C.A.M(Xander)_de_Haan.bsky.social
@xdh.bsky.social
Molecular Virology, IAV, PMV, CoV, RSV, EEHV, Associate professor at Utrecht University.
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus - npj Viruses
npj Viruses - Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus
www.nature.com
July 30, 2025 at 4:20 PM
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
July 30, 2025 at 4:54 PM
Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
July 30, 2025 at 3:28 PM
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
Virion motility of sialoglycan-cleaving respiratory viruses - npj Viruses
npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses
doi.org
July 29, 2025 at 3:24 PM
New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
July 22, 2025 at 11:33 AM
We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social
Full article: Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening. Nice work by former PhD student Xuesheng Wu. Many thanks to our collaborators!
July 21, 2025 at 2:05 PM
Full article: Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening. Nice work by former PhD student Xuesheng Wu. Many thanks to our collaborators!
Reposted by C.A.M(Xander)_de_Haan.bsky.social
We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!
June 11, 2025 at 11:42 AM
We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!
www.cell.com/iscience/ful... Great work by Mengying Liu and others!
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection
Biological sciences; Microbiology; Natural sciences; Virology
www.cell.com
June 11, 2025 at 11:54 AM
www.cell.com/iscience/ful... Great work by Mengying Liu and others!
Reposted by C.A.M(Xander)_de_Haan.bsky.social
There's still time to submit your molecular biology abstracts to this year's #ESWI2025 meeting on #Influenza, #RSV and #SARSCoV2. The ESWI meetings are a brilliant way to see your work in context, as they consider these respiratory viruses all the way from molecular biology to policy...
#ESWI2025 🚀 Extra call for abstracts in Molecular Virology – now open!
🚨 Deadline is 31 July 2025 at 23:59 CET
📢 Don’t miss your chance to contribute — submit now!
➡️ eswiconference.org/abstract-sub...
🚨 Deadline is 31 July 2025 at 23:59 CET
📢 Don’t miss your chance to contribute — submit now!
➡️ eswiconference.org/abstract-sub...
June 4, 2025 at 7:46 PM
There's still time to submit your molecular biology abstracts to this year's #ESWI2025 meeting on #Influenza, #RSV and #SARSCoV2. The ESWI meetings are a brilliant way to see your work in context, as they consider these respiratory viruses all the way from molecular biology to policy...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Eurosurveillanc : Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023
Dirk Eggink et al
www.eurosurveillance.org/content/10.2...
Dirk Eggink et al
www.eurosurveillance.org/content/10.2...
May 15, 2025 at 8:32 PM
Eurosurveillanc : Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023
Dirk Eggink et al
www.eurosurveillance.org/content/10.2...
Dirk Eggink et al
www.eurosurveillance.org/content/10.2...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 7:51 PM
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Also - we eradicated rinderpest in 2010 (joining smallpox as only diseases eradicated).
Turns out fewer anti-vaxxers among cattle 🤦🏻♂️
Turns out fewer anti-vaxxers among cattle 🤦🏻♂️
Measles likely came from cows (via rinderpest) around the 6th century BCE.
For 2,500 years, we didn’t evolve superhuman resistance—children just died. Real protection only came in the 1960s, with vaccines.
Our superpower isn’t evolving into superhumans. It’s outthinking pathogens.
For 2,500 years, we didn’t evolve superhuman resistance—children just died. Real protection only came in the 1960s, with vaccines.
Our superpower isn’t evolving into superhumans. It’s outthinking pathogens.
Measles virus and rinderpest virus divergence dated to the sixth century BCE
Measles virus diverged from rinderpest virus in the sixth century BCE, indicating an early origin for human measles.
www.science.org
May 12, 2025 at 7:42 PM
Also - we eradicated rinderpest in 2010 (joining smallpox as only diseases eradicated).
Turns out fewer anti-vaxxers among cattle 🤦🏻♂️
Turns out fewer anti-vaxxers among cattle 🤦🏻♂️
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease journals.asm.org/doi/10.1128/...
Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease | Journal of Virology
There is a great need to better understand correlates of protection (CoP) against
influenza A and B viruses (IAV/IBV). In our study, we analyzed paired plasma and nasal
swabs from patients presenting ...
journals.asm.org
May 13, 2025 at 4:08 PM
Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease journals.asm.org/doi/10.1128/...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Saudi Arabia confirms 9 MERS cases, including hospital cluster www.cidrap.umn.edu/mers-cov/sau...
Saudi Arabia confirms 9 MERS cases, including hospital cluster
www.cidrap.umn.edu
May 13, 2025 at 8:14 PM
Saudi Arabia confirms 9 MERS cases, including hospital cluster www.cidrap.umn.edu/mers-cov/sau...
Next week I will move to the lab of Adolfo Garcia-Sastre at Mount Sinai for a three month sabbatical. Looking forward to meeting many old and new colleagues and friends and to visiting NYC itself!
April 24, 2025 at 6:32 PM
Next week I will move to the lab of Adolfo Garcia-Sastre at Mount Sinai for a three month sabbatical. Looking forward to meeting many old and new colleagues and friends and to visiting NYC itself!
