Immunology & Microbial Pathogenesis (IMP) Program
@wcm-imp.bsky.social
IMP is a joint graduate school program and partnership between Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Hospital for Special Surgery
Learn More: https://gradschool.weill.cornell.edu/programs/immunology-microbial-pathogenesis
Learn More: https://gradschool.weill.cornell.edu/programs/immunology-microbial-pathogenesis
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🚀 New to Bluesky? Dive into the Immunology & Microbial Pathogenesis (IMP) community! 🌟 Follow our starter pack of IMP faculty accounts to stay connected, learn, and engage with the latest in research & updates: go.bsky.app/97vN2qB
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🚨Thrilled to share our latest work, published online today
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/
www.nature.com/articles/s41...
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/
www.nature.com/articles/s41...
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome - Nature
Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
www.nature.com
November 4, 2025 at 12:52 AM
🚨Thrilled to share our latest work, published online today
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/
www.nature.com/articles/s41...
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/
www.nature.com/articles/s41...
Our IMP Retreat also featured an exciting poster session showcasing outstanding research from our students and postdocs. Congratulations to this year’s poster award winners for their excellent presentations and contributions to our vibrant scientific community!
October 27, 2025 at 4:58 PM
Our IMP Retreat also featured an exciting poster session showcasing outstanding research from our students and postdocs. Congratulations to this year’s poster award winners for their excellent presentations and contributions to our vibrant scientific community!
IMP Program held its annual scientific retreat last week, we heard presentations from our faculty, students, and postdocs. A keynote address by Dr. Brian Brown from the Icahn School of Medicine. Though held locally on campus this year, it was an engaging celebration of our program community!
October 27, 2025 at 4:55 PM
IMP Program held its annual scientific retreat last week, we heard presentations from our faculty, students, and postdocs. A keynote address by Dr. Brian Brown from the Icahn School of Medicine. Though held locally on campus this year, it was an engaging celebration of our program community!
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1
Antigen-presenting cells as arbiters of mucosal tolerance and immunity
Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.
urldefense.com
October 17, 2025 at 12:22 PM
Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1
Sound advice from IMP faculty member Roberta Zappasodi:
“be creative in your science, but be equally inventive—and strategic—in how you chart your course toward the research program you want to build.”
“be creative in your science, but be equally inventive—and strategic—in how you chart your course toward the research program you want to build.”
Latest in our #WomenInSTEM series from researchers discussing their science and the process of setting up a lab as an independent researcher, as well as the unique challenges they face as women scientists in their respective scientific environments: rupress.org/jem/article/...
October 23, 2025 at 3:05 PM
Sound advice from IMP faculty member Roberta Zappasodi:
“be creative in your science, but be equally inventive—and strategic—in how you chart your course toward the research program you want to build.”
“be creative in your science, but be equally inventive—and strategic—in how you chart your course toward the research program you want to build.”
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Meet #MSKPostdoc Jin Gyu Cheong from the Niec Lab! He studies how blood stem cells “remember” inflammation - shaping future immune responses and fueling diseases like Crohn’s. He’s also exploring links to colitis from cancer immunotherapy. #NPAW2025🇰🇷
September 29, 2025 at 3:55 PM
Meet #MSKPostdoc Jin Gyu Cheong from the Niec Lab! He studies how blood stem cells “remember” inflammation - shaping future immune responses and fueling diseases like Crohn’s. He’s also exploring links to colitis from cancer immunotherapy. #NPAW2025🇰🇷
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Meet #MSKPostdoc Xiao Huang (@drxiaohuang.bsky.social) from the Rudensky Lab! Xiao investigates how different subsets of regulatory T (Treg) cells adapt to tissues and immune challenges to maintain immune balance in health and disease. #NPAW2025 🇨🇳
September 30, 2025 at 6:32 PM
Meet #MSKPostdoc Xiao Huang (@drxiaohuang.bsky.social) from the Rudensky Lab! Xiao investigates how different subsets of regulatory T (Treg) cells adapt to tissues and immune challenges to maintain immune balance in health and disease. #NPAW2025 🇨🇳
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Working with rare immune populations? We describe an optimized low-input ATAC-seq workflow for tissue ILCs, allowing for reproducible epigenetic profiling. Technical report now out at EJI @EurJImmunol: onlinelibrary.wiley.com/doi/10.1002/.... Have a look!
Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells
Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is valid...
onlinelibrary.wiley.com
October 6, 2025 at 7:06 AM
Working with rare immune populations? We describe an optimized low-input ATAC-seq workflow for tissue ILCs, allowing for reproducible epigenetic profiling. Technical report now out at EJI @EurJImmunol: onlinelibrary.wiley.com/doi/10.1002/.... Have a look!
Congratulations to the lab of IMP faculty member Sasha Rudensky on their latest study! @mskcancercenter.bsky.social
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells - Nature Immunology
Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for Treg cell transcriptional and functional programs.
www.nature.com
October 9, 2025 at 5:16 AM
Congratulations to the lab of IMP faculty member Sasha Rudensky on their latest study! @mskcancercenter.bsky.social
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Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:
National Academy of Medicine to Present Hamburg Award to Carl F. Nathan for Seminal Discoveries That Improve Understanding of Innate Immunity - NAM
WASHINGTON — The National Academy of Medicine (NAM) today announced that Carl F. Nathan is the recipient of the 2025 David and Beatrix Hamburg Award for
nam.edu
September 26, 2025 at 7:23 PM
Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
It's been a great & productive summer, we had fantastic #undergraduates :) but September is HERE and we are looking for new #POSTDOCS - effective immediately! please spread the word and if interested - let us know! We are into #transcription #inflammation #epigenomics #NuclearReceptors #macrophages
August 29, 2025 at 4:15 AM
It's been a great & productive summer, we had fantastic #undergraduates :) but September is HERE and we are looking for new #POSTDOCS - effective immediately! please spread the word and if interested - let us know! We are into #transcription #inflammation #epigenomics #NuclearReceptors #macrophages
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
The #cancer #microbiome: the facts, the myth, and our take on it- with @abdohlman.bsky.social , Xiangyu Pan and Laurence Zitvogel. Out now @natmicrobiol.nature.com just in time for the start of the academic year @wcm-imp.bsky.social. www.nature.com/articles/s41...
The multi-kingdom cancer microbiome - Nature Microbiology
This Review discusses what comprises the ‘cancer microbiome’, summarizing the studies on tumour-associated microbes, examining the evidence and assessing their impact on the disease.
www.nature.com
September 10, 2025 at 3:26 PM
The #cancer #microbiome: the facts, the myth, and our take on it- with @abdohlman.bsky.social , Xiangyu Pan and Laurence Zitvogel. Out now @natmicrobiol.nature.com just in time for the start of the academic year @wcm-imp.bsky.social. www.nature.com/articles/s41...
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Closing the 1st part of the #MSKPostdoc Symposium: Adriana Mujal, Kravis WiSE Fellow from the Sun lab, explores what drives natural killer (NK) cell activation across tissues. These immune warriors rapidly destroy infected or malignant cells - key to our body’s defense🛡️ #NPAW2025
September 18, 2025 at 7:53 PM
Closing the 1st part of the #MSKPostdoc Symposium: Adriana Mujal, Kravis WiSE Fellow from the Sun lab, explores what drives natural killer (NK) cell activation across tissues. These immune warriors rapidly destroy infected or malignant cells - key to our body’s defense🛡️ #NPAW2025
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Good news shouldn’t wait, but it’s been a hectic work-heavy summer. I am delighted and honored to be among the Kenneth Rainin Foundation 2025 Innovator Award Grantees. Thank you to @krfoundation.org for supporting our work.
krfoundation.org/news/health/...
krfoundation.org/our-work/hea...
krfoundation.org/news/health/...
krfoundation.org/our-work/hea...
Over $4 Million Awarded In IBD Research Grants - Kenneth Rainin Foundation
The 2025 Innovator Awards grantee projects explore new ways to reduce inflammation and restore gut health, targeted treatment options with fewer side effects and the chance for lasting healing, and th...
krfoundation.org
September 19, 2025 at 7:22 PM
Good news shouldn’t wait, but it’s been a hectic work-heavy summer. I am delighted and honored to be among the Kenneth Rainin Foundation 2025 Innovator Award Grantees. Thank you to @krfoundation.org for supporting our work.
krfoundation.org/news/health/...
krfoundation.org/our-work/hea...
krfoundation.org/news/health/...
krfoundation.org/our-work/hea...
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 5, 2025 at 6:53 PM
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Congratulations to IMP faculty member David Artis and his team on their new paper investigating how the neuropeptide adrenomedullin 2 promotes protective gut ILC2 responses and reduces inflammation, highlighting a novel neuro-immune circuit!
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology
Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.
www.nature.com
August 19, 2025 at 4:58 AM
Congratulations to IMP faculty member David Artis and his team on their new paper investigating how the neuropeptide adrenomedullin 2 promotes protective gut ILC2 responses and reduces inflammation, highlighting a novel neuro-immune circuit!
