@tony-li-sf.bsky.social
Reposted
Our work developing a parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording is now out @natbiotech.nature.com
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - Nature Biotechnology
Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.
go.nature.com
November 12, 2025 at 6:06 PM
Our work developing a parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording is now out @natbiotech.nature.com
Reposted
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - Nature Biotechnology
Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.
go.nature.com
November 11, 2025 at 4:36 PM
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
Reposted
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
November 4, 2025 at 3:10 PM
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
Reposted
Jay Shendure elected to National Academy of Medicine
newsroom.uw.edu/blog/jay-she...
newsroom.uw.edu/blog/jay-she...
Jay Shendure elected to National Academy of Medicine - UW Medicine | Newsroom
newsroom.uw.edu
October 28, 2025 at 3:17 PM
Jay Shendure elected to National Academy of Medicine
newsroom.uw.edu/blog/jay-she...
newsroom.uw.edu/blog/jay-she...
Reposted
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
www.science.org
August 21, 2025 at 5:13 PM
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
So proud of my lab students Tiffany and Amanda for winning the Roman Scholarship from @uwgenome.bsky.social! I always love the story about how yeast genetics got its start at UW because corn wouldn’t grow in Seattle www.gs.washington.edu/about/histor...
50 Years of Genetics at the UW
www.gs.washington.edu
August 15, 2025 at 2:34 AM
So proud of my lab students Tiffany and Amanda for winning the Roman Scholarship from @uwgenome.bsky.social! I always love the story about how yeast genetics got its start at UW because corn wouldn’t grow in Seattle www.gs.washington.edu/about/histor...
Reposted
Capture C identifies promoter interacting sequences. MPRA tests sequences for regulatory activity. Here, we combined them both to test sequences with their target promoter. Amazing work by @colinearnould.bsky.social, Pia Keukeleire, Martin Kircher and many others.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Capture-C MPRA: A high-throughput method to simultaneously characterize promoter interactions and regulatory activity
Cis regulatory elements (CREs) interact with their target promoters over long genomic distances and can be identified using chromatin conformation capture (3C) assays. Their regulatory activity can be...
www.biorxiv.org
June 15, 2025 at 6:29 PM
Capture C identifies promoter interacting sequences. MPRA tests sequences for regulatory activity. Here, we combined them both to test sequences with their target promoter. Amazing work by @colinearnould.bsky.social, Pia Keukeleire, Martin Kircher and many others.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com
June 5, 2025 at 2:15 PM
Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com
Reposted
Happy to share our new review on molecular circuits for genomic recording with @chenomics.bsky.social! Here, we present our views on the remaining challenges in the field of genomic recording for reconstructing cell-fate decisions. (1/2)
Online now -- a new Review:
"Molecular circuits for genomic recording of cellular events"
by Wei Chen & Junhong Choi (@choijunhong.bsky.social)
FREE to read till June 25th using this link:
authors.elsevier.com/a/1l2gMcQbJF...
"Molecular circuits for genomic recording of cellular events"
by Wei Chen & Junhong Choi (@choijunhong.bsky.social)
FREE to read till June 25th using this link:
authors.elsevier.com/a/1l2gMcQbJF...
May 6, 2025 at 2:39 PM
Happy to share our new review on molecular circuits for genomic recording with @chenomics.bsky.social! Here, we present our views on the remaining challenges in the field of genomic recording for reconstructing cell-fate decisions. (1/2)
Reposted
I am hiring for a research technician role in my new lab at UC Irvine studying how transcription factors control cell identity. If you know any graduating undergrads or postbacs looking for a position, please spread the word! Apply by May 9 for full consideration. recruit.ap.uci.edu/JPF09594
Junior / Assistant Specialist: Kim Lab, Developmental & Cell Biology
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
April 25, 2025 at 4:55 AM
I am hiring for a research technician role in my new lab at UC Irvine studying how transcription factors control cell identity. If you know any graduating undergrads or postbacs looking for a position, please spread the word! Apply by May 9 for full consideration. recruit.ap.uci.edu/JPF09594
Reposted
I added the alt text for this very important message
March 7, 2025 at 11:57 PM
I added the alt text for this very important message