Jack - amatica health
@jackamatica.bsky.social
New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths.
Let’s break it down🧵
Let’s break it down🧵
November 14, 2025 at 2:09 PM
New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths.
Let’s break it down🧵
Let’s break it down🧵
1/ New study tested blood from ME/CFS patients for 185 human viruses.
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
November 13, 2025 at 1:50 PM
1/ New study tested blood from ME/CFS patients for 185 human viruses.
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
This is just one example of research papers we can review to gain insights from in relation to RNA data.
You can test all your RNA (20,000 markers per person) and see how you compare to Herberg et al., findings below:
amaticahealth.com/me-cfs-long-...
You can test all your RNA (20,000 markers per person) and see how you compare to Herberg et al., findings below:
amaticahealth.com/me-cfs-long-...
September 22, 2025 at 4:29 PM
This is just one example of research papers we can review to gain insights from in relation to RNA data.
You can test all your RNA (20,000 markers per person) and see how you compare to Herberg et al., findings below:
amaticahealth.com/me-cfs-long-...
You can test all your RNA (20,000 markers per person) and see how you compare to Herberg et al., findings below:
amaticahealth.com/me-cfs-long-...
The key idea is this:
- High IFI44L, low FAM89A → viral infection
- High FAM89A, low IFI44L → bacterial infection
We applied this rule to each preliminary cluster to infer possible infection type.
- High IFI44L, low FAM89A → viral infection
- High FAM89A, low IFI44L → bacterial infection
We applied this rule to each preliminary cluster to infer possible infection type.
September 22, 2025 at 4:29 PM
The key idea is this:
- High IFI44L, low FAM89A → viral infection
- High FAM89A, low IFI44L → bacterial infection
We applied this rule to each preliminary cluster to infer possible infection type.
- High IFI44L, low FAM89A → viral infection
- High FAM89A, low IFI44L → bacterial infection
We applied this rule to each preliminary cluster to infer possible infection type.
🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
September 22, 2025 at 4:29 PM
🔬We identified five preliminary immune clusters (C1–C5) in our Long COVID & ME/CFS cohort using two RNA markers: IFI44L and FAM89A.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
Research shows these genes can help distinguish bacterial from viral infections.
Let’s break down which clusters likely fall into each category.
All markers above can be tested through our full RNA seq panel - 20,000 results per participant:
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
September 20, 2025 at 2:11 PM
All markers above can be tested through our full RNA seq panel - 20,000 results per participant:
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
Study 1: Long COVID + Brain Fog
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
September 20, 2025 at 2:11 PM
Study 1: Long COVID + Brain Fog
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
We are accepting participants into our RNA seq testing @amaticahealth
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
September 20, 2025 at 2:11 PM
We are accepting participants into our RNA seq testing @amaticahealth
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
September 20, 2025 at 2:11 PM
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
As mentioned - markers into everything discussed above can be checked here - 17 spots left in batch 7:
amaticahealth.com/me-cfs-long-...
amaticahealth.com/me-cfs-long-...
September 19, 2025 at 3:18 PM
As mentioned - markers into everything discussed above can be checked here - 17 spots left in batch 7:
amaticahealth.com/me-cfs-long-...
amaticahealth.com/me-cfs-long-...
How do mitochondria produce energy - and what happens when this process breaks down in disease?
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
September 19, 2025 at 3:18 PM
How do mitochondria produce energy - and what happens when this process breaks down in disease?
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
This thread explains mitochondrial energy metabolism in health, cancer, neurodegenerative diseases, and metabolic disorders. 🧵
Checking ADRA2A in our @amaticahealth cohort and it looks like a subgroup is high and low.
Which matches as not all ME/CFS patients respond the same.
Some actually show decreases in ADRA2A after exercise.
This diversity suggests different CDR profiles across patients.
Which matches as not all ME/CFS patients respond the same.
Some actually show decreases in ADRA2A after exercise.
This diversity suggests different CDR profiles across patients.
September 18, 2025 at 3:29 PM
Checking ADRA2A in our @amaticahealth cohort and it looks like a subgroup is high and low.
Which matches as not all ME/CFS patients respond the same.
Some actually show decreases in ADRA2A after exercise.
This diversity suggests different CDR profiles across patients.
Which matches as not all ME/CFS patients respond the same.
Some actually show decreases in ADRA2A after exercise.
This diversity suggests different CDR profiles across patients.
The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury.
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
September 18, 2025 at 3:29 PM
The Cell Danger Response (CDR) is a potential protective process cells use when they're under threat - from infection, toxins, or injury.
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
It's theorised as how your body begins healing.
But when CDR doesn’t complete properly, it can lead to chronic illness - possible ME/CFS & LC. 🧵
🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog.
