First time on Bsky and first big announcement!

I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.

Our manuscript is here: www.nature.com/articles/s41....

When do machine learning models actually outperform standard polygenic scores? 🤔

In our new preprint, we benchmark how non-additive genetic effects (i.e, dominance deviations) shape polygenic prediction across simulated and UK Biobank traits.

👉 www.medrxiv.org/content/10.1...

🧵 1/6

Some recent work led by @peterjonghona.bsky.social and myself at @yaleschoolofmed.bsky.social looks at environmental, psychiatric, and genetic predictors of alcohol use disorder.

Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):

psychiatryonline.org/doi/10.1176/...

I'm looking for a PhD student to do some trailblazing at the frontier of personality genomics and lifespan gene-environment transactions (start Fall 2026)! If you want to work with me: psychology.msu.edu/graduatestud...
(PS @drmeltemyucel.bsky.social is taking a student too, in moral psych/dev!)

Now on CRAN, ggdiagram is a #ggplot2 extension that draws diagrams programmatically in #Rstats. Allows for precise control in how objects, labels, and equations are placed in relation to each other.
wjschne.github.io/ggdiagram/ar...

The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits

Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n

Examining the sensitivity for environmental influences by conducting a GWAS on differences between identical twins - very clever design!

Out now in @nathumbehav.nature.com : www.nature.com/articles/s41...

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...

(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

New study from the @pgcgenetics.bsky.social:

Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.

www.cell.com/cell/fulltex...

Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...

Finally, the DDD outcomes paper is fully published - it took many people and many years, but we definitely had an impact on patient care! Genetic diagnoses changed management for >28% of patients, and connected families with support groups, key resources, and reproductive counseling bit.ly/3Zy0Dpq

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣

Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

Just posting this to #popgen
Here's a link to my notes on population & quantitative genetics:
github.com/cooplab/popg...
Hoping to extend it more after the winter holidays, as I'm just finishing up teaching the undergrad version of class.

Lots of new arrivals in the psychiatric and statistical genetics starterpack, time to browse it again to find your old friends go.bsky.app/9643dwo