Again: "The LC group was characterized by persistent immune activation and proinflammatory responses for more than 180 days after initial infection compared with convalescent controls". E.g. more IFNg, more IL-6.
3/7
3/7
December 12, 2025 at 7:25 PM
Again: "The LC group was characterized by persistent immune activation and proinflammatory responses for more than 180 days after initial infection compared with convalescent controls". E.g. more IFNg, more IL-6.
3/7
3/7
I'm probably late in discovering Cleo Reed, but this is too good not to share out. www.youtube.com/watch?v=iFng...
Cleo Reed — "Always The Horse, Never The Jockey" (Live Performance)
YouTube video by Cleo Reed
www.youtube.com
December 12, 2025 at 5:56 PM
I'm probably late in discovering Cleo Reed, but this is too good not to share out. www.youtube.com/watch?v=iFng...
An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy https://www.biorxiv.org/content/10.64898/2025.12.08.693087v1
December 11, 2025 at 11:46 PM
An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy https://www.biorxiv.org/content/10.64898/2025.12.08.693087v1
An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy https://www.biorxiv.org/content/10.64898/2025.12.08.693087v1
December 11, 2025 at 11:46 PM
An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy https://www.biorxiv.org/content/10.64898/2025.12.08.693087v1
Pts w/ MRD+ MM undergoing autoHCT (MEL->ASCT->ARM coated NK cells-> IL-2). No DLTs seen at 5-10 million cells/kg. NK cells expand/persist for 60d, are functional, have cytotoxic gene signature enriched for IFNg, infiltrate BM. Too early to assess clinical impact vs SOC ASCT (2/2) #ASH25
December 6, 2025 at 7:47 PM
Pts w/ MRD+ MM undergoing autoHCT (MEL->ASCT->ARM coated NK cells-> IL-2). No DLTs seen at 5-10 million cells/kg. NK cells expand/persist for 60d, are functional, have cytotoxic gene signature enriched for IFNg, infiltrate BM. Too early to assess clinical impact vs SOC ASCT (2/2) #ASH25
Cleo Reed — "Always The Horse, Never The Jockey" (Live Performance)
YouTube video by Cleo Reed
www.youtube.com
December 6, 2025 at 8:57 AM
and make 50 ng/ml, and upon stimulation they make 100 ng, that is a 2-fold increase. But, which cells make more IFNg? That is 100 ng vs 4 ng. Like with proportions, be very carefull what you are actually looking at, and what conclusion it does or not, support.
3/10
3/10
December 4, 2025 at 3:35 PM
and make 50 ng/ml, and upon stimulation they make 100 ng, that is a 2-fold increase. But, which cells make more IFNg? That is 100 ng vs 4 ng. Like with proportions, be very carefull what you are actually looking at, and what conclusion it does or not, support.
3/10
3/10
Before looking at the data, it is important to uderstand what "fold-change" is. Fold-change shows relative change, not actual impact! If your cells make little IFNg (1 ng/ml), but upon stimulation a little more (4 ng), that is a 4-fold increase. If you cells are more active
2/10
2/10
December 4, 2025 at 3:35 PM
Before looking at the data, it is important to uderstand what "fold-change" is. Fold-change shows relative change, not actual impact! If your cells make little IFNg (1 ng/ml), but upon stimulation a little more (4 ng), that is a 4-fold increase. If you cells are more active
2/10
2/10
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
November 16, 2025 at 2:00 PM
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
November 10, 2025 at 5:15 PM
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
The strongest transcriptional signal in ICI-AIN is a IFNg response signature. Interestingly, the IFNg is mostly produced by CD8 T cells that have a more exhausted/tissue-resident phenotype.
Likely consequences of IFNg include reduced OxPhos in tubules and ... 4/n
Likely consequences of IFNg include reduced OxPhos in tubules and ... 4/n
November 5, 2025 at 6:24 PM
The strongest transcriptional signal in ICI-AIN is a IFNg response signature. Interestingly, the IFNg is mostly produced by CD8 T cells that have a more exhausted/tissue-resident phenotype.
Likely consequences of IFNg include reduced OxPhos in tubules and ... 4/n
Likely consequences of IFNg include reduced OxPhos in tubules and ... 4/n
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
November 5, 2025 at 6:24 PM
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
scRNA-seq & flow cytometry showed AcAc increases tumor MAIT cells and enhances their expression of cytotoxic effectors like IFNg and granzyme B.
Crucially, the anti-tumor effect was lost in mice lacking MAIT cells, showing they are essential for the anti-tumor effects. (4/10)
Crucially, the anti-tumor effect was lost in mice lacking MAIT cells, showing they are essential for the anti-tumor effects. (4/10)
November 2, 2025 at 2:30 PM
scRNA-seq & flow cytometry showed AcAc increases tumor MAIT cells and enhances their expression of cytotoxic effectors like IFNg and granzyme B.
Crucially, the anti-tumor effect was lost in mice lacking MAIT cells, showing they are essential for the anti-tumor effects. (4/10)
Crucially, the anti-tumor effect was lost in mice lacking MAIT cells, showing they are essential for the anti-tumor effects. (4/10)
NK cell definitely as a Jedi:
Travelling the Galaxy (BM to Liver and beyond)
Innately sensing the force (Receptors & antigens on other cells)
Controlling it (IFNg secretion)
Wielding a lightsaber (cytotoxic granules)
....If they embrace the dark side, immunopathology 👻
Travelling the Galaxy (BM to Liver and beyond)
Innately sensing the force (Receptors & antigens on other cells)
Controlling it (IFNg secretion)
Wielding a lightsaber (cytotoxic granules)
....If they embrace the dark side, immunopathology 👻
🎃 Happy Halloween! Ever wondered what your immune cells would wear to a costume party?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?
