Vini John
@vjohn07.bsky.social
Post-doc at Frey lab @ CHLA. Interested in studying mucosal immunity.
Reposted by Vini John
Time for the August episode of the #MucosalMonday MI Podcast featuring a discussion with @michael-silverman.bsky.social, @marionbrunck.bsky.social, and Agnes Garcias Lopez; Medical mystery from @ashu-mangalam.bsky.social; and MI research with @kknoop.bsky.social open.spotify.com/show/0Q4Ve1x...
Timing Exposure to Microbes
open.spotify.com
August 25, 2025 at 7:34 PM
Time for the August episode of the #MucosalMonday MI Podcast featuring a discussion with @michael-silverman.bsky.social, @marionbrunck.bsky.social, and Agnes Garcias Lopez; Medical mystery from @ashu-mangalam.bsky.social; and MI research with @kknoop.bsky.social open.spotify.com/show/0Q4Ve1x...
Reposted by Vini John
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling in this work from @saraalonsomera.bsky.social @edelblumlab.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...
August 13, 2025 at 3:54 PM
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling in this work from @saraalonsomera.bsky.social @edelblumlab.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...
Reposted by Vini John
🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
July 31, 2025 at 3:00 PM
🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
Reposted by Vini John
It’s great to hear about the various career paths in the #RegenerativeMedicine field—from R&D and lab work to policy and #SciComms. Thank you to our panelists for sharing their experiences and insights. #CIRMTraineeConference
July 28, 2025 at 5:26 PM
It’s great to hear about the various career paths in the #RegenerativeMedicine field—from R&D and lab work to policy and #SciComms. Thank you to our panelists for sharing their experiences and insights. #CIRMTraineeConference
Reposted by Vini John
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice
#gdTcells @natcomms.nature.com
#gdTcells @natcomms.nature.com
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice - Nature Communications
Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meni...
www.nature.com
July 28, 2025 at 9:52 AM
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice
#gdTcells @natcomms.nature.com
#gdTcells @natcomms.nature.com
Reposted by Vini John
The perfect end to a great #gammadeltatoronto conference: our latest review has just been published in Advances in Immunology!
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
May 23, 2025 at 8:37 PM
The perfect end to a great #gammadeltatoronto conference: our latest review has just been published in Advances in Immunology!
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
Reposted by Vini John
Reposted by Vini John
Secretory IgM regulates gut microbiota homeostasis and metabolism @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology
Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.
www.nature.com
May 23, 2025 at 5:03 PM
Secretory IgM regulates gut microbiota homeostasis and metabolism @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vini John
We’re excited to share our recently published story
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing
The intestine is a semipermeable tissue responsible for the absorption of essential
nutrients while limiting exposure to harmful environmental factors. To maintain these
functions, the intestinal epit...
www.mucosalimmunology.org
May 14, 2025 at 8:17 PM
We’re excited to share our recently published story
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
Check out this paper on the role of ACC1 in γδT17 cells in vivo in a psoriatic mouse model #gdtcells
I am so excited to share our new publication on Nature Metabolism about the metabolic reprogramming in gamma delta T cells in response to inflammation.
#gdt #immunometabolism
Thanks for my research team in groups of @timsparwasser.bsky.social in Germany and Princeton @lydialynch.bsky.social 🙌🏻
#gdt #immunometabolism
Thanks for my research team in groups of @timsparwasser.bsky.social in Germany and Princeton @lydialynch.bsky.social 🙌🏻
May 14, 2025 at 5:45 AM
Check out this paper on the role of ACC1 in γδT17 cells in vivo in a psoriatic mouse model #gdtcells
Reposted by Vini John
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
www.nature.com/articles/s41...
@natimmunol.bsky.social
www.nature.com/articles/s41...
@natimmunol.bsky.social
May 6, 2025 at 10:46 PM
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
www.nature.com/articles/s41...
@natimmunol.bsky.social
www.nature.com/articles/s41...
