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Inhibitors ＆ Agonists | Proteins | Drug Screening Platform
Inhibitors ＆ Agonists | Proteins | Drug Screening Platform
👩Maternal Cholesterol & Baby’s #Heart Health
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
November 28, 2025 at 9:15 PM
👩Maternal Cholesterol & Baby’s #Heart Health
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
🚀From Bench to Paper | Unlocking the Secrets of Social Memory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
November 28, 2025 at 8:30 PM
🚀From Bench to Paper | Unlocking the Secrets of Social Memory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
📰New & Featured | A #Nature study reveals that #IL-1β promotes social withdrawal during sickness in #animals by regulating #IL-1R1-expressing neurons in the dorsal raphe nucleus (#DRN).
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
November 28, 2025 at 6:02 PM
📰New & Featured | A #Nature study reveals that #IL-1β promotes social withdrawal during sickness in #animals by regulating #IL-1R1-expressing neurons in the dorsal raphe nucleus (#DRN).
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
🔥Hot Off the Press | #ADHD diagnoses are on the rise
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
November 28, 2025 at 4:00 PM
🔥Hot Off the Press | #ADHD diagnoses are on the rise
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
🐘Happy Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
November 28, 2025 at 3:02 AM
🐘Happy Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
📰New & Featured | A study in #Nature: #POU2F3 forms a DNA-dependent complex with #OCA-T1 or #OCA-T2
🔸Suppression of POU2F3/OCA-T1 results in tuft cell-like #SCLC xenograft regression
🔸Vulnerabilities in #POU2F3-OCA-T complex that might be susceptible to therapeutic disruption
🔸Suppression of POU2F3/OCA-T1 results in tuft cell-like #SCLC xenograft regression
🔸Vulnerabilities in #POU2F3-OCA-T complex that might be susceptible to therapeutic disruption
November 27, 2025 at 11:01 PM
📚#Microglia in #AD switch to pro-inflammatory glycolysis under Aβ, become energy-depleted, and impair phagocytosis. Linked to LDAM and TREM2/APOE. Potential interventions: glycolytic boost, mitochondrial recovery, lipid clearance, NLRP3 inhibition.
🔗https://ow.ly/OZOj50XyvGo
🔗https://ow.ly/OZOj50XyvGo
November 27, 2025 at 10:15 PM
📚#Microglia in #AD switch to pro-inflammatory glycolysis under Aβ, become energy-depleted, and impair phagocytosis. Linked to LDAM and TREM2/APOE. Potential interventions: glycolytic boost, mitochondrial recovery, lipid clearance, NLRP3 inhibition.
🔗https://ow.ly/OZOj50XyvGo
🔗https://ow.ly/OZOj50XyvGo
🔥Hot Off the Press | New in #ACS: #Leishmania major exploits its metalloprotease #GP63 to stabilize parasitophorous vacuoles.
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
November 26, 2025 at 7:02 PM
🔥Hot Off the Press | New in #ACS: #Leishmania major exploits its metalloprotease #GP63 to stabilize parasitophorous vacuoles.
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
🐘Happy #Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
November 26, 2025 at 3:15 PM
🐘Happy #Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.
November 26, 2025 at 3:59 AM
🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.
📢Join Our Upcoming Webinar | Advances in #Pancreatic #Cancer Therapy
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
November 26, 2025 at 2:29 AM
📢Join Our Upcoming Webinar | Advances in #Pancreatic #Cancer Therapy
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
📰New & Featured | #Cell: Human PSCs transfer RNA into mouse PSCs via TNT-like structures, triggering RIG-I/MDA5 → MAVS activation and competitive elimination.
Mavs-KO in mouse embryos boosts human cell survival & chimerism across all germ layers.
Read more: www.cell.com/cell/abstrac...
Mavs-KO in mouse embryos boosts human cell survival & chimerism across all germ layers.
Read more: www.cell.com/cell/abstrac...
November 25, 2025 at 11:00 PM
📰New & Featured | #Cell: Human PSCs transfer RNA into mouse PSCs via TNT-like structures, triggering RIG-I/MDA5 → MAVS activation and competitive elimination.
Mavs-KO in mouse embryos boosts human cell survival & chimerism across all germ layers.
Read more: www.cell.com/cell/abstrac...
Mavs-KO in mouse embryos boosts human cell survival & chimerism across all germ layers.
Read more: www.cell.com/cell/abstrac...
🔥Hot Off the Press | #Nature: MAPK-induced epithelial plasticity is associated with #CRC therapeutic resistance
🔸Approaches designed to control stem cell fate and #epithelial plasticity, or target #tumors with limited heterogeneity could improve therapeutic effectiveness.
#MAPK
🔸Approaches designed to control stem cell fate and #epithelial plasticity, or target #tumors with limited heterogeneity could improve therapeutic effectiveness.
