Luke Yaeger
@yaegerluke.bsky.social
Burrows Lab McMaster U 🧫 -> Lewis Lab Northeastern U 💊 -> Cowen Lab U Toronto 🍄 Natural Product Antimicrobials and Microbial Cell Envelope Genetics
Reposted by Luke Yaeger
Streptavidins play a multifunctional role within a biotin-pathway antibiotic network encoded in a biosynthetic supercluster https://www.biorxiv.org/content/10.1101/2025.11.10.687665v1
November 12, 2025 at 2:16 AM
Streptavidins play a multifunctional role within a biotin-pathway antibiotic network encoded in a biosynthetic supercluster https://www.biorxiv.org/content/10.1101/2025.11.10.687665v1
Reposted by Luke Yaeger
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg
October 20, 2025 at 7:46 AM
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg
Reposted by Luke Yaeger
I'm delighted to share a useful FREE web-based app portal of powerful bioinformatics tools for microbial genomes and shotgun microbiome sequences!
It's called Micromics and is built by Middle Author Bioinformatics, led by co-founder @ironark.bsky.social
omix.midauthorbio.com
It's called Micromics and is built by Middle Author Bioinformatics, led by co-founder @ironark.bsky.social
omix.midauthorbio.com
Microbial Omics
A suite of bioinformatics tools for microbial genome and metagenome analysis.
omix.midauthorbio.com
April 8, 2025 at 12:11 PM
I'm delighted to share a useful FREE web-based app portal of powerful bioinformatics tools for microbial genomes and shotgun microbiome sequences!
It's called Micromics and is built by Middle Author Bioinformatics, led by co-founder @ironark.bsky.social
omix.midauthorbio.com
It's called Micromics and is built by Middle Author Bioinformatics, led by co-founder @ironark.bsky.social
omix.midauthorbio.com
Reposted by Luke Yaeger
New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM
February 3, 2025 at 8:52 AM
New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM
Reposted by Luke Yaeger
Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...
LoVis4u: a locus visualization tool for comparative genomics and coverage profiles
Abstract. Comparative genomic analysis often involves visualization of alignments of genomic loci. While several software tools are available for this task
academic.oup.com
February 25, 2025 at 7:27 AM
Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...
Reposted by Luke Yaeger
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients
It is widely believed that due to nutrient limitations in natural environments, bacteria spend most of their life in non-growing states. However, very little is known about how bacteria change their p...
www.biorxiv.org
January 15, 2025 at 11:12 AM
What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Luke Yaeger
Confirmed speakers for the next Great Wall Symposium is coming along! thegreatwall-symposium.org/program/
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
January 10, 2025 at 9:44 AM
Confirmed speakers for the next Great Wall Symposium is coming along! thegreatwall-symposium.org/program/
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
Abstracts will open next week 15th so start thinking!
September 15-17th, Catania, Sicily
Its a Microbiological opportunity you cant refuse!
Reposted by Luke Yaeger
A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae https://www.biorxiv.org/content/10.1101/2024.12.27.630553v1
December 28, 2024 at 8:21 AM
A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae https://www.biorxiv.org/content/10.1101/2024.12.27.630553v1
Reposted by Luke Yaeger
Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2024.12.05.627103v1
December 7, 2024 at 2:16 AM
Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2024.12.05.627103v1
Reposted by Luke Yaeger
tagging #MicroSky
December 5, 2024 at 2:09 PM
tagging #MicroSky
Reposted by Luke Yaeger
🚨 PhD opportunity 🚨 The Whelan lab, along w @brockhurstlab.bsky.social, are looking for a PhD student w bioinformatic experience/interest to investigate the evolution of transmissibility in bacterial pathogens, with a focus on P. aeruginosa. More info & link to apply below.
Please spread the word!
Please spread the word!
www.findaphd.com
December 3, 2024 at 12:49 PM
🚨 PhD opportunity 🚨 The Whelan lab, along w @brockhurstlab.bsky.social, are looking for a PhD student w bioinformatic experience/interest to investigate the evolution of transmissibility in bacterial pathogens, with a focus on P. aeruginosa. More info & link to apply below.
Please spread the word!
Please spread the word!
Reposted by Luke Yaeger
Just in time for #WAAW - new collab paper with the Strynadka lab at UBC on structure/function of #peptidoglycan fragment recycling transporter AmpG involved in AmpC-related beta lactam resistance. www.nature.com/articles/s41... @yaegerluke.bsky.social
Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance - Nature Communications
AmpG is an MFS importer of bacterial cell wall fragments. Here, authors present a cryoEM structure and supporting mutagenesis to illuminate AmpG’s essential role in bacterial fitness and derepression ...
www.nature.com
November 19, 2024 at 12:18 PM
Just in time for #WAAW - new collab paper with the Strynadka lab at UBC on structure/function of #peptidoglycan fragment recycling transporter AmpG involved in AmpC-related beta lactam resistance. www.nature.com/articles/s41... @yaegerluke.bsky.social