Dr. Scott C. Ritchie
@sritchie73.bsky.social
British Heart Foundation Cambridge Centre for Research Excellence Fellow & Assistant Professor of Research in the Department of Public Health and Primary Care at the University of Cambridge
https://scholar.google.com/citations?user=K8qTnLUAAA
https://scholar.google.com/citations?user=K8qTnLUAAA
At #EASD and interested in learning about how polygenic risk scores can be use to improve prediction and prevention of type 2 diabetes? Come see my talk at 17:25 today in the Milan Hall as part of the EASD-ADA Joint Symposium. I'll also be around until Friday afternoon if anyone wants to chat.
September 16, 2025 at 12:44 PM
At #EASD and interested in learning about how polygenic risk scores can be use to improve prediction and prevention of type 2 diabetes? Come see my talk at 17:25 today in the Milan Hall as part of the EASD-ADA Joint Symposium. I'll also be around until Friday afternoon if anyone wants to chat.
Reposted by Dr. Scott C. Ritchie
⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
Research Associate*/Research Assistant in Sustainability of AI (Fixed Term)
An exciting opportunity has arisen for a talented researcher to join our team as part of the Green Algorithms Initiative, one of the leading academic teams in the field of sustainable computing. The
www.cam.ac.uk
September 15, 2025 at 8:50 AM
⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
Reposted by Dr. Scott C. Ritchie
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
June 16, 2025 at 10:33 AM
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
May 17, 2025 at 10:29 PM
Reposted by Dr. Scott C. Ritchie
Reposted by Dr. Scott C. Ritchie
Feeling mildly emotional that this is Green’s last election coverage. He’s covered every Aus election I’ve ever seen, it won’t be the same without him #auspol
May 3, 2025 at 6:56 AM
Feeling mildly emotional that this is Green’s last election coverage. He’s covered every Aus election I’ve ever seen, it won’t be the same without him #auspol
Reposted by Dr. Scott C. Ritchie
Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org !
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease | Molecular Systems Biology
imageimageUsing genetically predicted metabolic reaction fluxes, the authors identify reactions
that can amplify or buffer the effect of coronary artery disease (CAD) risk alleles
on disease susceptib...
www.embopress.org
April 3, 2025 at 4:57 PM
Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org !
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
www.embopress.org/doi/full/10....
A short thread on our key findings 🧵👇
Reposted by Dr. Scott C. Ritchie
📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41...
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
March 4, 2025 at 10:27 AM
📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41...
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
Reposted by Dr. Scott C. Ritchie
Wonderful to see our collaboration @astrazeneca.bsky.social @dphpc.bsky.social out! Identification of plasma proteomic markers underlying polygenic risk of T2D and related comorbidities @naturecomms.bsky.social www.nature.com/articles/s41...
Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!
Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!
March 3, 2025 at 3:01 PM
Wonderful to see our collaboration @astrazeneca.bsky.social @dphpc.bsky.social out! Identification of plasma proteomic markers underlying polygenic risk of T2D and related comorbidities @naturecomms.bsky.social www.nature.com/articles/s41...
Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!
Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!
Reposted by Dr. Scott C. Ritchie
New pre-print led by @hwang_seongwon: "Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes": www.medrxiv.org/content/10.1.... Brief thread follows:
Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes
Background: Statins lower low-density lipoprotein cholesterol (LDL-C) and reduce the risk of coronary artery disease (CAD). However, they also increase the risk of type 2 diabetes (T2D). Methods: We c...
www.medrxiv.org
February 12, 2025 at 11:43 PM
New pre-print led by @hwang_seongwon: "Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes": www.medrxiv.org/content/10.1.... Brief thread follows:
Reposted by Dr. Scott C. Ritchie
Our latest Study just went online:
Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Comparative Analysis Between Olink‐PEA and Alamar‐NULISA Proteomic Technologies Applied to a Critically Ill COVID‐19 Cohort
We aim to verify and validate low-abundant plasma proteins from severe COVID-19 cases and controls through a comparative analysis between Olink and Alamar performances. Eighty-three severe cases and ....
analyticalsciencejournals.onlinelibrary.wiley.com
February 11, 2025 at 12:15 PM
Our latest Study just went online:
Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Dr. Scott C. Ritchie
Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)
February 6, 2025 at 11:09 AM
Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)
Out today in Nature Cardiovascular Research, Rasooly and colleagues utilise multiple sources of multi-omic evidence to identify new drug targets for heart failure with reduced and preserved ejection fraction: www.nature.com/articles/s44...
Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction - Nature Cardiovascular Research
Combining human proteome and transcriptome analyses and Mendelian randomization on a large genetic dataset of HFpEF and HFrEF cases, Rasooly et al. identified 58 potential therapeutic targets specific...
www.nature.com
February 6, 2025 at 12:29 PM
Out today in Nature Cardiovascular Research, Rasooly and colleagues utilise multiple sources of multi-omic evidence to identify new drug targets for heart failure with reduced and preserved ejection fraction: www.nature.com/articles/s44...
Reposted by Dr. Scott C. Ritchie
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease academic.oup.com/eurheartj/ad...
A clinical consensus statement of the ESC Council on Cardiovascular Genomics, ESC Cardiovascular Risk Collaboration and European Association of Preventive Cardiology
A clinical consensus statement of the ESC Council on Cardiovascular Genomics, ESC Cardiovascular Risk Collaboration and European Association of Preventive Cardiology
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular...
