#PCLS
Always a pleasure to see the paper come out in print & this one is very special because it indicates how Pulmonary Fibrosis drug discovery can be liberated from Col1A1, ASMA, using AI, human & PCLS scRNAseq data
Kudos Drs Zheng and Ding #CurePF4ALL
www.nature.com/articles/s41...
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases - Nature Biomedical Engineering
UNAGI deciphers cellular dynamics from human disease time-series single-cell data and facilitates in silico drug perturbations to discover drugs potentially active against complex human diseases.
www.nature.com
December 17, 2025 at 2:59 PM
Hi Ben, how are your PCLs doing?
December 15, 2025 at 3:41 PM
Pierce County Library System (PCLS): Sicherheitsvorfall #Einbruch #Datendiebstahl #infosec #TeamInfoSec #cyberangriff
Pierce County Library System (PCLS): Sicherheitsvorfall
Hacker kompromittieren Daten von 340.000 Personen bei Bibliothek.
www.security-incidents.de
December 15, 2025 at 8:35 AM
ピアース郡図書館のデータ侵害、34万人に影響

ピアース郡図書館システム(PCLS)は、データ侵害により34万人以上の個人情報が侵害されたことを通知しています。 公共図書館であるPCLSによると、2025年4月15日から4月21日の間に、脅威アクターがPCLSのネットワークへアクセスし、システムから特定のデータを盗み出しました。 「問題を発見するとすぐに、PCLSはその性質と範囲を確認し、どの情報が影響を受けた可能性があるかを特定するための調査を直ちに開始しました」と、PCLSは自社ウェブサイト上のインシデント通知で述べています。…
ピアース郡図書館のデータ侵害、34万人に影響
ピアース郡図書館システム(PCLS)は、データ侵害により34万人以上の個人情報が侵害されたことを通知しています。 公共図書館であるPCLSによると、2025年4月15日から4月21日の間に、脅威アクターがPCLSのネットワークへアクセスし、システムから特定のデータを盗み出しました。 「問題を発見するとすぐに、PCLSはその性質と範囲を確認し、どの情報が影響を受けた可能性があるかを特定するための調査を直ちに開始しました」と、PCLSは自社ウェブサイト上のインシデント通知で述べています。 図書館によると、このデータ侵害は利用者だけでなく、現在および過去の職員とその家族にも影響を及ぼしています。 利用者については、侵害された個人情報には氏名と生年月日が含まれます。 職員およびその家族については、氏名、生年月日、社会保障番号、運転免許証番号、パスポート番号、金融情報、クレジットカード情報、健康保険および医療情報が含まれます。 PCLSは、このインシデントが340,101人に影響を与え、これらの人々に書面による通知を送付していると、メイン州司法長官事務所に伝えました。 影響を受けた人々には、12か月間の無料クレジットモニタリングおよび本人確認保護サービスが提供されています。 PCLSは、このインシデントの原因となった脅威アクターに関する詳細を公表していません。既知のランサムウェアグループがこのデータ侵害の犯行声明を出しているのも、SecurityWeekは確認していません。 翻訳元:
blackhatnews.tokyo
December 11, 2025 at 1:04 PM
Aw, poor little sweetheart.

My first dog, Lucy, tore both her PCLs at the dog park 9 months apart. Thank god for pet insurance
December 9, 2025 at 3:31 PM
## Dynamic Photonic Crystal Lattice Bandgap Engineering via Reinforcement Learning and Digital Twin Simulation

**Abstract:** This paper introduces a novel method for dynamically engineering the bandgap of photonic crystal lattices (PCLs) using reinforcement learning (RL) coupled with a digital…
## Dynamic Photonic Crystal Lattice Bandgap Engineering via Reinforcement Learning and Digital Twin Simulation
**Abstract:** This paper introduces a novel method for dynamically engineering the bandgap of photonic crystal lattices (PCLs) using reinforcement learning (RL) coupled with a digital twin simulation environment. Traditional PCL design relies on computationally intensive, static optimization techniques. Our approach leverages RL to create a self-learning agent that iteratively modifies PCL parameters – specifically, the geometric parameters of the lattice unit cell (period, radius, and filling fraction) – to achieve target bandgap characteristics, such as desired stopband width, central frequency, and dynamic tunability.
freederia.com
November 29, 2025 at 5:31 PM
Review the epidemiology of PCLs, the most common cyst types, relevant guideline recommendations, and innovative new diagnostic and therapeutic technologies, particularly as they relate to the care of older adults.

👉 buff.ly/HDQobQT

#GastroSky
Pancreatic Cystic Lesions in the Older Patient: A Review of Clinical Guidelines and Management
Review the epidemiology of PCLs, the most common cyst types, relevant guideline recommendations, and innovative new diagnostic and therapeutic technologies, particularly as they relate to the care of…
buff.ly
November 27, 2025 at 9:01 AM
Focus on Tax-Free Cash: The amount taken as tax-free cash (officially the Pension Commencement Lump Sum, or PCLS) saw an even larger spike, increasing by 61% to £18.3 billion.
November 26, 2025 at 10:39 AM
As above, its a reduction in the amount of NI you can only avoid paying by using salary sacrifice. It's a reduction of a benefit that (mainly) favours high earners.