@natimmunol.bsky.social
If you are at #AAI25 in Hawaii and interested in learning about intestinal epithelial and IEL crosstalk. Please do stop by my poster # 1107 today from 10:30-11:45am.
Session Title: MUC6P -Regulation of Mucosal Immunity.
@squeakyanimal.bsky.social #Immunology2025
Session Title: MUC6P -Regulation of Mucosal Immunity.
@squeakyanimal.bsky.social #Immunology2025
May 6, 2025 at 6:33 PM
If you are at #AAI25 in Hawaii and interested in learning about intestinal epithelial and IEL crosstalk. Please do stop by my poster # 1107 today from 10:30-11:45am.
Session Title: MUC6P -Regulation of Mucosal Immunity.
@squeakyanimal.bsky.social #Immunology2025
Session Title: MUC6P -Regulation of Mucosal Immunity.
@squeakyanimal.bsky.social #Immunology2025
Reposted by Vini John
The Parse team is presenting one more scientific poster this morning at @aai.org! Meet us at board 1187 at 10:30 to learn about how Evercode technology as the only all-in-one solution for humanized transgenic mice.
www.parsebiosciences.com/aai-2025/
www.parsebiosciences.com/aai-2025/
May 6, 2025 at 5:54 PM
The Parse team is presenting one more scientific poster this morning at @aai.org! Meet us at board 1187 at 10:30 to learn about how Evercode technology as the only all-in-one solution for humanized transgenic mice.
www.parsebiosciences.com/aai-2025/
www.parsebiosciences.com/aai-2025/
Reposted by Vini John
1/ My group is at #IMMUNOLOGY2025 presenting our research. For those of you following along from home I want to share 1 min videos of each presenting their posters. @PaigeSHansen did an incredible job here presenting her about Lyme disease and gynepathologies.
May 6, 2025 at 8:51 AM
1/ My group is at #IMMUNOLOGY2025 presenting our research. For those of you following along from home I want to share 1 min videos of each presenting their posters. @PaigeSHansen did an incredible job here presenting her about Lyme disease and gynepathologies.
Reposted by Vini John
May 4, 2025 at 9:20 PM
Reposted by Vini John
Aloha!🌺 Super excited for another year at #Immunology2025 representing the Chu Lab👩🏻🔬 @chulab.bsky.social
This time I’ll be sharing the induction of pro-inflammatory responses by B. fragilis isolated from an IBD patient👀
Want to hear all about it? Stop by poster #1046☕️
#LatinaInSTEM
This time I’ll be sharing the induction of pro-inflammatory responses by B. fragilis isolated from an IBD patient👀
Want to hear all about it? Stop by poster #1046☕️
#LatinaInSTEM
May 3, 2025 at 8:10 PM
Aloha!🌺 Super excited for another year at #Immunology2025 representing the Chu Lab👩🏻🔬 @chulab.bsky.social
This time I’ll be sharing the induction of pro-inflammatory responses by B. fragilis isolated from an IBD patient👀
Want to hear all about it? Stop by poster #1046☕️
#LatinaInSTEM
This time I’ll be sharing the induction of pro-inflammatory responses by B. fragilis isolated from an IBD patient👀
Want to hear all about it? Stop by poster #1046☕️
#LatinaInSTEM
Reposted by Vini John
Can't make it to #IMMUNOLOGY2025?
Brenda and Jason will be recording from Honolulu to keep you up to date!🎙️
Our first daily episode will be released on May 4. Stay tuned!
#AAI2025
Brenda and Jason will be recording from Honolulu to keep you up to date!🎙️
Our first daily episode will be released on May 4. Stay tuned!
#AAI2025
May 2, 2025 at 5:58 PM
Can't make it to #IMMUNOLOGY2025?
Brenda and Jason will be recording from Honolulu to keep you up to date!🎙️
Our first daily episode will be released on May 4. Stay tuned!
#AAI2025
Brenda and Jason will be recording from Honolulu to keep you up to date!🎙️
Our first daily episode will be released on May 4. Stay tuned!
