Zhaoming Wu
@zhaoming-wu.bsky.social
Assistant Professor at The University of Hong Kong Faculty of Dentistry. Developmental biologist. Craniofacial development. He/him/他/佢.
Reposted by Zhaoming Wu
Activity and retinoic acid drive hair cell spatial patterning in the zebrafish utricle https://www.biorxiv.org/content/10.1101/2025.11.17.687290v1
November 18, 2025 at 10:31 AM
Activity and retinoic acid drive hair cell spatial patterning in the zebrafish utricle https://www.biorxiv.org/content/10.1101/2025.11.17.687290v1
Reposted by Zhaoming Wu
Those who migrate together, develop together.
Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures. #preprint from Axel Newton & team #PaskLab #DevBio
#prelight by Heather Pollington ⬇️👀
prelights.biologists.com/highlights/g...
Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures. #preprint from Axel Newton & team #PaskLab #DevBio
#prelight by Heather Pollington ⬇️👀
prelights.biologists.com/highlights/g...
Getting a head start: Craniofacial heterochrony in marsupials involves dynamic changes to molecular and cellular mechanisms underlying neural crest development - preLights
Those who migrate together, develop together: Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures, providing a potential mechanism that promotes acce...
prelights.biologists.com
November 17, 2025 at 1:36 PM
Those who migrate together, develop together.
Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures. #preprint from Axel Newton & team #PaskLab #DevBio
#prelight by Heather Pollington ⬇️👀
prelights.biologists.com/highlights/g...
Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures. #preprint from Axel Newton & team #PaskLab #DevBio
#prelight by Heather Pollington ⬇️👀
prelights.biologists.com/highlights/g...
Reposted by Zhaoming Wu
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Single-cell susceptibility to viral infection is driven by variable cell states
Not all cells that can be infected by a virus become infected with that virus. Single-cell
clone tracing reveals intrinsic cell states with variable expression patterns that
increase susceptibility to...
www.cell.com
November 14, 2025 at 4:47 PM
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Zhaoming Wu
@xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social reveal cellular mechanisms of tissue fusion in the developing face. They demonstrate that actomyosin-generated forces drive tissue fusion, necessitating an elevated cadherin threshold. rupress.org/jcb/article/...
November 13, 2025 at 5:03 PM
@xsciteng.bsky.social et al. of the @jeffbush.bsky.social lab @ctbatucsf.bsky.social reveal cellular mechanisms of tissue fusion in the developing face. They demonstrate that actomyosin-generated forces drive tissue fusion, necessitating an elevated cadherin threshold. rupress.org/jcb/article/...
Reposted by Zhaoming Wu
I'm thrilled to be able to share this new paper from post-doc Camilla Teng @xsciteng.bsky.social and our collaborators in the Leslie-Clarkson lab @emorygenetics.bsky.social on mechanisms of tissue fusion and cleft lip url: rupress.org/jcb/article/...
Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion | Journal of Cell Biology | Rockefeller University Press
Teng et al. investigate the cellular basis for tissue fusion during mammalian lip formation. They demonstrate that actomyosin contractility drives fusion,
rupress.org
November 13, 2025 at 6:35 PM
I'm thrilled to be able to share this new paper from post-doc Camilla Teng @xsciteng.bsky.social and our collaborators in the Leslie-Clarkson lab @emorygenetics.bsky.social on mechanisms of tissue fusion and cleft lip url: rupress.org/jcb/article/...
Reposted by Zhaoming Wu
Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
James Watson in his own words
“Some anti-Semitism is justified” “Whenever you interview fat people, you feel bad, because you know you’re not going to hire them” “Japan should be bombed for d…
liorpachter.wordpress.com
November 8, 2025 at 4:29 AM
Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
Reposted by Zhaoming Wu
#DBfeature Review
Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth
by Ping Wu et al
www.sciencedirect.com/science/arti...
Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth
by Ping Wu et al
www.sciencedirect.com/science/arti...
November 3, 2025 at 2:22 PM
#DBfeature Review
Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth
by Ping Wu et al
www.sciencedirect.com/science/arti...
Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth
by Ping Wu et al
www.sciencedirect.com/science/arti...
Reposted by Zhaoming Wu
When all your PCRs fail, except for the negative control 😱
October 30, 2025 at 7:43 PM
When all your PCRs fail, except for the negative control 😱
Reposted by Zhaoming Wu
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
October 27, 2025 at 10:31 PM
Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn
Reposted by Zhaoming Wu
Buffering of genetic defects in animal development by regeneration programs https://www.biorxiv.org/content/10.1101/2025.10.25.684558v1
October 27, 2025 at 3:31 AM
Buffering of genetic defects in animal development by regeneration programs https://www.biorxiv.org/content/10.1101/2025.10.25.684558v1
Reposted by Zhaoming Wu
Dorsal forerunner cells transmit epiboly forces to extend the zebrafish notochord https://www.biorxiv.org/content/10.1101/2025.10.24.684459v1
October 25, 2025 at 10:31 AM
Dorsal forerunner cells transmit epiboly forces to extend the zebrafish notochord https://www.biorxiv.org/content/10.1101/2025.10.24.684459v1
Reposted by Zhaoming Wu
Cell-supracellular structural relations solve the French Flag Problem without graded molecular control https://www.biorxiv.org/content/10.1101/2025.10.24.683925v1
October 25, 2025 at 4:31 AM
Cell-supracellular structural relations solve the French Flag Problem without graded molecular control https://www.biorxiv.org/content/10.1101/2025.10.24.683925v1
Reposted by Zhaoming Wu
Fazekas, Kaszás, Vámosi et al @enyedilab.bsky.social describe a #fibroblast-specific synthetic promoter that enables #biosensor expression & targeted ablation in #zebrafish fins & reveal a role for fibroblasts in osmotic surveillance by wound-induced calcium patterns rupress.org/jcb/article/...
October 22, 2025 at 4:01 PM
Fazekas, Kaszás, Vámosi et al @enyedilab.bsky.social describe a #fibroblast-specific synthetic promoter that enables #biosensor expression & targeted ablation in #zebrafish fins & reveal a role for fibroblasts in osmotic surveillance by wound-induced calcium patterns rupress.org/jcb/article/...
Reposted by Zhaoming Wu
ALDH1L1 links folic acid and retinoic acid to prevent neural tube defects https://www.biorxiv.org/content/10.1101/2025.10.14.681787v1
October 15, 2025 at 6:31 AM
ALDH1L1 links folic acid and retinoic acid to prevent neural tube defects https://www.biorxiv.org/content/10.1101/2025.10.14.681787v1
Reposted by Zhaoming Wu
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Reposted by Zhaoming Wu
🐟 Talk about jaw-dropping evolution! 😮 Bahamian pupfishes show huge craniofacial diversity with tiny genetic tweaks. 🎏 Here’s C. desquamator, where 🟠 atp8a1 Is expressed just the jaw muscles (🩷tpm3b)🔬image from @fishfena.bsky.social
#FluorescenceFriday #EvoDevo
#FluorescenceFriday #EvoDevo
October 10, 2025 at 7:51 PM
🐟 Talk about jaw-dropping evolution! 😮 Bahamian pupfishes show huge craniofacial diversity with tiny genetic tweaks. 🎏 Here’s C. desquamator, where 🟠 atp8a1 Is expressed just the jaw muscles (🩷tpm3b)🔬image from @fishfena.bsky.social
#FluorescenceFriday #EvoDevo
#FluorescenceFriday #EvoDevo
Reposted by Zhaoming Wu
Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish https://www.biorxiv.org/content/10.1101/2025.10.10.681632v1
October 12, 2025 at 3:31 AM
Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish https://www.biorxiv.org/content/10.1101/2025.10.10.681632v1
Reposted by Zhaoming Wu
Twilight Sparkle if fully funded! 🦄
Thanks to your generosity, she’ll receive the medication she needs to manage her seizures and live a comfortable life. We’ll keep you pupdated on her journey here ❤️🩹
