Alex Gitlin
gitlinlabmsk.bsky.social
Alex Gitlin
@gitlinlabmsk.bsky.social
Assistant Member/Professor, Lab Head @MSKCancerCenter. #PhysicianScientist #Immunologist. Views my own.
Pinned
🚨Thrilled to share our latest work, published online today
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/

www.nature.com/articles/s41...
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome - Nature
Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
www.nature.com
Reposted by Alex Gitlin
🚨Thrilled to share our latest work, published online today
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/

www.nature.com/articles/s41...
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome - Nature
Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
www.nature.com
November 4, 2025 at 12:52 AM
Reposted by Alex Gitlin
🚨Thrilled to share our latest work, published online today
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/

www.nature.com/articles/s41...
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome - Nature
Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
www.nature.com
November 4, 2025 at 12:52 AM
Reposted by Alex Gitlin
Congratulations to IMP faculty members Chryssie Brown @chrysothemisbrown.bsky.social and Alex Gitlin @gitlinlabmsk.bsky.social on receiving the 2025 Pershing Square Prize!! 🎉
May 31, 2025 at 6:25 AM
Reposted by Alex Gitlin
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 6, 2025 at 9:30 PM
Reposted by Alex Gitlin
Congratulations to Dr. Adriana Mujal on this @cp-immunity.bsky.social study demonstrating a new role for an age old cytokine! www.cell.com/immunity/ful...
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells
NK cells possess innate and adaptive features, but unlike T and B cells, NK cells are not thought to require priming in lymphoid organs. Mujal et al. demonstrate that the spleen supports enhanced expa...
www.cell.com
February 28, 2025 at 6:25 PM
Reposted by Alex Gitlin
Attempting to read the language of B cell and T cell receptor sequences to diagnose immunological diseases:
Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social.
Link: buff.ly/3QvxSVf
February 21, 2025 at 1:26 PM
Reposted by Alex Gitlin
Deep thanks to our many collaborators and all research participants. #immunology #science 🧪 @science.org @sarahhross.bsky.social

NIH funding was the lifeblood of this work, as it is for almost all biomedical discoveries and therapies in the U.S. @niaidnews.bsky.social
February 21, 2025 at 1:27 PM
Hi everyone! Our team, the Cell Cyclers, are raising funds this year as part of #cycleforsurvival to support rare cancer research. 100% of donations will go to @mskcancercenter.bsky.social for this cause and are being matched dollar for dollar today! 🙏To donate:
secure2.convio.net/mskcc/site/T...
secure2.convio.net
February 4, 2025 at 11:33 PM
Reposted by Alex Gitlin
I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report:

Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036
December 12, 2024 at 7:05 PM
Reposted by Alex Gitlin
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 6:57 PM
Reposted by Alex Gitlin
If you are interested in pursuing a PhD in biomedical sciences in New York City, it is still time to apply to the BCMB program run jointly by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center ! Deadline: Dec 1, 2024.
November 22, 2024 at 4:37 PM
Reposted by Alex Gitlin
This is a very cool paper that I will add to my Mol Bio course. Specific tRNA recruitment of mRNA degradation complex to ribosome through the P site tRNA interactions with CCR4-NOT complex 1/ www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 21, 2024 at 8:03 PM
Reposted by Alex Gitlin

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
November 20, 2024 at 10:46 AM
Reposted by Alex Gitlin
Our latest issue dropped. On the cover, the developmental biology of #dogs (and other mammal) noses!

🐶🧪

👉https://www.cell.com/current-biology/issue?pii=S0960-9822(23)X0023-2
November 19, 2024 at 4:17 PM
Reposted by Alex Gitlin
radioactive gRNAs? could they enhance mutagenesis ... did anyone try this?!?
November 19, 2024 at 2:27 PM