#MAPK
November 25, 2025 at 9:01 PM
🔥Hot Off the Press | #Nature: MAPK-induced epithelial plasticity is associated with #CRC therapeutic resistance
🔸Approaches designed to control stem cell fate and #epithelial plasticity, or target #tumors with limited heterogeneity could improve therapeutic effectiveness.
#MAPK
🔸Approaches designed to control stem cell fate and #epithelial plasticity, or target #tumors with limited heterogeneity could improve therapeutic effectiveness.
#MAPK
📰New & Featured | 🌶️Scientists have built a synthetic tongue that can rank #chilli heat
💡Chemical sensors and machine learning to deliver heat ratings.
👉Made of a gel: milk powder + acrylic acid + choline chloride
👉Binds #capsaicinoids
#SyntheticTongue #Heatlevels #Spicy
💡Chemical sensors and machine learning to deliver heat ratings.
👉Made of a gel: milk powder + acrylic acid + choline chloride
👉Binds #capsaicinoids
#SyntheticTongue #Heatlevels #Spicy
November 25, 2025 at 7:02 PM
📰New & Featured | 🌶️Scientists have built a synthetic tongue that can rank #chilli heat
💡Chemical sensors and machine learning to deliver heat ratings.
👉Made of a gel: milk powder + acrylic acid + choline chloride
👉Binds #capsaicinoids
#SyntheticTongue #Heatlevels #Spicy
💡Chemical sensors and machine learning to deliver heat ratings.
👉Made of a gel: milk powder + acrylic acid + choline chloride
👉Binds #capsaicinoids
#SyntheticTongue #Heatlevels #Spicy
📰New & Featured | A Cell study reports that de novo heme biosynthesis is a selective dependency in #AML
👉Leukemic stem cells ⬇️heme biosynthesis enzymes (#HBE) and ⬆️their self-renewal
👉HBE inhibition induces #cuproptosis
💡Provides a potential therapeutic strategy for AML.
👉Leukemic stem cells ⬇️heme biosynthesis enzymes (#HBE) and ⬆️their self-renewal
👉HBE inhibition induces #cuproptosis
💡Provides a potential therapeutic strategy for AML.
November 24, 2025 at 11:00 PM
📰New & Featured | A Cell study reports that de novo heme biosynthesis is a selective dependency in #AML
👉Leukemic stem cells ⬇️heme biosynthesis enzymes (#HBE) and ⬆️their self-renewal
👉HBE inhibition induces #cuproptosis
💡Provides a potential therapeutic strategy for AML.
👉Leukemic stem cells ⬇️heme biosynthesis enzymes (#HBE) and ⬆️their self-renewal
👉HBE inhibition induces #cuproptosis
💡Provides a potential therapeutic strategy for AML.
💊FDA Approval Update | #Hyrnuo (#sevabertinib)
🔸For #HER2-mutant non-small cell lung cancer #NSCLC
⚙️Reversible tyrosine kinase inhibitor targets #EGFR and #HER2 protein
🌟MedChemExpress provides #Sevabertinib for research use.
#NSCLC #TyrosineKinaseInhibitor #TKI #FDA #FDAApproval
🔸For #HER2-mutant non-small cell lung cancer #NSCLC
⚙️Reversible tyrosine kinase inhibitor targets #EGFR and #HER2 protein
🌟MedChemExpress provides #Sevabertinib for research use.
#NSCLC #TyrosineKinaseInhibitor #TKI #FDA #FDAApproval
November 24, 2025 at 9:01 PM
💊FDA Approval Update | #Hyrnuo (#sevabertinib)
🔸For #HER2-mutant non-small cell lung cancer #NSCLC
⚙️Reversible tyrosine kinase inhibitor targets #EGFR and #HER2 protein
🌟MedChemExpress provides #Sevabertinib for research use.
#NSCLC #TyrosineKinaseInhibitor #TKI #FDA #FDAApproval
🔸For #HER2-mutant non-small cell lung cancer #NSCLC
⚙️Reversible tyrosine kinase inhibitor targets #EGFR and #HER2 protein
🌟MedChemExpress provides #Sevabertinib for research use.
#NSCLC #TyrosineKinaseInhibitor #TKI #FDA #FDAApproval
🔥Hot Off the Press | #Cell: Synthetic-biased agonists against #CCKBR-Gq signaling can be beneficial for AD:
👉CCKBR activation alleviates memory decline in vivo
👉#3r1 ameliorates memory impairment in animal models
👉3r1 diminishes #Aβ deposition + inhibits #tau phosphorylation
👉CCKBR activation alleviates memory decline in vivo
👉#3r1 ameliorates memory impairment in animal models
👉3r1 diminishes #Aβ deposition + inhibits #tau phosphorylation
November 24, 2025 at 7:01 PM
📰 New & Featured | #Glycosylation site-specific ADCs (#gsADCs) harness the #Asn297 N-glycosylation site on the #IgG Fc for precise drug loading.