Thanks to your generosity, she’ll receive the medication she needs to manage her seizures and live a comfortable life. We’ll keep you pupdated on her journey here ❤️🩹
October 10, 2025 at 9:35 PM
Twilight Sparkle if fully funded! 🦄
Thanks to your generosity, she’ll receive the medication she needs to manage her seizures and live a comfortable life. We’ll keep you pupdated on her journey here ❤️🩹
Thanks to your generosity, she’ll receive the medication she needs to manage her seizures and live a comfortable life. We’ll keep you pupdated on her journey here ❤️🩹
Reposted by Zhaoming Wu
CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis https://www.biorxiv.org/content/10.1101/2025.10.08.681206v1
October 9, 2025 at 2:31 AM
CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis https://www.biorxiv.org/content/10.1101/2025.10.08.681206v1
Reposted by Zhaoming Wu
I am co-organising a @cclguk.bsky.social @dmmjournal.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk on 8/6/2026. Great speaker line up, affordable registration and available slots for short talks-spread the word! www.cclg.org.uk/information-...
Developmental origins of paediatric cancer symposium
A one-day event showcasing the latest cutting-edge research on the modelling, biology and treatment of paediatric cancers in the context of their developmental origins.
www.cclg.org.uk
October 6, 2025 at 4:05 PM
I am co-organising a @cclguk.bsky.social @dmmjournal.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk on 8/6/2026. Great speaker line up, affordable registration and available slots for short talks-spread the word! www.cclg.org.uk/information-...
Reposted by Zhaoming Wu
Developmental Biology and Disability.
“Developmental biology is fundamentally beautiful. We are no less beautiful for our variation. Instead, perhaps we are more so. Perhaps we are remarkable. Perhaps we are full of wonder.”
Insightful post by Bethan ⬇️👀
thenode.biologists.com/developmenta...
“Developmental biology is fundamentally beautiful. We are no less beautiful for our variation. Instead, perhaps we are more so. Perhaps we are remarkable. Perhaps we are full of wonder.”
Insightful post by Bethan ⬇️👀
thenode.biologists.com/developmenta...
Developmental Biology and Disability - the Node
Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.
thenode.biologists.com
October 6, 2025 at 12:05 PM
Developmental Biology and Disability.
“Developmental biology is fundamentally beautiful. We are no less beautiful for our variation. Instead, perhaps we are more so. Perhaps we are remarkable. Perhaps we are full of wonder.”
Insightful post by Bethan ⬇️👀
thenode.biologists.com/developmenta...
“Developmental biology is fundamentally beautiful. We are no less beautiful for our variation. Instead, perhaps we are more so. Perhaps we are remarkable. Perhaps we are full of wonder.”
Insightful post by Bethan ⬇️👀
thenode.biologists.com/developmenta...
Reposted by Zhaoming Wu
TWIST1 Modulates Cilia Length, Endocytic Vesicle Dynamics, and Cell-Cell Junctions during Neural Tube Morphogenesis https://www.biorxiv.org/content/10.1101/2025.10.03.680308v1
October 4, 2025 at 7:31 AM
TWIST1 Modulates Cilia Length, Endocytic Vesicle Dynamics, and Cell-Cell Junctions during Neural Tube Morphogenesis https://www.biorxiv.org/content/10.1101/2025.10.03.680308v1
Reposted by Zhaoming Wu
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
October 2, 2025 at 5:11 PM
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
Reposted by Zhaoming Wu
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids
Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.
journals.biologists.com
October 3, 2025 at 9:54 AM
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Reposted by Zhaoming Wu
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