🚨 New preprint from the lab!
We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...

tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

Super excited to see beginning integration of PredictDB into OmicsPred!

We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org

More on its way... a wonderful collab with @hakyim.bsky.social & co!

We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors

We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org

More info www.omicspred.org/publication/...

Can deep-learning be used for polygenic risk scores?

New paper out in @natcomms.nature.com!

To find out more read here: www.nature.com/articles/s41...

@mikeinouye.bsky.social @aidanbutty.bsky.social @yuxu.bsky.social

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/

Flexible funding - many research areas in scope + ideas welcome

Check out our group www.inouyelab.org/home

And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

Looks like a nice resource:
* Array genetic data for 80,638 Japanese children
* 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental)
* Parental environmental exposures

www.medrxiv.org/content/10.1...

Interesting week reads and resources on human genetics, omics & precision medicine🧵

1⃣From a dog GWAS to a new obesity target!

DENND1B variants were the top GWAS signal for obesity in 241 Labrador retrievers—DENND1B variants were also associated with BMI in UK Biobank

🔗 science.org/doi/10.1126/...

Wonderful to see our collaboration @astrazeneca.bsky.social @dphpc.bsky.social out! Identification of plasma proteomic markers underlying polygenic risk of T2D and related comorbidities @naturecomms.bsky.social www.nature.com/articles/s41...

Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!

Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)

A month ago we @vevotherapeutics.bsky.social announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with NVidia health to train cell state models.

I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:

📣WOOT! Just out from the lab: Pitfalls of machine learning models for protein-protein interaction networks academic.oup.com/bioinformati...

We benchmark various approaches then dig into why they do well and not so well. Led by @loiclnlg.bsky.social (also of Green Algorithms fame)!

For my debut to bluesky, I am pleased to announce a new preprint:

medrxiv.org/content/10.1...

Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention

Thread 1/3:

📣Cool new print from Scott Ritchie & the lab (www.inouyelab.org)!

Cardiovascular risk prediction using metabolomic biomarkers & polygenic risk scores: A cohort study & modelling analyses medrxiv.org/content/10.1...

tldr Integrating NMR scores & PRSs with SCORE2 may have moderate pop health benefit