Glad to see everyone!
October 17, 2025 at 6:31 PM
Glad to see everyone!
Reposted by Zeyun Lu 鲁泽沄
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk - Nature Genetics
SuShiE is a multiancestry fine-mapping method for molecular quantitative trait loci that leverages linkage disequilibrium heterogeneity to improve resolution, infer cross-ancestry effect size correlat...
www.nature.com
July 21, 2025 at 1:56 PM
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Super happy!!!!!
Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025.
These things can take time and patience is key!
These things can take time and patience is key!
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
July 21, 2025 at 8:07 PM
Super happy!!!!!
Reposted by Zeyun Lu 鲁泽沄
I'm become quite partial to cell-type-biased (population-biased) terminology rather than cell-type-specific (population-specific) when it comes to QTLs, because it reflects better that these are a result of power, rather than biological differences.
July 8, 2025 at 4:59 PM
I'm become quite partial to cell-type-biased (population-biased) terminology rather than cell-type-specific (population-specific) when it comes to QTLs, because it reflects better that these are a result of power, rather than biological differences.
Reposted by Zeyun Lu 鲁泽沄
Congrats on the first PhD work!! Very nicely done! @alnahid.bsky.social
traceax: a JAX-based framework for stochastic trace estimation https://www.biorxiv.org/content/10.1101/2025.07.14.662216v1
July 18, 2025 at 11:15 PM
Congrats on the first PhD work!! Very nicely done! @alnahid.bsky.social
Reposted by Zeyun Lu 鲁泽沄
👋 Hi everyone! We're the Center for Genetic Epidemiology, here at Keck School of Medicine, USC! Please follow us for updates on our member's research, community engagement, and activities! Stay tuned for more content 🧬 🧪 💻 👨🔬 👩🔬
November 15, 2023 at 5:56 PM
👋 Hi everyone! We're the Center for Genetic Epidemiology, here at Keck School of Medicine, USC! Please follow us for updates on our member's research, community engagement, and activities! Stay tuned for more content 🧬 🧪 💻 👨🔬 👩🔬
Reposted by Zeyun Lu 鲁泽沄
Our paper on mutli-omics analysis of ischemic stroke is now online! Initiated and led by Dr. Junghyun Jung (now at Cedars) with wonderful support of @adamdesmith.bsky.social . 🧬 academic.oup.com/hmg/advance-...
Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association s...
Abstract. Stroke, characterized by sudden neurological deficits, is the second leading cause of death worldwide. Although genome-wide association studies (GWAS)
academic.oup.com
November 6, 2023 at 5:58 PM
Our paper on mutli-omics analysis of ischemic stroke is now online! Initiated and led by Dr. Junghyun Jung (now at Cedars) with wonderful support of @adamdesmith.bsky.social . 🧬 academic.oup.com/hmg/advance-...
Thank you so much!!!
Great talk from Zeyun Lu on integrating cis-eQTLs with perturb-seq to increase discovery in Mendelian randomization #ASHG2023 !
November 5, 2023 at 12:17 PM
Thank you so much!!!
Reposted by Zeyun Lu 鲁泽沄
Dear statgen friends at #ASHG2023 #ASHG23, my lab is #hiring #phds #postdocs to work on heterogeneity and trajectories of psychiatric disorders using EHR/cohorts across US/Europe/Asia (incl. data from PGC), lots of cool stuff to be done!
Please reach out by email!
Ad link: tinyurl.com/7tae8k
Please reach out by email!
Ad link: tinyurl.com/7tae8k
Postdoctoral Fellow in Statistical Genetics (f/m/x)
tinyurl.com
November 4, 2023 at 11:40 AM
Thank you so much!
Just when I was getting tired of MR - very cool method from @nmancuso.bsky.social and @sashagusevposts.bsky.social, great work and talk by Zeyun Lu!
November 3, 2023 at 9:55 PM
Thank you so much!
Reposted by Zeyun Lu 鲁泽沄
Meet Rosace, a robust deep mutational scanning analysis tool that incorporates positional information and mean-variance shrinkage. Check it out if you are running DMS experiments or handling DMS data! (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance sh...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
October 30, 2023 at 5:11 PM
Meet Rosace, a robust deep mutational scanning analysis tool that incorporates positional information and mean-variance shrinkage. Check it out if you are running DMS experiments or handling DMS data! (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Zeyun Lu 鲁泽沄
I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies. gusevlab.org/projects/hsq/
October 31, 2023 at 5:45 PM
I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies. gusevlab.org/projects/hsq/
Reposted by Zeyun Lu 鲁泽沄
Excited to see Dong's work on a bayesian approach for scalable, ultra-sparse PCA models 🎉
We apply extend the wonderful variational approach of sum of single effects in regression modeling (i.e. SuSiE) to latent factors in order to compute PIPs of loadings. 🧬💻
www.sciencedirect.com/science/arti...
