Matthew Thompson
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thompsonlab-lyon.bsky.social
Matthew Thompson
@thompsonlab-lyon.bsky.social
Thompson Lab at Lyon College 🧬🧬🧬

Studying helicases, conjugative transfer, and genomics!
Reposted by Matthew Thompson
Weird word of the day: "kleptosquamy." The testate amoeba Awerintzewia cyclostoma steals scales from other amoeboid organisms to build its own shell. This one has robbed Quadrulella, Netzelia, various euglyphids, and even an Acanthocystis. Kleptosquamy! #amoebae #ProtistsOnSky #biology #nature
November 21, 2025 at 12:00 AM
Reposted by Matthew Thompson
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
rdcu.be
September 1, 2025 at 10:04 AM
Reposted by Matthew Thompson
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
Reposted by Matthew Thompson
27 simulations of capturing hundreds of lipid scrambling events reveal mechanisms of lipid translocation.

However, according to reviewers, more evidence is needed on outside-the-groove scramblase activity.
buff.ly/ehMBnBn
August 30, 2025 at 10:01 AM
Reposted by Matthew Thompson
Listed are some of the many NIH research training programs that were terminated! Together, these programs supported thousands of trainees, whose careers are now in limbo. Such a great loss for discovery and innovation. We must protect our next generation of scientists!
#HandsOffNIH #ProtectScience
We LOVE our trainees ! From @nihvigils.bsky.social today ❤️❤️
August 25, 2025 at 9:58 PM
Reposted by Matthew Thompson
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
Reposted by Matthew Thompson
Happy Birthday, Rosalind Franklin. She captured an X-ray diffraction image of DNA and stated that a helical structure was probable. Watson and Crick then created a detailed model based on her results. They initially received credit for the discovery and were awarded the Nobel Prize after her death.🧪
July 26, 2025 at 6:05 AM
Reposted by Matthew Thompson
I'm excited to share our new paper from @thompsonlab-lyon.bsky.social.
Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments url: academic.oup.com/nar/article/...
Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments
Abstract. G-quadruplex DNA structures (G4s) form within single-stranded DNA in nucleosome-free chromatin. G4s modulate gene expression and genomic stabilit
academic.oup.com
July 21, 2025 at 8:53 PM
Reposted by Matthew Thompson
It’s been 25 years since the UCSC Genome Browser launched. Nature profiles how the website remains an essential tool for navigating the genome and understanding its structure, function, and clinical impact. #Academicsky 🧬 🧪
’We couldn’t live without it’: the UCSC Genome Browser turns 25
After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.
go.nature.com
July 4, 2025 at 4:15 PM
Reposted by Matthew Thompson
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
July 2, 2025 at 5:01 PM
Reposted by Matthew Thompson
I'm excited that my first graduate student, @thompsonlab-lyon.bsky.social, is now Dr. Matthew Thompson! He's had a busy week with a first author paper accepted and his dissertation defense. Starting this fall, Dr. Thompson will be an Assistant Professor of Chemistry at Lyon College.
June 27, 2025 at 6:58 PM