executive officer, effective Jan. 12, 2026.
Learn more: bit.ly/4pHt2nF
Learn more: bit.ly/4pHt2nF
December 18, 2025 at 11:48 PM
Reposted by Paul Adamson MD MPH
Who is at greatest risk for severe West Nile disease and mortality? Using a large national cohort, we identified multiple risk factors
#IDsky
#Episky
#WestNile
#IDsky
#Episky
#WestNile
Risk for #WestNile neuroinvasive disease (WNND) and mortality were associated with older age, chronic kidney disease, and cerebrovascular disease in the US, 2013-2024. @sethdjudson ja.ma/3XO9PEI
December 11, 2025 at 3:54 PM
Reposted by Paul Adamson MD MPH
The corrupted CDC website refers to a Danish study (Andersson et al) and "a statistically significant 67% increased risk of Asperger's syndrome per 1 mg increase in aluminum exposure among children born between 2007 and 2018 (Supplement Figure 4)." It's worth putting this into context. Short 🧵
November 20, 2025 at 5:20 PM
The corrupted CDC website refers to a Danish study (Andersson et al) and "a statistically significant 67% increased risk of Asperger's syndrome per 1 mg increase in aluminum exposure among children born between 2007 and 2018 (Supplement Figure 4)." It's worth putting this into context. Short 🧵
Reposted by Paul Adamson MD MPH
🔦 Funding theme spotlight: Seeking diagnostics for typhoid fever for low-resource settings.
There are 11–21M cases of typhoid fever globally each year, mostly among children and in LMICs. #IDSky 🧪
🔗 Learn about our targeted theme + updated eligibility criteria: bit.ly/4dTKvDj
There are 11–21M cases of typhoid fever globally each year, mostly among children and in LMICs. #IDSky 🧪
🔗 Learn about our targeted theme + updated eligibility criteria: bit.ly/4dTKvDj
November 20, 2025 at 4:47 PM
🔦 Funding theme spotlight: Seeking diagnostics for typhoid fever for low-resource settings.
There are 11–21M cases of typhoid fever globally each year, mostly among children and in LMICs. #IDSky 🧪
🔗 Learn about our targeted theme + updated eligibility criteria: bit.ly/4dTKvDj
There are 11–21M cases of typhoid fever globally each year, mostly among children and in LMICs. #IDSky 🧪
🔗 Learn about our targeted theme + updated eligibility criteria: bit.ly/4dTKvDj
Excited to share our new paper, led by UCLA med student Ursula Biba!
Point-of-care #syphilis testing is important, but can be challenging in high-prevalence populations. We field-tested a dual treponemal/non-trep #POCT in a #HIV #PrEP program in Hanoi 🇻🇳
#STIsky
🔗 sti.bmj.com/content/earl...
Point-of-care #syphilis testing is important, but can be challenging in high-prevalence populations. We field-tested a dual treponemal/non-trep #POCT in a #HIV #PrEP program in Hanoi 🇻🇳
#STIsky
🔗 sti.bmj.com/content/earl...
Field evaluation of a dual treponemal/non-treponemal point-of-care test for syphilis within an HIV pre-exposure prophylaxis programme in Hanoi, Vietnam
Objectives Syphilis infections are high among men who have sex with men (MSM) on HIV pre-exposure prophylaxis (PrEP). Point-of-care (POC) testing may improve diagnosis and treatment. We performed a fi...
sti.bmj.com
November 20, 2025 at 5:38 PM
Congratulations to Maldives on achieving #tripleelimination!!
Awesome public health news:
Maldives becomes the first country to achieve ‘triple elimination’ of
1. mother-to-child transmission of HIV,
2. Syphilis and
3. Hepatitis B
www.who.int/news/item/13...
Maldives becomes the first country to achieve ‘triple elimination’ of
1. mother-to-child transmission of HIV,
2. Syphilis and
3. Hepatitis B
www.who.int/news/item/13...
Maldives becomes the first country to achieve ‘triple elimination’ of mother-to-child transmission of HIV, syphilis and hepatitis B
In a landmark public health achievement, WHO has validated the Maldives for eliminating mother-to-child transmission (EMTCT) of hepatitis B, while maintaining its earlier validation (in 2019) for EMTCT of HIV and syphilis. This makes the Maldives the first country in the world to achieve ‘triple elimination’.
www.who.int
October 15, 2025 at 4:35 AM
Congratulations to Maldives on achieving #tripleelimination!!
Dr. Marrazzo is not only a role-model physician-scientist and tireless health advocate, but also a brave leader in these trying times.