Fantastic to see two former IMP postdocs @thepenkpanther.bsky.social and @coraline-mly.bsky.social highlighted by JEM in this Viewpoint! #WomeninSTEM
In this Viewpoint, we asked women researchers across multiple research fields about their story of becoming an independent researcher and unique challenges they face as #WomenInSTEM in their respective scientific environments: rupress.org/jem/article/...
August 10, 2025 at 3:31 AM
Fantastic to see two former IMP postdocs @thepenkpanther.bsky.social and @coraline-mly.bsky.social highlighted by JEM in this Viewpoint! #WomeninSTEM
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Have a look at this new study by Dr. Celeste Dang in @natimmunol.nature.com showing an interesting new role for the transcription factor TCF19 in driving antiviral NK cell function. Congrats Celeste for driving this one to the finish line! @mskcancercenter.bsky.social
TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells - Nature Immunology
Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral in...
www.nature.com
August 8, 2025 at 1:17 PM
Have a look at this new study by Dr. Celeste Dang in @natimmunol.nature.com showing an interesting new role for the transcription factor TCF19 in driving antiviral NK cell function. Congrats Celeste for driving this one to the finish line! @mskcancercenter.bsky.social
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Thrilled to share that I was selected for the @hhmi.org Gilliam Fellowship! Extremely grateful to my PI @justinperryphd.bsky.social and my lab mates (Jesús and Shasha) for their incredible support! Excited for many discoveries and outreach within @wcm-imp.bsky.social
www.hhmi.org/programs/gil...
www.hhmi.org/programs/gil...
The 2025 Gilliam Fellows & Advisors | HHMI
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
www.hhmi.org
August 7, 2025 at 9:57 PM
Thrilled to share that I was selected for the @hhmi.org Gilliam Fellowship! Extremely grateful to my PI @justinperryphd.bsky.social and my lab mates (Jesús and Shasha) for their incredible support! Excited for many discoveries and outreach within @wcm-imp.bsky.social
www.hhmi.org/programs/gil...
www.hhmi.org/programs/gil...
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Exciting first post! With @drshrutinaik.bsky.social and many others! www.nature.com/articles/s41...
PD-1 is requisite for skin TRM cell formation and specification by TGFβ - Nature Immunology
Anandasabapathy and colleagues show that the inhibitory receptor PD-1 impacts the specification of tissue-resident memory T cells in the skin.
www.nature.com
July 29, 2025 at 3:18 PM
Exciting first post! With @drshrutinaik.bsky.social and many others! www.nature.com/articles/s41...
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
www.biorxiv.org
July 28, 2025 at 9:43 PM
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
It's official. I'm happy to announce that I have been promoted to Associate Member @mskcancercenter.bsky.social. It is sincere when I say that this would not have been possible w/o the incredible work of the members of my lab. In fact, exciting news about them coming soon. Stay tuned.
July 26, 2025 at 6:58 PM
It's official. I'm happy to announce that I have been promoted to Associate Member @mskcancercenter.bsky.social. It is sincere when I say that this would not have been possible w/o the incredible work of the members of my lab. In fact, exciting news about them coming soon. Stay tuned.
🎉Huge congrats to Kathleen Mills, PhD, on being named a 2025 ICIS Young Investigator Awardee! Her success reflects the drive and excellence we see across our IMP students! You've done amazing work in the Hohl lab.👏We wish you the best, onward and upward! signals.cytokinesociety.org/2025/07/14/2...
Congratulations 2025 ICIS Young Investigators! - Biweekly newsletter of the International Cytokine & Interferon Society
The International Cytokine & Interferon Society proudly announces these 2025 Young Investigator Award winners. The Sidney & Joan Pestka Graduate and Post-Graduate Awards, sponsored by PBL Assay Services Post-graduate awardee, Alexander Lercher, PhD, The Rockefeller University is currently an HFSP long-term fellow and Harvey L. Karp postdoctoral fellow in the laboratory of Charles M. Rice
signals.cytokinesociety.org
July 17, 2025 at 4:23 PM
🎉Huge congrats to Kathleen Mills, PhD, on being named a 2025 ICIS Young Investigator Awardee! Her success reflects the drive and excellence we see across our IMP students! You've done amazing work in the Hohl lab.👏We wish you the best, onward and upward! signals.cytokinesociety.org/2025/07/14/2...
Reposted by Immunology & Microbial Pathogenesis (IMP) Program
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...