You still get tax relief on your pension contributions in. You get 25% tax free PCLS, then you get taxed on your pension income.
November 26, 2025 at 7:14 AM
Yes, i did sleep the whole way here. And i had the strangest dream about….library inservice day.

Don’t ask. We’ve had one at PCLS in my six years there. And i don’t think it went over very well.

Plane dreams. 🤷🏾‍♀️
November 24, 2025 at 12:44 PM
Advances in Ultra-High-Gradient #MRI: High-Resolution Imaging for Accurate Diagnosis of Pancreatic Cystic Lesions
by Liang Zhu, MD; et al. (PUMC Hospital, Beijing, China).

Learn more: marketing.webassets.siemens-healthineers.com/8d6fae1515f7...

#RadSky #OncoSky #MagnetomWorld #SiemensHealthineers
November 13, 2025 at 7:48 AM
hey Sarah! it's Lexa :) are you still working at PCLS? I've got a question about how the district/union is dealing with something. do you have a Signal?
November 9, 2025 at 3:10 AM
With all the speculation about whether the Govt would cap PCLS, I asked AI whether they should...

youtu.be/PJ1vlYSBaYI?...
Should pension tax-free cash lump sums be capped?
YouTube video by DEbITES
youtu.be
October 27, 2025 at 5:26 PM
🏆 Amazing work Julia Limper!

Congrats to our HI CBT training director, recognised as an ‘Outstanding Individual’ in our PCLS Teaching & Learning awards for work integrating lived experience in psychological therapies training.
Click below for more info about our HI CBT training:
bit.ly/47zET0s
October 20, 2025 at 11:48 AM
Dear Roger Staubach - please let us get this win and leave with the same number of ACLs and MCLs and PCLs intact as we had at 11:30>
Amen
October 5, 2025 at 5:03 PM
See also: Telegraph hysteria over HMRC refusing to unravel people who panicked and took PCLS 12 months ago.
October 3, 2025 at 3:56 PM
The CMS is failing to adapt to modern pension systems. Our latest article from Chartered Financial Planner Greg Neall reveals a loophole that allows some over-55s to avoid child maintenance payments by living on PCLS rather than an income. Read the full analysis: www.moneymarketing.c...
September 22, 2025 at 1:33 PM
Our latest application note, drumroll please, is on precision cut liver slices (PCLS)!

Many thanks to Dr Ben Leaker for giving us insights into the how and why PCLS are a useful tool!

If you are interested you can read the full application note here: campdeninstruments.com/downloads/ap...
September 22, 2025 at 11:13 AM
Because collecting library cards is fun: Seattle residents can also get cards from King County (KCLS), Sno-Isle, Kitsap (KRL), Everett, Pierce County (PCLS), Tacoma (TPL), Timberland, and Puyallup!

All reachable by transit (sometimes a day trip).

www.spl.org/using-the-li...
Reciprocal Agreements with Nearby Library Systems
We have reciprocal agreements in place with a number of nearby library systems, giving our patrons access to more books, programs and services.
www.spl.org
September 21, 2025 at 5:11 PM
Optimized vibratome settings are key to reproducible, viable PCLS.

See how @campdeninstruments.bsky.social vibrating microtomes support high-quality PCLS prep across diverse research applications:
campdeninstruments.com/pages/precis...

#LiverResearch #PCLS #ExVivo #Hepatology #Toxicology
Precision Cut Liver Slices for Ex Vivo Research | Campden Instruments
Precision-Cut Liver Slices (PCLS) are emerging as a gold-standard ex vivo model for liver research, offering a structurally and functionally intact hepatic microenvironment.
campdeninstruments.com
September 17, 2025 at 2:08 PM
A few weeks ago, we shared insights on Precision-Cut Lung Slices (PCLS), but did you know the other PCLS acronym stands for Precision-Cut Liver Slices?

These slices are emerging as a gold-standard ex vivo model in liver research. 🔬 🧵
September 17, 2025 at 2:07 PM
Now for modelling lung development, repair and disease at #BALR2025, Dr Charlotte Dean from @imperialnhli.bsky.social who is going to present on her PCLS models to study lung injury and repair.
September 10, 2025 at 8:49 AM
Most PCLs require periodic surveillance, but some warrant biopsy or surgical excision.

Explore the diagnostic accuracy of imaging and the role of endoscopic and molecular tools when assessing malignant potential.

👉 buff.ly/1X3PXUA

#GastroSky #OncSky
Identifying Neoplastic Versus Non-neoplastic Pancreatic Cystic Lesions—What Is the Current Evidence?
Most PCLs require periodic surveillance, but some warrant biopsy or surgical excision. Explore the diagnostic accuracy of imaging and the role of endoscopic and molecular tools when assessing…
buff.ly
September 5, 2025 at 3:15 PM
Consistent, high-quality #PCLS start with the right tools. That's why our 9000smz and 5100mz-Plus vibrating microtomes are engineered for precision.

Learn more about Campden Vibrating Microtomes
campdeninstruments.com/listing/vibr...
Vibratomes for Neuroscience, Cardiac, Lung, Liver, Plant Research | Campden Instruments
Explore Campden's range of vibratomes for neuroscience, cardiac, liver, lung, organoid, plant research. Precision tissue slicers trusted by researchers worldwide. View models and specs now.
campdeninstruments.com
August 20, 2025 at 1:50 PM