Abstract. Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (
academic.oup.com
February 5, 2025 at 10:48 AM
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease academic.oup.com/eurheartj/ad...
A clinical consensus statement of the ESC Council on Cardiovascular Genomics, ESC Cardiovascular Risk Collaboration and European Association of Preventive Cardiology
A clinical consensus statement of the ESC Council on Cardiovascular Genomics, ESC Cardiovascular Risk Collaboration and European Association of Preventive Cardiology
Reposted by Dr. Scott C. Ritchie
A platform for the biomedical application of large language models https://www.nature.com/articles/s41587-024-02534-3 (read free: https://rdcu.be/d68Ih) MIT licensed https://github.com/biocypher/biochatter 🧬🖥️🧪
January 22, 2025 at 4:30 PM
A platform for the biomedical application of large language models https://www.nature.com/articles/s41587-024-02534-3 (read free: https://rdcu.be/d68Ih) MIT licensed https://github.com/biocypher/biochatter 🧬🖥️🧪
Reposted by Dr. Scott C. Ritchie
Excited to be tutoring at the Leena Peltonen School of Human Genetics on July 27-31, alongside a stellar crew. If you’re a late-stage or recently graduated PhD student this is an awesome opportunity to get 1:1 time with faculty at the cutting edge of genomics.
Apply by March 7th at lpshg.com
Apply by March 7th at lpshg.com
December 19, 2024 at 11:37 AM
Excited to be tutoring at the Leena Peltonen School of Human Genetics on July 27-31, alongside a stellar crew. If you’re a late-stage or recently graduated PhD student this is an awesome opportunity to get 1:1 time with faculty at the cutting edge of genomics.
Apply by March 7th at lpshg.com
Apply by March 7th at lpshg.com
Reposted by Dr. Scott C. Ritchie
⏳ Just one more week to apply! 5 roles open in my group working on the Green Algorithms project: 3 research, a Software Engineer Lead and a Community manager/project coordinator
🌱 More details and links to all adverts there: www.green-algorithms.org/join-us/
Closing 25/11
#AcademicSky #SciSky
🌱 More details and links to all adverts there: www.green-algorithms.org/join-us/
Closing 25/11
#AcademicSky #SciSky
🚨We're recruiting! Interested in making science and computing more environmentally friendly? Now's the time!
Very excited to build a research group at Cambridge Uni to expand our Green Algorithms work thanks to the support of the Wellcome Trust
www.green-algorithms.org/join-us
#AcademicSky #SciSky
Very excited to build a research group at Cambridge Uni to expand our Green Algorithms work thanks to the support of the Wellcome Trust
www.green-algorithms.org/join-us
#AcademicSky #SciSky
Interested in joining us?
The Green Algorithms project promotes environmentally sustainable computational science through an online calculator, training material and other tools.
www.green-algorithms.org
November 19, 2024 at 10:08 AM
⏳ Just one more week to apply! 5 roles open in my group working on the Green Algorithms project: 3 research, a Software Engineer Lead and a Community manager/project coordinator
🌱 More details and links to all adverts there: www.green-algorithms.org/join-us/
Closing 25/11
#AcademicSky #SciSky
🌱 More details and links to all adverts there: www.green-algorithms.org/join-us/
Closing 25/11
#AcademicSky #SciSky
Reposted by Dr. Scott C. Ritchie
check out our new preprint led by Charles Zhou and supervised by Mengjie Chen and me doi.org/10.1101/2024... where we present scPrediXcan which integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework
scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type–specific transcriptome-wide association study framework
Transcriptome-wide association studies (TWAS) help identify disease causing genes, but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity ...
doi.org
November 15, 2024 at 2:28 AM
check out our new preprint led by Charles Zhou and supervised by Mengjie Chen and me doi.org/10.1101/2024... where we present scPrediXcan which integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework
Announcing version 3.2.0 of the ukbnmr R package now available on CRAN: cran.r-project.org/web/packages...
This is a major update that makes the package compatible with the UK Biobank Research Analysis Platform and shows removal of technical variation on the full NMR data release coming Jan 2025
This is a major update that makes the package compatible with the UK Biobank Research Analysis Platform and shows removal of technical variation on the full NMR data release coming Jan 2025
ukbnmr: Removal of Unwanted Technical Variation from UK Biobank NMR Metabolomics Biomarker Data
A suite of utilities for working with the UK Biobank <<a href="https://www.ukbiobank.ac.uk/" target="_top">https://www.ukbiobank.ac.uk/</a>> Nuclear Magnetic Resonance spectroscopy (NMR) metabol...
cran.r-project.org
November 20, 2024 at 5:46 PM
Announcing version 3.2.0 of the ukbnmr R package now available on CRAN: cran.r-project.org/web/packages...
This is a major update that makes the package compatible with the UK Biobank Research Analysis Platform and shows removal of technical variation on the full NMR data release coming Jan 2025
This is a major update that makes the package compatible with the UK Biobank Research Analysis Platform and shows removal of technical variation on the full NMR data release coming Jan 2025
For my debut to bluesky, I am pleased to announce a new preprint:
medrxiv.org/content/10.1...
Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention
Thread 1/3:
medrxiv.org/content/10.1...
Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention
Thread 1/3:
November 20, 2024 at 5:46 PM
For my debut to bluesky, I am pleased to announce a new preprint:
medrxiv.org/content/10.1...
Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention
Thread 1/3:
medrxiv.org/content/10.1...
Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention
Thread 1/3: