Toril Holien
@torilhol.bsky.social
Prof. Cell & molecular biology. Educating biomedical scientists. Myeloma. TGFbeta. Cell signaling. Cancer. @NTNU Norway. She/Her 🧪🧬🩸🔬 Orcid: https://orcid.org/my-orcid?orcid=0000-0002-2051-5824
Reposted by Toril Holien
European Respiratory Journal: The activin signalling inhibitor sotatercept may transform PAH therapy by targeting pulmonary vascular remodelling, but unique safety risks demand careful monitoring https://bit.ly/3UBsPVj
October 17, 2025 at 11:45 AM
European Respiratory Journal: The activin signalling inhibitor sotatercept may transform PAH therapy by targeting pulmonary vascular remodelling, but unique safety risks demand careful monitoring https://bit.ly/3UBsPVj
Reposted by Toril Holien
BMP9 enhances osteogenic differentiation in rheumatoid arthritis. BMP9 is down-regulated in synovial tissue of RA patients. In arthritis mice model BMP9 enhances osteogenic differentiation of synovial cells. Han Zhang et al. J Transl Med 2025 Feb 28 tinyurl.com/y65xbekk
March 3, 2025 at 9:12 AM
BMP9 enhances osteogenic differentiation in rheumatoid arthritis. BMP9 is down-regulated in synovial tissue of RA patients. In arthritis mice model BMP9 enhances osteogenic differentiation of synovial cells. Han Zhang et al. J Transl Med 2025 Feb 28 tinyurl.com/y65xbekk
Reposted by Toril Holien
BMP9 regulates the endothelial secretome to drive pulmonary hypertension https://www.biorxiv.org/content/10.1101/2025.08.29.673113v1
September 5, 2025 at 1:03 AM
BMP9 regulates the endothelial secretome to drive pulmonary hypertension https://www.biorxiv.org/content/10.1101/2025.08.29.673113v1
Our preprint is out! We induced apoptosis in myeloma cells with BMP9 and did a whole genome KO screen to find regulators of apoptosis (and BMP-SMAD signaling). ID3 induced by SMAD activity inhibited TCF3 and induced apoptosis.
This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇
This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇
Whole genome CRISPR knockout screen reveals ID3 as a key regulator of myeloma cell survival via TCF3 and c-MYC https://www.biorxiv.org/content/10.1101/2025.09.09.675036v1
September 17, 2025 at 7:47 PM
Our preprint is out! We induced apoptosis in myeloma cells with BMP9 and did a whole genome KO screen to find regulators of apoptosis (and BMP-SMAD signaling). ID3 induced by SMAD activity inhibited TCF3 and induced apoptosis.
This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇
This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇
Reposted by Toril Holien
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...
#Reproducibility
#Reproducibility
September 3, 2025 at 2:15 PM
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...
#Reproducibility
#Reproducibility
Reposted by Toril Holien
Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...
August 25, 2025 at 3:25 PM
Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...
Reposted by Toril Holien
SMAD7: riding on fibrosis-limiting routes and beyond
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
SMAD7: riding on fibrosis-limiting routes and beyond | EMBO Molecular Medicine
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
August 8, 2025 at 7:30 PM
SMAD7: riding on fibrosis-limiting routes and beyond
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Nice work! Temporal patterns of genomic evolution in multiple myeloma showing importance of timing of events for progression and prognosis. #myeloma #multiplemyeloma #hemesky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Temporal genomic dynamics shape clinical trajectory in multiple myeloma - Nature Genetics
This analysis of whole-genome sequencing data from 421 multiple myeloma samples elucidates the timing of key genomic events and shows associations between the timing of 1q gain and clinical outcome.
www.nature.com
August 24, 2025 at 7:44 AM
Nice work! Temporal patterns of genomic evolution in multiple myeloma showing importance of timing of events for progression and prognosis. #myeloma #multiplemyeloma #hemesky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Toril Holien
GCK inhibition induces IKZF1 degradation through a CRBN-independent mechanism in MM. buff.ly/B79qqYd #hemesky
August 22, 2025 at 9:00 PM
GCK inhibition induces IKZF1 degradation through a CRBN-independent mechanism in MM. buff.ly/B79qqYd #hemesky
📣 Save the date 📣
The next FASEB Science Research Conference on TGF-β Family in Development and Disease will take place:
July 26-30, 2026 in Porto, Portugal!