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
September 17, 2025 at 3:05 PM
🔬 A new study sheds light on why people with Myalgic Encephalomyelitis (ME) experience post-exertional crashes and brain fog.
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
It focuses on a blood protein called haptoglobin (Hp) and how its different genetic forms affect symptoms. 🧵
In the blood, alterations in genes were seen that could indicate a burn out profile and reduced testosterone signalling.
We @amaticahealth will review these markers in participants blood to see if we achieve similar findings.
You can test yours here:
amaticahealth.com/me-cfs-long-...
We @amaticahealth will review these markers in participants blood to see if we achieve similar findings.
You can test yours here:
amaticahealth.com/me-cfs-long-...
September 17, 2025 at 2:01 PM
In the blood, alterations in genes were seen that could indicate a burn out profile and reduced testosterone signalling.
We @amaticahealth will review these markers in participants blood to see if we achieve similar findings.
You can test yours here:
amaticahealth.com/me-cfs-long-...
We @amaticahealth will review these markers in participants blood to see if we achieve similar findings.
You can test yours here:
amaticahealth.com/me-cfs-long-...
🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain.
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
September 17, 2025 at 2:01 PM
🔬 A new study looked at RNA inside the spinal fluid of women with neuropsychiatric Long COVID (brain fog, etc) to understand what’s going wrong in the brain.
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
Let’s break it down 🧵
You can also test your RNA in blood here:
amaticahealth.com/me-cfs-long-...
We @amaticahealth have also found raised NKG2A & TIGIT (suppressive markers on NK cells & hinder immune response)
You can get info on your NK cell function via testing:
amaticahealth.com/me-cfs-long-...
You can get info on your NK cell function via testing:
amaticahealth.com/me-cfs-long-...
September 16, 2025 at 4:36 PM
We @amaticahealth have also found raised NKG2A & TIGIT (suppressive markers on NK cells & hinder immune response)
You can get info on your NK cell function via testing:
amaticahealth.com/me-cfs-long-...
You can get info on your NK cell function via testing:
amaticahealth.com/me-cfs-long-...
🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS.
And into DecodeME findings.
Simplified breakdown 🧵
And into DecodeME findings.
Simplified breakdown 🧵
September 16, 2025 at 4:36 PM
🔬 A large genetic study just found links between specific immune receptor variants (called KIR alleles) and ME/CFS.
And into DecodeME findings.
Simplified breakdown 🧵
And into DecodeME findings.
Simplified breakdown 🧵
All markers above can be tested through our full RNA seq panel - 20,000 results per participant:
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
September 16, 2025 at 3:54 PM
All markers above can be tested through our full RNA seq panel - 20,000 results per participant:
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
amaticahealth.com/me-cfs-long-...
For Research Use Only - not for use in diagnostic procedures. Results are educational, not medical advice, and not validated to assess BBB function.
Study 1: Long COVID + Brain Fog
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
September 16, 2025 at 3:54 PM
Study 1: Long COVID + Brain Fog
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
Researchers sequenced immune cells from Long COVID patients with brain fog. They found:
Increased clotting and complement genes
Decreased adaptive immune genes
This matched signs of a leaky BBB on MRI.
We are accepting participants into our RNA seq testing @amaticahealth
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
September 16, 2025 at 3:54 PM
We are accepting participants into our RNA seq testing @amaticahealth
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
All RNA discussed are included and you can see how your gene expression compares to research.
amaticahealth.com/me-cfs-long-...
Disclaimer: the research & test are not validated as a BBB function diagnostic
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
September 16, 2025 at 3:54 PM
🔬Can we understand the health of the blood-brain barrier (BBB) from a simple blood draw?
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
According to research, yes - by sequencing RNA in whole blood, we can detect changes in genes that affect or reflect BBB function
Here’s how it works and how it’s been done in research 🧵
Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream.
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
September 15, 2025 at 1:06 PM
Leaky gut is when the barrier in your intestines becomes too porous, letting bacteria, toxins, or food particles slip into your bloodstream.
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
This thread breaks down what mRNAs are involved in that process - in plain language and how you can test yourself:
amaticahealth.com/me-cfs-long-...
You can test your own TIGIT - alongside 20,000 other markers, gaining insight into your own disease - while helping progress research:
amaticahealth.com/me-cfs-long-...
amaticahealth.com/me-cfs-long-...
September 12, 2025 at 2:10 PM
You can test your own TIGIT - alongside 20,000 other markers, gaining insight into your own disease - while helping progress research:
amaticahealth.com/me-cfs-long-...
amaticahealth.com/me-cfs-long-...
New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
September 12, 2025 at 2:10 PM
New @amaticahealth preliminary findings: elevated TIGIT in Long COVID & ME/CFS
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively
TIGIT is found on immune cells like T & NK cells
It helps regulate the immune system by acting as a "immune system brake"
This can prevent the body from fighting cancer or infections effectively