Vangeli Geshkovski
@vgeshkovski.bsky.social
Postdoc at The Sainsbury Lab | Nobori Group | chromatin & immunity 👨🔬🌱🧬🦠 PhD from CEA/LPCV Grenoble
Reposted by Vangeli Geshkovski
Please share, deadline approaching soon!
The 2026 plant science conference travel award program is open!
Awards are given to student/mentor pairs.
At lease one of the pair must be a member of SACNAS or MANRRS or AISES.
Please share, applications due by Dec 5, 2025.
@sacnas.bsky.social
rootandshoot.org/2026-root-sh...
Awards are given to student/mentor pairs.
At lease one of the pair must be a member of SACNAS or MANRRS or AISES.
Please share, applications due by Dec 5, 2025.
@sacnas.bsky.social
rootandshoot.org/2026-root-sh...
November 10, 2025 at 9:27 PM
Please share, deadline approaching soon!
Reposted by Vangeli Geshkovski
Conrad Hal Waddington was born OTD in 1905.
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
November 8, 2025 at 4:03 PM
Reposted by Vangeli Geshkovski
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Vangeli Geshkovski
It is possible to recognise that Watson's treatment of Franklin was despicable and at the same time to acknowledge that Matthew is right.
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
November 8, 2025 at 10:25 AM
It is possible to recognise that Watson's treatment of Franklin was despicable and at the same time to acknowledge that Matthew is right.
Reposted by Vangeli Geshkovski
Reposted by Vangeli Geshkovski
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 7, 2025 at 9:25 PM
On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...
Reposted by Vangeli Geshkovski
Looking for a good read?
@tatsuyanobori.bsky.social is featured on The Scientist sharing his scientific journey from Japan to the UK.
“It circles back to my initial ecological interest and how single-cell level interactions might have a ripple effect on the actual ecosystem."
@tatsuyanobori.bsky.social is featured on The Scientist sharing his scientific journey from Japan to the UK.
“It circles back to my initial ecological interest and how single-cell level interactions might have a ripple effect on the actual ecosystem."
Living Maps: Uncovering the Spatial Biology of Plants
Tatsuya Nobori brings high-resolution multiomic approaches to plant biology to map how plants interact with microbes on a cellular level in 3D.
www.the-scientist.com
November 6, 2025 at 6:03 PM
Looking for a good read?
@tatsuyanobori.bsky.social is featured on The Scientist sharing his scientific journey from Japan to the UK.
“It circles back to my initial ecological interest and how single-cell level interactions might have a ripple effect on the actual ecosystem."
@tatsuyanobori.bsky.social is featured on The Scientist sharing his scientific journey from Japan to the UK.
“It circles back to my initial ecological interest and how single-cell level interactions might have a ripple effect on the actual ecosystem."
Reposted by Vangeli Geshkovski
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Vangeli Geshkovski
Promising epigenome editing paper by the @c-jake-harris.bsky.social lab! www.nature.com/articles/s41...
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis - Nature Communications
Binenbaum et al. demonstrate that precise CRISPR-based targeting of a key chromatin mark (H3K4me3) can switch on genes, boost disease resistance, and unlock meiotic recombination in plants, opening ne...
www.nature.com
November 4, 2025 at 2:12 PM
Promising epigenome editing paper by the @c-jake-harris.bsky.social lab! www.nature.com/articles/s41...
Reposted by Vangeli Geshkovski
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Origins of the Lab Mouse
How the mouse found its way from Victorian novelty to a biomedical mainstay.
www.asimov.press
November 3, 2025 at 6:25 PM
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Reposted by Vangeli Geshkovski
Actually not true. He applied twice, but the first was for $30k. Which he got. He only applied once for *major* funding ($6m – around $20m today). he got $900k, still pretty good.
November 3, 2025 at 5:47 PM
Actually not true. He applied twice, but the first was for $30k. Which he got. He only applied once for *major* funding ($6m – around $20m today). he got $900k, still pretty good.
Reposted by Vangeli Geshkovski
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 1:55 PM
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
"he applied for a grant only once in his life"
Terrific review of CRICK by Georgina Ferry in this week's @nature.com (the print title of the review is less clickbaity):
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
A thoroughly researched account of the history and relationships that shaped the scientist who co-discovered the structure of DNA.
www.nature.com
November 3, 2025 at 4:42 PM
"he applied for a grant only once in his life"
Reposted by Vangeli Geshkovski
#plantjob If you are interested on the evolution of plant-microbe interactions and have a PhD degree obtained between 1st January 2024 and 31st December 2025, come join us and apply to the "Juan de la Cierva" postdoctoral contracts!. Drop a mail with your CV + motivation letter!
