Takahiro Maeda
@tmhemonc.bsky.social
Physician scientist, hematology/oncology
https://precision.kyushu-u.ac.jp/en/
https://precision.kyushu-u.ac.jp/en/
Excited to share our new paper in Blood (@bloodjournals.hematology.org), where we explore how XPO7 (Exportin 7) and histone gene regulation intersect with p53 functional status in AML. Congrats to Yuichiro and the team! ashpublications.org/blood/articl...
November 1, 2025 at 5:30 AM
Excited to share our new paper in Blood (@bloodjournals.hematology.org), where we explore how XPO7 (Exportin 7) and histone gene regulation intersect with p53 functional status in AML. Congrats to Yuichiro and the team! ashpublications.org/blood/articl...
very intersting work!
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 11:20 PM
very intersting work!
An mRNA Crime | Science | AAAS www.science.org/content/blog...
An mRNA Crime
www.science.org
August 7, 2025 at 2:17 AM
An mRNA Crime | Science | AAAS www.science.org/content/blog...
A beautiful review by Stu Orkin—a true giant in transcriptional regulation, hematopoiesis, and sickle cell research!
Franklin H. Epstein Lecture: The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for mutant β-globin. Learn more in a new review: nej.md/455rPiJ
#MedSky
#MedSky
The Fetal-to-Adult Hemoglobin Switch — Mechanism and Therapy | NEJM
The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic
manipulation of BCL11A improves disease outcomes by turning γ-globin expression back
on to compensate for mutant β-...
nej.md
June 5, 2025 at 1:17 AM
A beautiful review by Stu Orkin—a true giant in transcriptional regulation, hematopoiesis, and sickle cell research!
Reposted by Takahiro Maeda
Mutations that stick: Unexpected discovery of molecular glue mimicry
Mutations that stick: Unexpected discovery of molecular glue mimicry
Recent elegant studies in Nature uncovered an unprecedented molecular glue-like mechanism of action for the preclinical drug UM171. This small molecule showed striking functional and structural similarities to brain-cancer mutations that prompt neomorphic protein interactions. This phenomenon of chemical-genetic convergence could be reverse-engineered to aid the rational design of induced proximity therapeutics.
dlvr.it
April 21, 2025 at 10:58 PM
Mutations that stick: Unexpected discovery of molecular glue mimicry
Reposted by Takahiro Maeda
A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...
Healing My Family’s Future
How genetics and IVF empowered a family to leave cancer behind.
press.asimov.com
March 17, 2025 at 12:38 AM
A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...
Reposted by Takahiro Maeda
While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support:
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 3:18 PM
While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support:
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Takahiro Maeda
A miniaturized #CRISPR system can edit DNA in monkey muscle, according to a new preprint.
A new ‘mini-CRISPR' flexes its editing power in monkey muscles
The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases
scim.ag
February 7, 2025 at 7:56 PM
A miniaturized #CRISPR system can edit DNA in monkey muscle, according to a new preprint.
Reposted by Takahiro Maeda
So proud of @katie-maurer.bsky.social and Cameron Park for showing the power of combining innovative #ML with what we call "Katie Intelligence" (our domain expert in the loop 👩🔬) for building impactful computational tools and applying them to obtain unexpected clinical insight!
Excited to share our work on cytotoxic CD8+ T cells in donor lymphocyte infusions for treatment of AML relapsed after HSCT, out today in @sciimmunology.bsky.social! Great working with @elhamazizi.bsky.social on this exciting area! www.science.org/doi/10.1126/...
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy
Response to donor lymphocyte infusion in AML is characterized by marrow immunological diversity and clonal expansion of CD8+ cytotoxic T cells.
www.science.org
January 24, 2025 at 8:49 PM
So proud of @katie-maurer.bsky.social and Cameron Park for showing the power of combining innovative #ML with what we call "Katie Intelligence" (our domain expert in the loop 👩🔬) for building impactful computational tools and applying them to obtain unexpected clinical insight!
Reposted by Takahiro Maeda
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 8:46 PM
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
Reposted by Takahiro Maeda
The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below!
go.bsky.app/EY3k2bE
go.bsky.app/EY3k2bE
November 20, 2024 at 3:17 PM
The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below!
go.bsky.app/EY3k2bE
go.bsky.app/EY3k2bE