Jack - amatica health
@jackamatica.bsky.social
🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
September 22, 2025 at 4:29 PM
🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
September 20, 2025 at 2:11 PM
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
How do mitochondria produce energy - and what happens when this process breaks down in disease?
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
September 19, 2025 at 3:18 PM
How do mitochondria produce energy - and what happens when this process breaks down in disease?
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury.
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
September 18, 2025 at 3:29 PM
The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury.
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog.
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
September 17, 2025 at 3:05 PM
🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog.
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain.
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
September 17, 2025 at 2:01 PM
🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain.
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS.
And into DecodeME findings.
Simplified breakdown 🧵
And into DecodeME findings.
Simplified breakdown 🧵
September 16, 2025 at 4:36 PM
🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS.
And into DecodeME findings.
Simplified breakdown 🧵
And into DecodeME findings.
Simplified breakdown 🧵
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
September 16, 2025 at 3:54 PM
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream.
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
September 15, 2025 at 1:06 PM
Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream.
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
September 12, 2025 at 2:10 PM
New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
A new study just showed that gut bacteria from people with fibromyalgia can cause pain when transplanted into mice.
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
September 11, 2025 at 2:24 PM
A new study just showed that gut bacteria from people with fibromyalgia can cause pain when transplanted into mice.
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
This is the strongest evidence yet that the gut microbiome plays a direct role in fibromyalgia.
Here's a full breakdown of what they found
Some diseases show up together. Others rarely appear in the same person
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
September 10, 2025 at 1:49 PM
Some diseases show up together. Others rarely appear in the same person
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
This study looked into whether gene activity (from RNA data) can help explain why
The answer: yes - more than we thought
Relevant as we are testing RNA in LC & ME/CFS patients @amaticahealth
Breakdown:
New @amaticahealth preliminary findings: elevated NKG2A in Long COVID & ME/CFS
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
September 9, 2025 at 2:12 PM
New @amaticahealth preliminary findings: elevated NKG2A in Long COVID & ME/CFS
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
NKG2A is a receptor found on NK cells & some T cells. It acts as an "immune system brake" when on
This is useful for preventing damage to healthy tissue - but can prevent proper clearance of viruses
New research shows Long COVID and chronic fatigue syndrome (ME/CFS) share the same biological problem: their bodies struggle to use oxygen properly during exercise.
Here's a full breakdown - and what it means.
Here's a full breakdown - and what it means.
September 8, 2025 at 1:08 PM
New research shows Long COVID and chronic fatigue syndrome (ME/CFS) share the same biological problem: their bodies struggle to use oxygen properly during exercise.
Here's a full breakdown - and what it means.
Here's a full breakdown - and what it means.
Reposting as important:
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
September 6, 2025 at 1:02 PM
Reposting as important:
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA.
Here’s what recent research has found in humans 🧵
🧵 T cell exhaustion - possibly one of the drivers of chronic infections in Long COVID & ME/CFS.
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
September 5, 2025 at 11:02 AM
🧵 T cell exhaustion - possibly one of the drivers of chronic infections in Long COVID & ME/CFS.
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
What is it, what genes are involved, and how we can gain insights with available testing.
Let’s break it down. 🧵
🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS.
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
September 4, 2025 at 3:55 PM
🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS.
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS.
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
September 4, 2025 at 3:54 PM
🔬A major new study shows clear evidence of immune overactivation, energy metabolism failure, gut issues, and worsening after exercise in ME/CFS.
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
Importantly - patients separated into subgroups, a focus by us @amaticahealth
Let’s break it down in simple language 🧵
🔬Viruses don’t just cause short-term illness.
Many stay in your body for life.
They speed up the aging process - in your immune system, organs, and even your DNA.
Here’s some examples, and why stopping them could help extend lifespan🧵
Many stay in your body for life.
They speed up the aging process - in your immune system, organs, and even your DNA.
Here’s some examples, and why stopping them could help extend lifespan🧵
September 4, 2025 at 11:03 AM
🔬Viruses don’t just cause short-term illness.
Many stay in your body for life.
They speed up the aging process - in your immune system, organs, and even your DNA.
Here’s some examples, and why stopping them could help extend lifespan🧵
Many stay in your body for life.
They speed up the aging process - in your immune system, organs, and even your DNA.
Here’s some examples, and why stopping them could help extend lifespan🧵
🔬Interesting aging study - removing a single protein (FTL1) from the brain of old mice restores memory and brain function.