We apply extend the wonderful variational approach of sum of single effects in regression modeling (i.e. SuSiE) to latent factors in order to compute PIPs of loadings. 🧬💻
www.sciencedirect.com/science/arti...
October 31, 2023 at 6:25 PM
Excited to see Dong's work on a bayesian approach for scalable, ultra-sparse PCA models 🎉
We apply extend the wonderful variational approach of sum of single effects in regression modeling (i.e. SuSiE) to latent factors in order to compute PIPs of loadings. 🧬💻
www.sciencedirect.com/science/arti...
We apply extend the wonderful variational approach of sum of single effects in regression modeling (i.e. SuSiE) to latent factors in order to compute PIPs of loadings. 🧬💻
www.sciencedirect.com/science/arti...
Reposted by Zeyun Lu 鲁泽沄
*street fighter voice* "Round 2"
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
Super excited to see my first first-author paper on AJHG, in which we created FactorGo as a scalable tool to learn shared genetic components across traits using thousands of GWAS summary stats. Thanks to mentorship by Drs. @nmancuso.bsky.social and Steven Gazal. www.sciencedirect.com/science/arti...
A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits...
Genome-wide association studies (GWASs) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While …
www.sciencedirect.com
October 25, 2023 at 2:50 AM
*street fighter voice* "Round 2"
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
Reposted by Zeyun Lu 鲁泽沄
Super excited to see my first first-author paper on AJHG, in which we created FactorGo as a scalable tool to learn shared genetic components across traits using thousands of GWAS summary stats. Thanks to mentorship by Drs. @nmancuso.bsky.social and Steven Gazal. www.sciencedirect.com/science/arti...
A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits...
Genome-wide association studies (GWASs) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While …
www.sciencedirect.com
October 25, 2023 at 1:36 AM
Super excited to see my first first-author paper on AJHG, in which we created FactorGo as a scalable tool to learn shared genetic components across traits using thousands of GWAS summary stats. Thanks to mentorship by Drs. @nmancuso.bsky.social and Steven Gazal. www.sciencedirect.com/science/arti...
Reposted by Zeyun Lu 鲁泽沄
Thrilled to see our paper published in AJHG today: Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics
with my amazing advisors @charleston.bsky.social @nmancuso.bsky.social
with my amazing advisors @charleston.bsky.social @nmancuso.bsky.social
Estimating heritability explained by local ancestry and evaluating stratification bias in admixture ...
This study reports a method to estimate heritability explained by local ancestry using
admixture mapping summary statistics and evaluates potential biases in admixture mapping.
The method provides a s...
www.cell.com
October 23, 2023 at 8:33 PM
Thrilled to see our paper published in AJHG today: Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics
with my amazing advisors @charleston.bsky.social @nmancuso.bsky.social
with my amazing advisors @charleston.bsky.social @nmancuso.bsky.social
Reposted by Zeyun Lu 鲁泽沄
So excited to see this out! Tsz Fung developed a model to estimate heritability in complex traits from admixture mapping summary statistics, in a way that adjusts for latent population structure. Please check it out! 🧬 🧬💻
Thrilled to see our paper published in AJHG today: Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics
with my amazing advisors @charleston.bsky.social @nmancuso.bsky.social
with my amazing advisors @charleston.bsky.social @nmancuso.bsky.social
Estimating heritability explained by local ancestry and evaluating stratification bias in admixture ...
This study reports a method to estimate heritability explained by local ancestry using
admixture mapping summary statistics and evaluates potential biases in admixture mapping.
The method provides a s...
www.cell.com
October 23, 2023 at 10:03 PM
So excited to see this out! Tsz Fung developed a model to estimate heritability in complex traits from admixture mapping summary statistics, in a way that adjusts for latent population structure. Please check it out! 🧬 🧬💻
Thrilled to receive this reward! Have learned so much through this conference. And shout out to my amazing advisor Nick!
🎉 Super proud of trainee @zeyunlu.bsky.social for his stellar abstract award and talk on multi ancestry fine mapping of molecular QTL data for PQG 2023! 🎉
October 19, 2023 at 4:54 PM
Thrilled to receive this reward! Have learned so much through this conference. And shout out to my amazing advisor Nick!
Reposted by Zeyun Lu 鲁泽沄
My first skeet on work from our group! In case you need weekend reading, very proud of the new preprint spearheaded by the superb recent PhD, Caoqi Fan, on leveraging the genealogical trees to better infer the demographic histories of human populations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A likelihood-based framework for demographic inference from genealogical trees
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
October 14, 2023 at 1:26 AM
My first skeet on work from our group! In case you need weekend reading, very proud of the new preprint spearheaded by the superb recent PhD, Caoqi Fan, on leveraging the genealogical trees to better infer the demographic histories of human populations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...