October 31, 2025 at 5:58 PM
NK cell definitely as a Jedi:
Travelling the Galaxy (BM to Liver and beyond)
Innately sensing the force (Receptors & antigens on other cells)
Controlling it (IFNg secretion)
Wielding a lightsaber (cytotoxic granules)
....If they embrace the dark side, immunopathology 👻
Travelling the Galaxy (BM to Liver and beyond)
Innately sensing the force (Receptors & antigens on other cells)
Controlling it (IFNg secretion)
Wielding a lightsaber (cytotoxic granules)
....If they embrace the dark side, immunopathology 👻
Correction: Genetic analysis of IFNG-AS1 implicates opposite effects to Leishmania guyanensis-cutaneous leishmaniasis: rs4913269 confers protection while rs7134599 enhances susceptibility and correlates with high plasma IL-4 and IL-10 levels pubmed.ncbi.nlm.nih.gov/41166220/
October 31, 2025 at 11:19 AM
Correction: Genetic analysis of IFNG-AS1 implicates opposite effects to Leishmania guyanensis-cutaneous leishmaniasis: rs4913269 confers protection while rs7134599 enhances susceptibility and correlates with high plasma IL-4 and IL-10 levels pubmed.ncbi.nlm.nih.gov/41166220/
More specifically, very recent infection displayed reduced IFNg production and more geared towards IL2 and TNF while TB disease was associated with dual production of IFNg and TNF.
October 29, 2025 at 1:45 PM
More specifically, very recent infection displayed reduced IFNg production and more geared towards IL2 and TNF while TB disease was associated with dual production of IFNg and TNF.
New paper on detection of Mtb-specific T cell responses in TB infection and disease using a multiplex FluoroSpot (quantifying IFNg, IL2, and TNF).
journals.asm.org/eprint/CIH3C...
journals.asm.org/eprint/CIH3C...
journals.asm.org
October 29, 2025 at 1:45 PM
New paper on detection of Mtb-specific T cell responses in TB infection and disease using a multiplex FluoroSpot (quantifying IFNg, IL2, and TNF).
journals.asm.org/eprint/CIH3C...
journals.asm.org/eprint/CIH3C...
Monocytes, gd T cells and NK cells cells secrete TNFa and IFNg, causing a strong inflammation and activation of all BBB cells, accounting for 20% of changes in the transcriptome.
October 21, 2025 at 11:06 AM
Monocytes, gd T cells and NK cells cells secrete TNFa and IFNg, causing a strong inflammation and activation of all BBB cells, accounting for 20% of changes in the transcriptome.
those people infected (red) have many of these T cells (depending on the HLA). In addition, you can find some (blue) in the memory (IFNg+) population of people who have not knowingly been infected.
The frequency is low, since they were not exposed.
The frequency is low, since they were not exposed.
October 21, 2025 at 10:14 AM
those people infected (red) have many of these T cells (depending on the HLA). In addition, you can find some (blue) in the memory (IFNg+) population of people who have not knowingly been infected.
The frequency is low, since they were not exposed.
The frequency is low, since they were not exposed.
A risk-scoring model using four ICD genes (CALR, IL1R1, IFNB1, IFNG) was validated, revealing that higher risk scores correlated with weaker anti-tumor immunity, more tumor-promoting elements, lower immunotherapy response, and shorter patient survival.
October 8, 2025 at 1:24 PM
A risk-scoring model using four ICD genes (CALR, IL1R1, IFNB1, IFNG) was validated, revealing that higher risk scores correlated with weaker anti-tumor immunity, more tumor-promoting elements, lower immunotherapy response, and shorter patient survival.
Beautiful talk by @ikinglab.bsky.social today @nyulangone.bsky.social talking IFNg, type 2, parasites, disease tolerance and gut:stroma axis. gorgeous microscopy and insightful new Frontiers in Hpb infections. 👏👏
October 2, 2025 at 4:09 PM
Beautiful talk by @ikinglab.bsky.social today @nyulangone.bsky.social talking IFNg, type 2, parasites, disease tolerance and gut:stroma axis. gorgeous microscopy and insightful new Frontiers in Hpb infections. 👏👏
aTIGIT mAb treatment reduced viral load and time to rebound after ATI in association with an increased splenic CD107a+ IFNg+ NKG2C+ CD57- adaptive NK cell precursors
September 17, 2025 at 4:26 PM
aTIGIT mAb treatment reduced viral load and time to rebound after ATI in association with an increased splenic CD107a+ IFNg+ NKG2C+ CD57- adaptive NK cell precursors
aKLRG1 mAb treatment reduced viral load and time to rebound after ART interruption in association with higher infiltration of IFNg+ CD8+ T cells
September 17, 2025 at 4:26 PM
aKLRG1 mAb treatment reduced viral load and time to rebound after ART interruption in association with higher infiltration of IFNg+ CD8+ T cells
A major gene that links inflammation to leakiness is MYLK (myosin light chain kinase).
It gets turned on by TNF and IFNG.
High MYLK → cells contract and pull junctions apart → leak increases.
It’s a key driver in many leaky gut conditions.
It gets turned on by TNF and IFNG.
High MYLK → cells contract and pull junctions apart → leak increases.
It’s a key driver in many leaky gut conditions.
September 15, 2025 at 1:06 PM
A major gene that links inflammation to leakiness is MYLK (myosin light chain kinase).
It gets turned on by TNF and IFNG.
High MYLK → cells contract and pull junctions apart → leak increases.
It’s a key driver in many leaky gut conditions.
It gets turned on by TNF and IFNG.
High MYLK → cells contract and pull junctions apart → leak increases.
It’s a key driver in many leaky gut conditions.