It also improves how brain cells use iron and energy.
Aging reversal is hope for me losing years to chronic illness - let’s break it down.🧵
It also improves how brain cells use iron and energy.
Aging reversal is hope for me losing years to chronic illness - let’s break it down.🧵
September 3, 2025 at 12:48 PM
🔬Interesting aging study - removing a single protein (FTL1) from the brain of old mice restores memory and brain function.
It also improves how brain cells use iron and energy.
Aging reversal is hope for me losing years to chronic illness - let’s break it down.🧵
It also improves how brain cells use iron and energy.
Aging reversal is hope for me losing years to chronic illness - let’s break it down.🧵
Natural Killer (NK) cells are an integral part of your immune system. They help get rid of infected or abnormal cells.
Having been found altered in ME/CFS and Long COVID and predictive for treatments like Daratumumab.
We can gain insights into NK cells through RNA sequencing🧵
Having been found altered in ME/CFS and Long COVID and predictive for treatments like Daratumumab.
We can gain insights into NK cells through RNA sequencing🧵
September 2, 2025 at 3:14 PM
Natural Killer (NK) cells are an integral part of your immune system. They help get rid of infected or abnormal cells.
Having been found altered in ME/CFS and Long COVID and predictive for treatments like Daratumumab.
We can gain insights into NK cells through RNA sequencing🧵
Having been found altered in ME/CFS and Long COVID and predictive for treatments like Daratumumab.
We can gain insights into NK cells through RNA sequencing🧵
🔬Most people think mast cells are only involved in allergies or rare conditions like MCAS or mastocytosis. That’s incorrect.
Research shows mast cells are active in many diseases, including neurodegenerative, autoimmune, infectious, heart, gut, and mental health conditions🧵
Research shows mast cells are active in many diseases, including neurodegenerative, autoimmune, infectious, heart, gut, and mental health conditions🧵
September 1, 2025 at 2:54 PM
🔬Most people think mast cells are only involved in allergies or rare conditions like MCAS or mastocytosis. That’s incorrect.
Research shows mast cells are active in many diseases, including neurodegenerative, autoimmune, infectious, heart, gut, and mental health conditions🧵
Research shows mast cells are active in many diseases, including neurodegenerative, autoimmune, infectious, heart, gut, and mental health conditions🧵
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA - no need for tissue biopsies.
Here’s what recent research has found in humans 🧵
Surprisingly, we can track how this is going using blood RNA - no need for tissue biopsies.
Here’s what recent research has found in humans 🧵
August 31, 2025 at 1:03 PM
🔬 Mitochondria help power cells, and they constantly split (fission) and join (fusion) to stay healthy.
Surprisingly, we can track how this is going using blood RNA - no need for tissue biopsies.
Here’s what recent research has found in humans 🧵
Surprisingly, we can track how this is going using blood RNA - no need for tissue biopsies.
Here’s what recent research has found in humans 🧵
A new study identifies a protein called SMPDL3B as a possible key factor in Myalgic Encephalomyelitis (ME/CFS).
It could explain immune problems, symptom severity, and even point to new treatments.
Here’s a full breakdown - our preliminary RNA data supports this finding: 🧵
It could explain immune problems, symptom severity, and even point to new treatments.
Here’s a full breakdown - our preliminary RNA data supports this finding: 🧵
August 30, 2025 at 1:01 PM
A new study identifies a protein called SMPDL3B as a possible key factor in Myalgic Encephalomyelitis (ME/CFS).
It could explain immune problems, symptom severity, and even point to new treatments.
Here’s a full breakdown - our preliminary RNA data supports this finding: 🧵
It could explain immune problems, symptom severity, and even point to new treatments.
Here’s a full breakdown - our preliminary RNA data supports this finding: 🧵
🔬 A major international study looked at what COVID-19 does to your blood vessels over time.
It found that people who had COVID - especially women - had “older” and stiffer arteries, even months later.
Here’s a simplified breakdown of what they found 🧵
It found that people who had COVID - especially women - had “older” and stiffer arteries, even months later.
Here’s a simplified breakdown of what they found 🧵
August 29, 2025 at 3:04 PM
🔬 A major international study looked at what COVID-19 does to your blood vessels over time.
It found that people who had COVID - especially women - had “older” and stiffer arteries, even months later.
Here’s a simplified breakdown of what they found 🧵
It found that people who had COVID - especially women - had “older” and stiffer arteries, even months later.
Here’s a simplified breakdown of what they found 🧵