Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪

Atrasentan significantly reduced proteinuria in IgA nephropathy patients compared to placebo, showing promise for kidney health.

by Heerspink HJL, Jardine M (...) Barratt J et 9 al. in N Engl J Med #MedSky

📖 read the article: http://www.nejm.org/doi/10.1056/NEJMoa2409415

**NEW BMJ PAPER**

"Uncertainty of risk estimates from clinical prediction models: rationale, challenges, and approaches"

- most models provide just a risk estimate
- we argue for presenting associated uncertainty too
- includes pros, cons, PPIE & methods

Hope helpful!
www.bmj.com/content/388/...

New in the February 13, 2025, issue of NEJM:

Colchicine in Acute Myocardial Infarction (CLEAR trial) nej.md/4i2U6dV

Routine Spironolactone in Acute Myocardial Infarction (CLEAR trial) nej.md/4ftkpIc

Cabozantinib in Advanced Neuroendocrine Tumors (CABINET trial) nej.md/3AYuEoI

#MedSky

A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6
www.science.org/doi/10.1126/...

Atrial fibrillation elevates stroke and heart failure risks, but lifestyle changes and targeted treatments can significantly improve outcomes.

by Ko D, Chung MK (...) Helm RH et 2 al. in JAMA #MedSky

📖 read the article:

A new editorial describes the science behind a clinical trial reported by Ruff et al. in which a monoclonal antibody targeting factors XI and XIa was evaluated for its effects on bleeding events in patients with atrial fibrillation. Read the full editorial: nej.md/3Eg76gw

#MedSky #ScienceSky

A new Science study in mice identifies cross-talk between muscle and the reproductive system and raises questions about interventions to increase muscle mass that might affect fertility.

Learn more in a new #SciencePerspective:

Now available in Open Access:
Body mass index affects imatinib exposure: Real-world evidence from TDM with adaptive dosing
onlinelibrary.wiley.com/doi/full/10....

#pharmacology #imatinib #pharmacokinetics #bodymassindex

1/2 Major release 6.9-0 of #RStats rms package now available on CRAN w/complete re-write of the binary/ordinal logistic regression function lrm. lrm began in 1980 as SAS PROC LOGIST so it was time for a re-do for iterative calculations. Details are at fharrell.com/post/mle

Most viewed in the last 7 days from JAMA: This review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, and management of atrial fibrillation.

https://ja.ma/3ZLQJzx

🧠 Exploration de l'intensité de l'effet placebo dans divers troubles psychiatriques.

💊 L'occasion de rappeler que la manière dont le médecin argumente l'intérêt du traitement (quel qu'il soit) auprès du patient est décisive pour optimiser cet effet placebo

On n'est pas tous égaux face au risque d'insuffisance rénale aiguë sous anti-HTA IV

Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization

www.ajkd.org/article/S027...

#AJKD

Un joli cas clinique pour réviser les effets indésirables hydro-électrolytiques des inhibiteurs de checkpoint ⤵

I've added a little code peer-review activity for the final week of my introductory research methods course. I came across this great concise article which outlines what elements to include for code-review in the sciences: onlinelibrary.wiley.com/doi/full/10....

Abd El Kader AIT TAYEB présente les serious games en Pharmacologie aux journées pédagogiques du @cnpm-fr.bsky.social
Un vrai bénéfice pour les étudiants qui y participent (+2 pts aux partiels) !