⚙️Workflow: glycosidase trim (e.g. endo S2) ➜ azide install via #GalT(#Y289L) ➜ cyclooctyne click → stable, uniform #ADCs.
⚙️Workflow: glycosidase trim (e.g. endo S2) ➜ azide install via #GalT(#Y289L) ➜ cyclooctyne click → stable, uniform #ADCs.
November 21, 2025 at 9:30 PM
📰 New & Featured | #Glycosylation site-specific ADCs (#gsADCs) harness the #Asn297 N-glycosylation site on the #IgG Fc for precise drug loading.
⚙️Workflow: glycosidase trim (e.g. endo S2) ➜ azide install via #GalT(#Y289L) ➜ cyclooctyne click → stable, uniform #ADCs.
⚙️Workflow: glycosidase trim (e.g. endo S2) ➜ azide install via #GalT(#Y289L) ➜ cyclooctyne click → stable, uniform #ADCs.
📰New & Featured | 3D bioprinting is an additive manufacturing technique utilizes to fabricate #cell-based #scaffold structures. #Bioink simulates the #ECM to facilitate cell adhesion, proliferation, and differentiation post-printing.
#3DBioprinting #BioTech
#3DBioprinting #BioTech
November 21, 2025 at 8:00 PM
📰New & Featured | 3D bioprinting is an additive manufacturing technique utilizes to fabricate #cell-based #scaffold structures. #Bioink simulates the #ECM to facilitate cell adhesion, proliferation, and differentiation post-printing.
#3DBioprinting #BioTech
#3DBioprinting #BioTech
💊#FDA Approval Update | #Komzifti (#ziftomenib) for relapsed or refractory #AML with #NPM1 mutation in adults
⚙️Blocks #menin-KMT2A interaction, disrupting leukemogenic gene expression
🌟MedChemExpress provides ziftomenib for research use.
#AcuteMyeloidLeukemia #Leukemia
⚙️Blocks #menin-KMT2A interaction, disrupting leukemogenic gene expression
🌟MedChemExpress provides ziftomenib for research use.
#AcuteMyeloidLeukemia #Leukemia
November 21, 2025 at 6:30 PM
💊#FDA Approval Update | #Komzifti (#ziftomenib) for relapsed or refractory #AML with #NPM1 mutation in adults
⚙️Blocks #menin-KMT2A interaction, disrupting leukemogenic gene expression
🌟MedChemExpress provides ziftomenib for research use.
#AcuteMyeloidLeukemia #Leukemia
⚙️Blocks #menin-KMT2A interaction, disrupting leukemogenic gene expression
🌟MedChemExpress provides ziftomenib for research use.
#AcuteMyeloidLeukemia #Leukemia
📰New & Featured | A study in #Cell introduces a new #macrophage-targeted #immunocytokine (#MiTE) reprograms #TREM2⁺ TAMs and locally activates #T/NK cells, delivering strong #anti-tumor immunity without #IL-2 toxicity.
🌟Opens up new path to overcome #immunosuppression.
🌟Opens up new path to overcome #immunosuppression.
November 21, 2025 at 5:02 PM
📰New & Featured | A study in #Cell introduces a new #macrophage-targeted #immunocytokine (#MiTE) reprograms #TREM2⁺ TAMs and locally activates #T/NK cells, delivering strong #anti-tumor immunity without #IL-2 toxicity.
🌟Opens up new path to overcome #immunosuppression.
🌟Opens up new path to overcome #immunosuppression.
🤝MedChemExpress on the Move
📅This week, MedChemExpress connected with you at conferences around the world — exploring scientific advances and sharing our comprehensive solutions. See you next time, and have a wonderful weekend!💜
📅This week, MedChemExpress connected with you at conferences around the world — exploring scientific advances and sharing our comprehensive solutions. See you next time, and have a wonderful weekend!💜
November 21, 2025 at 8:42 AM
🤝MedChemExpress on the Move
📅This week, MedChemExpress connected with you at conferences around the world — exploring scientific advances and sharing our comprehensive solutions. See you next time, and have a wonderful weekend!💜
📅This week, MedChemExpress connected with you at conferences around the world — exploring scientific advances and sharing our comprehensive solutions. See you next time, and have a wonderful weekend!💜
📰New & Featured | A new study in #Cell: #nutrient competition offers a predictive framework to anticipating and potentially reducing drug-induced side effects on the #gut #microbiota
🧐Read more: www.cell.com/cell/abstrac...
#NutrientCompetition #GutMicrobiota
🧐Read more: www.cell.com/cell/abstrac...
#NutrientCompetition #GutMicrobiota
November 20, 2025 at 11:00 PM
📰New & Featured | A new study in #Cell: #nutrient competition offers a predictive framework to anticipating and potentially reducing drug-induced side effects on the #gut #microbiota
🧐Read more: www.cell.com/cell/abstrac...
#NutrientCompetition #GutMicrobiota
🧐Read more: www.cell.com/cell/abstrac...
#NutrientCompetition #GutMicrobiota