#IDSky
#IDSky
Dr. Jeanne Marrazzo, former Director of NIAID, is Fired by Health and Human Services Secretary Kennedy in Retaliation for Filing Whistleblower Complaint with the Office of Special Counsel
bit.ly/4gRA3yx
bit.ly/4gRA3yx
October 2, 2025 at 4:18 AM
Dr. Marrazzo is not only a role-model physician-scientist and tireless health advocate, but also a brave leader in these trying times.
#IDSky
#IDSky
Reposted by Paul Adamson MD MPH
The proportion of Treponema pallidum PCR-positive primary syphilis infections which are seronegative for syphilis: a systematic review and meta-analysis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
The proportion of Treponema pallidum PCR-positive primary syphilis infections which are seronegative for syphilis: a systematic review and meta-analysis
Earlier syphilis detection is needed to reduce infectiousness, transmission and to improve control. Polymerase chain reaction (PCR) for...
doi.org
August 15, 2025 at 9:11 PM
The proportion of Treponema pallidum PCR-positive primary syphilis infections which are seronegative for syphilis: a systematic review and meta-analysis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Paul Adamson MD MPH
Alrighty, post vacay and ready to talk about @stihiv2025.org
Some amazing research and presentations:
1- Intense discussion about the need for screening for G/C in asymptomatic MSM. The evidence wasn't fully compelling but what it speaks to is the need for shared decision making in our field
Some amazing research and presentations:
1- Intense discussion about the need for screening for G/C in asymptomatic MSM. The evidence wasn't fully compelling but what it speaks to is the need for shared decision making in our field
August 5, 2025 at 6:54 PM
Alrighty, post vacay and ready to talk about @stihiv2025.org
Some amazing research and presentations:
1- Intense discussion about the need for screening for G/C in asymptomatic MSM. The evidence wasn't fully compelling but what it speaks to is the need for shared decision making in our field
Some amazing research and presentations:
1- Intense discussion about the need for screening for G/C in asymptomatic MSM. The evidence wasn't fully compelling but what it speaks to is the need for shared decision making in our field
Great talk by @ericpfchow.bsky.social about a ton of amazing work being done on #HPV #vaccination by he and many colleagues at MSHC in Australia.
Happy to have him at @dgsomucla.bsky.social to inspire the next generation of #STI researchers!
Happy to have him at @dgsomucla.bsky.social to inspire the next generation of #STI researchers!
August 4, 2025 at 8:14 PM
Great talk by @ericpfchow.bsky.social about a ton of amazing work being done on #HPV #vaccination by he and many colleagues at MSHC in Australia.
Happy to have him at @dgsomucla.bsky.social to inspire the next generation of #STI researchers!
Happy to have him at @dgsomucla.bsky.social to inspire the next generation of #STI researchers!
At least 500 federal grants to #UCLA have been suspended so far.
This is devastating to the scientific community here, but also threatens the science that fuels innovation, cures disease, and powers our economy.
When #science is attacked like this, we all lose.
chancellor.ucla.edu/messages/the...
This is devastating to the scientific community here, but also threatens the science that fuels innovation, cures disease, and powers our economy.
When #science is attacked like this, we all lose.
chancellor.ucla.edu/messages/the...
August 1, 2025 at 10:52 PM
At least 500 federal grants to #UCLA have been suspended so far.
This is devastating to the scientific community here, but also threatens the science that fuels innovation, cures disease, and powers our economy.
When #science is attacked like this, we all lose.
chancellor.ucla.edu/messages/the...
This is devastating to the scientific community here, but also threatens the science that fuels innovation, cures disease, and powers our economy.
When #science is attacked like this, we all lose.
chancellor.ucla.edu/messages/the...
Reposted by Paul Adamson MD MPH
Yet another blow to science and academic freedom. Cutting research funding - especially at institutions like UCLA - is a short sighted move that undermines innovation, public health, and progress. Feeling for all my colleagues in academia there 💔
BREAKING: The Trump administration has canceled $200 million in research grants to UCLA, citing allegations over antisemitism. The move came after Atty. Gen. Pam Bondi said UCLA would pay a "heavy price" over its handling of last year's pro-Palestinian encampment www.latimes.com/california/s...
August 1, 2025 at 10:30 PM
Yet another blow to science and academic freedom. Cutting research funding - especially at institutions like UCLA - is a short sighted move that undermines innovation, public health, and progress. Feeling for all my colleagues in academia there 💔
BREAKING: The Trump administration has canceled $200 million in research grants to UCLA, citing allegations over antisemitism. The move came after Atty. Gen. Pam Bondi said UCLA would pay a "heavy price" over its handling of last year's pro-Palestinian encampment www.latimes.com/california/s...
