Molecular Psychiatry - Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025. SignificanceTactile perception reshapes the brain when exploring a novel environment. Our study has demonstrated that Piezo2-mediated Merkel cell mechanotransduction facilitates environmental enrichment-induced neurogenesis and cognitive enhancement. This ...

**Abstract:** This research investigates a novel automated pipeline for reconstructing neuronal circuits within the adult brain, significantly accelerating research into adult neurogenesis. Leveraging a combination of optical microscopy, immunohistochemistry, and electrophysiology data, our system employs a multi-layered evaluation pipeline guided by a proprietary HyperScore metric to achieve unprecedented accuracy and efficiency in circuit mapping. This technology offers a 10x improvement over manual reconstruction efforts, offering substantial acceleration in the discovery of neurogenic mechanisms and potential therapeutic targets for neurological disorders.

Gaskon Ibarretxe describe el funcionamiento de los mecanismos que intervienen en la plasticidad cerebral, como la neurogénesis

**Abstract:** This research proposes a novel framework for accelerating zebrafish ( *Danio rerio* ) embryonic development through real-time, automated pattern recognition of neurogenesis events. Existing methods for monitoring neurogenesis rely on manual observation and are inherently limited in resolution and speed. We present a multi-modal, AI-driven system leveraging advanced image processing, semantic decomposition, and hyper-score evaluation to detect and analyze neurogenesis patterns with unprecedented accuracy and speed.

Understanding the architectural principles shape human brain networks is a major challenge for systems neuroscience. Here, authors show embryogenic age is associated with functional and structural bra...