Zhongxia Yi
@yzhongxia.bsky.social
Reposted by Zhongxia Yi
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...
rdcu.be
August 5, 2025 at 1:19 PM
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
Reposted by Zhongxia Yi
Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...
Translational activity of 80S monosomes varies dramatically across different tissues
Abstract. Translational regulation at the stage of initiation can impact the number of ribosomes translating each mRNA molecule. However, the translational
academic.oup.com
May 14, 2025 at 4:03 PM
Delighted to share paper on translational activity of 80S monosomes across different tissues in 🪰 in @narjournal.bsky.social thanks to fabulous team Albert Blandy Tayah Hopes Elton Vasconcelos @amy-turner96.bsky.social Bulat Fatkhullin Michaela Agapiou Juan Fontana academic.oup.com/nar/article/...
Reposted by Zhongxia Yi
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 3, 2025 at 7:38 AM
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Zhongxia Yi
They tried this in 2016. There was a big mobilization by scientific societies and us calling representatives, and they stopped. Call your senators. Call them every day. On every issue. Some of them actually care about science because America first or whatever. Use it to protect your trainees.
“Republican lawmakers are considering a change to tax policy that would make college more expensive for students receiving grants and scholarships to help pay their tuition bill.”
Republican Proposal Would Make College Scholarships Taxable Income
Republican lawmakers are considering making college scholarships fully taxable to help pay for continuing tax cuts that mostly benefit wealthy families.
www.forbes.com
January 27, 2025 at 1:00 PM
They tried this in 2016. There was a big mobilization by scientific societies and us calling representatives, and they stopped. Call your senators. Call them every day. On every issue. Some of them actually care about science because America first or whatever. Use it to protect your trainees.
Reposted by Zhongxia Yi
Ohio State stonewalled us on a records request for over six months until we sued them in the Court of Claims.
In retrospect, the Spring Commencement Ceremony's fiasco was somehow even more predictable than we first thought.
www.rooster.info/p/chris-pan-...
In retrospect, the Spring Commencement Ceremony's fiasco was somehow even more predictable than we first thought.
www.rooster.info/p/chris-pan-...
The commencement fiasco emails Ohio State didn't want you to see
The Rooster sued Ohio State in the Court of Claims and won. Here's what we found.
www.rooster.info
January 16, 2025 at 1:48 PM
Ohio State stonewalled us on a records request for over six months until we sued them in the Court of Claims.
In retrospect, the Spring Commencement Ceremony's fiasco was somehow even more predictable than we first thought.
www.rooster.info/p/chris-pan-...
In retrospect, the Spring Commencement Ceremony's fiasco was somehow even more predictable than we first thought.
www.rooster.info/p/chris-pan-...
Reposted by Zhongxia Yi
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
November 30, 2024 at 8:48 PM
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
Reposted by Zhongxia Yi
Breaking:
Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints
$SAVA CEO: "(T)he loss of cognition in the placebo group was less pronounced than ... in other placebo-controlled studies in AD. We are working to understand this better".
www.globenewswire.com/news-release...
Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints
$SAVA CEO: "(T)he loss of cognition in the placebo group was less pronounced than ... in other placebo-controlled studies in AD. We are working to understand this better".
www.globenewswire.com/news-release...
Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints
Simufilam did not show a significant reduction in cognitive or functional decline versus placebo in patients with mild-to-moderate Alzheimer’s disease in...
www.globenewswire.com
November 25, 2024 at 3:32 PM
Breaking:
Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints
$SAVA CEO: "(T)he loss of cognition in the placebo group was less pronounced than ... in other placebo-controlled studies in AD. We are working to understand this better".
www.globenewswire.com/news-release...
Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints
$SAVA CEO: "(T)he loss of cognition in the placebo group was less pronounced than ... in other placebo-controlled studies in AD. We are working to understand this better".
www.globenewswire.com/news-release...
Reposted by Zhongxia Yi
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 22, 2024 at 6:09 PM
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Zhongxia Yi
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
November 19, 2024 at 2:55 AM
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025