Trump freezes $200 million in UCLA science, medical research funding, citing antisemitism
The Trump administration has frozen roughly $200 million in National Science Foundation, National Institutes of Health and other federal agency-funded research UCLA, citing allegations that UCLA discr...
www.latimes.com
August 1, 2025 at 4:33 AM
Reposted by Paul Adamson MD MPH
Got to present the LIMIT Trial @stihiv2025.org looking at adding lidocaine to prefilled Bicillin shots to see if it could affect pain at 10 mins and 24hrs after injection vs control w/saline. 4 pt decline in pain at 10 mins, no difference at 24 hrs. This is prelim analysis but is promising #STISky
July 28, 2025 at 7:29 PM
Got to present the LIMIT Trial @stihiv2025.org looking at adding lidocaine to prefilled Bicillin shots to see if it could affect pain at 10 mins and 24hrs after injection vs control w/saline. 4 pt decline in pain at 10 mins, no difference at 24 hrs. This is prelim analysis but is promising #STISky
Reposted by Paul Adamson MD MPH
Got to present @stihiv2025.org on risk based messaging in sexual health settings, focusing on person centered language, removal of risk based questions, and overall trying to not make your patients feel awful for their sex lives
July 30, 2025 at 7:30 PM
Got to present @stihiv2025.org on risk based messaging in sexual health settings, focusing on person centered language, removal of risk based questions, and overall trying to not make your patients feel awful for their sex lives
Reposted by Paul Adamson MD MPH
#stihiv2025 🧪
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
July 30, 2025 at 9:19 PM
#stihiv2025 🧪
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
Closing plenary @drjeannem.bsky.social
Great promise of long-acting HIV PrEP, if available, accessible, in a functioning health system
All it takes is a disaster…
Like withdrawal of PEPFAR - a humanitarian crisis
👇 @avac.org counter of preventable deaths
Reposted by Paul Adamson MD MPH
Always an inspiration Dr. Marrazzo - provides loads of hope, keep passionately advocating! We need honest conversations, work with our community partners and don’t lose ground - fantastic #STIHIV2025
July 30, 2025 at 9:30 PM
Always an inspiration Dr. Marrazzo - provides loads of hope, keep passionately advocating! We need honest conversations, work with our community partners and don’t lose ground - fantastic #STIHIV2025
Reposted by Paul Adamson MD MPH
“Silence equals death. We cannot go back there. We must resist erasure and rebuild trust with communities we’ve abandoned.” — Jeanne Marrazzo at the #STIHIV2025 closing, calling for renewed #STI & #HIV activism, diversified funding & unapologetic advocacy.
@stihiv2025.org
@stihiv2025.org
July 30, 2025 at 9:38 PM
“Silence equals death. We cannot go back there. We must resist erasure and rebuild trust with communities we’ve abandoned.” — Jeanne Marrazzo at the #STIHIV2025 closing, calling for renewed #STI & #HIV activism, diversified funding & unapologetic advocacy.
@stihiv2025.org
@stihiv2025.org
Thank you @stihiv2025.org for a fantastic conference!
Great to see so many colleagues. There were some amazing talks, it was so fun to learn from the best! Leaving feeling very inspired, even in these dark times.
And #Montreal was a great host city!
#STIHIV2025
Pic of the team from Vietnam 👋🏽
Great to see so many colleagues. There were some amazing talks, it was so fun to learn from the best! Leaving feeling very inspired, even in these dark times.
And #Montreal was a great host city!
#STIHIV2025
Pic of the team from Vietnam 👋🏽
July 31, 2025 at 1:37 AM
Thank you @stihiv2025.org for a fantastic conference!
Great to see so many colleagues. There were some amazing talks, it was so fun to learn from the best! Leaving feeling very inspired, even in these dark times.
And #Montreal was a great host city!
#STIHIV2025
Pic of the team from Vietnam 👋🏽
Great to see so many colleagues. There were some amazing talks, it was so fun to learn from the best! Leaving feeling very inspired, even in these dark times.
And #Montreal was a great host city!
#STIHIV2025
Pic of the team from Vietnam 👋🏽
Really interesting talk on penA among commensal Neisseria by team at Maastricht.
They looked at species distribution and penA mutations before/after treatment for #gonorrhea. They did not find a trend in ceftriaxone resistance mutations after treatment.
#STIHIV2025 @stihiv2025.org #AMR
They looked at species distribution and penA mutations before/after treatment for #gonorrhea. They did not find a trend in ceftriaxone resistance mutations after treatment.
#STIHIV2025 @stihiv2025.org #AMR
July 31, 2025 at 1:26 AM
Really interesting talk on penA among commensal Neisseria by team at Maastricht.
They looked at species distribution and penA mutations before/after treatment for #gonorrhea. They did not find a trend in ceftriaxone resistance mutations after treatment.
#STIHIV2025 @stihiv2025.org #AMR
They looked at species distribution and penA mutations before/after treatment for #gonorrhea. They did not find a trend in ceftriaxone resistance mutations after treatment.
#STIHIV2025 @stihiv2025.org #AMR