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Time for the Dutch Annual Virology Symposium, in the beautiful Geertekerk in Utrecht. Stoked to present our work on antibody sequencing 😁
March 21, 2025 at 8:29 AM
Time for the Dutch Annual Virology Symposium, in the beautiful Geertekerk in Utrecht. Stoked to present our work on antibody sequencing 😁
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Uganda’s Ebola Sudan outbreak appears stable
No transmission has been found outside of a single chain, and eight patients in treatment are stable.
www.cidrap.umn.edu/e...
Photo: NIAID/Flickr cc
No transmission has been found outside of a single chain, and eight patients in treatment are stable.
www.cidrap.umn.edu/e...
Photo: NIAID/Flickr cc
February 13, 2025 at 9:43 PM
Uganda’s Ebola Sudan outbreak appears stable
No transmission has been found outside of a single chain, and eight patients in treatment are stable.
www.cidrap.umn.edu/e...
Photo: NIAID/Flickr cc
No transmission has been found outside of a single chain, and eight patients in treatment are stable.
www.cidrap.umn.edu/e...
Photo: NIAID/Flickr cc
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Do you like doing experiments on influenza virus particles but want them to be super-squeaky clean? Or perhaps you'd like to work with filamentous influenza virions but don't know how? Jack Hirst has the protocol chapter for you: link.springer.com/protocol/10....
Purification of Influenza Virions
This chapter describes basic workflows for concentrating and for purifying influenza virions. It presents several ways in which ultracentrifugation can be used to concentrate influenza virions from th...
link.springer.com
February 4, 2025 at 3:28 PM
Do you like doing experiments on influenza virus particles but want them to be super-squeaky clean? Or perhaps you'd like to work with filamentous influenza virions but don't know how? Jack Hirst has the protocol chapter for you: link.springer.com/protocol/10....
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Clear statement from the virology community
Dear Virology Community, please see ASV’s statement to our members and the scientific community. asv.org/asv-statemen...
ASV Statement for our Members | American Society for Virology
Our American Society for Virology (ASV) promotes the study and combatting of viruses, more than ever recognizing their importance and responding to them with research and education. Our academic…
asv.org
February 14, 2025 at 3:33 PM
Clear statement from the virology community
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens journals.asm.org/doi/10.1128/...
Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens | Journal of Virology
Avian influenza poses significant economic challenges to the poultry industry and
presents potential risks to human health. Understanding the molecular mechanisms that
facilitate the emergence of chic...
journals.asm.org
February 14, 2025 at 3:46 PM
Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens journals.asm.org/doi/10.1128/...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes www.nature.com/articles/s41...
Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes - Nature Communications
Structurally convergent antibodies targeting the conserved influenza HA anchor epitope have provided a template for next-generation vaccine development. The authors identified four anchor antibodies e...
www.nature.com
February 7, 2025 at 12:18 PM
Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes www.nature.com/articles/s41...
Reposted by C.A.M(Xander)_de_Haan.bsky.social
With participation of Jimin Lee, Jack Brown, Risako Gen, @dabiophysicist.bsky.social, Cameron Stewart in our lab & in collaboration with the labs of Huan Yan and Tyler Starr
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses
Two coronaviruses related to MERS-CoV, which infect European Pipistrellus bats, have
been found to use ACE2 as their receptor. These viruses target an ACE2 surface region
distant from those recognized...
www.cell.com
February 7, 2025 at 4:12 PM
With participation of Jimin Lee, Jack Brown, Risako Gen, @dabiophysicist.bsky.social, Cameron Stewart in our lab & in collaboration with the labs of Huan Yan and Tyler Starr
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Since the emergence of clade 2.3.4.4 H5 viruses, they have shown a remarkable ability to team up with other NA subtypes (and with N1 without a stalk deletion). This in contrast to the “old” H5. Presumably linked to changes in receptor binding. After N2, N6, and N8, we now find N9.
Tests identify H5N9 avian flu at California duck farm www.cidrap.umn.edu/avian-influe...
Tests identify H5N9 avian flu at California duck farm
www.cidrap.umn.edu
January 28, 2025 at 7:30 AM
Since the emergence of clade 2.3.4.4 H5 viruses, they have shown a remarkable ability to team up with other NA subtypes (and with N1 without a stalk deletion). This in contrast to the “old” H5. Presumably linked to changes in receptor binding. After N2, N6, and N8, we now find N9.
Reposted by C.A.M(Xander)_de_Haan.bsky.social
This is bad news. It suggests reassortment of circulating H5N1 viruses with viruses containing N9 NA.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
1st U.S. case of H5N9 bird flu (different from H5N1) reported on California duck farm
1st U.S. case of H5N9 bird flu reported on California duck farm - National | Globalnews.ca
The United States has reported its first outbreak of H5N9 bird flu in poultry on a duck farm in California, the World Organization for Animal Health (WOAH) said on Monday.
globalnews.ca
January 27, 2025 at 10:43 PM
This is bad news. It suggests reassortment of circulating H5N1 viruses with viruses containing N9 NA.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.
Although this indicates reassortment with avian viruses, it's still bad. Reassortment makes pandemics. The last 3/4 flu pandemics (and likely 1918 too) were reassortant viruses.