November 3, 2025 at 11:20 AM
#plantjob If you are interested on the evolution of plant-microbe interactions and have a PhD degree obtained between 1st January 2024 and 31st December 2025, come join us and apply to the "Juan de la Cierva" postdoctoral contracts!. Drop a mail with your CV + motivation letter!
Reposted by Vangeli Geshkovski
My article in tomorrow's @theobserveruk.bsky.social now online. But go and buy a copy!
Francis Crick: The science genius with poetry in his DNA
He is celebrated for co‑discovering the double helix, but it was Crick’s poetic appreciation of the world that was key to how his mind worked
observer.co.uk
November 1, 2025 at 11:37 AM
My article in tomorrow's @theobserveruk.bsky.social now online. But go and buy a copy!
Reposted by Vangeli Geshkovski
It‘s not officially out for another week (2 weeks in the US), but some copies have escaped into the wild! Happy reading!
It's a big one @matthewcobb.bsky.social; can't wait to read it! Thanks @turchil.bsky.social for the birthday gift 🤓
October 31, 2025 at 5:52 PM
It‘s not officially out for another week (2 weeks in the US), but some copies have escaped into the wild! Happy reading!
It's a big one @matthewcobb.bsky.social; can't wait to read it! Thanks @turchil.bsky.social for the birthday gift 🤓
October 31, 2025 at 5:40 PM
It's a big one @matthewcobb.bsky.social; can't wait to read it! Thanks @turchil.bsky.social for the birthday gift 🤓
Reposted by Vangeli Geshkovski
1/ 🚀 AEBP2 isn’t what we thought.
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
October 31, 2025 at 10:53 AM
1/ 🚀 AEBP2 isn’t what we thought.
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
Reposted by Vangeli Geshkovski
When all your PCRs fail, except for the negative control 😱
October 30, 2025 at 7:43 PM
When all your PCRs fail, except for the negative control 😱
Reposted by Vangeli Geshkovski
Spooky season has arrived! 👻
We held our annual Pumpkin Carving Competition at @thesainsburylab.bsky.social —vote for your favourite carve! 🎃🕯️
We held our annual Pumpkin Carving Competition at @thesainsburylab.bsky.social —vote for your favourite carve! 🎃🕯️
October 30, 2025 at 11:15 AM
Spooky season has arrived! 👻
We held our annual Pumpkin Carving Competition at @thesainsburylab.bsky.social —vote for your favourite carve! 🎃🕯️
We held our annual Pumpkin Carving Competition at @thesainsburylab.bsky.social —vote for your favourite carve! 🎃🕯️
Reposted by Vangeli Geshkovski
Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!
Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates
Nature Communications - Here, the authors investigate chromatin-based gene regulation in the closest relative of animal, choanoflagellates. They uncover a putative dual role for the histone...
rdcu.be
October 29, 2025 at 1:40 PM
Very happy to see our paper published online natcomms.nature.com. Thank you to @wellcometrust.bsky.social for funding this work during my time with @robklose.bsky.social and David Booth! Thanks also to collaborators @garcialabms.bsky.social @alexdemendoza.bsky.social and the other authors!
Reposted by Vangeli Geshkovski
Very excited to announce that our collaborative manifesto for 🌱 #PlantScience #Education has now been published! Educators from >10 countries and 30 institutions have contributed to it and we are incredibly proud of the final output. Here is a short thread 🧵1/4 doi.org/10.1002/ppp3...
A manifesto for plant science education
Plants provide oxygen, food, shelter, medicines and environmental services, without which human society could not exist. Tackling pressing and global challenges requires well-trained plant scientists....
doi.org
October 29, 2025 at 9:09 AM
Very excited to announce that our collaborative manifesto for 🌱 #PlantScience #Education has now been published! Educators from >10 countries and 30 institutions have contributed to it and we are incredibly proud of the final output. Here is a short thread 🧵1/4 doi.org/10.1002/ppp3...
Reposted by Vangeli Geshkovski
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Vangeli Geshkovski
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
Reposted by Vangeli Geshkovski
In 1911, Impressionist painter Mary Cassatt was diagnosed with cataracts, where lenses in the eye become clouded with protein deposits as we age.
A failed cataract surgery left her essentially blind. Her last painting was 1914.
Claude Monet was diagnosed with cataracts in 1912...
A failed cataract surgery left her essentially blind. Her last painting was 1914.
Claude Monet was diagnosed with cataracts in 1912...
October 28, 2025 at 1:03 AM
In 1911, Impressionist painter Mary Cassatt was diagnosed with cataracts, where lenses in the eye become clouded with protein deposits as we age.
A failed cataract surgery left her essentially blind. Her last painting was 1914.
Claude Monet was diagnosed with cataracts in 1912...
A failed cataract surgery left her essentially blind. Her last painting was 1914.
Claude Monet was diagnosed with cataracts in 1912...