#AAI2025
Reposted by Vini John
Excited to participate in the 2025 annual American Association of Immunologists meeting in Honolulu 🏝️
Looking forward to seeing my colleagues and learning about the latest advances in immunology.
#AAI2025 and #Immunology2025
@aai.org
Looking forward to seeing my colleagues and learning about the latest advances in immunology.
#AAI2025 and #Immunology2025
@aai.org
May 2, 2025 at 4:04 PM
Excited to participate in the 2025 annual American Association of Immunologists meeting in Honolulu 🏝️
Looking forward to seeing my colleagues and learning about the latest advances in immunology.
#AAI2025 and #Immunology2025
@aai.org
Looking forward to seeing my colleagues and learning about the latest advances in immunology.
#AAI2025 and #Immunology2025
@aai.org
Reposted by Vini John
ICOS+CD4 T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis
@jci-insight.bsky.social
insight.jci.org/articles/vie...
@jci-insight.bsky.social
insight.jci.org/articles/vie...
April 8, 2025 at 4:59 PM
ICOS+CD4 T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis
@jci-insight.bsky.social
insight.jci.org/articles/vie...
@jci-insight.bsky.social
insight.jci.org/articles/vie...
Reposted by Vini John
Heading to #IMMUNOLOGY2025™? Want to maximize your experience? Join our webinar for insider tips on scientific highlights, networking in our new MHC collaboration zones, social events, and more. Register now and ask your questions live: ow.ly/veEt50Vv9Iq. #Immunology
April 5, 2025 at 3:07 PM
Heading to #IMMUNOLOGY2025™? Want to maximize your experience? Join our webinar for insider tips on scientific highlights, networking in our new MHC collaboration zones, social events, and more. Register now and ask your questions live: ow.ly/veEt50Vv9Iq. #Immunology
Reposted by Vini John
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
www.nature.com
April 4, 2025 at 2:09 AM
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Reposted by Vini John
#APS2025 starts in three weeks! We're excited to share some programming highlights, including our #NobelLaureate and prestigious award winners who are keynote speakers, and our game-changer sessions. Read more: ow.ly/Re2950VtNTa #WeArePhysiology🧪
April 3, 2025 at 4:00 PM
#APS2025 starts in three weeks! We're excited to share some programming highlights, including our #NobelLaureate and prestigious award winners who are keynote speakers, and our game-changer sessions. Read more: ow.ly/Re2950VtNTa #WeArePhysiology🧪
Super proud of my former lab mate and friend. It’s been amazing to witness this journey from the very beginning to the grand finale hehehe. Thrilled to be a part of it-Congratulations, Sree! ☺️ 🎉🎉🎉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
www.nature.com
April 1, 2025 at 8:06 PM
Super proud of my former lab mate and friend. It’s been amazing to witness this journey from the very beginning to the grand finale hehehe. Thrilled to be a part of it-Congratulations, Sree! ☺️ 🎉🎉🎉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vini John
📣 New preprint drop! In #ScienceImmunology, we found that regulatory #CD39 γδ IELs are reduced in #IBD, now @saraalonsomera.bsky.social shows that gut #microbiota promote enhanced CD39 expression in γδ IELs through #TCR and IL-15 activation. #gdTcells #GIresearch #Gastrosky @sinaiimmuno.bsky.social
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling https://www.biorxiv.org/content/10.1101/2025.03.22.644616v1
March 26, 2025 at 2:26 PM
📣 New preprint drop! In #ScienceImmunology, we found that regulatory #CD39 γδ IELs are reduced in #IBD, now @saraalonsomera.bsky.social shows that gut #microbiota promote enhanced CD39 expression in γδ IELs through #TCR and IL-15 activation. #gdTcells #GIresearch #Gastrosky @sinaiimmuno.bsky.social
Reposted by Vini John
If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...
www.biorxiv.org
March 25, 2025 at 8:15 PM
If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!