The Cranberries · No Need To Argue (The Complete Sessions 1994-1995) · Song · 1994

To the  Editor—Traditional automated susceptibility testing methods, which take on average 3 days to finalize, can prolong the hospitalizations of patients who are clinically stable with gram-negative bacilli (GNB) bloodstream infections (BSIs) [1, 2]. A rapid blood culture identification and phenotype technology, Accelerate Pheno, performs organism identification via automated fluorescence in situ hybridization and phenotypic antimicrobial susceptibility testing via morphokinetic cellular analysis for a number of organisms included on a predetermined panel. Ventres et al implemented Accelerate Pheno to provide organism identification and susceptibilities within 8 hours of blood culture positivity, facilitating antibiotic optimization, switch to an oral agent, and hospital discharge in GNB BSI [1, 3, 4]. Patients with GNB BSI are a heterogeneous population; many have fewer comorbidities, experience rapid source control, and reach clinical stability sooner than others [1, 2, 5, 6]. Recent observational data suggest that early discharge and ambulatory management of some BSIs are safe [6]. There is an opportunity to leverage rapid phenotype reports when treating patients who are stable and have early clinical responses to therapy.

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