@faseborg.bsky.social
With Mythreye Karthikeyan @mythreye.bsky.social, Rosemary Akhurst and Andrew Hinck
web.cvent.com/event/af5f6d...
The next FASEB Science Research Conference on TGF-β Family in Development and Disease will take place:
July 26-30, 2026 in Porto, Portugal!
@faseborg.bsky.social
With Mythreye Karthikeyan @mythreye.bsky.social, Rosemary Akhurst and Andrew Hinck
web.cvent.com/event/af5f6d...
August 23, 2025 at 12:06 PM
📣 Save the date 📣
The next FASEB Science Research Conference on TGF-β Family in Development and Disease will take place:
July 26-30, 2026 in Porto, Portugal!
@faseborg.bsky.social
With Mythreye Karthikeyan @mythreye.bsky.social, Rosemary Akhurst and Andrew Hinck
web.cvent.com/event/af5f6d...
The next FASEB Science Research Conference on TGF-β Family in Development and Disease will take place:
July 26-30, 2026 in Porto, Portugal!
@faseborg.bsky.social
With Mythreye Karthikeyan @mythreye.bsky.social, Rosemary Akhurst and Andrew Hinck
web.cvent.com/event/af5f6d...
Reposted by Toril Holien
Elskar når folk som ikkje anar noko om landbruk skal romantisere denne livsstilen, og så lage tv av at dei ikkje er førebudd på det betyr å vere bonde. Då blir det rør. Heggdal er god til å rydde opp.
Øystein Heggdal med voksenopplæring til Jon Almaas og drømmerier om at økologisk jordbruk er bedre for klode og mennesker www.nrk.no/ytring/jon-b...
Jon blir aktivist
Når Jon Almaas blander seg i politikken, går det helt i surr.
www.nrk.no
August 17, 2025 at 4:00 PM
Elskar når folk som ikkje anar noko om landbruk skal romantisere denne livsstilen, og så lage tv av at dei ikkje er førebudd på det betyr å vere bonde. Då blir det rør. Heggdal er god til å rydde opp.
Reposted by Toril Holien
Vi må ta kampen mot brøl-apene som maksimerer utnyttelsen av urimelige konflikter, gjennom sort-hull effektene på vår oppmerksomhet. Men hvordan? Her er iallefall bilde av rett person @froyasjursaether.bsky.social
August 7, 2025 at 9:47 AM
Vi må ta kampen mot brøl-apene som maksimerer utnyttelsen av urimelige konflikter, gjennom sort-hull effektene på vår oppmerksomhet. Men hvordan? Her er iallefall bilde av rett person @froyasjursaether.bsky.social
Reposted by Toril Holien
Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)
July 28, 2025 at 8:36 AM
Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)
Reposted by Toril Holien
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Reposted by Toril Holien
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 20, 2025 at 7:39 PM
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Toril Holien
Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels.
July 19, 2025 at 8:46 AM
Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels.
Reposted by Toril Holien
I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
July 18, 2025 at 3:30 AM
I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
Reposted by Toril Holien
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
July 17, 2025 at 1:25 AM
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Toril Holien
Cells size variation is often an important factor to consider when thinking about the biological scales & mechanisms.
It's also also a relevant technical factor when analyzing omics data www.nature.com/articles/s41...
It's also also a relevant technical factor when analyzing omics data www.nature.com/articles/s41...
July 16, 2025 at 2:49 PM
Cells size variation is often an important factor to consider when thinking about the biological scales & mechanisms.
It's also also a relevant technical factor when analyzing omics data www.nature.com/articles/s41...
It's also also a relevant technical factor when analyzing omics data www.nature.com/articles/s41...
July 12, 2025 at 9:42 PM
Reposted by Toril Holien
Now that we can assay thousands of plasma proteins in 1-2 ml of blood, there's discovery and validation of many new cancer biomarkers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer biomarkers discovered using pan-cancer plasma proteomic profiling - Nature Biomedical Engineering
Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.
www.nature.com
July 2, 2025 at 4:13 PM
Now that we can assay thousands of plasma proteins in 1-2 ml of blood, there's discovery and validation of many new cancer biomarkers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Toril Holien
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
The Somatic Mosaicism across Human Tissues Network - Nature
The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
nature.com
July 2, 2025 at 4:21 PM
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
July 5, 2025 at 10:02 PM
Reposted by Toril Holien
